Abstract：
:Osteoarthritis (OA) has become one of the most common disabilities among elders, especially in females. Obesity and mechanical injuries caused by OA are attributed to joint loading, cartilage disintegration, and bone loss, as well as inflammation. Pharmacological and non-pharmacological treatments can be used for OA. Fucoidan possesses several bioactivities such as antitumor, antiviral, anticoagulation, anti-obesity, and immunomodulation. This study aims to investigate the effect of fucoidan in surgery-induced OA on rats with diet-induced obesity. OA was induced by an anterior cruciate ligament transection and a partial medial meniscectomy (ACLT + MMx). The male SD rats were fed with a high-fat diet (HFD) for 4 weeks to induce obesity before causing ACLT + MMx to induce OA. The OA rats were administered with intragastric water or fucoidan in three different concentrations (32 mg/kg, 64 mg/kg, and 320 mg/kg) after the surgeries for 40 days with an HFD. We observed that the swelling in the knee joint was alleviated and the hind paw weight distribution was rectified after feeding them with fucoidan and that there was no significant effect on the weight gain and feed intake. Fucoidan administration indicated no significant variation on the high-density lipoprotein (HDL)-Cholesterol level, but it did indicate reduced plasma triglycerides and low-density lipoprotein (LDL)-Cholesterol levels. In addition, the weight-bearing tests showed an improvement in the fucoidan-treated group. Our results suggested that fucoidan may improve meniscal/ligamentous injury and obesity-induced OA.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Sudirman S,Ong AD,Chang HW,Kong ZLdoi
10.3390/nu10060686subject
Has Abstractpub_date
2018-05-28 00:00:00issue
6issn
2072-6643pii
nu10060686journal_volume
10pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Chronic low-grade inflammation is a primary characteristic of obesity and can lead to other metabolic complications including insulin resistance and type 2 diabetes (T2D). Several anti-inflammatory dietary bioactives decrease inflammation that accompanies metabolic diseases. We are specifically interested in delta-toc...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113356
更新日期：2020-10-30 00:00:00
abstract：:Gut microbiota metabolization of dietary choline may promote atherosclerosis through trimethylamine (TMA), which is rapidly absorbed and converted in the liver to proatherogenic trimethylamine-N-oxide (TMAO). The aim of this study was to verify whether TMAO urinary levels may be associated with the fecal relative abun...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12010062
更新日期：2019-12-25 00:00:00
abstract：:Epidemiological and experimental studies reveal that Western dietary patterns contribute to chronic kidney disease, whereas dietary restriction (DR) or dietary polyphenols such as green tea polyphenols (GTPs) can ameliorate the progression of kidney injury. This study aimed to investigate the renal protective effects ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9050497
更新日期：2017-05-14 00:00:00
abstract：:Benign prostatic hyperplasia (BPH) is a common chronic disease of the urinary system among elderly men. Especially, the metabolic imbalance of androgen in elderly men is one of the leading causes of BPH. Dihydrotestosterone (DHT) and converted testosterone by 5-α reductase type 2 (5AR2), binding with androgen receptor...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102444
更新日期：2019-10-14 00:00:00
abstract：:Previous studies demonstrated that hyperglycemic glucose concentrations are observed in children that are overweight or have obesity. The aim of this study was to evaluate the effect of a 12 month lifestyle intervention on free-living glycemic profiles in children that were overweight or had obesity, and the associati...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051228
更新日期：2020-04-26 00:00:00
abstract：:This review aims to examine the relationship of sodium and potassium intake and cardiovascular disease (CVD) among older people. METHODS:We performed a literature search using PubMed and Web of Science (January 2015 to July 2020) without language restriction. Observational and experimental studies that reported the r...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12113447
更新日期：2020-11-10 00:00:00
abstract：:Studies suggest that the bidirectional relationship existent between the gut microbiome (GM) and the central nervous system (CNS), or so-called the microbiome-gut-brain axis (MGBA), is involved in diverse neuropsychiatric diseases in children and adults. In pediatric age, most studies have focused on patients with aut...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu13010249
更新日期：2021-01-16 00:00:00
