Abstract：
:Angiopoietin-like protein 4 (ANGPTL-4) regulates lipidic metabolism and affects energy homeostasis. However, its function in children with obesity remains unknown. We investigated plasma ANGPTL-4 levels in children and its relationship with body mass index (BMI) and different lipidic parameters such as free fatty acids (FFA). Plasma ANGPTL-4 levels were analyzed in two different cohorts. In the first cohort (n = 150, age 3-17 years), which included children with normal weight or obesity, we performed a cross-sectional study. In the second cohort, which included only children with obesity (n = 20, age 5-18 years) followed up for two years after an intervention for weight loss, in which we performed a longitudinal study measuring ANGPTL-4 before and after BMI-loss. In the cross-sectional study, circulating ANGPTL-4 levels were lower in children with obesity than in those with normal weight. Moreover, ANGPTL-4 presented a negative correlation with BMI, waist circumference, weight, insulin, homeostasis model assessment of insulin resistance index (HOMA index), triglycerides, and leptin, and a positive correlation with FFA and vitamin-D. In the longitudinal study, the percent change in plasma ANGPTL-4 was correlated with the percent change in FFA, total-cholesterol and high-density lipoprotein cholesterol. This study reveals a significant association of ANGPTL-4 with pediatric obesity and plasma lipid profile.
journal_name
Nutrientsjournal_title
Nutrientsauthors
Barja-Fernández S,Folgueira C,Castelao C,Pena-León V,González-Saenz P,Vázquez-Cobela R,Aguilera CM,Gil-Campos M,Bueno G,Gil Á,Moreno LA,Ruiz-Piñon M,García-Palacios M,Casanueva FF,Diéguez C,Nogueiras R,Leis R,Seoane LMdoi
10.3390/nu11061340subject
Has Abstractpub_date
2019-06-14 00:00:00issue
6issn
2072-6643pii
nu11061340journal_volume
11pub_type
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