Somatotropic Axis and Obesity: Is There Any Role for the Mediterranean Diet?

Abstract:

:Obesity is associated with reduced spontaneous and stimulated growth hormone (GH) secretion and basal insulin-like growth factor I (IGF-1) levels-which in turn is associated with increased prevalence of cardiovascular risk factors. The aim of this study was to investigate: (1) the association of somatotropic axis with cardiometabolic status; (2) the association of somatotropic axis with the Mediterranean diet and nutritional pattern in people with obesity. Cross-sectional observational study was carried out in 200 adult women, aged 36.98 ± 11.10 years with severe obesity (body mass index-BMI of 45.19 ± 6.30 kg/m2). The adherence to the Mediterranean diet and the total calorie intake was assessed. Anthropometric measurements, body composition and biochemical profile were determined along with Growth Hormone (GH)/Insulin like Growth Factor 1 (IGF-1) axis and insulin resistance (homeostatic model assessment for insulin resistance-HoMA-IR). The enrolled subjects were compared after being divided according to GH peak response and according to IGF-1 standard deviation scores (SDS). Derangements of GH peak were detected in 61.5% of studied patients while IGF-1 deficiency was detected in 71% of the population. Both blunted GH peak response and IGF-1 SDS were indicators of derangements of somatotropic axis and were associated with comparable results in terms of cardiometabolic sequelae. Both GH peak and IGF-1 levels were inversely associated with anthropometric and metabolic parameters. The adherence to the Mediterranean diet predicts GH peak response. Fatty liver index (FLI), fat mass (FM) and phase angle (PhA) were predictive factors of GH peak response as well. In conclusion derangements of somatotropic axis is associated with a worse cardiometabolic profile in people with obesity. A high adherence to the Mediterranean diet-and in particular protein intake-was associated with a better GH status.

journal_name

Nutrients

journal_title

Nutrients

authors

Muscogiuri G,Barrea L,Laudisio D,Di Somma C,Pugliese G,Salzano C,Colao A,Savastano S

doi

10.3390/nu11092228

subject

Has Abstract

pub_date

2019-09-16 00:00:00

issue

9

issn

2072-6643

pii

nu11092228

journal_volume

11

pub_type

杂志文章
  • Maternal Fat-1 Transgene Protects Offspring from Excess Weight Gain, Oxidative Stress, and Reduced Fatty Acid Oxidation in Response to High-Fat Diet.

    abstract::Overweight and obesity accompanies up to 70% of pregnancies and is a strong risk factor for offspring metabolic disease. Maternal obesity-associated inflammation and lipid profile are hypothesized as important contributors to excess offspring liver and skeletal muscle lipid deposition and oxidative stress. Here, we te...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12030767

    authors: Boyle KE,Magill-Collins MJ,Newsom SA,Janssen RC,Friedman JE

    更新日期:2020-03-14 00:00:00

  • Supplement Use and Dietary Sources of Folate, Vitamin D, and n-3 Fatty Acids during Preconception: The GLIMP2 Study.

    abstract::An adequate nutritional status during the preconception period is important, particularly for folate, vitamin D, and n-3 fatty acids (i.e., EPA+DHA). We aimed to determine supplement intake and the main dietary sources of folate, vitamin D, and EPA+DHA using the data of 66 Dutch women aged 18⁻40 years who wished to be...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10080962

    authors: Looman M,van den Berg C,Geelen A,Samlal RAK,Heijligenberg R,Klein Gunnewiek JMT,Balvers MGJ,Leendertz-Eggen CL,Wijnberger LDE,Feskens EJM,Brouwer-Brolsma EM

    更新日期:2018-07-25 00:00:00

  • Fermented Food and Non-Communicable Chronic Diseases: A Review.

    abstract::Fermented foods represent a significant fraction of human diets. Although their impact on health is positively perceived, an objective evaluation is still missing. We have, therefore, reviewed meta-analyses of randomized controlled trials (RCT) investigating the relationship between fermented foods and non-transmissib...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu10040448

    authors: Gille D,Schmid A,Walther B,Vergères G

    更新日期:2018-04-04 00:00:00

  • Immunomodulatory Effects of Glutathione, Garlic Derivatives, and Hydrogen Sulfide.

