Abstract:
BACKGROUND:The microbiota composition is now considered as one of the main modifiable risk factors for health. No controlled study has been performed on the association between microbiota composition and renal function. We applied Mendelian randomization (MR) to estimate the casual impact of eight microbiota genera on renal function and the risk of chronic kidney disease (CKD). METHODS:MR was implemented by using summary-level data from the largest-ever genome-wide association studies (GWAS) conducted on microbiota genera, CKD and renal function parameters. The inverse-variance weighted method (IVW), weighted median (WM)-based method, MR-Egger, MR-Robust Adjusted Profile Score (RAPS), MR-Pleiotropy RESidual Sum and Outlier (PRESSO) were applied. A sensitivity analysis was conducted using the leave-one-out method. RESULTS:The Anaerostipes genus was associated with higher estimated glomerular filtration rate (eGFR) in the overall population (IVW: β = 0.003, p = 0.021) and non-diabetes mellitus (DM) subgroup (IVW: β = 0.003, p = 0.033), while it had a non-significant association with the risk of CKD and eGFR in DM patients. Subjects with higher abundance of Desulfovibrio spp. had a significantly lower level of eGFR (IVW: β = -0.001, p = 0.035); the same results were observed in non-DM (IVW: β = -0.001, p = 0.007) subjects. Acidaminococcus, Bacteroides, Bifidobacterium, Faecalibacterium, Lactobacillus and Megamonas had no significant association with eGFR in the overall population, DM and non-DM subgroups (IVW: p > 0.105 for all groups); they also presented no significant association with the risk of CKD (IVW: p > 0.201 for all groups). Analyses of MR-PRESSO did not highlight any outlier. The pleiotropy test, with very negligible intercept and insignificant p-value, also indicated no chance of pleiotropy for all estimations. The leave-one-out method demonstrated that the observed links were not driven by single single-nucleotide polymorphism. CONCLUSIONS:Our results suggest an adverse association of Desulfovibrio spp. and a beneficial association of Anaerostipes spp. with eGFR. Further studies using multiple robust instruments are needed to confirm these results.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Mazidi M,Shekoohi N,Covic A,Mikhailidis DP,Banach Mdoi
10.3390/nu12082216subject
Has Abstractpub_date
2020-07-25 00:00:00issue
8issn
2072-6643pii
nu12082216journal_volume
12pub_type
杂志文章相关文献
Nutrients文献大全abstract::Cardiometabolic diseases are a leading global health challenge. Their incidence as well as progression is strongly affected by diet. Consumption of Pleurotus ostreatus (P. ostreatus), an edible oyster mushroom rich in functional ingredients (e.g., β-glucans), may improve glucose and lipid metabolism, blood pressure, b...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041134
更新日期:2020-04-17 00:00:00
abstract::Botanical herbs are consumed globally not only as an essential diet but also as medicines or as functional/recreational food supplements. The extract of the Apocynum venetum leaves (AVLE), also known as Luobuma, exerts its antihypertensive effect via dilating the blood vessels in an endothelium- and concentration-depe...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7075220
更新日期:2015-06-30 00:00:00
abstract::Severe iodine deficiency in mothers is known to impair foetal development. Pregnant women in the UK may be iodine insufficient, but recent assessments of iodine status are limited. This study assessed maternal urinary iodine concentrations (UIC) and birth outcomes in three UK cities. Spot urines were collected from 54...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11020441
更新日期:2019-02-20 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD), along with obesity, is increasing world-wide and is one of the major causes of chronic hepatic disease. The present study evaluated the ameliorative effect of extract of Psoralea corylifolia L. seed (PCS) on high fat diet-induced NAFLD in C57BL/6 mice after daily administratio...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8020083
更新日期:2016-02-06 00:00:00
abstract::Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the e...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu2050532
更新日期:2010-05-01 00:00:00
abstract::A cohort of 50-year-olds from Canterbury, New Zealand (N = 404), representative of midlife adults, undertook comprehensive health and dietary assessments. Fasting plasma vitamin C concentrations (N = 369) and dietary vitamin C intake (N = 250) were determined. The mean plasma vitamin C concentration was 44.2 µmol/L (9...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9080831
更新日期:2017-08-03 00:00:00
