Abstract:
:Methotrexate (MTX), a folic acid antagonist, is widely used in cancer treatment. However, treatment with MTX reduces hippocampal neurogenesis, leading to memory deficits. Hesperidin (Hsd) is a flavonoid glycoside that promotes anti-inflammation, acts as an antioxidant, and has neuroprotective properties. Consumption of Hsd enhances learning and memory. In the present study, we investigated the protective effects of Hsd against MTX-induced impairments of memory and neurogenesis; male Sprague Dawley rats were administered with a single dose of MTX (75 mg/kg) by intravenous (i.v.) injection on days 8 and 15 or Hsd (100 mg/kg) by oral gavage for 21 days. Memory was tested using novel object location (NOL) and novel object recognition (NOR) tasks. Immunofluorescence staining of Ki-67, bromodeoxyuridine (BrdU), and doublecortin (DCX) was performed to assess cell proliferation, survival, and immature neurons. The data showed that Hsd and MTX did not disable locomotor ability. The MTX animals exhibited memory deficits in both memory tests. There were significant decreases in the numbers of cell proliferation, survival, and immature neurons in the MTX animals. However, co-administration with MTX and Hsd alleviated memory loss and neurogenesis decline. These results revealed that Hsd could protect against MTX side effects in the animals in this study.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Naewla S,Sirichoat A,Pannangrong W,Chaisawang P,Wigmore P,Welbat JUdoi
10.3390/nu11040936subject
Has Abstractpub_date
2019-04-25 00:00:00issue
4issn
2072-6643pii
nu11040936journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract::Increasing the insufficient intake of vegetables in children may be difficult, due to the influence of parents and at-home accessibility. The aim of this study was to analyze the association between self-reported vegetable consumption behaviors and preferences of mothers and the behaviors and preferences of their chil...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11051078
更新日期:2019-05-15 00:00:00
abstract::Trimethylamine-N-oxide (TMAO) is a small organic molecule, derived from the intestinal and hepatic metabolism of dietary choline and carnitine. Although the involvement of TMAO in the framework of many chronic diseases has been recently described, no evidence on its putative role in the central nervous system has been...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9101053
更新日期:2017-09-22 00:00:00
abstract::This study examined the effect of the Dietary Approaches to Stop Hypertension (DASH) diet containing lean red meat on measures of body composition and muscle strength in a cohort of obese adults 65 and older; 36 males (n = 15) and females (n = 21) consumed 1800 kcal/day for 12 weeks under controlled feeding conditions...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12010102
更新日期:2019-12-30 00:00:00
abstract::Breast milk (BM) is beneficial due to its content in a wide range of different antioxidants, particularly relevant for preterm infants, who are at higher risk of oxidative stress. We hypothesize that BM antioxidants are adapted to gestational age and are negatively influenced by maternal age. Fifty breastfeeding women...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092569
更新日期:2020-08-25 00:00:00
abstract::Reduction in cholesterol blood levels represents one of the therapeutic goals to achieve in order to reduce the occurrence of cardiovascular diseases. Commonly, this goal is attempted by promoting healthy lifestyle behaviors and low-fat diets. Recently, several nutraceuticals have been shown to possess cholesterol-low...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11010163
更新日期:2019-01-14 00:00:00
abstract::Metabolomics is a powerful tool for the investigation of interactions between diet, nutrients, and human metabolism. Ecklonia cava is an edible brown alga that is abundantly found in Korea and Japan and contains unique polyphenols referred to as phlorotannins. However, there are few metabolomics studies related to the...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12051407
更新日期:2020-05-14 00:00:00
abstract::Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analys...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123723
更新日期:2020-12-02 00:00:00
abstract::Necrotizing enterocolitis (NEC) remains a significant cause of morbidity and mortality in preterm infants. Formula feeding is a risk factor for NEC and osmolality, which is increased by the fortification that is required for adequate growth of the infant, has been suggested as a potential cause. Our laboratory has sho...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12040900
更新日期:2020-03-26 00:00:00
abstract::Hyperhomocysteinemia (HHcy) is recognized as a risk factor for cardiovascular disease. However, the prevalence of HHcy and its role in association with target organ damage in patients with chronickidney disease (CKD) are not well understood. This cross-sectional study included 1042 CKD patients who were admitted to ou...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8100645
更新日期:2016-10-20 00:00:00
abstract::Orthorexia nervosa (OrNe) describes a behavior where eating overly healthy develops into an obsession leading to significant impairment and stress. Initial studies support a bi-dimensional structure of orthorexic eating with one dimension healthy orthorexia (HeOr, interest in healthy eating), which can be distinguishe...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123662
更新日期:2020-11-28 00:00:00
abstract::As the population is aging rapidly, there is a strong increase in the number of individuals with chronic disease and physical limitations. The decrease in skeletal muscle mass and function (sarcopenia) and the increase in fat mass (obesity) are important contributors to the development of physical limitations, which a...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10050605
更新日期:2018-05-12 00:00:00
abstract:BACKGROUND:A clear evidence on the benefits of reducing salt in people with chronic kidney disease (CKD) is still lacking. Salt restriction in CKD may allow better control of blood pressure (BP) as shown in a previous systematic review while the effect on proteinuria reduction remains poorly investigated. METHODS:We p...
