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Tomato (Lycopersicon esculentum) Supplementation Induces Changes in Cardiac miRNA Expression, Reduces Oxidative Stress and Left Ventricular Mass, and Improves Diastolic Function.

Abstract：

:The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n = 16), in which animals received a control diet + 0.5 mL of corn oil/kg body weight/day, and a tomato group (T; n = 16), in which animals received a control diet supplemented with tomato +0.5 mL of corn oil/kg body weight/day. After three months, morphological, functional, and biochemical analyses were performed. Animals supplemented with tomato had a smaller left atrium diameter and myocyte cross-sectional area (CSA) compared to the control group (C group: 474 (415-539); T group: 273 (258-297) µm²; p = 0.004). Diastolic function was improved in rats supplemented with tomato. In addition, lipid hydroperoxide was lower (C group: 267 ± 46.7; T group: 219 ± 23.0 nmol/g; p = 0.039) in the myocardium of rats supplemented with tomato. Tomato intake was also associated with up-regulation of miR-107 and miR-486 and down-regulation of miR-350 and miR-872. In conclusion, tomato supplementation induces changes in miRNA expression and reduces oxidative stress. In addition, these alterations may be responsible for CSA reduction and diastolic function improvement.

journal_name

Nutrients

journal_title

Nutrients

authors

Pereira BL,Arruda FC,Reis PP,Felix TF,Santos PP,Rafacho BP,Gonçalves AF,Claro RT,Azevedo PS,Polegato BF,Okoshi K,Fernandes AA,Paiva SA,Zornoff LA,Minicucci MF

doi

10.3390/nu7115493

subject

Has Abstract

pub_date

2015-11-19 00:00:00

pages

9640-9

issue

11

issn

2072-6643

pii

nu7115493

journal_volume

7

pub_type

杂志文章

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