当前位置： SCI文献检索 > Nutrients期刊下所有文献 > Somatotropic Axis and Obesity: Is There Any Role for the Mediterranean Diet?

Somatotropic Axis and Obesity: Is There Any Role for the Mediterranean Diet?

Abstract：

:Obesity is associated with reduced spontaneous and stimulated growth hormone (GH) secretion and basal insulin-like growth factor I (IGF-1) levels-which in turn is associated with increased prevalence of cardiovascular risk factors. The aim of this study was to investigate: (1) the association of somatotropic axis with cardiometabolic status; (2) the association of somatotropic axis with the Mediterranean diet and nutritional pattern in people with obesity. Cross-sectional observational study was carried out in 200 adult women, aged 36.98 ± 11.10 years with severe obesity (body mass index-BMI of 45.19 ± 6.30 kg/m2). The adherence to the Mediterranean diet and the total calorie intake was assessed. Anthropometric measurements, body composition and biochemical profile were determined along with Growth Hormone (GH)/Insulin like Growth Factor 1 (IGF-1) axis and insulin resistance (homeostatic model assessment for insulin resistance-HoMA-IR). The enrolled subjects were compared after being divided according to GH peak response and according to IGF-1 standard deviation scores (SDS). Derangements of GH peak were detected in 61.5% of studied patients while IGF-1 deficiency was detected in 71% of the population. Both blunted GH peak response and IGF-1 SDS were indicators of derangements of somatotropic axis and were associated with comparable results in terms of cardiometabolic sequelae. Both GH peak and IGF-1 levels were inversely associated with anthropometric and metabolic parameters. The adherence to the Mediterranean diet predicts GH peak response. Fatty liver index (FLI), fat mass (FM) and phase angle (PhA) were predictive factors of GH peak response as well. In conclusion derangements of somatotropic axis is associated with a worse cardiometabolic profile in people with obesity. A high adherence to the Mediterranean diet-and in particular protein intake-was associated with a better GH status.

journal_name

Nutrients

journal_title

Nutrients

authors

Muscogiuri G,Barrea L,Laudisio D,Di Somma C,Pugliese G,Salzano C,Colao A,Savastano S

doi

10.3390/nu11092228

subject

Has Abstract

pub_date

2019-09-16 00:00:00

issue

9

issn

2072-6643

pii

nu11092228

journal_volume

11

pub_type

杂志文章

相关文献

Nutrients文献大全
  • Serum fatty acid reference ranges: percentiles from a New Zealand national nutrition survey.

    abstract：:Serum fatty acids are increasingly used in cross-sectional surveys and cohort studies as biomarkers of dietary fat intake; however, it is currently difficult to judge whether an individual has low or high fatty acid status, or whether the distribution of fatty acids of a group of people is low or high due to a lack of...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu3010152

    authors： Bradbury KE,Skeaff CM,Crowe FL,Green TJ,Hodson L

    更新日期：2011-01-01 00:00:00

  • Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals.

    abstract：:Matcha Green Tea Powder contains a variety of active ingredients beneficial to health, such as tea catechins, lutein and vitamin K. It is also known that these ingredients confer benefits upon cognitive functions of elderly people. Therefore, we aimed to investigate the relationship between a daily supplementation of ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12123639

    authors： Sakurai K,Shen C,Ezaki Y,Inamura N,Fukushima Y,Masuoka N,Hisatsune T

    更新日期：2020-11-26 00:00:00

  • Food intake of Kansans over 80 years of age attending congregate meal sites.

    abstract：:As the population of the United States continues to age, it has become increasingly more important to recognize the food intake and eating habits of older adults. The objective of this study was to describe the food group intake, factors predicting food group intake, and the food choices of community-dwelling Kansans,...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu2121297

    authors： Weeden AM,Remig VM

    更新日期：2010-12-01 00:00:00

  • Identifying Interactions between Dietary Sodium, Potassium, Sodium-Potassium Ratios, and FGF5 rs16998073 Variants and Their Associated Risk for Hypertension in Korean Adults.

