Abstract：
:This study compares the absorption characteristics of two iron-based dietary supplements and their biocompatibility to bisglycinate iron, a common chelated iron form. The Caco-2 cell line-a model of human intestinal absorption-and GTL-16 cell line-a model of gastric epithelial cells-were used to perform the experiments; in the first experiments, the kinetics of absorption have been evaluated analyzing the divalent metal transporter 1 (DMT1) expression. Three different iron combinations containing 50 µM iron (named Fisioeme®, Sideral® and bisglycinate) were used for different stimulation times (1-24 h). After this, the effects of the three iron formulations were assessed in both a short and a long time, in order to understand the extrusion mechanisms. The effects of the three different formulations were also analyzed at the end of stimulation period immediately after iron removal, and after some time in order to clarify whether the mechanisms were irreversibly activated. Findings obtained in this study demonstrate that Fisioeme® was able to maintain a significant beneficial effect on cell viability compared to control, to Sideral®, and to iron bisglycinate. This observation indicates that Fisioeme® formulation is the most suitable for gastric and intestinal epithelial cells.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Uberti F,Morsanuto V,Ghirlanda S,Molinari Cdoi
10.3390/nu9091008subject
Has Abstractpub_date
2017-09-13 00:00:00issue
9issn
2072-6643pii
nu9091008journal_volume
9pub_type
杂志文章相关文献
Nutrients文献大全abstract：:In human cells, mitochondria provide the largest part of cellular energy in the form of adenosine triphosphate generated by the process of oxidative phosphorylation (OXPHOS). Impaired OXPHOS activity leads to a heterogeneous group of inherited diseases for which therapeutic options today remain very limited. Potential...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9091017
更新日期：2017-09-14 00:00:00
abstract：:Nephrolithiasis is a common medical condition influenced by multiple environmental factors, including diet. Since nutritional habits play a relevant role in the genesis and recurrence of kidney stones disease, dietary manipulation has become a fundamental tool for the medical management of nephrolithiasis. Dietary adv...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12030779
更新日期：2020-03-15 00:00:00
abstract：:Levels of physical inactivity, a major contributor to burden of disease, are high in many countries. Some preliminary research suggests that circulating lutein concentrations are associated with high levels of physical activity (PA). We aimed to assess whether the intake of lutein-containing foods, including vegetable...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究
doi：10.3390/nu7095378
更新日期：2015-09-18 00:00:00
abstract：INTRODUCTION:The effects of bariatric surgery on skeletal health raise many concerns. Trabecular bone score (TBS) is obtained through the analysis of lumbar spine dual X-ray absorptiometry (DXA) images and allows an indirect assessment of skeletal microarchitecture (MA). The aim of our study was to evaluate the changes...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9121314
更新日期：2017-12-02 00:00:00
abstract：:Microbiota contributes to the regulation of eating behavior and might be implicated in the pathophysiology of anorexia nervosa. ClpB (Caseinolytic peptidase B) protein produced mainly by the Enterobacteriaceae family has been identified as a conformational mimetic of α-MSH, which could result in similar anorexigenic e...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102514
更新日期：2019-10-18 00:00:00
abstract：:The snacking prevalence, frequency of daily snack consumption, and the contribution of snacks to daily energy intake have substantially increased globally. The aim of this study was to examine the patterns of snack consumption among a representative sample of Canadians aged 2 and older. Nationally representative dieta...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11051152
更新日期：2019-05-23 00:00:00
abstract：:The association of dietary cholesterol intake with dyslipidemia and subtypes is controversial. This study aimed to examine the association of dietary cholesterol intake with dyslipidemia and subtypes in Chinese adults. Using data from the China Health and Nutrition Survey (CHNS) in 2015, the present study selected 438...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11122885
更新日期：2019-11-27 00:00:00
abstract：:Several theories have emerged to study types of eating behavior leading to obesity, but most of the applied models are mainly related to food choice decisions and food consumer behavior. The purpose of this paper was to examine the eating attitudes of Hungarian consumers by applying the Three-Factor Eating Questionnai...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113514
更新日期：2020-11-15 00:00:00
abstract：:Poor vitamin D status has been associated with increased risk and severity of respiratory tract infections. Whether or not inflammation and infection affects 25-hydroxy vitamin D (25(OH)D) concentration is controversial and is important in the interpretation of observational studies using plasma-25(OH)D as a biomarker...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9010052
更新日期：2017-01-17 00:00:00
abstract：:The biologically active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3), modulates innate and adaptive immunity via genes regulated by the transcription factor vitamin D receptor (VDR). In order to identify the key vitamin D target genes involved in these processes, transcriptome-wide datasets were compare...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12041140
更新日期：2020-04-19 00:00:00
abstract：:Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency durin...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9020159
更新日期：2017-02-20 00:00:00
abstract：:Immigrants in the U.S. may encounter challenges of acculturation, including dietary habits, as they adapt to new surroundings. We examined Vietnamese and Hispanic immigrant children's American food consumption patterns in a convenience sample of 63 Vietnamese and Hispanic children in grades four to six who were attend...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9050460
更新日期：2017-05-05 00:00:00
abstract：:The French Cancer Barometer, a population-based-survey, is carried out every five years and is, to date, one of the few national studies conducted to investigate individual perception linked to cancer risk factors. The aims of the present study were to describe the perceptions of the French population in 2015 and to a...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11102491
更新日期：2019-10-16 00:00:00
