Abstract：
:Microbiota contributes to the regulation of eating behavior and might be implicated in the pathophysiology of anorexia nervosa. ClpB (Caseinolytic peptidase B) protein produced mainly by the Enterobacteriaceae family has been identified as a conformational mimetic of α-MSH, which could result in similar anorexigenic effects. The aim of this study was to highlight the role of the microbiome and the ClpB protein in deregulation and self-maintenance of anorexia pathology. Male C57Bl/6 mice were undergone to the ABA (Activity-Based Anorexia) protocol: after 5 days of acclimatization, both ABA and LFA (Limited Food Access) mice had progressively limited access to food until D17. At the end of protocol, the plasma ClpB concentration and Enterobacteriaceae DNA in colonic content were measured. As expected, dietary restriction induced lost weight in LFA and ABA mice. At D10, colonic permeability and plasma concentration of the ClpB protein were significantly increased in LFA and ABA mice vs. controls. At D17, plasma concentration of ClpB was increased in LFA and ABA mice and, it was correlated with proportion of Enterobacteriaceae in the faeces. These abnormally high ClpB concentrations and all associated factors, and therefore might contribute to the initiation and/or perpetuation of anorexia nervosa by interfering with satiety signaling.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Dominique M,Legrand R,Galmiche M,Azhar S,Deroissart C,Guérin C,do Rego JL,Leon F,Nobis S,Lambert G,Lucas N,Déchelotte Pdoi
10.3390/nu11102514subject
Has Abstractpub_date
2019-10-18 00:00:00issue
10issn
2072-6643pii
nu11102514journal_volume
11pub_type
杂志文章相关文献
Nutrients文献大全abstract：:As the relationship between vitamin D and various diseases or health conditions has become known, interest in the contribution of vitamin D to overall health-related quality of life (QoL) has increased. We examined the relationship between vitamin D status and QoL in 273 participants aged 65 years and older. Serum lev...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112748
更新日期：2019-11-12 00:00:00
abstract：:Tyrosinemia type 1 (TT1) treatment with 2-(2-nitro-4-trifluormethyl-benzyl)-1,3-cyclohexanedione (NTBC) and a phenylalanine-tyrosine restricted diet is associated with low phenylalanine concentrations. Phenylalanine supplementation is prescribed without comprehensive consideration about its effect on metabolic control...
journal_title：Nutrients
pub_type： 杂志文章,多中心研究
doi：10.3390/nu11112816
更新日期：2019-11-18 00:00:00
abstract：:Late-onset sepsis (LOS) and other systemic bloodstream infections are notable causes of neonatal mortality, particularly in prematurely born very low birth weight infants. Breastfeeding in early life has numerous health benefits, impacting the health of the newborn in both the short-term and in the long-term. Though t...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12041045
更新日期：2020-04-10 00:00:00
abstract：:Sweet taste receptors are composed of a heterodimer of taste 1 receptor member 2 (T1R2) and taste 1 receptor member 3 (T1R3). Accumulating evidence shows that sweet taste receptors are ubiquitous throughout the body, including in the gastrointestinal tract as well as the hypothalamus. These sweet taste receptors are h...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu9070653
更新日期：2017-06-24 00:00:00
abstract：:Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is as...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12113528
更新日期：2020-11-17 00:00:00
abstract：:This pilot study aimed to investigate the effect of simple sugar ingestion, in amounts typical of common ingestion, on appetite and the gut-derived hormone response. Seven healthy men ingested water (W) and equicaloric solutions containing 39.6 g glucose monohydrate (G), 36 g fructose (F), 36 g sucrose (S), and 19.8 g...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu9020135
更新日期：2017-02-14 00:00:00
abstract：:Obesity and iron deficiency (ID) are two of the most common nutritional disorders in the world. In children both conditions deserve particular attention. Several studies revealed an association between obesity and iron deficiency in children and, in some cases, a reduced response to oral supplementation. The connectin...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu7115458
更新日期：2015-11-06 00:00:00
abstract：:Adequate docosahexaenoic acid (DHA) is essential for the optimal growth and development of the fetus. Maternal DHA content fluctuates during pregnancy. The correlation of DHA content with dietary intake might be varied over the course of pregnancy. We aimed to compare the dietary DHA intake, estimated by a DHA-specifi...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9111256