abstract：:Ocoxin Oral Solution (OOS) is a nutritional supplement whose formulation includes several plant extracts and natural products with demonstrated antitumoral properties. This review summarizes the antitumoral action of the different constituents of OOS. The action of this formulation on different preclinical models as w...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12092661
更新日期：2020-08-31 00:00:00
abstract：:Male C57BL/6J mice were used to determine the possible therapeutic effects of our previously described tart cherry extract in a chronic obesity mouse model on metabolic parameters, glucose tolerance, inflammatory mediators, and antioxidant capacity. The control group received standard mouse chow, and the high fat cont...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11091966
更新日期：2019-08-21 00:00:00
abstract：:The aim of this study was to determine the effect of polyphenol-rich ethanol extract of bee pollen (EEP) on atherosclerosis induced by a high-fat diet in ApoE-knockout mice. EEP was given with feed in two doses of 0.1 and 1 g/kg body mass (BM). The studies have been conducted in a period of 16 weeks. The following fac...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9121369
更新日期：2017-12-18 00:00:00
abstract：:Our group built a genetic risk score (GRS) of the plasma triglyceride (TG) response to an omega-3 (n-3) fatty acid (FA) supplementation in Caucasian Canadians that explained 21.53% of the TG variance. The objective was to refine the GRS by fine mapping and to test its association with the TG response in young Mexican ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040737
更新日期：2019-03-29 00:00:00
abstract：:People with sarcopenic obesity (SO) are characterized by both low muscle mass (sarcopenia) and high body fat (obesity); they have greater risks of metabolic diseases and physical disability than people with sarcopenia or obesity alone. Exercise and nutrition have been reported to be effective for both obesity and sarc...
journal_title：Nutrients
pub_type： 杂志文章,meta分析,评审
doi：10.3390/nu11092163
更新日期：2019-09-09 00:00:00
abstract：:Vegetarian diets provide an abundance of nutrients when carefully planned. However, vegetarian diets may have lower protein quality compared to omnivorous diets, a reflection of less favorable amino acid profiles and bioavailability. Hence, the current recommended dietary allowance for protein may not be adequate for ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11123016
更新日期：2019-12-10 00:00:00
abstract：:Type 2 diabetes mellitus (T2DM) is a disease associated with dysfunctional metabolic processes that lead to abnormally high levels of blood glucose. Preceding the development of T2DM is insulin resistance (IR), a disorder associated with suppressed or delayed responses to insulin. The effects of this response are pred...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11020408
更新日期：2019-02-15 00:00:00
abstract：:A high intake of refined carbohydrates, particularly the monosaccharide fructose, has been attributed to the growing epidemics of obesity and type-2 diabetes. Animal studies have helped elucidate the metabolic effects of dietary fructose, however, variations in study design make it difficult to draw conclusions. The a...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8090577
更新日期：2016-09-20 00:00:00
abstract：:Gastric lipase is one of the prepancreatic lipases found in some mammalian species and in humans. Our knowledge of the hormonal regulation of gastric lipase secretion in children and adolescents is still very limited. The aim of this study was to compare the activity of human gastric lipase (HGL) in gastric juice in h...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu5082924
更新日期：2013-07-29 00:00:00
abstract：:This study aimed to investigate the effect of a high-protein diet on growth, body composition, and protein nutritional status of young rats. Newly-weaned Wistar rats, weighing 45-50 g, were distributed in two experimental groups, according to their diets, which contained 12% (G12) or 26% protein (G26), over a period o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu4091328
更新日期：2012-09-01 00:00:00
abstract：:Dietary antioxidants may protect against poor ventilatory function. We assessed the relation between ventilatory function and antioxidant components of diet in young Chileans. Forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), and the ratio FEV1/FVC were measured in 1232 adults aged 22-28 years, usin...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7042879
更新日期：2015-04-15 00:00:00
abstract：:Metabolic syndrome is a cluster of metabolic abnormalities characterized by obesity, insulin resistance, hypertension and dyslipidemia. Ferulic acid (FA) is the major phenolic compound found in rice oil and various fruits and vegetables. In this study, we examined the beneficial effects of FA in minimizing insulin res...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7085283
