Magnetic resonance image segmentation using pattern recognition, and applied to image registration and quantitation.

abstract：:Development and evaluation of new anticancer drugs are expedited when minimally invasive biomarkers of pharmacokinetic and pharmacodynamic behaviour are available. Gene-directed enzyme prodrug therapy (GDEPT) is a suicide gene therapy in which the anticancer drug is activated in the tumor by an exogenous enzyme previo...

journal_title：NMR in biomedicine

authors： Mancini L,Davies L,Friedlos F,Falck-Miniotis M,Dzik-Jurasz AS,Springer CJ,Leach MO,Payne GS

更新日期：2009-06-01 00:00:00

abstract：:Standard functional MRI (fMRI), which includes resting-state or paradigm-driven designs, is widely used in studies of brain function, aging, and disease. These fMRI studies typically use two-dimensional gradient echo-planar imaging, which inherently contains phase data that enables quantitative susceptibility mapping ...

journal_title：NMR in biomedicine

authors： Sun H,Seres P,Wilman AH

更新日期：2017-04-01 00:00:00

abstract：:MRI and MRS in small rodents demand very high sensitivity. Cryogenic transmit/receive radiofrequency probes (CryoProbes) designed for (1) H MRI of mouse brain provide an attractive option for increasing the performance of small-animal MR systems. As the Larmor frequency of (13) C nuclei is four times lower than that f...

journal_title：NMR in biomedicine

authors： Sack M,Wetterling F,Sartorius A,Ende G,Weber-Fahr W

更新日期：2014-06-01 00:00:00

abstract：:The goal of this study was to validate metabolite quantification at short TE, with particular focus on how to best account for the macromolecular signal contribution. A robust, short-TE PRESS protocol is presented, which allows reliable quantification, in vivo, of metabolite signals at 3 T in human brain. Water suppre...

journal_title：NMR in biomedicine

authors： Gottschalk M,Lamalle L,Segebarth C

更新日期：2008-06-01 00:00:00

abstract：:This paper describes the use of off-resonance saturation to further manipulate the blood oxygenation level dependent (BOLD) contrast of fMRI. A customized narrow bandwidth radiofrequency pulse, applied with a range of frequency offsets prior to selection of each slice, was designed and incorporated into a gradient ech...

journal_title：NMR in biomedicine

authors： Song AW,Wolff SD,Balaban RS,Jezzard P

更新日期：1997-06-01 00:00:00

abstract：:Polycystic kidney disease (PKD) is a life-threatening disease that leads to a grotesque enlargement of the kidney and significant loss of function. Several imaging studies with MRI have demonstrated that cyst size in polycystic kidneys can determine disease severity and progression. In the present study, we found that...

journal_title：NMR in biomedicine

authors： Xie L,Qi Y,Subashi E,Liao G,Miller-DeGraff L,Jetten AM,Johnson GA

更新日期：2015-05-01 00:00:00

abstract：:The accurate diagnosis of glioma subtypes is critical for appropriate treatment, but conventional histopathologic diagnosis often exhibits significant intra-observer variability and sampling error. The aim of this study was to investigate whether histogram analysis using an automatically segmented region of interest (...

journal_title：NMR in biomedicine

authors： Lee J,Choi SH,Kim JH,Sohn CH,Lee S,Jeong J

更新日期：2014-09-01 00:00:00

abstract：:The purpose of this work was to harmonize data acquisition and post-processing of single voxel proton MRS ((1) H-MRS) at 7 T, and to determine metabolite concentrations and the accuracy and reproducibility of metabolite levels in the adult human brain. This study was performed in compliance with local institutional hu...

journal_title：NMR in biomedicine

authors： van de Bank BL,Emir UE,Boer VO,van Asten JJ,Maas MC,Wijnen JP,Kan HE,Oz G,Klomp DW,Scheenen TW

更新日期：2015-03-01 00:00:00

abstract：:The purpose of the present study was to characterize the metabolic profile of the visual cortex in streptozotocin-induced Type 1 diabetic rats by means of in vivo proton MRS. Several metabolite concentration ratios in the visual cortex were calculated. In addition, postmortem histologic analyses for retinal ganglion c...

journal_title：NMR in biomedicine

authors： Li S,Wang X,Yang J,Lei H,Wang X,Xiang Y

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To investigate the feasibility of using multiple flip angles in dynamic contrast enhanced (DCE) MRI to reduce the uncertainty in estimation of intracellular water lifetime (τi ). METHODS:Numerical simulation studies were conducted to assess the uncertainty in estimation of τi using dynamic contrast enhanced MR...

