Abstract：
:The inherited metabolic disease phenylketonuria (PKU) is characterized by increased concentrations of phenylalanine in the blood and brain, and as a consequence neurotransmitter metabolism, white matter, and synapse functioning are affected. A specific nutrient combination (SNC) has been shown to improve synapse formation, morphology and function. This could become an interesting new nutritional approach for PKU. To assess whether treatment with SNC can affect synapses, we treated PKU mice with SNC or an isocaloric control diet and wild-type (WT) mice with an isocaloric control for 12 weeks, starting at postnatal day 31. Immunostaining for post-synaptic density protein 95 (PSD-95), a post-synaptic density marker, was carried out in the hippocampus, striatum and prefrontal cortex. Compared to WT mice on normal chow without SNC, PKU mice on the isocaloric control showed a significant reduction in PSD-95 expression in the hippocampus, specifically in the granular cell layer of the dentate gyrus, with a similar trend seen in the cornus ammonis 1 (CA1) and cornus ammonis 3 (CA3) pyramidal cell layer. No differences were found in the striatum or prefrontal cortex. PKU mice on a diet supplemented with SNC showed improved expression of PSD-95 in the hippocampus. This study gives the first indication that SNC supplementation has a positive effect on hippocampal synaptic deficits in PKU mice.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Bruinenberg VM,van Vliet D,Attali A,de Wilde MC,Kuhn M,van Spronsen FJ,van der Zee EAdoi
10.3390/nu8040185subject
Has Abstractpub_date
2016-03-26 00:00:00pages
185issue
4issn
2072-6643pii
nu8040185journal_volume
8pub_type
杂志文章相关文献
Nutrients文献大全abstract：BACKGROUND:Malnutrition is a frequent condition in the elderly, and is associated with prolonged hospitalization and increased mortality. However, the impacts of malnutrition among elderly patients with acute myocardial infarction have not been clarified yet. METHODS AND RESULTS:We enrolled 174 patients aged 65 years ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020224
更新日期：2019-01-22 00:00:00
abstract：:The AUSNUT 2011-13 food composition database was expanded to include Australian choline values. The development began with a systematic literature review of published studies. Analytical data from the food studies were extracted and aligned with their equivalent AUSNUT food identification code. Global food composition...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040913
更新日期：2019-04-23 00:00:00
abstract：:Chronic joint inflammatory disorders such as osteoarthritis and rheumatoid arthritis have in common an upsurge of inflammation, and oxidative stress, resulting in progressive histological alterations and disabling symptoms. Currently used conventional medication (ranging from pain-killers to biological agents) is pote...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9010070
更新日期：2017-01-16 00:00:00
abstract：:Breastfeeding is recommended beyond 12 months of age, but little is known about the contribution of breastmilk and infant formula to the nutritional intake of toddlers as they transition to a family diet in the second year of life. This study is a cross-sectional analysis of data collected from a birth cohort study in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8080501
更新日期：2016-08-16 00:00:00
abstract：:Binge eating is a core diagnostic feature of bulimia nervosa, binge eating disorder, anorexia nervosa binge/purge type, and is a common feature of "other specified" and "unspecified" feeding and eating disorders. It has been suggested that specific metacognitive beliefs about food, eating, and binge eating may play a ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10091306
更新日期：2018-09-14 00:00:00
abstract：:Despite their low cost and high nutrient density, the contribution of eggs to nutrient intake and dietary quality among Mexican-American postpartum women has not been evaluated. Nutrient intake and dietary quality, as assessed by the Healthy Eating Index 2010 (HEI-2010), were measured in habitually sedentary overweigh...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7105402
更新日期：2015-10-02 00:00:00
abstract：:Restricting animal-based products from diet may exert beneficial effects on weight status; however, less is known about such a diet and emotional health. Moreover, personality traits, for example high neuroticism, may contribute to restrictive eating habits and potentially confound diet-health associations. We aim to ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051492
更新日期：2020-05-20 00:00:00