    abstract：:Hypertension is affected by both genetic and dietary factors. This study aimed to examine the interaction between dietary sodium/potassium intake, sodium-potassium ratios, and FGF5 rs16998073 and link these with increased risk for developing hypertension. Using data from the Health Examinee (HEXA) Study of the Korean ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12072121

    authors： Jeong H,Jin HS,Kim SS,Shin D

    更新日期：2020-07-17 00:00:00

  • Clustering of Excess Body Weight-Related Behaviors in a Sample of Brazilian Adolescents.

    abstract：:The aim of the study was to identify the existence of clusters in multiple lifestyle behaviors, including consumption of fruits/vegetables, sugary products/soft drinks, physical activity and sedentary behavior. The association between identified clusters and excess body weight in a sample of adolescents from Dourados,...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10101505

    authors： de Souza Dantas M,Dos Santos MC,Lopes LAF,Guedes DP,Guedes MRA,Oesterreich SA

    更新日期：2018-10-15 00:00:00

  • Adverse Impact of Desulfovibrio spp. and Beneficial Role of Anaerostipes spp. on Renal Function: Insights from a Mendelian Randomization Analysis.

    abstract：BACKGROUND:The microbiota composition is now considered as one of the main modifiable risk factors for health. No controlled study has been performed on the association between microbiota composition and renal function. We applied Mendelian randomization (MR) to estimate the casual impact of eight microbiota genera on ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12082216

    authors： Mazidi M,Shekoohi N,Covic A,Mikhailidis DP,Banach M

    更新日期：2020-07-25 00:00:00

  • Dietary Fiber and Its Source Are Associated with Cardiovascular Risk Factors in Korean Adults.

    abstract：:We examined the associations of dietary fiber and its source with cardiovascular risk factors in Korean adults. This cross-sectional study involved 16,792 adults from the 2013-2018 Korea National Health and Nutrition Examination Survey data. Dietary data were obtained using a 24 h recall method and used to evaluate in...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu13010160

    authors： Song S,Song Y

    更新日期：2021-01-06 00:00:00

  • Impact of Donor Human Milk in the Preterm Very Low Birth Weight Gut Transcriptome Profile by Use of Exfoliated Intestinal Cells.

    abstract：BACKGROUND:Own mother's milk (OMM) is the optimal nutrition for preterm infants. However, pasteurized donor human milk (DHM) is a valid alternative. We explored the differences of the transcriptome in exfoliated epithelial intestinal cells (EEIC) of preterm infants receiving full feed with OMM or DHM. METHODS:The pros...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11112677

    authors： Parra-Llorca A,Gormaz M,Lorente-Pozo S,Cernada M,García-Robles A,Torres-Cuevas I,Kuligoswki J,Collado MC,Serna E,Vento M

    更新日期：2019-11-05 00:00:00

  • Exercise Mitigates the Loss of Muscle Mass by Attenuating the Activation of Autophagy during Severe Energy Deficit.

    abstract：:The loss of skeletal muscle mass with energy deficit is thought to be due to protein breakdown by the autophagy-lysosome and the ubiquitin-proteasome systems. We studied the main signaling pathways through which exercise can attenuate the loss of muscle mass during severe energy deficit (5500 kcal/day). Overweight men...

    journal_title：Nutrients

    pub_type： 杂志文章,随机对照试验

    doi：10.3390/nu11112824

    authors： Martin-Rincon M,Pérez-López A,Morales-Alamo D,Perez-Suarez I,de Pablos-Velasco P,Perez-Valera M,Perez-Regalado S,Martinez-Canton M,Gelabert-Rebato M,Juan-Habib JW,Holmberg HC,Calbet JAL

    更新日期：2019-11-19 00:00:00

  • Biological variability and impact of oral contraceptives on vitamins B(6), B(12) and folate status in women of reproductive age.

    abstract：:Vitamins B(6), B(12) and folate play crucial metabolic roles especially during the reproductive years for women. There is limited reporting of within-subject variability of these vitamins. This study aimed to determine the within and between subject variability in serum vitamins B(6), B(12), folate and erythrocyte fol...

