Abstract:
:Eggplant (Solanum melongena) is a globally popular vegetable and its significant health effect has not been reported in randomized controlled trials. Recently, we reported that eggplant was rich in choline esters, including acetylcholine (ACh), and had an antihypertensive effect in spontaneously hypertensive rats. Here, we evaluated the effects of a continuous intake of eggplant powder on blood pressure (BP), stress, and psychological state (PS) in 100 stressed participants with normal-high BP or grade 1 hypertension in a randomized, double-blind, placebo-controlled, parallel-group comparative study. The participants were randomly assigned to the eggplant or placebo group. Participants in the eggplant group ingested capsules containing eggplant powder (1.2 g/day; 2.3 mg of ACh/day) for 12 weeks, whereas participants in the placebo group ingested placebo capsules. The primary outcome assessed was hospital BP. Secondary outcomes were stress and PS. Eggplant powder intake significantly decreased the hospital diastolic blood pressure (DBP) at week 8 overall and in the normal-high BP group, and the systolic blood pressure (SBP) and DBP at week 12 overall and in the grade 1 hypertension group, compared to those of the placebo group. It also improved negative PSs at week 8 or 12 in the normal-high BP group. This is the first evidence of the BP- and PS-improving effects of eggplant intake in humans. The functional substance responsible for the effects was estimated to be eggplant-derived choline ester, namely ACh.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Nishimura M,Suzuki M,Takahashi R,Yamaguchi S,Tsubaki K,Fujita T,Nishihira J,Nakamura Kdoi
10.3390/nu11112797subject
Has Abstractpub_date
2019-11-16 00:00:00issue
11issn
2072-6643pii
nu11112797journal_volume
11pub_type
杂志文章,随机对照试验相关文献
Nutrients文献大全abstract::Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acid...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11061340
更新日期:2019-06-14 00:00:00
abstract::The objective of the present study is to investigate the relationships between body composition, nutritional profile, muscular fitness (MF) and bone health in a sample of children and adolescents from Colombia. Participants included 1118 children and adolescents (54.6% girls). Calcaneal broadband ultrasound attenuatio...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9020106
更新日期:2017-02-03 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a disease associated with dysfunctional metabolic processes that lead to abnormally high levels of blood glucose. Preceding the development of T2DM is insulin resistance (IR), a disorder associated with suppressed or delayed responses to insulin. The effects of this response are pred...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11020408
更新日期:2019-02-15 00:00:00
abstract::Age-appropriate feeding practice (ADF) during early childhood are vital for optimal nutrition. This longitudinal study determined the effect of selected risk factors and ADF, as described by the National Nutritional Recommendations, on linear and ponderal growth of children below 24 months of age. Weight and length me...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12010012
更新日期:2019-12-19 00:00:00
abstract::Immigrants in the U.S. may encounter challenges of acculturation, including dietary habits, as they adapt to new surroundings. We examined Vietnamese and Hispanic immigrant children's American food consumption patterns in a convenience sample of 63 Vietnamese and Hispanic children in grades four to six who were attend...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu9050460
更新日期:2017-05-05 00:00:00
abstract::Vitamin D deficiency has been associated with depressive symptoms and reduced physical functioning. The aim of the study was to characterize the relationship between polymorphisms of the vitamin D receptor (VDR) gene and the quality of life in patients with autoimmune hepatitis (AIH) and primary biliary cholangitis (P...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12082244
更新日期:2020-07-27 00:00:00
abstract::The popularity of yogurt has increased among consumers due to its perceived health benefits. This study examined the cross-sectional association between yogurt consumption and nutrient intake/adequacy, dietary quality, and body weight in children and adults. National Health and Nutrition Examination Survey 2001-2016 d...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12113435
更新日期:2020-11-09 00:00:00