    abstract::Glutathione and aged garlic extract are sulfur-containing products that play important protective and regulatory roles within the immune system and in oxidative processes. Hydrogen sulfide (H₂S), an endogenous, gaseous, signaling transmitter, has also been shown to be involved in the regulation of inflammation. Recent...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu11020295

    authors: Rodrigues C,Percival SS

    更新日期:2019-01-30 00:00:00

  • Nutritional Interventions in the Management of Fibromyalgia Syndrome.

    abstract::Fibromyalgia (FM) is a multifactorial syndrome of unknown etiology, characterized by widespread chronic pain and various somatic and psychological manifestations. The management of FM requires a multidisciplinary approach combining both pharmacological and nonpharmacological strategies. Among nonpharmacological strate...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12092525

    authors: Pagliai G,Giangrandi I,Dinu M,Sofi F,Colombini B

    更新日期:2020-08-20 00:00:00

  • Study on the Prevalence of Severe Anemia among Non-Pregnant Women of Reproductive Age in Rural China: A Large Population-Based Cross-Sectional Study.

    abstract::Globally, severe anemia impacts millions of non-pregnant women. However, studies on the prevalence of severe anemia through large epidemiologic surveys among non-pregnant women have been scarce in China. In this study, we aimed to study the prevalence of severe anemia and its determinants among non-pregnant women livi...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu9121298

    authors: Ma Q,Zhang S,Liu J,Wang Q,Shen H,Zhang Y,Liu M

    更新日期:2017-11-28 00:00:00

  • Type-4 Resistant Starch in Substitution for Available Carbohydrate Reduces Postprandial Glycemic Response and Hunger in Acute, Randomized, Double-Blind, Controlled Study.

    abstract::Resistant starch (RS) is a type of dietary fiber that has been acknowledged for multiple physiological benefits. Resistant starch type 4 (RS4) is a subcategory of RS that has been more intensively studied as new types of RS4 emerge in the food supply. The primary aim of this randomized, double-blind, controlled study ...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu10020129

    authors: Stewart ML,Wilcox ML,Bell M,Buggia MA,Maki KC

    更新日期:2018-01-26 00:00:00

  • Agricultural Food Production Diversity and Dietary Diversity among Female Small Holder Farmers in a Region of the Ecuadorian Andes Experiencing Nutrition Transition.

    abstract::Some rural areas of Ecuador, including the Imbabura Province of the Andes Highlands, are experiencing a double burden of malnutrition where micronutrient deficiencies persist at the same time obesity is increasing as many traditional home-grown foods are being replaced with more commercially prepared convenience foods...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12082454

    authors: Melby CL,Orozco F,Averett J,Muñoz F,Romero MJ,Barahona A

    更新日期:2020-08-15 00:00:00

  • Resveratrol Regulates BDNF, trkB, PSA-NCAM, and Arc Expression in the Rat Cerebral Cortex after Bilateral Common Carotid Artery Occlusion and Reperfusion.

    abstract::The polyphenol resveratrol (RVT) may drive protective mechanisms of cerebral homeostasis during the hypoperfusion/reperfusion triggered by the transient bilateral common carotid artery occlusion followed by reperfusion (BCCAO/R). This immunochemical study investigates if a single dose of RVT modulates the plasticity-r...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11051000

    authors: Serra MP,Boi M,Poddighe L,Melis T,Lai Y,Carta G,Quartu M

    更新日期:2019-05-01 00:00:00

  • Curcumin, Gut Microbiota, and Neuroprotection.

    abstract::Curcumin, a nontoxic, naturally occurring polyphenol, has been recently proposed for the management of neurodegenerative and neurological diseases. However, a discrepancy exists between the well-documented pharmacological activities that curcumin seems to possess in vivo and its poor aqueous solubility, bioavailabilit...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu11102426

    authors: Di Meo F,Margarucci S,Galderisi U,Crispi S,Peluso G

    更新日期:2019-10-11 00:00:00

  • Carrot Intake and Risk of Colorectal Cancer: A Prospective Cohort Study of 57,053 Danes.