更新日期：2017-11-16 00:00:00
abstract：:This study aimed to observe the relationship between iodine nutrition status (dietary iodine intake and estimated iodine intake based on urinary iodine concentration (UIC)) and thyroid disease-related hormones. This study involved 6090 subjects >19 years old with valid UIC, assessed between 2013 and 2015 by the Korean...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112757
更新日期：2019-11-13 00:00:00
abstract：:Breast cancer is a common cancer that occurs due to different epigenetic alterations and genetic mutations. Various epidemiological studies have demonstrated an inverse correlation between breast cancer incidence and flavonoid intake. The anti-cancer action of flavonoids, a class of polyphenolic compounds that are pre...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12030761
更新日期：2020-03-13 00:00:00
abstract：:We performed an external cross-validation study of 10 equations to estimate resting energy expenditure (REE) in 2037 children with and 389 without obesity. Inclusion criteria were Caucasian ethnicity, age ≤ 18 years, and availability of REE. REE was measured using indirect calorimetry. The correct classification fract...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12051421
更新日期：2020-05-14 00:00:00
abstract：:Patients with Parkinson's disease (PD) manifest nonmotor and motor symptoms. Autonomic cardiovascular dysregulation is a common nonmotor manifestation associated with increased morbimortality. Conventional clinical treatment alleviates motor signs but does not change disease progression and fails in handling nonmotor ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu12061551
更新日期：2020-05-26 00:00:00
abstract：:Taste receptors, first identified on the tongue, are best known for their role in guiding our dietary preferences. The expression of taste receptors for umami, sweet, and bitter have been demonstrated in tissues outside of the oral cavity, including in the airway, brain, gastrointestinal tract, and reproductive organs...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11092017
更新日期：2019-08-28 00:00:00
abstract：:The aim of the study was to assess the amount of orally administered carbohydrates needed to maintain euglycemia during moderate-intensity exercise in individuals with type 1 diabetes. Nine participants with type 1 diabetes (four women, age 32.1 ± 9.0 years, BMI 25.5 ± 3.9 kg/m2, HbA1c 55 ± 7 mmol/mol (7.2 ± 0.6%)) on...
journal_title：Nutrients
pub_type： 杂志文章,随机对照试验
doi：10.3390/nu11061287
更新日期：2019-06-06 00:00:00
abstract：:Purpose: To examine the effects of commercially available sports beverages with various components on substrate metabolism and subsequent performance. Methods: Two studies were conducted in a double-blinded, counterbalanced manner. Study I was designed to determine the glycemic index, while study II determined the uti...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9040377
更新日期：2017-04-12 00:00:00
abstract：:Few studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, and decaffeinated coffee consumption. We also assessed the ability of metabolites to discriminate ...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11051032
更新日期：2019-05-08 00:00:00
abstract：:Infants rely on their innate immune systems to protect them from infection. Human milk (HM) contains fatty acids (FAs) and monoacylglycerols that are known to exhibit antiviral and antibacterial properties in vitro. The specific fat content of HM may potentially affect the efficacy of this antimicrobial activity. This...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9091034
更新日期：2017-09-19 00:00:00
abstract：:Vitamin A insufficiency has profound adverse effects on embryonic development. Major advances in understanding the role of vitamin A in vertebrate heart formation have been made since the discovery that the vitamin A active form, all-trans-retinoic acid, regulates many genes, including developmental genes. Among the e...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu2050532
更新日期：2010-05-01 00:00:00
abstract：:Alperujo-a two-phase olive mill waste that is composed of olive vegetation water and solid skin, pulp, and seed fragments - is a highly valuable olive by-product due to its high content in phenolic compounds. In this study, we assessed whether β-cyclodextrin (β-CD), which is used to extract and protect alpejuro phenol...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu10111653
更新日期：2018-11-03 00:00:00