abstract::Ingredients delivering functional and nutritional benefits are of interest to food manufacturers. Isomaltooligosaccharides (IMOs) which serve as alternate sweeteners fit into this category. IMOs are a mixture of α-(1 → 6) and α-(1 → 4)-linked glucose oligomers, synthesized by an enzymatic reaction from starch (corn, t...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu10030301
更新日期:2018-03-03 00:00:00
abstract::Ocoxin Oral Solution (OOS) is a nutritional supplement whose formulation includes several plant extracts and natural products with demonstrated antitumoral properties. This review summarizes the antitumoral action of the different constituents of OOS. The action of this formulation on different preclinical models as w...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12092661
更新日期:2020-08-31 00:00:00
abstract::The fatty acid (FA) composition of red blood cell (RBC) membrane phospholipids of cancer patients can reflect tumor status, dietary intakes, and cancer type or therapy. However, the characteristic membrane profiles have so far not yet defined as a potential biomarker to monitor disease evolution. The present work prov...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10121853
更新日期:2018-12-01 00:00:00
abstract::The purpose of the study was to investigate the relationship between mindful eating, disordered eating and mood in university students in health-related disciplines. A total of 221 university students participated in the study; 102 students studied sport and exercise science (SS), 54 students pharmacy sciences (PS), a...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12020396
更新日期:2020-02-02 00:00:00
abstract::The effects of allulose and two probiotic species on diet-induced obese (DIO) mice were investigated. Lactobacillus sakei LS03 (10⁸ cfu/day) and Leuconostoc kimchii GJ2 (10⁸ cfu/day) were used as probiotics, and allulose (AL) as a prebiotic. The synergistic effect of prebiotics and probiotics in improving obesity was ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10111797
更新日期:2018-11-19 00:00:00
abstract::The number of patients with mental illnesses is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. It is suggested that inflammatory molecules derived from microglia play crucial roles for the pathophysiology of depression. In the present study, we discovered that leucine-h...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11092161
更新日期:2019-09-09 00:00:00
abstract::Little evidence is available regarding the relationship between zinc and sleep in school children. The present study aimed to examine the cross-sectional and longitudinal associations between blood zinc concentrations and sleep quality throughout childhood. A total of 1295 children from the Jintan Child Cohort in Chin...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu7075247
更新日期:2015-07-13 00:00:00
abstract::Accumulating epidemiological evidence suggests that anthocyanin intake is associated with reduced risks of cardiometabolic disorders, highlighting the importance of incorporating the phytochemical in our diets. Numerous food-based intervention studies have examined, in controlled meal settings, the role of anthocyanin...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12123781
更新日期:2020-12-09 00:00:00
abstract::This secondary analysis study addressed a gap of knowledge: whether perceived stress reduction created by a lifestyle intervention might serve as a mediator for reducing fat and fast food intakes in low-income overweight or obese mothers of young children. This analysis included 338 low-income overweight or obese moth...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12123606
更新日期:2020-11-24 00:00:00
abstract::Limited work is available on the benefits of nutritional support enriched with arginine and n-3 fatty acids in surgical patients with head and neck cancer, particularly if well-nourished. We conducted a pilot study in these patients to examine effects on inflammatory markers and clinical outcome. Patients scheduled fo...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu5041186
更新日期:2013-04-09 00:00:00
abstract::Accumulating evidence clarifies that intestinal barrier function, for example, by the mucus layer, antimicrobial peptides, immune systems, and epithelial tight junctions, plays crucial roles in maintaining our health. We reported previously that yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 an...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11122998
更新日期:2019-12-07 00:00:00
abstract::The human intestinal microbiota, establishing a symbiotic relationship with the host, plays a significant role for human health. It is also well known that a disease status is frequently characterized by a dysbiotic condition of the gut microbiota. A probiotic treatment can represent an alternative therapy for enteric...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10111723
