Abstract：
:We can now sequence and identify genome wide epigenetic patterns and perform a variety of "genomic experiments" within relatively short periods of time-ranging from days to weeks. Yet, despite these technological advances, we have a poor understanding of the inter-relationships between epigenetics, genome structure-function, and nutrition. Perhaps this limitation lies, in part, in our propensity to study epigenetics in terms of the linear arrangement of elements and genes. Here we propose that a more complete understanding of how nutrition impacts on epigenetics and cellular development resides within the inter-relationships between DNA and histone modification patterns and genome function, in the context of spatial organization of chromatin and the epigenome.
journal_name
Nutrientsjournal_title
Nutrientsauthors
O'Sullivan JM,Doynova MD,Antony J,Pichlmuller F,Horsfield JAdoi
10.3390/nu6125724subject
Has Abstractpub_date
2014-12-10 00:00:00pages
5724-39issue
12issn
2072-6643pii
nu6125724journal_volume
6pub_type
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