Coffee Silverskin Extract: Nutritional Value, Safety and Effect on Key Biological Functions.

Abstract:

:This study aimed to complete the scientific basis for the validation of a coffee silverskin extract (CSE) as a novel food ingredient according to European legislation. Nutritional value, safety, effects on biochemical biomarkers and excretion of short chain fatty acids (SCFAs) in vivo of CSE were assessed. Proteins, amino acids, fat, fatty acids, fiber, simple sugars and micronutrients were analyzed. For the first time, toxicological and physiological effects were evaluated in vivo by a repeated-dose study in healthy Wistar rats. Hormone secretion, antioxidant (enzymatic and no-enzymatic) and anti-inflammatory biomarkers, and dietary fiber fermentability of CSE (analysis of SCFAs in feces) were studied in biological samples. This unique research confirms the feasibility of CSE as a human dietary supplement with several nutrition claims: "source of proteins (16%), potassium, magnesium, calcium and vitamin C, low in fat (0.44%) and high in fiber (22%)". This is the first report demonstrating that its oral administration (1 g/kg) for 28 days is innocuous. Hormone secretion, antioxidant or anti-inflammatory biomarkers were not affected in heathy animals. Total SCFAs derived from CSE fiber fermentation were significantly higher (p < 0.05) in male treated rats compared to male control rats. All the new information pinpoints CSE as a natural, sustainable and safe food ingredient containing fermentable fiber able to produce SCFAs with beneficial effects on gut microbiota.

journal_name

Nutrients

journal_title

Nutrients

authors

Iriondo-DeHond A,Rios MB,Herrera T,Rodriguez-Bertos A,Nuñez F,San Andres MI,Sanchez-Fortun S,Del Castillo MD

doi

10.3390/nu11112693

subject

Has Abstract

pub_date

2019-11-07 00:00:00

issue

11

issn

2072-6643

pii

nu11112693

journal_volume

11

pub_type

杂志文章
  • Modeling Associations between Chemosensation, Liking for Fats and Sweets, Dietary Behaviors and Body Mass Index in Chronic Smokers.

    abstract::Chronic smokers have a greater risk for altered chemosensation, unhealthy dietary patterns, and excessive adiposity. In an observational study of chronic smokers, we modeled relationships between chemosensation, fat/carbohydrate liking, smoking-associated dietary behaviors, and body mass index (BMI). Also tested in th...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11020271

    authors: Larsen BA,Litt MD,Huedo-Medina TB,Duffy VB

    更新日期:2019-01-26 00:00:00

  • Effect of Dietary Incorporation of Linseed Alone or Together with Tomato-Red Pepper Mix on Laying Hens' Egg Yolk Fatty Acids Profile and Health Lipid Indexes.

    abstract::This study evaluated the effect of linseed incorporation in laying hens' feed (alone or along with a tomato-red pepper mix) on laying hens' egg yolk fatty acids profile, as well as on their atherogenic (IA) and thrombogenic (IT) health lipid indexes, and the ratio between the hypocholesterolemic and hypercholesterolem...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11040813

    authors: Omri B,Chalghoumi R,Izzo L,Ritieni A,Lucarini M,Durazzo A,Abdouli H,Santini A

    更新日期:2019-04-10 00:00:00

  • Improved Information and Educational Messages on Outer Packaging of Micronutrient Powders Distributed in Indonesia Increase Caregiver Knowledge and Adherence to Recommended Use.

    abstract::The objective of this study was to examine the influence of improved information and educational messages on outer packaging of a micronutrient powder (MNP), locally known as “Taburia”, on knowledge and adherence to recommended use. A community-based cluster randomized controlled trial was conducted among ...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu10060747

    authors: Sutrisna A,Vossenaar M,Poonawala A,Mallipu A,Izwardy D,Menon R,Tumilowicz A

    更新日期:2018-06-08 00:00:00

  • Socio-Ecological Factors That Influence Infant and Young Child Nutrition in Kiribati: A Biocultural Perspective.

