Abstract：
:Egg-yolk based supplements have demonstrated biological effects. We have developed a novel processed egg-yolk (PEY) complement, and we have tested whether it has inflammation modulatory properties. These were evaluated in a lipopolysaccharide (LPS)-challenge in 1-month male rats by in vivo circulating cytokine profiles measured by multiplexing techniques. Cell culture was used to explore ex vivo properties of derived serum samples. We explored growth factor composition, and mass-spectrometry metabolome and lipidome analyses of PEY to characterize it. PEY significantly prevented LPS-induced increase in IL-1 β, TNF-α, and MCP-1. Further, serum from PEY-treated animals abrogated LPS-induced iNOS build-up of the Raw 264.7 macrophage-like cell line. Immunochemical analyses demonstrated increased concentrations of insulin-like growth factor 1 (IGF-1), connective tissue growth factor (CTGF), and platelet-derived growth factor (PDGF) in the extract. PEY vs. egg-yolk comparative metabolomic analyses showed significative differences in the concentrations of at least 140 molecules, and in 357 in the lipidomic analyses, demonstrating the complexity of PEY. Globally, PEY acts as an orally-bioavailable immunomodulatory extract that may be of interest in those conditions associated with disarranged inflammation, such as inflammaging.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Cunill J,Babot C,Santos L,Serrano JCE,Jové M,Martin-Garí M,Portero-Otín Mdoi
10.3390/nu12092699subject
Has Abstractpub_date
2020-09-04 00:00:00issue
9issn
2072-6643pii
nu12092699journal_volume
12pub_type
杂志文章相关文献
Nutrients文献大全abstract：:Cow's milk proteins cause allergic symptoms in 2% to 3% of all infants. In these individuals, the physiological mechanism of tolerance is broken with subsequent possible sensitization to antigens, which can lead eventually to allergic responses. The present review aims to provide an overview of different aspects of im...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11061399
更新日期：2019-06-21 00:00:00
abstract：:Prader-Willi syndrome (PWS) is the most common genetic inherited obesity syndrome. Obesity-related complications, mostly related to chronic low-grade systemic inflammation (LGI), are the commonest cause of mortality and morbidity in PWS adults. Phase angle (PhA) is an easy tool to screen a state of LGI in healthy subj...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12072065
更新日期：2020-07-11 00:00:00
abstract：:Health claims on foods are a way of informing consumers about the health benefits of a food product. Traditionally, these claims are based on scientific evaluation of markers originating from a pharmacological view on health. About a decade ago, the definition of health has been rephrased to 'the ability to adapt' tha...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12102945
更新日期：2020-09-25 00:00:00
abstract：:The effect of a raised body mass index (BMI) on the outcome of assisted reproduction technology (ART) still represents a controversial issue. Even less clear is whether BMI acts with a potential detrimental effect on IVF outcomes via a deleterious effect on innate quality of oocytes or on the environmental milieu with...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu8030109
更新日期：2016-02-23 00:00:00
abstract：:Gut appetite hormone responses may be influenced by meal macronutrients and obesity. The primary aim of this study was to examine in adolescents with obesity and of healthy weight the effect of a high-protein and a high-carbohydrate meal on postprandial gut appetite hormones. A postprandial cross-over study with adole...