abstract：:This systematic review aims to evaluate the association of adiponectin (ADIPOQ) and leptin (LEP) gene variants with energy intake. Cross-sectional, cohort, and case⁻control studies that reported an association of leptin and/or adiponectin gene variants with energy intake were included in this review. Human studies wit...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11040750
更新日期：2019-03-30 00:00:00
abstract：:A particularly phenolic-rich fraction extracted from red wine from the São Francisco valley (Northeastern Brazil) was chemically characterized and its hypotensive and antioxidant effects on spontaneously hypertensive rats were studied both in vitro and in vivo. The liquid-liquid pH dependent fractionation scheme affor...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9060574
更新日期：2017-06-03 00:00:00
abstract：BACKGROUND:Oropharyngeal dysphagia (OD) and malnutrition are highly prevalent in older patients that are discharged from general hospitals (47% and 30%, respectively). AIMS:To develop a nutritional plan for these patients involving a triple adaptation of their traditional diet: (a) rheological adaptation (texture and ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020425
更新日期：2019-02-18 00:00:00
abstract：:This study assesses the impact of an integrated infant and young child feeding (IYCF) and micronutrient powder (MNP) intervention on children's risk of anemia and IYCF practices in Madagascar. Quantitative baseline and endline surveys were conducted in representative households with children 6-23 months from two distr...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9060581
更新日期：2017-06-07 00:00:00
abstract：:Many infant formulas are fortified with iron at 8-14 mg/L whereas breast milk contains about 0.3 mg/L. Another major difference between breast milk and infant formula is its high concentration of lactoferrin, a bioactive iron-binding protein. The aim of the present study was to investigate how reducing the iron conten...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13010003
更新日期：2020-12-22 00:00:00
abstract：:This study investigated the effects of long-term treatment with rifaximin and the probiotic VSL#3 on uro-genital and gastrointestinal symptoms in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) plus diarrhoea-predominant irritable bowel syndrome (D-IBS) compared with patients with D-IBS alone....
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9111208
更新日期：2017-11-03 00:00:00
abstract：:Both vitamin D deficiency and cognitive impairment are common in patients with chronic kidney disease (CKD). Vitamin D exerts neuroprotective and regulatory roles in the central nervous system. Hypovitaminosis D has been associated with muscle weakness and bone loss, cardiovascular diseases (hypertension, diabetes and...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8050291
更新日期：2016-05-13 00:00:00
abstract：BACKGROUND:Malnutrition is a frequent condition in the elderly, and is associated with prolonged hospitalization and increased mortality. However, the impacts of malnutrition among elderly patients with acute myocardial infarction have not been clarified yet. METHODS AND RESULTS:We enrolled 174 patients aged 65 years ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11020224
更新日期：2019-01-22 00:00:00
abstract：:The Special Issue "Food Choice and Nutrition" deals with the relationship between the food choices of different population groups or consumer segments and its impact on the nutritional status, improvement of dietary quality, food and nutrition-related behaviour, food preferences, taste education, sensory characteristi...
journal_title：Nutrients
pub_type： 社论
doi：10.3390/nu12020502
更新日期：2020-02-16 00:00:00
abstract：:Standardized sex-specific cut-offs for sarcopenia in cirrhosis are needed to identify the risk of clinical complications and to discriminate the severity of sarcopenia. We aimed to compare clinical characteristics between patients with cirrhosis categorized according to the severity of sarcopenia. Computed tomography ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113463
更新日期：2020-11-11 00:00:00
abstract：:One of the brief methods enabling the assessment of the zinc intake and identification of individuals characterized by insufficient zinc intake, is zinc-specific food frequency questionnaire. The aim of the study was to assess the validity and reproducibility of the elaborated zinc-specific food frequency questionnair...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10010104
更新日期：2018-01-19 00:00:00
abstract：:Folate, vitamin B6, and vitamin B12 intake can be important regulators for obesity development. Thus, we investigated the possible association between the intake of these vitamins and the excess body weight or obesity prevalence in the participants of the Cohort of Universities in Minas Gerais (CUME project). This stu...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11030518
更新日期：2019-02-28 00:00:00
abstract：:We examined whether gastric acidity would affect the activity of myrosinase, co-delivered with glucoraphanin (GR), to convert GR to sulforaphane (SF). A broccoli seed and sprout extract (BSE) rich in GR and active myrosinase was delivered before and after participants began taking the anti-acid omeprazole, a potent pr...
journal_title：Nutrients
pub_type： 临床试验,杂志文章
doi：10.3390/nu11071489
更新日期：2019-06-29 00:00:00
abstract：:Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a considerable variation in the extent of disease and functional impairment risk, revealing a need for valid biomarkers to aid in characterizing the complex aging processes. The identification of...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8060338
更新日期：2016-06-02 00:00:00
abstract：:Several diet-derived compounds have been reported to exert antioxidant, anti-proliferative and anti-angiogenic effects in numerous cancers and could be beneficial in cancer prevention. Olive oil production involves the generation of an aqueous phase defined as olive mill wastewater (OMWW), a polluting effluent rich in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12040903
更新日期：2020-03-26 00:00:00
abstract：:The term glycaemic-index (GI) originally appeared in the literature in the early 1980s. GI categorizes carbohydrate according to glycaemic effect postprandially. Since its inception, GI has obtained and maintained interest of academics and clinicians globally. Upon review of GI literature, it becomes clear that the cl...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu3030330
更新日期：2011-03-01 00:00:00
abstract：:Glial activation and neuroinflammation play significant roles in apoptosis as well as in the development of cognitive and memory deficits. Neuroinflammation is also a critical feature in the pathogenesis of neurodegenerative disorders such as Alzheimer and Parkinson's diseases. Previously, hesperetin has been shown to...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11030648
更新日期：2019-03-17 00:00:00