    abstract::This study sought to elucidate the multi-level factors that influence behaviors underlying high childhood stunting and widespread micronutrient deficiencies in Kiribati. This two-phase formative research study had an emergent and iterative design using the socio-ecological model as the guiding theoretical framework. P...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11061330

    authors: Kodish SR,Grey K,Matean M,Palaniappan U,Gwavuya S,Gomez C,Iuta T,Timeon E,Northrup-Lyons M,McLean J,Erasmus W

    更新日期:2019-06-13 00:00:00

  • Metformin Treatment and Homocysteine: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    abstract::The aim of this systematic review is to assess whether metformin could change the concentration of serum homocysteine (Hcy) with and without simultaneous supplementation of B-group vitamins or folic acid. A literature search was conducted in PubMed, EmBase, and Cochrane Central Register of Controlled Trials (CENTRAL) ...

    journal_title:Nutrients

    pub_type: 杂志文章,meta分析,评审

    doi:10.3390/nu8120798

    authors: Zhang Q,Li S,Li L,Li Q,Ren K,Sun X,Li J

    更新日期:2016-12-09 00:00:00

  • Nutritional Status and Risk Factors for Frailty in Community-Dwelling Older People: A Cross-Sectional Study.

    abstract:OBJECTIVE:This study aims to assess the relationship that frailty has with nutritional status and functional risk factors in community-dwelling older adults. METHODS:Cross-sectional study in community-dwelling older people, independent for walking and without impaired cognition. Frailty was assessed by Fried criteria....

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12041041

    authors: Pérez-Ros P,Vila-Candel R,López-Hernández L,Martínez-Arnau FM

    更新日期:2020-04-10 00:00:00

  • A Specific Nutrient Combination Attenuates the Reduced Expression of PSD-95 in the Proximal Dendrites of Hippocampal Cell Body Layers in a Mouse Model of Phenylketonuria.

    abstract::The inherited metabolic disease phenylketonuria (PKU) is characterized by increased concentrations of phenylalanine in the blood and brain, and as a consequence neurotransmitter metabolism, white matter, and synapse functioning are affected. A specific nutrient combination (SNC) has been shown to improve synapse forma...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu8040185

    authors: Bruinenberg VM,van Vliet D,Attali A,de Wilde MC,Kuhn M,van Spronsen FJ,van der Zee EA

    更新日期:2016-03-26 00:00:00

  • Eveningness in Energy Intake among Adolescents with Implication on Anthropometric Indicators of Nutritional Status: The CRO-PALS Longitudinal Study.

    abstract::Shifting of energy intake towards a later time in the day is associated with an increased risk of obesity in adults. However, there is a lack of data for adolescents. The aim of this study was to investigate adolescents eveningness in energy intake (EV) and its association with anthropometric indicators of nutritional...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12061710

    authors: Rešetar J,Pfeifer D,Mišigoj-Duraković M,Sorić M,Gajdoš Kljusurić J,Šatalić Z

    更新日期:2020-06-07 00:00:00

  • Characterization of the Types of Sweeteners Consumed in Honduras.

    abstract::Sweeteners are found in all types of foods, and their high consumption is associated with chronic degenerative diseases, such as diabetes and obesity, among others. A characterization was carried out of food products with sweeteners from the three biggest supermarkets at a national level; they were identified by the l...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10030338

    authors: Hernández A,Di Iorio AB,Lansdale J,Salazar MB

    更新日期:2018-03-11 00:00:00

  • Nutrition in Ultra-Endurance: State of the Art.

    abstract::Athletes competing in ultra-endurance sports should manage nutritional issues, especially with regards to energy and fluid balance. An ultra-endurance race, considered a duration of at least 6 h, might induce the energy balance (i.e., energy deficit) in levels that could reach up to ~7000 kcal per day. Such a negative...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu10121995

    authors: Nikolaidis PT,Veniamakis E,Rosemann T,Knechtle B

    更新日期:2018-12-16 00:00:00

  • Changes in Free-Living Glycemic Profiles after 12 Months of Lifestyle Intervention in Children with Overweight and with Obesity.