更新日期：2015-08-04 00:00:00
abstract：:Zinc (Zn) deficiency is a prevalent micronutrient insufficiency. Although the gut is a vital organ for Zn utilization, and Zn deficiency is associated with impaired intestinal permeability and a global decrease in gastrointestinal health, alterations in the gut microbial ecology of the host under conditions of Zn defi...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu7125497
更新日期：2015-11-27 00:00:00
abstract：:The association of high vitamin A intake and low bone mineral density (BMD) is still controversial. To determine the association of dietary vitamin A intake and serum 25-hydroxyvitamin D (25(OH)D) concentration with BMD, a total of 6481 subjects (2907 men and 3574 women) aged ≥50 years from the Korean National Health ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7031716
更新日期：2015-03-10 00:00:00
abstract：:Osteoarthritis (OA) is considered one of the most common joint disorders worldwide and its prevalence is constantly increasing due to the global longevity and changes in eating habits and lifestyle. In this context, the role of gut microbiota (GM) in the pathogenesis of OA is still unclear. Perturbation of GM biodiver...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12020574
更新日期：2020-02-22 00:00:00
abstract：:Currently, there are inconsistencies in the recommendations of when to obtain an esophagogastroduodenoscopy (EGD) in children with feeding difficulties. The aim of our study was to identify EGD findings in patients presenting to a large, outpatient feeding program. Additionally, we investigated the presence of any rel...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092822
更新日期：2020-09-15 00:00:00
abstract：:Oligosaccharides (OS) are commonly added to infant formulas, however, their physiological impact, particularly on adult health programming, is poorly described. In adult animals, OS modify microbiota and stimulate colonic fermentation and enteroendocrine cell (EEC) activity. Since neonatal changes in microbiota and/or...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11091967
更新日期：2019-08-21 00:00:00
abstract：:Obesity in the postmenopausal period is associated with an increased risk of cardiovascular diseases in women. One of the key drivers of cardiovascular risk is endothelial dysfunction; thus, this is also a crucial point for studies on new therapeutic methods of cardioprotective properties. The aim of the current study...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10111672
更新日期：2018-11-05 00:00:00
abstract：:Cholesterol is an essential molecule that exerts pleiotropic actions. Although its presence is vital to the cell, its excess can be harmful and, therefore, sustaining cholesterol homeostasis is crucial to maintaining proper cellular functioning. It is well documented that high plasma cholesterol concentration increase...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu10060760
更新日期：2018-06-13 00:00:00
abstract：:A cohort of 50-year-olds from Canterbury, New Zealand (N = 404), representative of midlife adults, undertook comprehensive health and dietary assessments. Fasting plasma vitamin C concentrations (N = 369) and dietary vitamin C intake (N = 250) were determined. The mean plasma vitamin C concentration was 44.2 µmol/L (9...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9080831
更新日期：2017-08-03 00:00:00
abstract：:Several studies have linked increased intake of dietary fibre to improvement in the management of body weight. Dietary fibre from resistant starch (RS) has been shown to have an impact on food intake in normal weight individuals, but its role in obesity is unknown. The present study aimed to investigate the short-term...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10121993
更新日期：2018-12-15 00:00:00
abstract：BACKGROUND:a large number of studies have linked vitamin B6 to inflammation and cardiovascular disease in the general population. However, it remains uncertain whether vitamin B6 is associated with cardiovascular outcome independent of inflammation. METHODS:we measured plasma pyridoxal 5'-phosphate (PLP), as an indica...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12092711
更新日期：2020-09-04 00:00:00
abstract：:Increases in the number of food outlets have been proposed as a key factor driving obesity. This study aimed to investigate the association between the densities of food establishments serving meals (excluding supermarkets and grocery stores), with body mass index (BMI), waist to hip ratio (WHR) and percentage of body...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12040890
更新日期：2020-03-25 00:00:00
