Abstract:
:Qualitative and quantitative (1) H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) (n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) (n = 9) and gallbladder cancer (GBC, malignant) (n = 8) was carried out to understand the mechanisms involved in the transformation of benign gallbladder tissue to intermediate and malignant tissue. The results revealed alterations in various tissue lipid components in gallbladder in CC, XGC and GBC. The difference in the nature of lipid components in benign and malignant disease may aid in the identification of the biological pathways involved in the etiopathogenesis of GBC. This is the first study on lipid profiling of gallbladder tissue by (1) H NMR spectroscopy, and has possible implications for the development of future diagnostic approaches.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Jayalakshmi K,Sonkar K,Behari A,Kapoor VK,Sinha Ndoi
10.1002/nbm.1594subject
Has Abstractpub_date
2011-05-01 00:00:00pages
335-42issue
4eissn
0952-3480issn
1099-1492journal_volume
24pub_type
杂志文章abstract::A method to extract shapes of bubble polyhedra from three-dimensional nuclear magnetic resonance image data of foam has been developed. The method consists of four steps: first, to compute series of maximum intensity projection images from the three-dimensional NMR image data of foam to visualize the network structure...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199701)10:1<13::aid-nbm443
更新日期:1997-01-01 00:00:00
abstract::Despite 40 years of NMR spectroscopy and 10 years of in vivo spectroscopy in humans, the break-even point for routine clinical diagnosis has not yet been reached. Obviously there are many factors that stimulate but also restrict the use of proton NMR spectroscopy in clinical routine. ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940070803
更新日期:1994-12-01 00:00:00
abstract::In this methodological paper I report the stereotactic correlation of different magnetic resonance imaging (MRI) techniques [MR angiography (MRA), MRI, blood bolus tagging (STAR), functional MRI, and high-resolution BOLD venography (HRBV)] in patients with cerebral arterio-venous malformations (AVM) and brain tumors. ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.714
更新日期:2001-11-01 00:00:00
abstract::Renal urea handling is central to the urine concentrating mechanism, and as such the ability to image urea transport in the kidney is an important potential imaging biomarker for renal functional assessment. Glucagon levels associated with changes in dietary protein intake have been shown to influence renal urea handl...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4028
更新日期:2019-01-01 00:00:00
abstract::Previous studies have demonstrated that using hyperpolarized [2-13 C]pyruvate as a contrast agent can reveal 13 C signals from metabolites associated with the tricarboxylic acid (TCA) cycle. However, the metabolites detectable from TCA cycle-mediated oxidation of [2-13 C]pyruvate are the result of several metabolic st...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3845
更新日期:2018-01-01 00:00:00
abstract::During the measurement of hyperpolarized 129 Xe magnetic resonance imaging (MRI), the diffusion-weighted imaging (DWI) technique provides valuable information for the assessment of lung morphometry at the alveolar level, whereas the chemical shift saturation recovery (CSSR) technique can evaluate the gas exchange func...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3730
更新日期:2017-08-01 00:00:00
abstract::Cerebrovascular reactivity (CVR) can give insight into the cerebrovascular function. CVR can be estimated by measuring a blood-oxygen-level-dependent (BOLD) response combined with breath-holding (BH). The reproducibility of this technique has been addressed and existing studies have focused on short-term reproducibili...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4195
更新日期:2020-03-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1159
更新日期:2008-02-01 00:00:00
abstract::Net ATP production rates in exercising human muscle were calculated from 31P MRS kinetic data collected with 1-8 s time resolution. During the exercise, the muscle output was measured using a force transducer. Muscle output (force/unit volume) is then divided by the calculated net ATP used to estimate the ATP cost of ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940040404
更新日期:1991-08-01 00:00:00
abstract::Following the impetus of early clinical and experimental investigations, in vivo and in vitro MRS studies of tumours pointed in the eighties to the possible significance of signals arising from phospholipid (PL) precursors and catabolites as novel biochemical indicators of in vivo tumour progression and response to th...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1492(199911)12:7<413::aid-nbm58
更新日期:1999-11-01 00:00:00
abstract::The aim of this study was to investigate the diffusion time dependence of signal-versus-b curves obtained from diffusion-weighted magnetic resonance imaging (DW-MRI) of sub-acute ischaemic lesions in stroke patients. In this case series study, 16 patients with sub-acute ischaemic stroke were examined with DW-MRI using...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1376
更新日期:2009-07-01 00:00:00
abstract::Quantitative magnetisation transfer imaging (qMTI) is an extension of conventional MT techniques and allows the measurement of parameters that reflect tissue ultrastructure through the properties of macromolecule-bound protons; these include the bound proton fraction and the relaxation times of free and bound proton p...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1614
更新日期:2011-06-01 00:00:00
abstract::Brain activation studies in humans have shown the dynamic nature of neuronal N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) based on changes in their MRS signals in response to stimulation. These studies demonstrated that upon visual stimulation there was a focal increase in cerebral blood flow (CBF) and...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3629