journal_title：Nutrients
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3390/nu11020340
更新日期：2019-02-05 00:00:00
abstract：:Vitamin D (VD) plays an essential role in mineral homeostasis and bone remodeling. A number of different VD-related genes (VDRG) are required for the metabolic activation of VD and the subsequent induction of its target genes. They include a set of genes that encode for VD-binding protein, metabolic enzymes, and the V...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12040962
更新日期：2020-03-30 00:00:00
abstract：:Cichoric acid (CA) belongs to the group of polyphenols, which occurs in a variety of plant species and it is characterized by anticancer, antibacterial, and antiviral properties. Selected polyphenols have the ability to combine with metal ions to form chelate complexes that reveal greater biological activity than free...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12010154
更新日期：2020-01-06 00:00:00
abstract：:Hypertension and arterial stiffening are independent predictors of cardiovascular mortality. Flavonoids may exert some vascular protection. We investigated the effects of black tea on blood pressure (BP) and wave reflections before and after fat load in hypertensives. According to a randomized, double-blind, controlle...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu7021037
更新日期：2015-02-04 00:00:00
abstract：:Thermogenic adipocytes burn nutrients in order to produce heat. Upon activation, brown adipose tissue (BAT) clears vast amounts of lipids and glucose from the circulation and thus substantially lowers plasma lipid levels. As a consequence, BAT activation protects from the development of atherosclerosis. However, it is...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020463
更新日期：2019-02-23 00:00:00
abstract：:The study objectives were to examine total and individual lignan intakes and their dietary sources in postmenopausal Polish women and to investigate the relationship between lignan intake and the prevalence of cardiovascular disease (CVD), hypertension, hypercholesterolemia and central obesity. A total of 2599 postmen...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究
doi：10.3390/nu10070865
更新日期：2018-07-04 00:00:00
abstract：:Vitamins B(6), B(12) and folate play crucial metabolic roles especially during the reproductive years for women. There is limited reporting of within-subject variability of these vitamins. This study aimed to determine the within and between subject variability in serum vitamins B(6), B(12), folate and erythrocyte fol...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu5093634
更新日期：2013-09-16 00:00:00
abstract：:Cancer is the main cause of mortality and morbidity worldwide. Although a large variety of therapeutic approaches have been developed and translated into clinical protocols, the toxic side effects of cancer treatments negatively impact patients, allowing cancer to grow. Brassica metabolites are emerging as new weapons...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12030868
更新日期：2020-03-24 00:00:00
abstract：:Sourdough fermented bread has been suggested to have beneficial health effects, in part mediated by increased satiety in the postprandial phase, but only limited research has been conducted to verify this. The current study aimed to investigate the effect of the amounts of sourdough and rye in soft bread on postprandi...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu10111594
更新日期：2018-10-30 00:00:00
abstract：:In human cells, mitochondria provide the largest part of cellular energy in the form of adenosine triphosphate generated by the process of oxidative phosphorylation (OXPHOS). Impaired OXPHOS activity leads to a heterogeneous group of inherited diseases for which therapeutic options today remain very limited. Potential...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9091017
更新日期：2017-09-14 00:00:00
abstract：:Infants rely on their innate immune systems to protect them from infection. Human milk (HM) contains fatty acids (FAs) and monoacylglycerols that are known to exhibit antiviral and antibacterial properties in vitro. The specific fat content of HM may potentially affect the efficacy of this antimicrobial activity. This...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9091034
更新日期：2017-09-19 00:00:00
abstract：:Probiotics possibly affect local and systemic immune reactions and maintain the intestinal immune homeostasis in healthy individuals and patients with diseases such as irritable bowel syndrome (IBS). In this single-center, blinded trial, we enrolled 40 individuals (20 patients with IBS and 20 healthy individuals) whos...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061706
更新日期：2020-06-07 00:00:00
abstract：:Mango (Mangifera indica L.) is a tropical fruit which is considered to be a source of dietary fiber (DF) and phenolic compounds (PCs). In this study, high DF mango-based fruit bars were developed from whole mango (peel and pulp). The bars were evaluated for their nutritional composition, the bioaccesibility of PCs dur...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071564
更新日期：2019-07-11 00:00:00