    abstract::Carrots are consumed worldwide. Several meta-analysis studies on carrot consumption have indicated that carrots play a central role as a protecting vegetable against development of different types of cancers. A cancer-preventive role of carrots is plausible because they are the main dietary source of the bioactive pol...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12020332

    authors: Deding U,Baatrup G,Christensen LP,Kobaek-Larsen M

    更新日期:2020-01-27 00:00:00

  • Dietary Salt Restriction in Chronic Kidney Disease: A Meta-Analysis of Randomized Clinical Trials.

    abstract:BACKGROUND:A clear evidence on the benefits of reducing salt in people with chronic kidney disease (CKD) is still lacking. Salt restriction in CKD may allow better control of blood pressure (BP) as shown in a previous systematic review while the effect on proteinuria reduction remains poorly investigated. METHODS:We p...

    journal_title:Nutrients

    pub_type: 杂志文章,meta分析,评审

    doi:10.3390/nu10060732

    authors: Garofalo C,Borrelli S,Provenzano M,De Stefano T,Vita C,Chiodini P,Minutolo R,De Nicola L,Conte G

    更新日期:2018-06-06 00:00:00

  • Parent Stress as a Consideration in Childhood Obesity Prevention: Results from the Guelph Family Health Study, a Pilot Randomized Controlled Trial.

    abstract::Parents' stress is independently associated with increased child adiposity, but parents' stress may also interfere with childhood obesity prevention programs. The disruptions to the family dynamic caused by participating in a behaviour change intervention may exacerbate parent stress and undermine overall intervention...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12061835

    authors: Hruska V,Darlington G,Haines J,Ma DWL

    更新日期:2020-06-19 00:00:00

  • Associations of Fat Mass and Fat-Free Mass with Physical Fitness in 4-Year-Old Children: Results from the MINISTOP Trial.

    abstract::Physical fitness is a powerful marker of health in youth. Studies in adolescents and adults suggest that higher fat mass is related to worse physical fitness. However, there is limited knowledge whether fat mass and fat-free mass are associated with physical fitness already in preschoolers. Baseline data from the MINI...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu8080473

    authors: Henriksson P,Cadenas-Sanchez C,Leppänen MH,Delisle Nyström C,Ortega FB,Pomeroy J,Ruiz JR,Löf M

    更新日期:2016-07-30 00:00:00

  • Effects of Yeast Mannan Which Promotes Beneficial Bacteroides on the Intestinal Environment and Skin Condition: A Randomized, Double-Blind, Placebo-Controlled Study.

    abstract::Yeast mannan (YM) is an indigestible water-soluble polysaccharide of the yeast cell wall. In vitro fecal fermentation studies showed that YM could exhibit a notable prebiotic effect. The aim of this randomized, double-blind, placebo-controlled study was to assess the efficacy of YM intake on the intestinal environment...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12123673

    authors: Tanihiro R,Sakano K,Oba S,Nakamura C,Ohki K,Hirota T,Sugiyama H,Ebihara S,Nakamura Y

    更新日期:2020-11-28 00:00:00

  • Vitamin D Status and Vitamin D-Dependent Apoptosis in Obesity.

    abstract::The role of vitamin D in obesity appears to be linked to vitamin D insufficient/deficient status. However, mechanistic understanding of the role of vitamin D in obesity is lacking. We have shown earlier that the vitamin D hormonal form, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), induces cell death by apoptosis in mature ...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12051392

    authors: Sergeev IN

    更新日期:2020-05-13 00:00:00

  • Perioperative immunonutrition in well-nourished patients undergoing surgery for head and neck cancer: evaluation of inflammatory and immunologic outcomes.

    abstract::Limited work is available on the benefits of nutritional support enriched with arginine and n-3 fatty acids in surgical patients with head and neck cancer, particularly if well-nourished. We conducted a pilot study in these patients to examine effects on inflammatory markers and clinical outcome. Patients scheduled fo...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu5041186

    authors: Turnock A,Calder PC,West AL,Izzard M,Morton RP,Plank LD

    更新日期:2013-04-09 00:00:00

  • Antioxidant Properties of Probiotic Bacteria.