    journal_title：Nutrients

    pub_type： 杂志文章,随机对照试验

    doi：10.3390/nu5093634

    authors： McArthur JO,Tang H,Petocz P,Samman S

    更新日期：2013-09-16 00:00:00

  • Cognitive and Neurochemical Changes Following Polyphenol-Enriched Diet in Rats.

    abstract：:Dietary recommendations are frequently developed based on nutrient deficiency or prevention of disease, but less attention has been paid to the dietary guidelines to promote brain health. Active and healthy aging is a prerequisite for improving quality of life as people age, and evidence is establishing a relationship...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu13010059

    authors： Ramis MR,Sarubbo F,Moranta D,Tejada S,Lladó J,Miralles A,Esteban S

    更新日期：2020-12-27 00:00:00

  • Release of Major Peanut Allergens from Their Matrix under Various pH and Simulated Saliva Conditions-Ara h2 and Ara h6 Are Readily Bio-Accessible.

    abstract：:The oral mucosa is the first immune tissue that encounters allergens upon ingestion of food. We hypothesized that the bio-accessibility of allergens at this stage may be a key determinant for sensitization. Light roasted peanut flour was suspended at various pH in buffers mimicking saliva. Protein concentrations and a...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10091281

    authors： Koppelman SJ,Smits M,Tomassen M,de Jong GAH,Baumert J,Taylor SL,Witkamp R,Veldman RJ,Pieters R,Wichers H

    更新日期：2018-09-11 00:00:00

  • Sex-Specific Differences in the Gut Microbiome in Response to Dietary Fiber Supplementation in IL-10-Deficient Mice.

    abstract：:There is growing interest in studying dietary fiber to stimulate microbiome changes that might prevent or alleviate inflammatory bowel disease (IBD). However, dietary fiber effects have shown varying degrees of efficacy, for reasons that are unclear. This study examined whether the effects of isomaltodextrin on gut mi...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12072088

    authors： Zhang Z,Hyun JE,Thiesen A,Park H,Hotte N,Watanabe H,Higashiyama T,Madsen KL

    更新日期：2020-07-15 00:00:00

  • Bioavailability of Dietary Omega-3 Fatty Acids Added to a Variety of Sausages in Healthy Individuals.

    abstract：:A low Omega-3 Index (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in erythrocytes) is associated with cardiac, cerebral, and other health issues. Intake of EPA and DHA, but not of alpha-linolenic acid (ALA), increases the Omega-3 Index. We investigated bioavailability, safety, palatability and tolerabili...

    journal_title：Nutrients

    pub_type： 杂志文章,随机对照试验

    doi：10.3390/nu9060629

    authors： Köhler A,Heinrich J,von Schacky C

    更新日期：2017-06-19 00:00:00

  • Energy requirements of US Army Special Operation Forces during military training.

    abstract：:Special Operations Forces (SOF) regularly engage in physically demanding combat operations and field training exercises, resulting in high daily energy expenditure, and thus increased energy requirements. However, the majority of studies assessing energy requirements of SOF have been conducted on soldiers going throug...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu6051945

    authors： Margolis LM,Crombie AP,McClung HL,McGraw SM,Rood JC,Montain SJ,Young AJ

    更新日期：2014-05-12 00:00:00

  • The Association between Dietary Vitamin A and Carotenes and the Risk of Primary Liver Cancer: A Case-Control Study.

    abstract：:Dietary intake of vitamin A (VA) and carotenes has shown beneficial effects for decreasing the risk of some types of cancer, but findings on the risk of primary liver cancer (PLC) are inconsistent. This case-control study explored the associations between the dietary intake of VA and carotenes and the risk of PLC. We ...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu8100624

    authors： Lan QY,Zhang YJ,Liao GC,Zhou RF,Zhou ZG,Chen YM,Zhu HL

    更新日期：2016-10-11 00:00:00

  • Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis.

