Hesperidin Alleviates Methotrexate-Induced Memory Deficits via Hippocampal Neurogenesis in Adult Rats.

Abstract:

:Methotrexate (MTX), a folic acid antagonist, is widely used in cancer treatment. However, treatment with MTX reduces hippocampal neurogenesis, leading to memory deficits. Hesperidin (Hsd) is a flavonoid glycoside that promotes anti-inflammation, acts as an antioxidant, and has neuroprotective properties. Consumption of Hsd enhances learning and memory. In the present study, we investigated the protective effects of Hsd against MTX-induced impairments of memory and neurogenesis; male Sprague Dawley rats were administered with a single dose of MTX (75 mg/kg) by intravenous (i.v.) injection on days 8 and 15 or Hsd (100 mg/kg) by oral gavage for 21 days. Memory was tested using novel object location (NOL) and novel object recognition (NOR) tasks. Immunofluorescence staining of Ki-67, bromodeoxyuridine (BrdU), and doublecortin (DCX) was performed to assess cell proliferation, survival, and immature neurons. The data showed that Hsd and MTX did not disable locomotor ability. The MTX animals exhibited memory deficits in both memory tests. There were significant decreases in the numbers of cell proliferation, survival, and immature neurons in the MTX animals. However, co-administration with MTX and Hsd alleviated memory loss and neurogenesis decline. These results revealed that Hsd could protect against MTX side effects in the animals in this study.

journal_name

Nutrients

journal_title

Nutrients

authors

Naewla S,Sirichoat A,Pannangrong W,Chaisawang P,Wigmore P,Welbat JU

doi

10.3390/nu11040936

subject

Has Abstract

pub_date

2019-04-25 00:00:00

issue

4

issn

2072-6643

pii

nu11040936

journal_volume

11

pub_type

杂志文章
  • Mothers' Vegetable Consumption Behaviors and Preferences as Factors Limiting the Possibility of Increasing Vegetable Consumption in Children in a National Sample of Polish and Romanian Respondents.

    abstract::Increasing the insufficient intake of vegetables in children may be difficult, due to the influence of parents and at-home accessibility. The aim of this study was to analyze the association between self-reported vegetable consumption behaviors and preferences of mothers and the behaviors and preferences of their chil...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11051078

    authors: Groele B,Głąbska D,Gutkowska K,Guzek D

    更新日期:2019-05-15 00:00:00

  • The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid.

    abstract::Trimethylamine-N-oxide (TMAO) is a small organic molecule, derived from the intestinal and hepatic metabolism of dietary choline and carnitine. Although the involvement of TMAO in the framework of many chronic diseases has been recently described, no evidence on its putative role in the central nervous system has been...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu9101053

    authors: Del Rio D,Zimetti F,Caffarra P,Tassotti M,Bernini F,Brighenti F,Zini A,Zanotti I

    更新日期:2017-09-22 00:00:00

  • A Calorie-Restricted DASH Diet Reduces Body Fat and Maintains Muscle Strength in Obese Older Adults.

    abstract::This study examined the effect of the Dietary Approaches to Stop Hypertension (DASH) diet containing lean red meat on measures of body composition and muscle strength in a cohort of obese adults 65 and older; 36 males (n = 15) and females (n = 21) consumed 1800 kcal/day for 12 weeks under controlled feeding conditions...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12010102

    authors: Perry CA,Van Guilder GP,Kauffman A,Hossain M

    更新日期:2019-12-30 00:00:00

  • Influence of Maternal Age and Gestational Age on Breast Milk Antioxidants During the First Month of Lactation.

    abstract::Breast milk (BM) is beneficial due to its content in a wide range of different antioxidants, particularly relevant for preterm infants, who are at higher risk of oxidative stress. We hypothesize that BM antioxidants are adapted to gestational age and are negatively influenced by maternal age. Fifty breastfeeding women...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12092569

    authors: Gila-Díaz A,Herranz Carrillo G,Cañas S,Saenz de Pipaón M,Martínez-Orgado JA,Rodríguez-Rodríguez P,López de Pablo ÁL,Martin-Cabrejas MA,Ramiro-Cortijo D,Arribas SM

    更新日期:2020-08-25 00:00:00

  • A Boost in Mitochondrial Activity Underpins the Cholesterol-Lowering Effect of Annurca Apple Polyphenols on Hepatic Cells.