abstract：BACKGROUND:Fruits and vegetables are key to a healthy diet, particularly in children; however, parents may be concerned about contaminants found in fruits and vegetables. Making informed food choices for children requires understanding and balancing the risks of contaminant exposure with the importance of providing a h...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111572
更新日期：2018-10-24 00:00:00
abstract：:Glycemic control and weight reduction are primary goals for the management of overweight and obese type 2 diabetes mellitus (T2DM). Effective management cannot be achieved without an appropriate diet. Our study aimed to evaluate the short- and long-term effects of oat intake and develop a reasonable dietary plan for o...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu8090549
更新日期：2016-09-07 00:00:00
abstract：:Bile acids play an active role in fat metabolism and, in high-fat diets, elevated concentrations of fecal bile acids may be related to an increased risk of colorectal cancer. This study investigated concentrations of fecal and serum bile acids in 36 vegans and 36 omnivores. The reduced rank regression was used to iden...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12010047
更新日期：2019-12-23 00:00:00
abstract：:A target-based approach has been used to develop novel drugs in many therapeutic fields. In the final stage of intracellular signaling, transcription factor-DNA interactions are central to most biological processes and therefore represent a large and important class of targets for human therapeutics. Thus, we focused ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu7115445
更新日期：2015-10-30 00:00:00
abstract：:This paper continues the systematic review on proanthocyanidins and flavan-3-ols in the prevention and treatment of periodontal disease and covers the immunomodulatory effects, and animal- and clinical studies, while the other part discussed the direct antibacterial properties. Inflammation as a major response of the ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu13010239
更新日期：2021-01-15 00:00:00
abstract：:Life expectancy is increasing and so is the prevalence of age-related non-communicable diseases (NCDs). Consequently, older people and patients present with multi-morbidities and more complex needs, putting significant pressure on healthcare systems. Effective nutrition interventions could be an important tool to addr...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12092555
更新日期：2020-08-24 00:00:00
abstract：:The effects of alcohol on cardiovascular health are heterogeneous and vary according toconsumption dose and pattern. These effects have classically been described as having a J-shapedcurve, in which low-to-moderate consumption is associated with less risk than lifetime abstention,and heavy drinkers show the highest ri...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12040912
更新日期：2020-03-27 00:00:00
abstract：:Workout capacity is energy-production driven. To produce peak metabolic power outputs, the organism predominantly relies more on anaerobic metabolism, but this undoubtedly has a negative and limiting impact on muscle function and performance. The aim of the study was to evaluate if an innovative polyphenol-based food ...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu9040421
更新日期：2017-04-24 00:00:00
abstract：:Malnutrition is very prevalent in geriatric patients with hip fracture. Nevertheless, its importance is not fully recognized. The objective of this paper is to review the impact of malnutrition and of nutritional treatment upon outcomes and mortality in older people with hip fracture. We searched the PubMed database f...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10050555
更新日期：2018-04-30 00:00:00
abstract：:The human microbiome is emerging as an interesting field in research into the prevention of health problems and recovery from illness in humans. The complex ecosystem formed by the microbiota is continuously interacting with its host and the environment. Diet could be assumed to be one of the most prominent factors in...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12061654
更新日期：2020-06-02 00:00:00
abstract：:Poor vitamin D status has been associated with increased risk and severity of respiratory tract infections. Whether or not inflammation and infection affects 25-hydroxy vitamin D (25(OH)D) concentration is controversial and is important in the interpretation of observational studies using plasma-25(OH)D as a biomarker...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9010052
更新日期：2017-01-17 00:00:00
abstract：:This study aimed to evaluate dietary nutrient intake among Chinese pregnant women by comparison with Chinese Dietary Reference Intakes (DRIs) and to explore the association between dietary nutrients and preterm birth. A case-control design was conducted in Beijing with 130 preterm delivery mothers in case group and 38...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究