abstract：:One of the deadliest cancers among women is a breast cancer. Research has shown that two natural substances occurring in propolis, caffeic acid (CA) and caffeic acid phenethyl ester (CAPE), have significant anticancer effects. The purpose of our in vitro study was to compare cytotoxic activity and migration rate inhib...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9101144
更新日期：2017-10-19 00:00:00
abstract：:Plant-based diets are associated with reduced risks of various chronic diseases in the general population. However, it is unclear how these benefits translate to Blacks living in the United States, who are disproportionately burdened with heart disease, cancer, diabetes, obesity, and chronic kidney disease. The object...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11122915
更新日期：2019-12-02 00:00:00
abstract：:This study compares the absorption characteristics of two iron-based dietary supplements and their biocompatibility to bisglycinate iron, a common chelated iron form. The Caco-2 cell line-a model of human intestinal absorption-and GTL-16 cell line-a model of gastric epithelial cells-were used to perform the experiment...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9091008
更新日期：2017-09-13 00:00:00
abstract：:The natural sweetener from Stevia rebaudiana Bertoni, steviol glycoside (SG), has been proposed to exhibit a range of antidiabetic properties. The objective of this systematic review was to critically evaluate evidence for the effectiveness of SGs on human health, particularly type 2 diabetic (T2D) biomarkers, collect...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu11091965
更新日期：2019-08-21 00:00:00
abstract：:Glycerol monolaurate (GML) has potent antimicrobial and anti-inflammatory activities. The present study aimed to assess the dose-dependent antimicrobial-effects of GML on the gut microbiota, glucose and lipid metabolism and inflammatory response in C57BL/6 mice. Mice were fed on diets supplemented with GML at dose of ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11091981
更新日期：2019-08-22 00:00:00
abstract：:Long term nut consumption is associated with reduced risk of coronary heart disease and better cognitive function. This study examined supplementing habitual diets with almonds or carbohydrate-rich snack foods (providing 15% energy) on biomarkers of cardiovascular and metabolic health, mood and cognitive performance. ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12041180
更新日期：2020-04-23 00:00:00
abstract：:The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process o...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu5030725
更新日期：2013-03-07 00:00:00
abstract：:The relationship between alcohol consumption and the prevalence of metabolic syndrome is not consistent and may vary between populations, depending on age, sex, ethnicity, cultural traditions and lifestyle. We have hypothesized that moderate alcohol consumption will be associated with the lowest risk of the syndrome. ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112764
更新日期：2019-11-14 00:00:00
abstract：:Hot water was used to obtain Chlorella sorokiniana hot water extract (HWE). Subsequently, this byproduct was freeze-dried, hydrolysed at 50 °C using Protease N to obtain C. sorokiniana protein hydrolysates (PN-1), and then digested with a gastrointestinal enzyme (PN-1G). The inhibitory effects of the HWE and hydrolysa...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10101397
更新日期：2018-10-01 00:00:00
abstract：:Since 1998, the U.S. has mandated folic acid (FA) fortification of certain grain products to reduce the risk of neural tube defects. Folate intake and red blood cell (RBC) folate concentrations increased substantially post-intervention, although recent studies raise concerns about the level of ongoing benefit. This st...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9090994
更新日期：2017-09-08 00:00:00
abstract：:In New Zealand, there is a high prevalence of childhood poverty and food insecurity, which can impact a family's ability to provide high quality, nutrient dense foods for their children. In an attempt to increase the quality of the food consumed by children attending a decile two (low socio-economic) kindergarten and ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9091031
更新日期：2017-09-18 00:00:00
abstract：:Findings on the association between long-term intake of fish or long-chain n-3 polyunsaturated fatty acids (PUFAs) and risk of atrial fibrillation (AF) are inconsistent in observational studies. We conducted a meta-analysis of prospective studies to separately examine the associations between fish consumption and diet...
journal_title：Nutrients
pub_type： 杂志文章,meta分析
doi：10.3390/nu9090955
更新日期：2017-08-29 00:00:00
abstract：:This study assessed personal and environmental correlates of Belgian university students' soft and energy drink consumption and investigated whether these associations were moderated by gender or residency. Four hundred twenty-five university students completed a self-reported on-line questionnaire assessing socio-dem...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu7085298
更新日期：2015-08-06 00:00:00