journal_title：NMR in biomedicine

authors： Zhang J,Kim SG

更新日期：2019-11-01 00:00:00

abstract：:The aim of this study was to evaluate the change of breast density in the normal breast of patients receiving neoadjuvant chemotherapy (NAC). Forty-four breast cancer patients were studied. MRI acquisition was performed before treatment (baseline), and 4 and 12 weeks after treatment. A computer-algorithm-based program...

journal_title：NMR in biomedicine

authors： Chen JH,Pan WF,Kao J,Lu J,Chen LK,Kuo CC,Chang CK,Chen WP,McLaren CE,Bahri S,Mehta RS,Su MY

更新日期：2013-12-01 00:00:00

abstract：:Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

journal_title：NMR in biomedicine

authors： Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

更新日期：2012-08-01 00:00:00

abstract：:While phase imaging with a gradient echo (GRE) sequence is popular, phase imaging with balanced steady-state free precession (bSSFP) has been underexplored. The purpose of this study was to investigate anatomical and functional phase imaging with multiple phase-cycled bSSFP, in expectation of increasing spatial covera...

journal_title：NMR in biomedicine

authors： Kim JW,Kim SG,Park SH

更新日期：2017-06-01 00:00:00

abstract：:The aim of the study was to establish the normal range and to evaluate the reproducibility of dynamic contrast enhanced MRI (DCE-MRI) parameter estimates in normal human pelvic tissues. Nineteen patients with prostate cancer, undergoing androgen deprivation treatment, had paired DCE-MRI examinations of the pelvis usin...

journal_title：NMR in biomedicine

authors： Padhani AR,Hayes C,Landau S,Leach MO

更新日期：2002-04-01 00:00:00

abstract：:1H MR spectroscopy was used to correlate the metabolite signals in 66 untreated metastatic brain tumors with the results of Gd-DTPA enhanced MRI. Cubic volumes containing brain metastases of lung cancer (n = 17), mammary carcinoma (n = 24), melanoma (n = 12) and those originating from other tumors (n = 13) were examin...

journal_title：NMR in biomedicine

authors： Sijens PE,Levendag PC,Vecht CJ,van Dijk P,Oudkerk M

更新日期：1996-04-01 00:00:00

abstract：:Several obstacles usually confound a straightforward perfusion analysis using dynamic-susceptibility contrast-based magnetic resonance imaging (DSC-MRI). In this work, it became possible to eliminate some of these sources of error by combining a multiple gradient-echo technique with parallel imaging (PI): first, the l...

journal_title：NMR in biomedicine

authors： Jochimsen TH,Newbould RD,Skare ST,Clayton DB,Albers GW,Moseley ME,Bammer R

更新日期：2007-06-01 00:00:00

abstract：:The aim of this study was to investigate physiological variations of the water T2 relaxation time in vertebral bone marrow with respect to age, body mass index (BMI), sex and proton density fat fraction (PDFF) based on single-voxel magnetic resonance spectroscopy (MRS) at 3 T. Multi-TE single-voxel STEAM MRS data of a...

journal_title：NMR in biomedicine

authors： Ruschke S,Syväri J,Dieckmeyer M,Junker D,Makowski MR,Baum T,Karampinos DC

更新日期：2020-11-17 00:00:00

abstract：:γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved sp...

journal_title：NMR in biomedicine

authors： Sanaei Nezhad F,Anton A,Michou E,Jung J,Parkes LM,Williams SR

更新日期：2018-01-01 00:00:00

abstract：:The purpose of this study was to investigate the feasibility of interventional MRI-guided local agent delivery into pig common bile duct (CBD) walls using a newly designed MR-compatible, needle-integrated balloon catheter system. We first designed a needle-integrated balloon catheter system that comprised of a 22 G MR...

journal_title：NMR in biomedicine

authors： Zhang F,Bai Z,Shi Y,Wang J,Li Y,Yang X

更新日期：2015-06-01 00:00:00

abstract：:By quantification of brain metabolites, localized brain proton MRS can non-invasively provide biochemical information from distinct regions of the brain. Quantification of short-TE signals is usually based on a metabolite basis set. The basis set can be obtained by two approaches: (1) by measuring the signals of metab...

journal_title：NMR in biomedicine

authors： Cudalbu C,Cavassila S,Rabeson H,van Ormondt D,Graveron-Demilly D

更新日期：2008-07-01 00:00:00

abstract：:This introductory article addresses approaches currently in use to process in vivo spectra. First, a brief overview is given of the information content represented by the parameters of MR signals. Subsequently, common steps in the processing of MR spectra such as pre-processing, normalisation and quantification and th...