doi：10.3390/nu9030221
更新日期：2017-03-01 00:00:00
abstract：:Sweet taste receptors are composed of a heterodimer of taste 1 receptor member 2 (T1R2) and taste 1 receptor member 3 (T1R3). Accumulating evidence shows that sweet taste receptors are ubiquitous throughout the body, including in the gastrointestinal tract as well as the hypothalamus. These sweet taste receptors are h...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9070653
更新日期：2017-06-24 00:00:00
abstract：:Protein is the most satiating macronutrient, increasing secretion of gastrointestinal hormones and diet induced thermogenesis. In phenylketonuria (PKU), natural protein is restricted with approximately 80% of intake supplied by a synthetic protein source, which may alter satiety response. Casein glycomacropeptide (CGM...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092704
更新日期：2020-09-04 00:00:00
abstract：:The etiology of inflammatory bowel disease (IBD) is complex but is thought to be linked to an intricate interaction between the host's immune system, resident gut microbiome and environment, i.e., diet. One dietary component that has a major impact on IBD risk and disease management is fiber. Fiber intakes in pediatri...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12103204
更新日期：2020-10-20 00:00:00
abstract：:Obesity is a condition of rising prevalence worldwide, with important socioeconomic implications, being considered as a growing public health concern. Frequently, obesity brings other complications in addition to itself-like Type 2 Diabetes Mellitus (T2DM)-sharing origin, risk factors and pathophysiological mechanisms...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12092749
更新日期：2020-09-09 00:00:00
abstract：:Several studies have linked increased intake of dietary fibre to improvement in the management of body weight. Dietary fibre from resistant starch (RS) has been shown to have an impact on food intake in normal weight individuals, but its role in obesity is unknown. The present study aimed to investigate the short-term...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10121993
更新日期：2018-12-15 00:00:00
abstract：:Polycystic ovarian syndrome (PCOS) is an endocrine, metabolic, and systemic disease. It is mainly characterized by hyperandrogenism, oligomenorrhea, and high levels of luteinizing hormone (LH). There is no obvious therapy for PCOS, so patients have received symptomatic therapy. Welsh onion (Allium fistulosum) is well-...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10101430
更新日期：2018-10-04 00:00:00
abstract：:Breast milk (BM) is beneficial due to its content in a wide range of different antioxidants, particularly relevant for preterm infants, who are at higher risk of oxidative stress. We hypothesize that BM antioxidants are adapted to gestational age and are negatively influenced by maternal age. Fifty breastfeeding women...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092569
更新日期：2020-08-25 00:00:00
abstract：:Historically, Mangifera indica L. cultivations have been widely planted in tropical areas of India, Africa, Asia, and Central America. However, at least 20 years ago its spreading allowed the development of some cultivars in Sicily, an island to the south of Italy, where the favourable subtropical climate and adapted ...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9050525
更新日期：2017-05-20 00:00:00
abstract：:Metabolic syndrome is a cluster of metabolic abnormalities characterized by obesity, insulin resistance, hypertension and dyslipidemia. Ferulic acid (FA) is the major phenolic compound found in rice oil and various fruits and vegetables. In this study, we examined the beneficial effects of FA in minimizing insulin res...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7085283
更新日期：2015-08-04 00:00:00
abstract：:Emerging research demonstrates polyphenol-rich diets like the Mediterranean diet may play a role in improving the outcomes of adult cancer therapy. To date, there are no trials assessing the intake or efficacy of polyphenol-rich diets in childhood cancer patients. In this study we collected dietary data on 59 childhoo...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112835
更新日期：2019-11-19 00:00:00
abstract：:The relationship between vitamin D status, calcium intake and the risk of developing type 2 diabetes (T2D) is a topic of growing interest. One of the most interesting non-skeletal functions of vitamin D is its potential role in glucose homeostasis. This possible association is related to the secretion of insulin by pa...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11030642
更新日期：2019-03-16 00:00:00