    abstract::Reduction in cholesterol blood levels represents one of the therapeutic goals to achieve in order to reduce the occurrence of cardiovascular diseases. Commonly, this goal is attempted by promoting healthy lifestyle behaviors and low-fat diets. Recently, several nutraceuticals have been shown to possess cholesterol-low...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11010163

    authors: Sommella E,Badolati N,Riccio G,Salviati E,Bottone S,Dentice M,Campiglia P,Tenore GC,Stornaiuolo M,Novellino E

    更新日期:2019-01-14 00:00:00

  • Urinary Metabolomic Profiling Analysis and Evaluation of the Effect of Ecklonia cava Extract Intake.

    abstract::Metabolomics is a powerful tool for the investigation of interactions between diet, nutrients, and human metabolism. Ecklonia cava is an edible brown alga that is abundantly found in Korea and Japan and contains unique polyphenols referred to as phlorotannins. However, there are few metabolomics studies related to the...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12051407

    authors: Kim J,Jung Y,Lee E,Jang S,Ryu DH,Kwon O,Hwang GS

    更新日期:2020-05-14 00:00:00

  • Alterations in One-Carbon Metabolism in Celiac Disease.

    abstract::Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analys...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12123723

    authors: Martín-Masot R,Mota-Martorell N,Jové M,Maldonado J,Pamplona R,Nestares T

    更新日期:2020-12-02 00:00:00

  • Feeding Formula Eliminates the Necessity of Bacterial Dysbiosis and Induces Inflammation and Injury in the Paneth Cell Disruption Murine NEC Model in an Osmolality-Dependent Manner.

    abstract::Necrotizing enterocolitis (NEC) remains a significant cause of morbidity and mortality in preterm infants. Formula feeding is a risk factor for NEC and osmolality, which is increased by the fortification that is required for adequate growth of the infant, has been suggested as a potential cause. Our laboratory has sho...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12040900

    authors: Lueschow SR,Kern SL,Gong H,Grobe JL,Segar JL,Carlson SJ,McElroy SJ

    更新日期:2020-03-26 00:00:00

  • High Prevalence of Hyperhomocysteinemia and Its Association with Target Organ Damage in Chinese Patients with Chronic Kidney Disease.

    abstract::Hyperhomocysteinemia (HHcy) is recognized as a risk factor for cardiovascular disease. However, the prevalence of HHcy and its role in association with target organ damage in patients with chronickidney disease (CKD) are not well understood. This cross-sectional study included 1042 CKD patients who were admitted to ou...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu8100645

    authors: Ye Z,Zhang Q,Li Y,Wang C,Zhang J,Ma X,Peng H,Lou T

    更新日期:2016-10-20 00:00:00

  • The Dark Side of Healthy Eating: Links between Orthorexic Eating and Mental Health.

    abstract::Orthorexia nervosa (OrNe) describes a behavior where eating overly healthy develops into an obsession leading to significant impairment and stress. Initial studies support a bi-dimensional structure of orthorexic eating with one dimension healthy orthorexia (HeOr, interest in healthy eating), which can be distinguishe...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12123662

    authors: Strahler J

    更新日期:2020-11-28 00:00:00

  • Exercise and Nutrition Strategies to Counteract Sarcopenic Obesity.

    abstract::As the population is aging rapidly, there is a strong increase in the number of individuals with chronic disease and physical limitations. The decrease in skeletal muscle mass and function (sarcopenia) and the increase in fat mass (obesity) are important contributors to the development of physical limitations, which a...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu10050605

    authors: Trouwborst I,Verreijen A,Memelink R,Massanet P,Boirie Y,Weijs P,Tieland M

    更新日期:2018-05-12 00:00:00

  • Dietary Salt Restriction in Chronic Kidney Disease: A Meta-Analysis of Randomized Clinical Trials.

    abstract:BACKGROUND:A clear evidence on the benefits of reducing salt in people with chronic kidney disease (CKD) is still lacking. Salt restriction in CKD may allow better control of blood pressure (BP) as shown in a previous systematic review while the effect on proteinuria reduction remains poorly investigated. METHODS:We p...

    journal_title:Nutrients

    pub_type: 杂志文章,meta分析,评审

    doi:10.3390/nu10060732

    authors: Garofalo C,Borrelli S,Provenzano M,De Stefano T,Vita C,Chiodini P,Minutolo R,De Nicola L,Conte G

    更新日期:2018-06-06 00:00:00

  • Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease.

    abstract::The prevention or alleviation of neurodegenerative diseases, including Alzheimer's disease (AD), is a challenge for contemporary health services. The aim of this study was to review the literature on the prevention or alleviation of AD by introducing an appropriate carnitine-rich diet, dietary carnitine supplements an...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12071987

    authors: Kepka A,Ochocinska A,Borzym-Kluczyk M,Skorupa E,Stasiewicz-Jarocka B,Chojnowska S,Waszkiewicz N