更新日期:2018-11-10 00:00:00
abstract:BACKGROUND:Fruits and vegetables are key to a healthy diet, particularly in children; however, parents may be concerned about contaminants found in fruits and vegetables. Making informed food choices for children requires understanding and balancing the risks of contaminant exposure with the importance of providing a h...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10111572
更新日期:2018-10-24 00:00:00
abstract::Widespread consumption of high-fructose and high-fat diets relates to the global epidemic of hypertension. Hypertension may originate from early life by a combination of prenatal and postnatal nutritional insults. We examined whether maternal high-fructose diet increases vulnerability to post-weaning high-fructose or ...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu10010056
更新日期:2018-01-09 00:00:00
abstract::The human intestine contains an intricate ecological community of dwelling bacteria, referred as gut microbiota (GM), which plays a pivotal role in host homeostasis. Multiple factors could interfere with this delicate balance, including genetics, age, antibiotics, as well as environmental factors, particularly diet, t...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11092216
更新日期:2019-09-13 00:00:00
abstract::Kynurenic acid, a metabolite of the kynurenine pathway of tryptophan catabolism, acts as an antagonist for both the α7 nicotinic acetylcholine receptor and glycine coagonist sites of the N-methyl-d-aspartic acid receptor at endogenous brain concentrations. Elevation of brain kynurenic acid levels reduces the release o...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu12051403
更新日期:2020-05-13 00:00:00
abstract::Research suggests that attention, mood, and satiety can be influenced by meal composition and postprandial activity. The present study examined whether this hypothesis applies to persons with a risk phenotype for the development of cardiovascular/neurodegenerative diseases. A randomized crossover trial was conducted i...
journal_title:Nutrients
pub_type: 杂志文章,随机对照试验
doi:10.3390/nu11102294
更新日期:2019-09-26 00:00:00
abstract::Consumers' perceptions of five front-of-pack nutrition label formats (health star rating (HSR), multiple traffic lights (MTL), Nutri-Score, reference intakes (RI) and warning label) were assessed across 12 countries (Argentina, Australia, Bulgaria, Canada, Denmark, France, Germany, Mexico, Singapore, Spain, the UK and...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu11081934
更新日期:2019-08-16 00:00:00
abstract::One-anastomosis gastric bypass is a promising type of bariatric surgery, but it may lead to a deficiency in important nutrients, such as fatty acids. The short-term effects of one-anastomosis gastric bypass on serum fatty acids have not been studied thus far. Therefore, the aim of this study was to determine the effec...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu12010187
更新日期:2020-01-09 00:00:00
abstract::Special Operations Forces (SOF) regularly engage in physically demanding combat operations and field training exercises, resulting in high daily energy expenditure, and thus increased energy requirements. However, the majority of studies assessing energy requirements of SOF have been conducted on soldiers going throug...
journal_title:Nutrients
pub_type: 杂志文章
doi:10.3390/nu6051945
更新日期:2014-05-12 00:00:00
abstract::Micronutrient deficiencies occur in segments of the adult population in the United States. Multivitamin/multimineral supplements (MVMS) are widely used by this population, which reduces inadequacies in micronutrient intake, but the potential for exceeding tolerable upper intake levels in others should be considered. T...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu10020248
更新日期:2018-02-22 00:00:00
abstract::Neurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of disability, and the lack of effective causal/disease-modifying treatments. There is a growing body of evidence indicating potentially favourable effects of carnosine, which is an over-t...
journal_title:Nutrients
pub_type: 杂志文章,评审
doi:10.3390/nu11061196
更新日期:2019-05-28 00:00:00
abstract::This study aimed to evaluate dietary nutrient intake among Chinese pregnant women by comparison with Chinese Dietary Reference Intakes (DRIs) and to explore the association between dietary nutrients and preterm birth. A case-control design was conducted in Beijing with 130 preterm delivery mothers in case group and 38...
journal_title:Nutrients
pub_type: 杂志文章,多中心研究
doi:10.3390/nu9030221
更新日期:2017-03-01 00:00:00