    abstract：:Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency durin...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu9020159

    authors： Cañete A,Cano E,Muñoz-Chápuli R,Carmona R

    更新日期：2017-02-20 00:00:00

  • Effects of a Voluntary Front-of-Pack Nutrition Labelling System on Packaged Food Reformulation: The Health Star Rating System in New Zealand.

    abstract：:Interpretive, front-of-pack (FOP) nutrition labels may encourage reformulation of packaged foods. We aimed to evaluate the effects of the Health Star Rating (HSR), a new voluntary interpretive FOP labelling system, on food reformulation in New Zealand. Annual surveys of packaged food and beverage labelling and composi...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu9080918

    authors： Mhurchu CN,Eyles H,Choi YH

    更新日期：2017-08-22 00:00:00

  • Assessment of Validity and Reproducibility of the Zinc-Specific Dietary Intake Questionnaire Conducted for Young Polish Female Respondents.

    abstract：:One of the brief methods enabling the assessment of the zinc intake and identification of individuals characterized by insufficient zinc intake, is zinc-specific food frequency questionnaire. The aim of the study was to assess the validity and reproducibility of the elaborated zinc-specific food frequency questionnair...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10010104

    authors： Głąbska D,Staniec A,Guzek D

    更新日期：2018-01-19 00:00:00

  • Whole Grains and Consumer Understanding: Investigating Consumers' Identification, Knowledge and Attitudes to Whole Grains.

    abstract：:Whole grains may assist in reducing risk of non-communicable disease, but consumption is limited in many countries. In Australia, the reasons for poor consumption are not well understood. The aim of this study was to investigate consumers' knowledge, attitudes and identification of whole grains, incorporating an explo...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12082170

    authors： Foster S,Beck E,Hughes J,Grafenauer S

    更新日期：2020-07-22 00:00:00

  • Daily Intake of Fermented Milk Containing Lactobacillus casei Shirota (Lcs) Modulates Systemic and Upper Airways Immune/Inflammatory Responses in Marathon Runners.

    abstract：BACKGROUND:Although Lactobacillus casei Shirota (LcS) can benefit the immune status, the effects of LcS in the immune/inflammatory responses of marathon runners has never been evaluated. Therefore, here we evaluated the effect of daily ingestion of fermented milk containing or not LcS in the systemic and upper airway i...

    journal_title：Nutrients

    pub_type： 临床试验,杂志文章

    doi：10.3390/nu11071678

    authors： Vaisberg M,Paixão V,Almeida EB,Santos JMB,Foster R,Rossi M,Pithon-Curi TC,Gorjão R,Momesso CM,Andrade MS,Araujo JR,Garcia MC,Cohen M,Perez EC,Santos-Dias A,Vieira RP,Bachi ALL

    更新日期：2019-07-22 00:00:00

  • Leptin in Human Milk and Child Body Mass Index: Results of the Ulm Birth Cohort Studies.

    abstract：:The objective of the study was to investigate the potential association of human milk leptin concentrations with child body mass index (BMI) and BMI trajectory patterns up to two years of age among children in the Ulm SPATZ Health Study. Leptin concentration was measured in skimmed human milk by ELISA (R&D System). Ch...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu11081883

    authors： Logan CA,Siziba LP,Koenig W,Carr P,Brenner H,Rothenbacher D,Genuneit J

    更新日期：2019-08-13 00:00:00

  • Natural Sources, Pharmacokinetics, Biological Activities and Health Benefits of Hydroxycinnamic Acids and Their Metabolites.

    abstract：:Hydroxycinnamic acids (HCAs) are important natural phenolic compounds present in high concentrations in fruits, vegetables, cereals, coffee, tea and wine. Many health beneficial effects have been acknowledged in food products rich in HCAs; however, food processing, dietary intake, bioaccessibility and pharmacokinetics...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12082190

    authors： Sova M,Saso L

    更新日期：2020-07-23 00:00:00

  • Dietary Protein and Muscle in Aging People: The Potential Role of the Gut Microbiome.