    更新日期:2020-07-03 00:00:00

  • Perioperative immunonutrition in well-nourished patients undergoing surgery for head and neck cancer: evaluation of inflammatory and immunologic outcomes.

    abstract::Limited work is available on the benefits of nutritional support enriched with arginine and n-3 fatty acids in surgical patients with head and neck cancer, particularly if well-nourished. We conducted a pilot study in these patients to examine effects on inflammatory markers and clinical outcome. Patients scheduled fo...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu5041186

    authors: Turnock A,Calder PC,West AL,Izzard M,Morton RP,Plank LD

    更新日期:2013-04-09 00:00:00

  • The Effects of Low-Nickel Diet Combined with Oral Administration of Selected Probiotics on Patients with Systemic Nickel Allergy Syndrome (SNAS) and Gut Dysbiosis.

    abstract:BACKGROUND:Nickel (Ni) oral consumption may elicit systemic reactions in patients affected by systemic nickel allergy syndrome (SNAS), including gastrointestinal symptoms, which in turn are associated with gut dysbiosis. We evaluated the effects of a low-Ni diet alone or in combination with the oral consumption of appr...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12041040

    authors: Lombardi F,Fiasca F,Minelli M,Maio D,Mattei A,Vergallo I,Cifone MG,Cinque B,Minelli M

    更新日期:2020-04-09 00:00:00

  • Modulation of Adenosine Receptors and Antioxidative Effect of Beer Extracts in in Vitro Models.

    abstract::The fight against neurodegenerative diseases is promoting the searching of nutrients, preferably of wide consumption, with proven effects on health. Beer is widely consumed and has potential benefits on health. In this work, three different extracts from dark beer (DB), non-alcoholic beer (NAB), and lager beer (LB) we...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11061258

    authors: Alonso-Andrés P,Martín M,Albasanz JL

    更新日期:2019-06-03 00:00:00

  • Next Generation Health Claims Based on Resilience: The Example of Whole-Grain Wheat.

    abstract::Health claims on foods are a way of informing consumers about the health benefits of a food product. Traditionally, these claims are based on scientific evaluation of markers originating from a pharmacological view on health. About a decade ago, the definition of health has been rephrased to 'the ability to adapt' tha...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12102945

    authors: Hoevenaars F,van der Kamp JW,van den Brink W,Wopereis S

    更新日期:2020-09-25 00:00:00

  • Bariatric Surgery and Precision Nutrition.

    abstract::This review provides a literature overview of new findings relating nutritional genomics and bariatric surgery. It also describes the importance of nutritional genomics concepts in personalized bariatric management. It includes a discussion of the potential role bariatric surgery plays in altering the three pillars of...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu9090974

    authors: Nicoletti CF,Cortes-Oliveira C,Pinhel MAS,Nonino CB

    更新日期:2017-09-06 00:00:00

  • Nutritional Interventions in the Management of Fibromyalgia Syndrome.

    abstract::Fibromyalgia (FM) is a multifactorial syndrome of unknown etiology, characterized by widespread chronic pain and various somatic and psychological manifestations. The management of FM requires a multidisciplinary approach combining both pharmacological and nonpharmacological strategies. Among nonpharmacological strate...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12092525

    authors: Pagliai G,Giangrandi I,Dinu M,Sofi F,Colombini B

    更新日期:2020-08-20 00:00:00

  • An Evaluation of the Pea Pod System for Assessing Body Composition of Moderately Premature Infants.

    abstract::(1) BACKGROUND: Assessing the quality of growth in premature infants is important in order to be able to provide them with optimal nutrition. The Pea Pod device, based on air displacement plethysmography, is able to assess body composition of infants. However, this method has not been sufficiently evaluated in prematu...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu8040238

    authors: Forsum E,Olhager E,Törnqvist C

    更新日期:2016-04-22 00:00:00

  • Myth or Reality-Transdermal Magnesium?

    abstract::In the following review, we evaluated the current literature and evidence-based data on transdermal magnesium application and show that the propagation of transdermal magnesium is scientifically unsupported. The importance of magnesium and the positive effects of magnesium supplementation are extensively documented in...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu9080813

    authors: Gröber U,Werner T,Vormann J,Kisters K

    更新日期:2017-07-28 00:00:00

  • Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus.

