Effect of Caloric Restriction on BMI, Gut Microbiota, and Blood Amino Acid Levels in Non-Obese Adults.

Abstract:

:Adequate calorie restriction (CR) as a healthy lifestyle is recommended not only for people with metabolic disorders but also for healthy adults. Previous studies have mainly focused on the beneficial metabolic effects of CR on obese subjects, while its effects on non-obese subjects are still scarce. Here, we conducted a three-week non-controlled CR intervention in 41 subjects, with approximately 40% fewer calories than the recommended daily energy intake. We measured BMI, and applied targeted metabolic profiling on fasting blood samples and shotgun metagenomic sequencing on fecal samples, before and after intervention. Subjects were stratified into two enterotypes according to their baseline microbial composition, including 28 enterotype Bacteroides (ETB) subjects and 13 enterotype Prevotella (ETP) subjects. CR decreased BMI in most subjects, and ETP subjects exhibited a significantly higher BMI loss ratio than the ETB subjects. Additionally, CR induced limited changes in gut microbial composition but substantial microbial-independent changes in blood AAs, including a significant increase in 3-methylhistidine, a biomarker of the skeletal muscle protein turnover. Finally, baseline abundances of seven microbial species, rather than baseline AA levels, could well predict CR-induced BMI loss. This non-controlled intervention study revealed associations between baseline gut microbiota and CR-induced BMI loss and provided evidence to accelerate the application of microbiome stratification in future personalized nutrition intervention.

journal_name

Nutrients

journal_title

Nutrients

authors

Zou H,Wang D,Ren H,Cai K,Chen P,Fang C,Shi Z,Zhang P,Wang J,Yang H,Zhong H

doi

10.3390/nu12030631

subject

Has Abstract

pub_date

2020-02-27 00:00:00

issue

3

issn

2072-6643

pii

nu12030631

journal_volume

12

pub_type

临床试验,杂志文章
  • Body Composition Analysis Allows the Prediction of Urinary Creatinine Excretion and of Renal Function in Chronic Kidney Disease Patients.

    abstract::The aim of this study was to predict urinary creatinine excretion (UCr), creatinine clearance (CCr) and the glomerular filtration rate (GFR) from body composition analysis. Body cell mass (BCM) is the compartment which contains muscle mass, which is where creatinine is generated. BCM was measured with body impedance a...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu9060553

    authors: Donadio C

    更新日期:2017-05-28 00:00:00

  • Food Timing, Circadian Rhythm and Chrononutrition: A Systematic Review of Time-Restricted Eating's Effects on Human Health.

    abstract:INTRODUCTION:Recent observations have shown that lengthening the daily eating period may contribute to the onset of chronic diseases. Time-restricted eating (TRE) is a diet that especially limits this daily food window. It could represent a dietary approach that is likely to improve health markers. The aim of this stud...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12123770

    authors: Adafer R,Messaadi W,Meddahi M,Patey A,Haderbache A,Bayen S,Messaadi N

    更新日期:2020-12-08 00:00:00

  • Polyphenols and human health: prevention of disease and mechanisms of action.

    abstract::Polyphenols are found ubiquitously in plants and their regular consumption has been associated with a reduced risk of a number of chronic diseases, including cancer, cardiovascular disease (CVD) and neurodegenerative disorders. Rather than exerting direct antioxidant effects, the mechanisms by which polyphenols expres...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu2111106

    authors: Vauzour D,Rodriguez-Mateos A,Corona G,Oruna-Concha MJ,Spencer JP

    更新日期:2010-11-01 00:00:00

  • Non-Celiac Gluten Sensitivity Has Narrowed the Spectrum of Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial.

    abstract::Several studies have shown that a large number of patients who are fulfilling the criteria for irritable bowel syndrome (IBS) are sensitive to gluten. The aim of this study was to evaluate the effect of a gluten-free diet on gastrointestinal symptoms in patients with IBS. In this double-blind randomized, placebo-contr...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu7064542

    authors: Shahbazkhani B,Sadeghi A,Malekzadeh R,Khatavi F,Etemadi M,Kalantri E,Rostami-Nejad M,Rostami K

    更新日期:2015-06-05 00:00:00

  • The Association between Sleep Duration and Metabolic Syndrome: The NHANES 2013/2014.