journal_title：NMR in biomedicine

authors： in 't Zandt H,van Der Graaf M,Heerschap A

更新日期：2001-06-01 00:00:00

abstract：:Qualitative and quantitative (1) H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) (n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) (n = 9) and gallbladder cancer (GBC, malignant) (n = 8) was carried out to understand the mechanisms involved in the transformati...

journal_title：NMR in biomedicine

authors： Jayalakshmi K,Sonkar K,Behari A,Kapoor VK,Sinha N

更新日期：2011-05-01 00:00:00

abstract：:The transverse relaxation rates R2 and R2* were measured at 3 T in the substantia nigra of the midbrain of adult normal human controls. The relaxation rate arising from magnetic inhomogeneities, R2', was calculated from the relationship R2* = R2 + R2'. No significant differences were found for any parameters between l...

journal_title：NMR in biomedicine

authors： Helpern JA,Ordidge RJ,Gorell JM,Deniau JC,Welch KM

更新日期：1995-02-01 00:00:00

abstract：:13C MRS was installed on a clinical scanner at 1.5 T in order to facilitate integrated MR examinations of human brain disorders. Using a simplified protocol, (1-(13)C) glucose and/or (1-(13)C) acetate were administered orally or by intravenous infusion. (13)C spectra of diagnostic quality were acquired in more than 10...

journal_title：NMR in biomedicine

authors： Ross B,Lin A,Harris K,Bhattacharya P,Schweinsburg B

更新日期：2003-10-01 00:00:00

abstract：:Citicoline supplementation has been used to ameliorate memory disturbances in older people and those with Alzheimer's disease. This study used MRS to characterize the effects of citicoline on high-energy phosphate metabolites and constituents of membrane synthesis in the frontal lobe. Phosphorus ((31)P) metabolite dat...

journal_title：NMR in biomedicine

authors： Silveri MM,Dikan J,Ross AJ,Jensen JE,Kamiya T,Kawada Y,Renshaw PF,Yurgelun-Todd DA

更新日期：2008-11-01 00:00:00

abstract：:Progress in the development of non-proton NMR applications in medical research has been hampered by the generally low sensitivity of these nuclides as well as the lack of instrumentation readily available for studying these spins. For example, custom head coils suitable for sodium imaging of the human head are either ...

journal_title：NMR in biomedicine

authors： Lim KO,Wolff S,Balaban RS

更新日期：1989-09-01 00:00:00

abstract：:High grade and metastatic brain tumours exhibit considerable spatial variations in proliferation, angiogenesis, invasion, necrosis and oedema. Vascular heterogeneity arising from vascular co-option in regions of invasive growth (in which the blood-brain barrier remains intact) and neoangiogenesis is a major challenge ...

journal_title：NMR in biomedicine

authors： Boult JK,Borri M,Jury A,Popov S,Box G,Perryman L,Eccles SA,Jones C,Robinson SP

更新日期：2016-11-01 00:00:00

abstract：:In imaging of human lungs with hyperpolarised noble gases, measurements of apparent diffusion coefficient (ADC) and relaxation time provide valuable information for the assessment of lung microstructure. In this work, a sequence was developed for interleaved acquisition of ventilation images, ADC, T(2)* and flip angle...

journal_title：NMR in biomedicine

authors： Ajraoui S,Parra-Robles J,Marshall H,Deppe MH,Clemence M,Wild JM

更新日期：2012-01-01 00:00:00

abstract：:Obesity causes damage to several organs, including the brain. Recent studies have been focusing on understanding the mechanisms through which obesity affects brain structure and function using neuroimaging techniques. A functional biomarker, such as cerebral blood flow (CBF), is a powerful tool that can be used to exp...

journal_title：NMR in biomedicine

authors： Peng SL,Chen CM

更新日期：2020-10-01 00:00:00

abstract：:Surface coil 13C nuclear magnetic resonance (NMR) spectroscopy was used to investigate the in vivo carbohydrate metabolism of rat C6 gliomas during and after infusion with [1-13C] glucose. In vivo 1H-decoupled 13C NMR spectra of the glioma following infusion with [1-13C]glucose revealed the direct production of [3-13C...

journal_title：NMR in biomedicine

authors： Ross BD,Higgins RJ,Boggan JE,Willis JA,Knittel B,Unger SW

更新日期：1988-02-01 00:00:00