abstract::The present study investigated the effects of breast tumors on the blood and tissue distribution of essential trace mineral selenium (Se), and oxidative stress status of mice. Female 10-week-old BALB/cByJNarl mice were randomly assigned into control (CNL) and breast tumor-bearing (TB) groups. TB mice were injected sub...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu5020594
更新日期:2013-02-20 00:00:00
abstract::Necrotizing enterocolitis (NEC), the first cause of short bowel syndrome (SBS) in the neonate, is a serious neonatal gastrointestinal disease with an incidence of up to 11% in preterm newborns less than 1500 g of birth weight. The rate of severe NEC requiring surgery remains high, and it is estimated between 20-50%. N...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu13020340
更新日期:2021-01-24 00:00:00
abstract::Neurological dementias such as Alzheimer's disease and Lewy body dementia are thought to be caused in part by the formation and deposition of characteristic insoluble fibrils of polypeptides such as amyloid beta (Aβ), Tau, and/or α-synuclein (αSyn). In this context, it is critical to suppress and remove such aggregate...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113480
更新日期:2020-11-13 00:00:00
abstract::Scientists are focusing on bioactive ingredients to counteract obesity. We evaluated whether a mix containing grape seed proanthocyanidin extract (GSPE), anthocyanins, conjugated linoleic acid (CLA), and chicken feet hydrolysate (CFH) could reduce body fat mass and also determined which mechanisms in the white adipose...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113251
更新日期:2020-10-23 00:00:00
abstract::Hearing loss (HL) is a major public health problem. Nutritional factors can affect a variety of diseases, such as HL, in humans. Thus far, several studies have evaluated the association between nutrition and hearing. These studies found that the incidence of HL was increased with the lack of single micro-nutrients suc...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11020307
更新日期:2019-02-01 00:00:00
abstract::Breast milk (BM) is beneficial due to its content in a wide range of different antioxidants, particularly relevant for preterm infants, who are at higher risk of oxidative stress. We hypothesize that BM antioxidants are adapted to gestational age and are negatively influenced by maternal age. Fifty breastfeeding women...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092569
更新日期:2020-08-25 00:00:00
abstract::One of the brief methods enabling the assessment of the zinc intake and identification of individuals characterized by insufficient zinc intake, is zinc-specific food frequency questionnaire. The aim of the study was to assess the validity and reproducibility of the elaborated zinc-specific food frequency questionnair...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10010104
更新日期:2018-01-19 00:00:00
abstract::As the population is aging rapidly, there is a strong increase in the number of individuals with chronic disease and physical limitations. The decrease in skeletal muscle mass and function (sarcopenia) and the increase in fat mass (obesity) are important contributors to the development of physical limitations, which a...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10050605
更新日期:2018-05-12 00:00:00
abstract::The present study evaluated the reliability of equations using spot urine (SU) samples in the estimation of 24-hour urine sodium excretion (24-HUNa). Equations estimating 24-HUNa from SU samples were derived from first-morning SU of 101 participants (52.4 ± 11.1 years, range 24-70 years). Equations developed by us and...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6062360
更新日期:2014-06-20 00:00:00
abstract:INTRODUCTION:Recent observations have shown that lengthening the daily eating period may contribute to the onset of chronic diseases. Time-restricted eating (TRE) is a diet that especially limits this daily food window. It could represent a dietary approach that is likely to improve health markers. The aim of this stud...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123770
更新日期:2020-12-08 00:00:00
abstract::In human cells, mitochondria provide the largest part of cellular energy in the form of adenosine triphosphate generated by the process of oxidative phosphorylation (OXPHOS). Impaired OXPHOS activity leads to a heterogeneous group of inherited diseases for which therapeutic options today remain very limited. Potential...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu9091017
更新日期:2017-09-14 00:00:00
abstract::Oligonol is a low-molecular-weight form of polyphenol and has antioxidant and anti-inflammatory activity, making it a potential promoter of immunity. This study investigates the effects of oligonol supplementation on leukocyte and immune cell counts after heat loading in 19 healthy male volunteers. The participants to...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6062466