    abstract:BACKGROUND:We aimed to assess the association of sleep with metabolic syndrome in the 2013/2014 National Health and Nutrition Examination Survey (NHANES). METHODS:Sample size included 2737 out of 2013 and 2014 NHANES surveys. Cross-sectional study of metabolic syndrome and sleep duration was conducted. Metabolic syndr...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu11112582

    authors: Smiley A,King D,Bidulescu A

    更新日期:2019-10-26 00:00:00

  • Nutritional Approaches for the Management of Nonalcoholic Fatty Liver Disease: An Evidence-Based Review.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is on the rise worldwide representing a public health issue. Its coexistence with obesity and other metabolic alterations is highly frequent. Therefore, current therapy interventions for NAFLD are mainly focused on progressive weight loss through modulation of overall calorie i...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12123860

    authors: Parra-Vargas M,Rodriguez-Echevarria R,Jimenez-Chillaron JC

    更新日期:2020-12-17 00:00:00

  • The Role of Avocados in Complementary and Transitional Feeding.

    abstract::Infant dietary patterns tend to be insufficient sources of fruits, vegetables, and fiber, as well as excessive in salt, added sugars, and overall energy. Despite the serious long-term health risks associated with suboptimal fruit and vegetable intake, a large percentage of infants and toddlers in the U.S. do not consu...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu8050316

    authors: Comerford KB,Ayoob KT,Murray RD,Atkinson SA

    更新日期:2016-05-21 00:00:00

  • Differential Impact of Calcium and Vitamin D on Body Composition Changes in Post-Menopausal Women Following a Restricted Energy Diet and Exercise Program.

    abstract::Vitamin D and calcium supplementation have been posited to improve body composition and different formulations of calcium may impact bioavailability. However, data are lacking regarding the combinatorial effects of exercise, diet, and calcium and/or vitamin D supplementation on body composition changes in post-menopau...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12030713

    authors: Kerksick CM,Roberts MD,Campbell BI,Galbreath MM,Taylor LW,Wilborn CD,Lee A,Dove J,Bunn JW,Rasmussen CJ,Kreider RB

    更新日期:2020-03-07 00:00:00

  • Exercise and Nutrition Strategies to Counteract Sarcopenic Obesity.

    abstract::As the population is aging rapidly, there is a strong increase in the number of individuals with chronic disease and physical limitations. The decrease in skeletal muscle mass and function (sarcopenia) and the increase in fat mass (obesity) are important contributors to the development of physical limitations, which a...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu10050605

    authors: Trouwborst I,Verreijen A,Memelink R,Massanet P,Boirie Y,Weijs P,Tieland M

    更新日期:2018-05-12 00:00:00

  • Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes.

    abstract::Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic disorders, including hepatic lipid accumulation and lipotoxicity. Plant-derived polyphenols have attracted considerable attention in the prevention of NAFLD. Lotus seedpod, rich in polyphenols, is a traditional Chinese herbal medicine. Prev...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11122895

    authors: Liu YT,Lai YH,Lin HH,Chen JH

    更新日期:2019-11-28 00:00:00

  • Association of Iron Storage Markers with Metabolic Syndrome and Its Components in Chinese Rural 6-12 Years Old Children: The 2010-2012 China National Nutrition and Health Survey.

    abstract:BACKGROUND:Elevated ferritin, which is often used to represent iron storage, is known to increase the risk of metabolic syndrome (MetS) or its components, but its increase is affected by many factors. Therefore, it is necessary to analyze the relationship between other indicators of iron storage, and MetS and its compo...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12051486

    authors: Zhang H,Wang L,Li S,Liu X,Li Y,He Y,Man Q,Yang L

    更新日期:2020-05-20 00:00:00

  • A Novel Peptide Oligomer of Bacitracin Induces M1 Macrophage Polarization by Facilitating Ca2+ Influx.

    abstract::Antimicrobial peptides (AMPs) are components of the innate immune system and form the first defense against pathogens for various organisms. In the present study, we assessed whether CSP32, a novel AMP oligomer of bacitracin isolated from a strain of Bacillus spp., regulates the polarization of murine macrophage-like ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12061603

    authors: Ji SY,Lee H,Hwangbo H,Hong SH,Cha HJ,Park C,Kim DH,Kim GY,Kim S,Kim HS,Yoo JC,Choi YH

    更新日期:2020-05-29 00:00:00

  • Appetite and Subsequent Food Intake Were Unaffected by the Amount of Sourdough and Rye in Soft Bread-A Randomized Cross-Over Breakfast Study.

    abstract::Sourdough fermented bread has been suggested to have beneficial health effects, in part mediated by increased satiety in the postprandial phase, but only limited research has been conducted to verify this. The current study aimed to investigate the effect of the amounts of sourdough and rye in soft bread on postprandi...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu10111594

    authors: Iversen KN,Johansson D,Brunius C,Andlid T,Andersson R,Langton M,Landberg R

    更新日期:2018-10-30 00:00:00

  • The Chinese Herbal Formula PAPZ Ameliorates Behavioral Abnormalities in Depressive Mice.