    abstract::Previous studies demonstrated that hyperglycemic glucose concentrations are observed in children that are overweight or have obesity. The aim of this study was to evaluate the effect of a 12 month lifestyle intervention on free-living glycemic profiles in children that were overweight or had obesity, and the associati...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12051228

    authors: Karnebeek K,Rijks JM,Dorenbos E,Gerver WM,Plat J,Vreugdenhil ACE

    更新日期:2020-04-26 00:00:00

  • Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial).

    abstract::Coronary artery calcification (CAC) develops early in the pathogenesis of atherosclerosis and is a strong and independent predictor of cardiovascular disease (CVD). Arterial calcification is caused by an imbalance in calcification regulatory mechanisms. An important inhibitor of calcification is vitamin K-dependent ma...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu7115443

    authors: Vossen LM,Schurgers LJ,van Varik BJ,Kietselaer BL,Vermeer C,Meeder JG,Rahel BM,van Cauteren YJ,Hoffland GA,Rennenberg RJ,Reesink KD,de Leeuw PW,Kroon AA

    更新日期:2015-10-28 00:00:00

  • Cross-Talk between Diet-Associated Dysbiosis and Hand Osteoarthritis.

    abstract::Hand osteoarthritis (OA) is a degenerative joint disease which leads to pain and disability. Recent studies focus on the role of obesity and metabolic syndrome in inducing or worsening joint damage in hand OA patients, suggesting that chronic low-grade systemic inflammation may represent a possible linking factor. The...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12113469

    authors: Silvestre MP,Rodrigues AM,Canhão H,Marques C,Teixeira D,Calhau C,Branco J

    更新日期:2020-11-12 00:00:00

  • Evaluation of the Proximity of Singaporean Children's Dietary Habits to Food-Based Dietary Guidelines.

    abstract::Dietary habits in children may not only impact current health status but could also shape future, lifelong dietary choices. Dietary intake data in Singaporean children are limited. The current study aimed to define the overall diet quality of Singaporean children using an existing cross-sectional dataset and to consid...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11112615

    authors: Brownlee IA,Low J,Duriraju N,Chun M,Ong JXY,Tay ME,Hendrie GA,Santos-Merx L

    更新日期:2019-11-01 00:00:00

  • Effect of Micronutrient Powder (MNP) with a Low-Dose of Iron on Hemoglobin and Iron Biomarkers, and Its Effect on Morbidities in Rural Bangladeshi Children Drinking Groundwater with a High-Level of Iron: A Randomized Controlled Trial.

    abstract::Micronutrient Powder (MNP) is beneficial to control anemia, but some iron-related side-effects are common. A high level of iron in the groundwater used for drinking may exacerbate the side-effects among MNP users. We conducted a randomized controlled trial examining the effect of a low-dose iron MNP compared with the ...

    journal_title:Nutrients

    pub_type: 杂志文章,随机对照试验

    doi:10.3390/nu11112756

    authors: Rahman S,Lee P,Raqib R,Roy AK,Khan MR,Ahmed F

    更新日期:2019-11-13 00:00:00

  • Protective Efficacy of a Dietary Supplement Based on Forskolin, Homotaurine, Spearmint Extract, and Group B Vitamins in a Mouse Model of Optic Nerve Injury.

    abstract::Glaucoma is a multifactorial blinding disease with a major inflammatory component ultimately leading to apoptotic retinal ganglion cell (RGC) death. Pharmacological treatments lowering intraocular pressure can help slow or prevent vision loss although the damage caused by glaucoma cannot be reversed. Recently, nutriti...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11122931

    authors: Locri F,Cammalleri M,Dal Monte M,Rusciano D,Bagnoli P

    更新日期:2019-12-03 00:00:00

  • Imbalance between Omega-6 and Omega-3 Polyunsaturated Fatty Acids in Early Pregnancy Is Predictive of Postpartum Depression in a Belgian Cohort.

