Iron Metabolism Dysregulation and Cognitive Dysfunction in Pediatric Obesity: Is There a Connection?

Abstract:

:Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connecting mechanism, however, is not completely known. This review is focused on: (1) iron deficiency in obese children and the role of hepcidin in the connection between body fat and poor iron status; (2) iron status and consequences on health, in particular on cognitive function; (3) cognitive function and obesity; (4) suggestion of a possible link between cognitive dysfunction and ID in pediatric obesity; and implications for therapy and future research.

journal_name

Nutrients

journal_title

Nutrients

authors

Grandone A,Marzuillo P,Perrone L,Del Giudice EM

doi

10.3390/nu7115458

subject

Has Abstract

pub_date

2015-11-06 00:00:00

pages

9163-70

issue

11

issn

2072-6643

pii

nu7115458

journal_volume

7

pub_type

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