    abstract::Oxidative stress defines a condition in which the prooxidant-antioxidant balance in the cell is disturbed, resulting in DNA hydroxylation, protein denaturation, lipid peroxidation, and apoptosis, ultimately compromising cells' viability. Probiotics have been known for many beneficial health effects, and the consumptio...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu9050521

    authors: Wang Y,Wu Y,Wang Y,Xu H,Mei X,Yu D,Wang Y,Li W

    更新日期:2017-05-19 00:00:00

  • Maternal Folate Status and the BHMT c.716G>A Polymorphism Affect the Betaine Dimethylglycine Pathway during Pregnancy.

    abstract::The effect of the betaine: homocysteine methyltransferase BHMT c.716G>A (G: guanosine; A: adenosine) single nucleotide polymorphism (SNP) on the BHMT pathway is unknown during pregnancy. We hypothesised that it impairs betaine to dimethylglycine conversion and that folate status modifies its effect. We studied 612 wom...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu8100621

    authors: Colomina JM,Cavallé-Busquets P,Fernàndez-Roig S,Solé-Navais P,Fernandez-Ballart JD,Ballesteros M,Ueland PM,Meyer K,Murphy MM

    更新日期:2016-10-09 00:00:00

  • The Effects of Tocotrienol-Rich Vitamin E (Tocovid) on Diabetic Neuropathy: A Phase II Randomized Controlled Trial.

    abstract::Chronic hyperglycemia increases oxidative stress, activates inflammatory pathways and reduces nerve growth factor (NGF) among diabetic patients, which contribute to development of diabetic peripheral neuropathy (DPN). Tocotrienol-Rich Vitamin E (Tocovid) possesses potent antioxidant and anti-inflammatory properties wh...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12051522

    authors: Ng YT,Phang SCW,Tan GCJ,Ng EY,Botross Henien NP,M Palanisamy UD,Ahmad B,Abdul Kadir K

    更新日期:2020-05-23 00:00:00

  • The Relationship between Abdominal Fat Phenotypes and Insulin Resistance in Non-Obese Individuals after Acute Pancreatitis.

    abstract::Both type 2 prediabetes/diabetes (T2DM) and new-onset prediabetes/diabetes after acute pancreatitis (NODAP) are characterized by impaired tissue sensitivity to insulin action. Although the outcomes of NODAP and T2DM are different, it is unknown whether drivers of insulin resistance are different in the two types of di...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12092883

    authors: Ko J,Skudder-Hill L,Cho J,Bharmal SH,Petrov MS

    更新日期:2020-09-21 00:00:00

  • [6S]-5-Methyltetrahydrofolic Acid and Folic Acid Pregnancy Diets Differentially Program Metabolic Phenotype and Hypothalamic Gene Expression of Wistar Rat Dams Post-Birth.

    abstract::[6S]-5-methyltetrahydrofolic acid (MTHF) is a proposed replacement for folic acid (FA) in diets and prenatal supplements. This study compared the effects of these two forms on maternal metabolism and hypothalamic gene expression. Pregnant Wistar rats received an AIN-93G diet with recommended FA (1X, 2 mg/kg, control),...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu13010048

    authors: Pannia E,Hammoud R,Simonian R,Arning E,Ashcraft P,Wasek B,Bottiglieri T,Pausova Z,Kubant R,Anderson GH

    更新日期:2020-12-25 00:00:00

  • Effects of Anserine/Carnosine Supplementation on Mild Cognitive Impairment with APOE4.

    abstract:BACKGROUND:Oral supplementation of anserine/carnosine helps preserve cognitive functions in healthy older adults. Mild cognitive impairment (MCI) is a transition between cognitive-normal and dementia. Therefore, it needs to investigate whether anserine/carnosine supplementation (ACS) has effects on subjects with MCI. ...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu11071626

    authors: Masuoka N,Yoshimine C,Hori M,Tanaka M,Asada T,Abe K,Hisatsune T

    更新日期:2019-07-17 00:00:00

  • Calorie Restriction Modulates Reproductive Development and Energy Balance in Pre-Pubertal Male Rats.