更新日期:2014-06-24 00:00:00
abstract::The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n = 16), in which animals received a control diet + 0.5 mL of corn oil/kg body weight/day, and a tomat...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7115493
更新日期:2015-11-19 00:00:00
abstract::High sugar-sweetened beverage (SSB) consumption has been linked with obesity. The present study examined the associations between adolescent SSB intake and body mass index (BMI), waist circumference (WC), and overweight status in early adulthood, and modelled the association of alternative beverage substitution with B...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11122928
更新日期:2019-12-03 00:00:00
abstract::Taste receptors, first identified on the tongue, are best known for their role in guiding our dietary preferences. The expression of taste receptors for umami, sweet, and bitter have been demonstrated in tissues outside of the oral cavity, including in the airway, brain, gastrointestinal tract, and reproductive organs...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11092017
更新日期:2019-08-28 00:00:00
abstract::Water is essential for the proper functioning of the body. Even though a recommendation exists for adequate water intake for Koreans, studies identifying actual water intake from all beverages and foods consumed daily in the Korean population are limited. Thus, we estimated total water intake from both beverages and f...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8100617
更新日期:2016-10-04 00:00:00
abstract::Evidence indicates that many forms of fructose-induced metabolic disturbance are associated with oxidative stress and mitochondrial dysfunction. Mitochondria are prominent targets of oxidative damage; however, it is not clear whether mitochondrial DNA (mtDNA) damage and/or its lack of repair are events involved in met...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9040323
更新日期:2017-03-24 00:00:00
abstract::The effects of different carbohydrate-protein (CHO + Pro) beverages were compared during recovery from cycling exercise. Twelve male cyclists (VO(2peak): 65 ± 7 mL/kg/min) completed ~1 h of high-intensity intervals (EX1). Immediately and 120 min following EX1, subjects consumed one of three calorically-similar beverag...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu4070568
更新日期:2012-07-01 00:00:00
abstract::Several studies have shown that a large number of patients who are fulfilling the criteria for irritable bowel syndrome (IBS) are sensitive to gluten. The aim of this study was to evaluate the effect of a gluten-free diet on gastrointestinal symptoms in patients with IBS. In this double-blind randomized, placebo-contr...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu7064542
更新日期:2015-06-05 00:00:00
abstract::Dietary habits in children may not only impact current health status but could also shape future, lifelong dietary choices. Dietary intake data in Singaporean children are limited. The current study aimed to define the overall diet quality of Singaporean children using an existing cross-sectional dataset and to consid...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112615
更新日期:2019-11-01 00:00:00
abstract::Diet and nutrition may be important modifiable risk factors for the development, progression and management of obstructive lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). This review examines the relationship between dietary patterns, nutrient intake and weight status in obstructive lung...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7031618
更新日期:2015-03-05 00:00:00
abstract::Consumption of low-glycemic index (GI) carbohydrates (CHO) may be superior to high-GI CHO before exercise by increasing fat oxidation and decreasing carbohydrate oxidation. We compared the effects of pre-exercise feeding of a low-GI lentil-based sports nutrition bar with a high-GI bar on metabolism and performance dur...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu12040982
更新日期:2020-04-02 00:00:00
abstract::This study concerns obesity-related atherosclerosis, hyperlipidemia, and chronic inflammation. We studied the anti-obesity and anti-atherosclerosis effects of phenethyl isothiocyanate (PEITC) and explored their underlying mechanisms. We established an animal model of high fat/cholesterol-induced obesity in C57BL/6 mic...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123657
更新日期:2020-11-27 00:00:00
abstract:BACKGROUND:The aim of this study was to investigate total water intake (TWI) from water, beverages and foods among Italian adults and the elderly. METHODS:Data of 2607 adults and the elderly, aged 18-75 years from the last national food consumption survey, INRAN-SCAI 2005-06, were used to evaluate the TWI. The INRAN-S...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8110674
更新日期:2016-10-26 00:00:00