    abstract::Major depressive disorder (MDD) is a chronic mental disorder characterized by mixed symptoms and complex pathogenesis. With long history of practical application, traditional Chinese medicine (TCM) offers many herbs for the treatment and rehabilitation of chronic disease. In this study, we developed a modified Chinese...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11040859

    authors: Chen H,Huang Q,Zhang S,Hu K,Xiong W,Xiao L,Cong R,Liu Q,Wang Z

    更新日期:2019-04-16 00:00:00

  • Distorted Taste and Impaired Oral Health in Patients with Sicca Complaints

    abstract::Senses of smell and taste, saliva flow, and dental status are considered as important factors for the maintenance of a good nutritional status. Salivary secretory rates, chemosensory function, burning mouth sensation, halitosis and dental status were investigated in 58 primary Sjögren's syndrome (pSS) patients, 22 non...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11020264

    authors: Singh PB,Young A,Homayouni A,Hove LH,Petrovski BÉ,Herlofson BB,Palm Ø,Rykke M,Jensen JL

    更新日期:2019-01-24 00:00:00

  • Understanding the Composition, Biosynthesis, Accumulation and Transport of Flavonoids in Crops for the Promotion of Crops as Healthy Sources of Flavonoids for Human Consumption.

    abstract::Flavonoids are a class of polyphenolic compounds that naturally occur in plants. Sub-groups of flavonoids include flavone, flavonol, flavanone, flavanonol, anthocyanidin, flavanol and isoflavone. The various modifications on flavonoid molecules further increase the diversity of flavonoids. Certain crops are famous for...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12061717

    authors: Ku YS,Ng MS,Cheng SS,Lo AW,Xiao Z,Shin TS,Chung G,Lam HM

    更新日期:2020-06-08 00:00:00

  • Ventilatory function in young adults and dietary antioxidant intake.

    abstract::Dietary antioxidants may protect against poor ventilatory function. We assessed the relation between ventilatory function and antioxidant components of diet in young Chileans. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and the ratio FEV1/FVC were measured in 1232 adults aged 22-28 years, usin...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu7042879

    authors: Garcia-Larsen V,Amigo H,Bustos P,Bakolis I,Rona RJ

    更新日期:2015-04-15 00:00:00

  • Dietary Folate Intake Is Negatively Associated with Excess Body Weight in Brazilian Graduates and Postgraduates (CUME Project).

    abstract::Folate, vitamin B6, and vitamin B12 intake can be important regulators for obesity development. Thus, we investigated the possible association between the intake of these vitamins and the excess body weight or obesity prevalence in the participants of the Cohort of Universities in Minas Gerais (CUME project). This stu...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11030518

    authors: Pereira GA,Bressan J,Oliveira FLP,Sant'Ana HMP,Pimenta AM,Lopes LL,Hermsdorff HHM

    更新日期:2019-02-28 00:00:00

  • Gluten and Functional Abdominal Pain Disorders in Children.

    abstract::In children, functional gastrointestinal disorders (FGIDs) are common at all ages. Consumption of certain foods, particularly gluten, is frequently associated with the development and persistence of FGIDs and functional abdominal pain disorders (FAPDs) in adults and children. However, this association is not well defi...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu10101491

    authors: Llanos-Chea A,Fasano A

    更新日期:2018-10-12 00:00:00

  • Dietary Carotenoid Intakes and Prostate Cancer Risk: A Case-Control Study from Vietnam.

    abstract::The incidence of prostate cancer has increased in Vietnam, but there have been few studies of the risk factors associated with this change. This retrospective case-control study investigated the relation of the intake of carotenoids and their food sources to prostate cancer risk. A sample of 652 participants (244 inci...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10010070

    authors: Van Hoang D,Pham NM,Lee AH,Tran DN,Binns CW

    更新日期:2018-01-11 00:00:00

  • Traditional Old Dietary Pattern of Castellana Grotte (Apulia) Is Associated with Healthy Outcomes.

    abstract:BACKGROUND:There is still room for further studies aimed at investigating the most widespread diets in the Mediterranean area. The objective of the study is to analyze the relation of food group intake to clinical chemical indicators of health, and also to compare the food group intake with healthy well-known diet indi...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12103097

    authors: Castellana F,Zupo R,Bortone I,Giannelli G,Donghia R,Lampignano L,Griseta C,De Pergola G,Boeing H,Cisternino AM,Logroscino G,Sardone R,Guerra V

    更新日期:2020-10-12 00:00:00

  • Agricultural Food Production Diversity and Dietary Diversity among Female Small Holder Farmers in a Region of the Ecuadorian Andes Experiencing Nutrition Transition.