    abstract::While studies revealed that the omega-3 polyunsaturated fatty acids (n-3 PUFA) and their mediators would be able to regulate several biological processes involved into the development of postpartum depression (PPD), evidence from observational studies remains mixed. The aim of the present study was to investigate the ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu11040876

    authors: Hoge A,Tabar V,Donneau AF,Dardenne N,Degée S,Timmermans M,Nisolle M,Guillaume M,Castronovo V

    更新日期:2019-04-18 00:00:00

  • β-Cyclodextrin Does not Alter the Bioaccessibility and the Uptake by Caco-2 Cells of Olive By-Product Phenolic Compounds.

    abstract::Alperujo-a two-phase olive mill waste that is composed of olive vegetation water and solid skin, pulp, and seed fragments - is a highly valuable olive by-product due to its high content in phenolic compounds. In this study, we assessed whether β-cyclodextrin (β-CD), which is used to extract and protect alpejuro phenol...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu10111653

    authors: Malapert A,Tomao V,Margier M,Nowicki M,Gleize B,Dangles O,Reboul E

    更新日期:2018-11-03 00:00:00

  • Current Hypothesis for the Relationship between Dietary Rice Bran Intake, the Intestinal Microbiota and Colorectal Cancer Prevention.

    abstract::Globally, colorectal cancer (CRC) is the third most common form of cancer. The development of effective chemopreventive strategies to reduce CRC incidence is therefore of paramount importance. Over the past decade, research has indicated the potential of rice bran, a byproduct of rice milling, in CRC chemoprevention. ...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu8090569

    authors: So WK,Law BM,Law PT,Chan CW,Chair SY

    更新日期:2016-09-15 00:00:00

  • A population model of folate-mediated one-carbon metabolism.

    abstract:BACKGROUND:Previous mathematical models for hepatic and tissue one-carbon metabolism have been combined and extended to include a blood plasma compartment. We use this model to study how the concentrations of metabolites that can be measured in the plasma are related to their respective intracellular concentrations. M...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu5072457

    authors: Duncan TM,Reed MC,Nijhout HF

    更新日期:2013-07-05 00:00:00

  • Vitamin-D Receptor-Gene Polymorphisms Affect Quality of Life in Patients with Autoimmune Liver Diseases.

    abstract::Vitamin D deficiency has been associated with depressive symptoms and reduced physical functioning. The aim of the study was to characterize the relationship between polymorphisms of the vitamin D receptor (VDR) gene and the quality of life in patients with autoimmune hepatitis (AIH) and primary biliary cholangitis (P...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12082244

    authors: Kempinska-Podhorodecka A,Adamowicz M,Chmielarz M,Janik MK,Milkiewicz P,Milkiewicz M

    更新日期:2020-07-27 00:00:00

  • Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition.

    abstract::Life expectancy is increasing and so is the prevalence of age-related non-communicable diseases (NCDs). Consequently, older people and patients present with multi-morbidities and more complex needs, putting significant pressure on healthcare systems. Effective nutrition interventions could be an important tool to addr...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12092555

    authors: Troesch B,Eggersdorfer M,Laviano A,Rolland Y,Smith AD,Warnke I,Weimann A,Calder PC

    更新日期:2020-08-24 00:00:00

  • Almonds and Cardiovascular Health: A Review.

    abstract::Several preventive strategies to reduce dyslipidemia have been suggested, of which dietary modification features as an important one. Dyslipidemia is a major risk factor for coronary heart disease and strategies to manage dyslipidemia have been shown to reduce the incidence of cardiovascular disease (CVD). Although th...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu10040468

    authors: Kalita S,Khandelwal S,Madan J,Pandya H,Sesikeran B,Krishnaswamy K

    更新日期:2018-04-11 00:00:00

  • Lipophilic compound-mediated gene expression and implication for intervention in reactive oxygen species (ROS)-related diseases: mini-review.