    abstract:BACKGROUND:The presence of β-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozoto...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11112720

    authors: Laurino LF,Viroel FJM,Caetano E,Spim S,Pickler TB,Rosa-Castro RM,Vasconcelos EA,Jozala AF,Hataka A,Grotto D,Gerenutti M

    更新日期:2019-11-09 00:00:00

  • Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?

    abstract::Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connectin...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu7115458

    authors: Grandone A,Marzuillo P,Perrone L,Del Giudice EM

    更新日期:2015-11-06 00:00:00

  • Know Your Noodles! Assessing Variations in Sodium Content of Instant Noodles across Countries.

    abstract::Reducing salt intake is a cost-effective public health intervention to reduce the global burden of non-communicable disease (NCDs). Ultra-processed foods contribute ~80% of dietary salt in high income countries, and are becoming prominent in low-middle income countries. Instant noodle consumption is particularly high ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu9060612

    authors: Farrand C,Charlton K,Crino M,Santos J,Rodriguez-Fernandez R,Ni Mhurchu C,Webster J

    更新日期:2017-06-16 00:00:00

  • Vitamin D Status during Pregnancy in a Multi-Ethnic Population-Representative Swedish Cohort.

    abstract::There is currently little information on changes in vitamin D status during pregnancy and its predictors. The aim was to study the determinants of change in vitamin D status during pregnancy and of vitamin D deficiency (<30 nmol/L) in early pregnancy. Blood was drawn in the first (T1) and third trimester (T3). Serum 2...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu8100655

    authors: Bärebring L,Schoenmakers I,Glantz A,Hulthén L,Jagner Å,Ellis J,Bärebring M,Bullarbo M,Augustin H

    更新日期:2016-10-22 00:00:00

  • Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions.

    abstract::This study aimed to complete the scientific basis for the validation of a coffee silverskin extract (CSE) as a novel food ingredient according to European legislation. Nutritional value, safety, effects on biochemical biomarkers and excretion of short chain fatty acids (SCFAs) in vivo of CSE were assessed. Proteins, a...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11112693

    authors: Iriondo-DeHond A,Rios MB,Herrera T,Rodriguez-Bertos A,Nuñez F,San Andres MI,Sanchez-Fortun S,Del Castillo MD

    更新日期:2019-11-07 00:00:00

  • Biomarkers of Aging: From Function to Molecular Biology.

    abstract::Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a considerable variation in the extent of disease and functional impairment risk, revealing a need for valid biomarkers to aid in characterizing the complex aging processes. The identification of...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu8060338

    authors: Wagner KH,Cameron-Smith D,Wessner B,Franzke B

    更新日期:2016-06-02 00:00:00

  • Muscle Protein Synthesis and Whole-Body Protein Turnover Responses to Ingesting Essential Amino Acids, Intact Protein, and Protein-Containing Mixed Meals with Considerations for Energy Deficit.

    abstract::Protein intake recommendations to optimally stimulate muscle protein synthesis (MPS) are derived from dose-response studies examining the stimulatory effects of isolated intact proteins (e.g., whey, egg) on MPS in healthy individuals during energy balance. Those recommendations may not be adequate during periods of ph...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12082457

    authors: Gwin JA,Church DD,Wolfe RR,Ferrando AA,Pasiakos SM

    更新日期:2020-08-15 00:00:00

  • Mothers' Nutrition Knowledge Is Unlikely to Be Related to Adolescents' Habitual Nutrient Intake Inadequacy in Japan: A Cross-Sectional Study of Japanese Junior High School Students.

    abstract::Dietary habits in adolescence persist into adulthood; thus, it is important to identify the factors that influence adolescent diet and establish a healthy diet. This study aimed to examine the association between mothers' nutrition knowledge and their children's nutrient intake inadequacy among Japanese junior high sc...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12092801

    authors: Matsumoto M,Hatamoto Y,Masumoto A,Sakamoto A,Ikemoto S

    更新日期:2020-09-13 00:00:00

  • Are Edentulousness, Oral Health Problems and Poor Health-Related Quality of Life Associated with Malnutrition in Community-Dwelling Elderly (Aged 75 Years and Over)? A Cross-Sectional Study.

    abstract::As the population ages, the risk of becoming malnourished increases. Research has shown that poor oral health can be a risk factor for malnutrition in institutionalized elderly. However, it remains unclear whether oral health problems, edentulousness and health-related quality of life also pose a risk for malnutrition...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10121965

    authors: Bakker MH,Vissink A,Spoorenberg SLW,Jager-Wittenaar H,Wynia K,Visser A

    更新日期:2018-12-12 00:00:00