    abstract::Some rural areas of Ecuador, including the Imbabura Province of the Andes Highlands, are experiencing a double burden of malnutrition where micronutrient deficiencies persist at the same time obesity is increasing as many traditional home-grown foods are being replaced with more commercially prepared convenience foods...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12082454

    authors: Melby CL,Orozco F,Averett J,Muñoz F,Romero MJ,Barahona A

    更新日期:2020-08-15 00:00:00

  • The Chemical Composition and Nutritional Value of Chia Seeds-Current State of Knowledge.

    abstract::Chia (Salvia hispanica) is an annual herbaceous plant, the seeds of which were consumed already thousands of years ago. Current research results indicate a high nutritive value for chia seeds and confirm their extensive health-promoting properties. Research indicates that components of chia seeds are ascribed a benefi...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu11061242

    authors: Kulczyński B,Kobus-Cisowska J,Taczanowski M,Kmiecik D,Gramza-Michałowska A

    更新日期:2019-05-31 00:00:00

  • Eating Alone at Each Meal and Associated Health Status among Community-Dwelling Japanese Elderly Living with Others: A Cross-Sectional Analysis of the KAGUYA Study.

    abstract::This cross-sectional study investigated the association between eating alone at each meal and health status, including functional capacity among community-dwelling Japanese elderly living with others. A self-administered questionnaire was mailed to all 8004 residents aged 65 or older, residing in the same Japanese tow...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12092805

    authors: Kushida O,Moon JS,Matsumoto D,Yamasaki N,Takatori K

    更新日期:2020-09-13 00:00:00

  • Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer.

    abstract::Breast cancer is a common cancer that occurs due to different epigenetic alterations and genetic mutations. Various epidemiological studies have demonstrated an inverse correlation between breast cancer incidence and flavonoid intake. The anti-cancer action of flavonoids, a class of polyphenolic compounds that are pre...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12030761

    authors: Selvakumar P,Badgeley A,Murphy P,Anwar H,Sharma U,Lawrence K,Lakshmikuttyamma A

    更新日期:2020-03-13 00:00:00

  • A Review of Recruitment, Adherence and Drop-Out Rates in Omega-3 Polyunsaturated Fatty Acid Supplementation Trials in Children and Adolescents.

    abstract:INTRODUCTION:The influence of n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA) supplementation on health outcomes has been studied extensively with randomized controlled trials (RCT). In many research fields, difficulties with recruitment, adherence and high drop-out rates have been reported. However, what is un...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu9050474

    authors: van der Wurff ISM,Meyer BJ,de Groot RHM

    更新日期:2017-05-10 00:00:00

  • First Trimester Serum Copper or Zinc Levels, and Risk of Pregnancy-Induced Hypertension.

    abstract::Early identification of women at risk of developing pregnancy-induced hypertension (PIH) is very important. The involvement of copper (Cu) and zinc (Zn) in the oxidative balance suggests the possibility of their association with this disease, in which oxidative stress plays a key role. However, it has not been establi...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11102479

    authors: Lewandowska M,Sajdak S,Marciniak W,Lubiński J

    更新日期:2019-10-16 00:00:00

  • Cultural Differences in Stress-Related Psychological, Nutrition, Physical Activity and Oral Health Factors of Professors.

    abstract::With the aim to explore cultural differences in stress-related psychological, nutrition, physical activity, and oral health factors between Spanish and Latin American professors, we analysed stress-related factors in 598 professors (39.9% male, 60.1% female, 41.3 ± 9.8 years) by a collection of questionnaires, which i...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12123644

    authors: Redondo-Flórez L,Fernández-Lucas J,Clemente-Suárez VJ

    更新日期:2020-11-27 00:00:00

  • What Is the Evidence for "Food Addiction?" A Systematic Review.

    abstract::The diagnostic construct of "food addiction" is a highly controversial subject. The current systematic review is the first to evaluate empirical studies examining the construct of "food addiction" in humans and animals. Studies were included if they were quantitative, peer-reviewed, and in the English language. The 52...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu10040477

    authors: Gordon EL,Ariel-Donges AH,Bauman V,Merlo LJ

    更新日期:2018-04-12 00:00:00

  • Recent advances and uses of grape flavonoids as nutraceuticals.

    abstract::Grape is one of the oldest fruit crops domesticated by humans. The numerous uses of grape in making wine, beverages, jelly, and other products, has made it one of the most economically important plants worldwide. The complex phytochemistry of the berry is characterized by a wide variety of compounds, most of which hav...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu6010391

    authors: Georgiev V,Ananga A,Tsolova V

    更新日期:2014-01-21 00:00:00