abstract：:Dietary Guidelines for Americans 2015-20 recommend replacing sugar sweetened beverages (SSBs) with plain water in order to promote adequate hydration while reducing added sugar intake. This study explored how water intakes from water, beverages, and foods are distributed across the day. The dietary intake data for 745...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11112707
更新日期：2019-11-08 00:00:00
abstract：:l-carnitine is an important co-factor in fatty-acid metabolism, and its deficiency is associated with insulin resistance, which is independently associated with arterial stiffness. This study evaluated the relationship between serum l-carnitine level and peripheral arterial stiffness (PAS) in kidney transplantation (K...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11092000
更新日期：2019-08-24 00:00:00
abstract：:Home environment and family lifestyle practices have an influence on child obesity risk, thereby making it critical to systematically examine these factors. Thus, parents (n = 489) of preschool children completed a cross-sectional online survey which was the baseline data collection conducted, before randomization, in...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu9060604
更新日期：2017-06-14 00:00:00
abstract：:The medicinal use of cocoa has a long history dating back almost five hundred years when Hernán Cortés's first experienced the drink in Mesoamerica. Doctors in Europe recommended the beverage to patients in the 1700s, and later American physicians followed suit and prescribed the drink in early America--ca. 1800s. Thi...
journal_title：Nutrients
pub_type： 历史文章,杂志文章,评审
doi：10.3390/nu5103854
更新日期：2013-09-26 00:00:00
abstract：:The immunological mechanism underlying Immunoglobuline E (IgE)-mediated cow's milk allergy has been subject to investigations for many years. Identification of the key immune cells (mast cells, B cells) and molecules (IgE) in the allergic process has led to the understanding that avoidance of IgE-crosslinking epitopes...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu11112734
更新日期：2019-11-11 00:00:00
abstract：:Quercetin, a medicinally important member of the flavonoid family, is one of the most prominent dietary antioxidants. It is present in a variety of foods-including fruits, vegetables, tea, wine, as well as other dietary supplements-and is responsible for various health benefits. Numerous pharmacological effects of que...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu8090529
更新日期：2016-08-29 00:00:00
abstract：:The polyphenol resveratrol (RVT) may drive protective mechanisms of cerebral homeostasis during the hypoperfusion/reperfusion triggered by the transient bilateral common carotid artery occlusion followed by reperfusion (BCCAO/R). This immunochemical study investigates if a single dose of RVT modulates the plasticity-r...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11051000
更新日期：2019-05-01 00:00:00
abstract：:Consumer demand for plant protein-based products is high and expected to grow considerably in the next decade. Factors contributing to the rise in popularity of plant proteins include: (1) potential health benefits associated with increased intake of plant-based diets; (2) consumer concerns regarding adverse health ef...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12123704
更新日期：2020-11-30 00:00:00
abstract：:To address limited food frequency questionnaire (FFQ) capacity in public health monitoring in Malaysia, we aimed to develop a semi-quantitative FFQ for an adult multiethnic population for comprehensive fatty acid (FA) profiling inclusive of saturated (SFA), monounsaturated (MUFA), polyunsaturated fatty acids (PUFA), P...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu13010120
更新日期：2020-12-31 00:00:00
abstract：:High sodium intake is estimated to cause approximately 3 million deaths per year worldwide. The estimated average sodium intake of 3.95 g/day far exceeds the recommended intake. Population sodium reduction should be a global priority, while simultaneously ensuring universal salt iodization. This article identifies hig...
journal_title：Nutrients
pub_type： 杂志文章,评审
doi：10.3390/nu12092543
更新日期：2020-08-22 00:00:00
abstract：BACKGROUND:To prevent malnutrition and food aspiration in children with chronic neuromuscular problems, enteral nutrition provided by gastrostomy is recommended. Long-term follow-up data about surgical and medical complications of PEG are available, but few papers have addressed all of the issues in the same series. M...
journal_title：Nutrients
pub_type： 杂志文章
doi：10.3390/nu11071555
更新日期：2019-07-10 00:00:00