    abstract：:Muscle mass, strength, and physical function are known to decline with age. This is associated with the development of geriatric syndromes including sarcopenia and frailty. Dietary protein is essential for skeletal muscle function. Resistance exercise appears to be the most beneficial form of physical activity for pre...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu10070929

    authors： Ni Lochlainn M,Bowyer RCE,Steves CJ

    更新日期：2018-07-20 00:00:00

  • The Effect of Vitamin D Supplementation on Hepcidin, Iron Status, and Inflammation in Pregnant Women in the United Kingdom.

    abstract：:Iron and vitamin D deficiencies are common during pregnancy. Our aim was to identify whether antenatal vitamin D₃ supplementation affects iron status (via hepcidin suppression) and/or inflammation. Using a subset of the UK multicenter Maternal Vitamin D Osteoporosis Study (MAVIDOS)-a double-blinded, randomized, placeb...

    journal_title：Nutrients

    pub_type： 杂志文章,随机对照试验

    doi：10.3390/nu11010190

    authors： Braithwaite VS,Crozier SR,D'Angelo S,Prentice A,Cooper C,Harvey NC,Jones KS,MAVIDOS Trial Group.

    更新日期：2019-01-18 00:00:00

  • Magnesium Deficiency Questionnaire: A New Non-Invasive Magnesium Deficiency Screening Tool Developed Using Real-World Data from Four Observational Studies.

    abstract：:Due to the high estimated prevalence of magnesium deficiency, there is a need for a rapid, non-invasive assessment tool that could be used by patients and clinicians to confirm suspected hypomagnesemia and substantiate laboratory testing. This study analyzed data from four large observational studies of hypomagnesemia...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12072062

    authors： Orlova S,Dikke G,Pickering G,Konchits S,Starostin K,Bevz A

    更新日期：2020-07-11 00:00:00

  • Erucic Acid (22:1n-9) in Fish Feed, Farmed, and Wild Fish and Seafood Products.

    abstract：:The European Food Safety Authority (EFSA) published a risk assessment of erucic acid (22:1n-9) in 2016, establishing a Tolerable Daily Intake (TDI) for humans of 7 mg kg-1 body weight per day. This report largely excluded the contribution of erucic acid from fish and seafood, due to this fatty acid often not being rep...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu10101443

    authors： Sissener NH,Ørnsrud R,Sanden M,Frøyland L,Remø S,Lundebye AK

    更新日期：2018-10-05 00:00:00

  • Mechanism of Anti-Cancer Activity of Curcumin on Androgen-Dependent and Androgen-Independent Prostate Cancer.

    abstract：:Prostate cancer (PCa) is a heterogeneous disease and ranked as the second leading cause of cancer-related deaths in males worldwide. The global burden of PCa keeps rising regardless of the emerging cutting-edge technologies for treatment and drug designation. There are a number of treatment options which are effective...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu12030679

    authors： Abd Wahab NA,Lajis NH,Abas F,Othman I,Naidu R

    更新日期：2020-03-02 00:00:00

  • The Role of Succinate in the Regulation of Intestinal Inflammation.

    abstract：:Succinate is a metabolic intermediate of the tricarboxylic acid (TCA) cycle within host cells. Succinate is also produced in large amounts during bacterial fermentation of dietary fiber. Elevated succinate levels within the gut lumen have been reported in association with microbiome disturbances (dysbiosis), as well a...

    journal_title：Nutrients

    pub_type： 杂志文章,评审

    doi：10.3390/nu11010025

    authors： Connors J,Dawe N,Van Limbergen J

    更新日期：2018-12-22 00:00:00

  • The Relevance of Thiamine Evaluation in a Practical Setting.

    abstract：:Thiamine is a crucial cofactor involved in the maintenance of carbohydrate metabolism and participates in multiple cellular metabolic processes. Although thiamine can be obtained from various food sources, some common food groups are deficient in thiamine, and it can be denatured by high temperature and pH. Additional...

    journal_title：Nutrients

    pub_type： 杂志文章

    doi：10.3390/nu12092810

    authors： Pacei F,Tesone A,Laudi N,Laudi E,Cretti A,Pnini S,Varesco F,Colombo C

    更新日期：2020-09-13 00:00:00