journal_title:Nutrients
pub_type: 杂志文章,meta分析,评审
doi:10.3390/nu10060732
更新日期:2018-06-06 00:00:00
abstract::The prevention or alleviation of neurodegenerative diseases, including Alzheimer's disease (AD), is a challenge for contemporary health services. The aim of this study was to review the literature on the prevention or alleviation of AD by introducing an appropriate carnitine-rich diet, dietary carnitine supplements an...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12071987
更新日期:2020-07-03 00:00:00
abstract::Limited work is available on the benefits of nutritional support enriched with arginine and n-3 fatty acids in surgical patients with head and neck cancer, particularly if well-nourished. We conducted a pilot study in these patients to examine effects on inflammatory markers and clinical outcome. Patients scheduled fo...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu5041186
更新日期:2013-04-09 00:00:00
abstract:BACKGROUND:Nickel (Ni) oral consumption may elicit systemic reactions in patients affected by systemic nickel allergy syndrome (SNAS), including gastrointestinal symptoms, which in turn are associated with gut dysbiosis. We evaluated the effects of a low-Ni diet alone or in combination with the oral consumption of appr...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12041040
更新日期:2020-04-09 00:00:00
abstract::The fight against neurodegenerative diseases is promoting the searching of nutrients, preferably of wide consumption, with proven effects on health. Beer is widely consumed and has potential benefits on health. In this work, three different extracts from dark beer (DB), non-alcoholic beer (NAB), and lager beer (LB) we...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11061258
更新日期:2019-06-03 00:00:00
abstract::Health claims on foods are a way of informing consumers about the health benefits of a food product. Traditionally, these claims are based on scientific evaluation of markers originating from a pharmacological view on health. About a decade ago, the definition of health has been rephrased to 'the ability to adapt' tha...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12102945
更新日期:2020-09-25 00:00:00
abstract::This review provides a literature overview of new findings relating nutritional genomics and bariatric surgery. It also describes the importance of nutritional genomics concepts in personalized bariatric management. It includes a discussion of the potential role bariatric surgery plays in altering the three pillars of...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu9090974
更新日期:2017-09-06 00:00:00
abstract::Fibromyalgia (FM) is a multifactorial syndrome of unknown etiology, characterized by widespread chronic pain and various somatic and psychological manifestations. The management of FM requires a multidisciplinary approach combining both pharmacological and nonpharmacological strategies. Among nonpharmacological strate...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12092525
更新日期:2020-08-20 00:00:00
abstract::(1) BACKGROUND: Assessing the quality of growth in premature infants is important in order to be able to provide them with optimal nutrition. The Pea Pod device, based on air displacement plethysmography, is able to assess body composition of infants. However, this method has not been sufficiently evaluated in prematu...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8040238
更新日期:2016-04-22 00:00:00
abstract::In the following review, we evaluated the current literature and evidence-based data on transdermal magnesium application and show that the propagation of transdermal magnesium is scientifically unsupported. The importance of magnesium and the positive effects of magnesium supplementation are extensively documented in...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu9080813
更新日期:2017-07-28 00:00:00
abstract:BACKGROUND:The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozoto...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112720
更新日期:2019-11-09 00:00:00
abstract::Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connectin...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu7115458
更新日期:2015-11-06 00:00:00
abstract::Reducing salt intake is a cost-effective public health intervention to reduce the global burden of non-communicable disease (NCDs). Ultra-processed foods contribute ~80% of dietary salt in high income countries, and are becoming prominent in low-middle income countries. Instant noodle consumption is particularly high ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9060612
更新日期:2017-06-16 00:00:00
abstract::There is currently little information on changes in vitamin D status during pregnancy and its predictors. The aim was to study the determinants of change in vitamin D status during pregnancy and of vitamin D deficiency (<30 nmol/L) in early pregnancy. Blood was drawn in the first (T1) and third trimester (T3). Serum 2...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu8100655
更新日期:2016-10-22 00:00:00
abstract::This study aimed to complete the scientific basis for the validation of a coffee silverskin extract (CSE) as a novel food ingredient according to European legislation. Nutritional value, safety, effects on biochemical biomarkers and excretion of short chain fatty acids (SCFAs) in vivo of CSE were assessed. Proteins, a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11112693
更新日期:2019-11-07 00:00:00
abstract::Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a considerable variation in the extent of disease and functional impairment risk, revealing a need for valid biomarkers to aid in characterizing the complex aging processes. The identification of...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu8060338
更新日期:2016-06-02 00:00:00
abstract::Protein intake recommendations to optimally stimulate muscle protein synthesis (MPS) are derived from dose-response studies examining the stimulatory effects of isolated intact proteins (e.g., whey, egg) on MPS in healthy individuals during energy balance. Those recommendations may not be adequate during periods of ph...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12082457
更新日期:2020-08-15 00:00:00
abstract::Dietary habits in adolescence persist into adulthood; thus, it is important to identify the factors that influence adolescent diet and establish a healthy diet. This study aimed to examine the association between mothers' nutrition knowledge and their children's nutrient intake inadequacy among Japanese junior high sc...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12092801
更新日期:2020-09-13 00:00:00
abstract::As the population ages, the risk of becoming malnourished increases. Research has shown that poor oral health can be a risk factor for malnutrition in institutionalized elderly. However, it remains unclear whether oral health problems, edentulousness and health-related quality of life also pose a risk for malnutrition...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10121965
更新日期:2018-12-12 00:00:00