    abstract::In addition to exhibiting antioxidant properties, conjugated linoleic acid (CLA) and vitamin E may modulate gene expression of endogenous antioxidant enzymes. Depending on cellular microenvironments, such modulation reflects either antioxidant or prooxidant outcomes. Although epidemiological/experimental studies have ...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu2070725

    authors: Nakamura YK,Omaye ST

    更新日期:2010-07-01 00:00:00

  • Association between dietary patterns during pregnancy and birth size measures in a diverse population in Southern US.

    abstract::Despite increased interest in promoting nutrition during pregnancy, the association between maternal dietary patterns and birth outcomes has been equivocal. We examined maternal dietary patterns during pregnancy as a determinant of offspring's birth weight-for-length (WLZ), weight-for-age (WAZ), length-for-age (LAZ), ...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu7021318

    authors: Colón-Ramos U,Racette SB,Ganiban J,Nguyen TG,Kocak M,Carroll KN,Völgyi E,Tylavsky FA

    更新日期:2015-02-16 00:00:00

  • Gut Microbiota Modulation by Dietary Barley Malt Melanoidins.

    abstract::Melanoidins are the final Maillard reaction products (protein-carbohydrate complexes) produced in food by prolonged and intense heating. We assessed the impact of the consumption of melanoidins from barley malts on gut microbiota. Seventy-five mice were assigned into five groups, where the control group consumed a non...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12010241

    authors: Aljahdali N,Gadonna-Widehem P,Anton PM,Carbonero F

    更新日期:2020-01-17 00:00:00

  • The Dietary Management of Patients with Irritable Bowel Syndrome: A Narrative Review of the Existing and Emerging Evidence.

    abstract::Even though irritable bowel syndrome (IBS) has been known for more than 150 years, it still remains one of the research challenges of the 21st century. According to the current diagnostic Rome IV criteria, IBS is characterized by abdominal pain associated with defecation and/or a change in bowel habit, in the absence ...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu11092162

    authors: Algera J,Colomier E,Simrén M

    更新日期:2019-09-09 00:00:00

  • Does Drinking Coffee and Tea Affect Bone Metabolism in Patients with Inflammatory Bowel Diseases?

    abstract::Patients suffering from Crohn's disease and ulcerative colitis are at higher risk of osteoporosis due to lower bone mineral density. Risk factors of osteoporosis are divided into unmodifiable, namely, age, gender, genetic factors, as well as modifiable, including diet, level of physical activity, and the use of stimul...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu13010216

    authors: Ratajczak AE,Szymczak-Tomczak A,Zawada A,Rychter AM,Dobrowolska A,Krela-Kaźmierczak I

    更新日期:2021-01-13 00:00:00

  • Scientific Evidence Supporting the Beneficial Effects of Isoflavones on Human Health.

    abstract::Isoflavones are phenolic compounds with a chemical structure similar to that of estradiol. They are present in several vegetables, mainly in legumes such as soy, white and red clover, alfalfa and beans. The most significant food source of isoflavones in humans is soy-derived products. Isoflavones could be used as an a...

    journal_title:Nutrients

    pub_type: 杂志文章,评审

    doi:10.3390/nu12123853

    authors: Gómez-Zorita S,González-Arceo M,Fernández-Quintela A,Eseberri I,Trepiana J,Portillo MP

    更新日期:2020-12-17 00:00:00

  • Beneficial Effects of Isoflavones in the Kidney of Obese Rats Are Mediated by PPAR-Gamma Expression.

    abstract::Several studies have demonstrated an important association between altered lipid metabolism and the development of kidney injury because of a high-fat diet. Fructose is also closely associated with renal injury. We opted for a combination of fructose and saturated fats in a diet (DH) that is a model known to induce re...

    journal_title:Nutrients

    pub_type: 杂志文章

    doi:10.3390/nu12061624

    authors: Pessoa EA,Convento MB,Castino B,Leme AM,de Oliveira AS,Aragão A,Fernandes SM,Carbonel A,Dezoti C,Vattimo MF,Schor N,Borges FT

    更新日期:2020-06-01 00:00:00