    abstract::The objective was to determine effects of feed restriction and refeeding on reproductive development and energy balance in pre-pubertal male rats. Sprague Dawley rats (n = 32, 24 days old, ~65 g), were randomly allocated into four treatments (n = 8/treatment): (1) Control (CON, ad libitum feed; (2) Mild Restriction (M...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11091993

    authors: Rizzoto G,Sekhar D,Thundathil JC,Chelikani PK,Kastelic JP

    更新日期:2019-08-23 00:00:00

  • Phenethyl Isothiocyanate Protects against High Fat/Cholesterol Diet-Induced Obesity and Atherosclerosis in C57BL/6 Mice.

    abstract::This study concerns obesity-related atherosclerosis, hyperlipidemia, and chronic inflammation. We studied the anti-obesity and anti-atherosclerosis effects of phenethyl isothiocyanate (PEITC) and explored their underlying mechanisms. We established an animal model of high fat/cholesterol-induced obesity in C57BL/6 mic...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12123657

    authors: Gwon MH,Im YS,Seo AR,Kim KY,Moon HR,Yun JM

    更新日期:2020-11-27 00:00:00

  • Nutrition of the critically ill — a 21st-century perspective.

    abstract::Health care-induced diseases constitute a fast-increasing problem. Just one type of these health care-associated infections (HCAI) constitutes the fourth leading cause of death in Western countries. About 25 million individuals worldwide are estimated each year to undergo major surgery, of which approximately 3 millio...

    journal_title:Nutrients

    pub_type: 历史文章,杂志文章,评审

    doi:10.3390/nu5010162

    authors: Bengmark S

    更新日期:2013-01-14 00:00:00

  • Severe periodontitis is inversely associated with coffee consumption in the maintenance phase of periodontal treatment.

    abstract::This cross-sectional study addressed the relationship between coffee consumption and periodontitis in patients during the maintenance phase of periodontal treatment. A total of 414 periodontitis patients in the maintenance phase of periodontal treatment completed a questionnaire including items related to coffee intak...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu6104476

    authors: Machida T,Tomofuji T,Ekuni D,Azuma T,Takeuchi N,Maruyama T,Mizutani S,Kataoka K,Kawabata Y,Morita M

    更新日期:2014-10-21 00:00:00

  • Effects of High-Fat Diet Induced Obesity and Fructooligosaccharide Supplementation on Cardiac Protein Expression.

    abstract::The mechanism by which high fat-diet induced obesity affects cardiac protein expression is unclear, and the extent to which this is modulated by prebiotic treatment is not known. These outcomes were assessed in rats initially fed a high-fat diet, then the top 40% weight gain group were randomly allocated to control (C...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12113404

    authors: Sarfaraz S,Singh S,Hawke A,Clarke ST,Ramdath DD

    更新日期:2020-11-05 00:00:00

  • Management of Cow's Milk Allergy from an Immunological Perspective: What Are the Options?

    abstract::The immunological mechanism underlying Immunoglobuline E (IgE)-mediated cow's milk allergy has been subject to investigations for many years. Identification of the key immune cells (mast cells, B cells) and molecules (IgE) in the allergic process has led to the understanding that avoidance of IgE-crosslinking epitopes...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu11112734

    authors: Knol EF,de Jong NW,Ulfman LH,Tiemessen MM

    更新日期:2019-11-11 00:00:00

  • Anti-Diabetic Effects of Madecassic Acid and Rotundic Acid.

    abstract::Anti-diabetic effects of madecassic acid (MEA) and rotundic acid (RA) were examined. MEA or RA at 0.05% or 0.1% was supplied to diabetic mice for six weeks. The intake of MEA, not RA, dose-dependently lowered plasma glucose level and increased plasma insulin level. MEA, not RA, intake dose-dependently reduced plasmino...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu7125512

    authors: Hsu YM,Hung YC,Hu L,Lee YJ,Yin MC

    更新日期:2015-12-02 00:00:00