更新日期:2016-12-01 00:00:00
abstract::The majority of functional MRI studies of pain processing in the brain use the blood oxygenation level-dependent (BOLD) imaging approach. However, the BOLD signal is complex as it depends on simultaneous changes in blood flow, vascular volume and oxygen metabolism. Arterial spin labeling (ASL) perfusion imaging is ano...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2911
更新日期:2013-06-01 00:00:00
abstract::Studies of cholesteryl ester transfer protein (CETP) function in lipoprotein mixtures pose many difficulties by conventional biochemical methods. For instance, studies on the effects of CETP on the composition of apolipoprotein B containing lipoproteins (very low and low density lipoproteins) in lipoprotein mixtures a...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199710)10:7<303::aid-nbm48
更新日期:1997-10-01 00:00:00
abstract::The presence of the e4 allele of the apolipoprotein E (APOE) gene is the best-known genetic risk factor for Alzheimer's disease. In this study, we investigated the link between functional and behavioural differences and regional brain volume and cortical thickness differences in those who carry the e4 allele (e4+) and...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3502
更新日期:2016-05-01 00:00:00
abstract::The goal of the study was to establish early hyperpolarized (HP) 13 C MRI metabolic and perfusion changes that predict effective high-intensity focused ultrasound (HIFU) ablation and lead to improved adjuvant treatment of partially treated regions. To accomplish this a combined HP dual-agent (13 C pyruvate and 13 C ur...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3962
更新日期:2019-10-01 00:00:00
abstract::Glucose metabolism in control and estrogen stimulated rat uteri was investigated using 13C NMR spectroscopy. By employing an NMR adapted perifusion system, and developing protocols and methods based on the application of [1-13C]glucose labeling, it was possible to measure, with a temporal resolution of 10 min, the kin...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940070503
更新日期:1994-08-01 00:00:00
abstract::The aim of this study was to investigate proton changes of the parotid gland after gustatory stimulation by semi-quantitative parameters and an empirical mathematical model (EMM) using high-temporal-resolution, double-echo, echo-planar imaging (EPI). Approved by a local institutional review board, this study examined ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3885
更新日期:2018-03-01 00:00:00
abstract::The intrinsic nonuniformities in the transmit radiofrequency field from standard quadrature volume resonators at high field are particularly problematic for localized MRS in areas such as the temporal lobe, where a low signal-to-noise ratio and poor metabolite quantification result from destructive B₁⁺ field interfere...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1638
更新日期:2011-08-01 00:00:00
abstract::Blood flow and phosphorus metabolites have been measured simultaneously in the murine RIF-1 tumour in vivo. Blood flow was measured using the H2 washout technique and 31P NMR spectroscopy was used to measure high energy phosphates, inorganic phosphate and intracellular pH within the tumour. Following NMR and flow meas...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940030406
更新日期:1990-08-01 00:00:00
abstract::Organs consist of several types of cells with specialized functions. This cellular localization of function is often referred to as compartmentation. Due to the intrinsic low sensitivity of MR methods it is generally not possible in vivo to obtain images or spectra of single cells. Instead the MRS signal is the sum of...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.692
更新日期:2001-04-01 00:00:00
abstract::In this study we aimed to assess the effects of continuous formalin fixation on diffusion and relaxation metrics of the ex vivo porcine heart at 7 T. Magnetic resonance imaging was performed on eight piglet hearts using a 7 T whole body system. Hearts were measured fresh within 3 hours of cardiac arrest followed by im...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4298
更新日期:2020-07-01 00:00:00
abstract::During magnetic resonance imaging (MRI) examinations, the average specific absorption rate (SAR) of the whole body is calculated as an index of global energy deposition in biological tissue without taking into account the presence of metallic implants or conductive materials. However, this global SAR calculation is no...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3849
更新日期:2018-01-01 00:00:00
abstract::Quantitative susceptibility mapping (QSM) is a recently developed MRI technique that provides a quantitative measure of tissue magnetic susceptibility. To compute tissue magnetic susceptibilities based on gradient echoes, QSM requires reliable unwrapping of the measured phase images and removal of contributions caused...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3056
更新日期:2014-02-01 00:00:00
abstract::This study tests the hypothesis that brief periods of ischemia result in an increase in myocardial lipids during early reperfusion. We conducted 1H NMR spectroscopy to serially measure myocardial lipids before and after regional ischemia. Localized 1H NMR spectra (spatial resolution of 1.25 mm) were obtained using a o...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940080206
更新日期:1995-04-01 00:00:00
abstract::Aminoacylase 1 deficiency is a novel inborn error of metabolism. The clinical significance of the deficiency is under discussion, as well as the possible consequences of the defect for brain metabolism and function. This study includes the five originally published cases as well as three novel ones. NMR spectroscopy o...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1170
更新日期:2008-02-01 00:00:00
abstract::The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test-retest studies performed on 10 normal su...
journal_title:NMR in biomedicine
pub_type: 临床试验,杂志文章
doi:10.1002/nbm.927
更新日期:2005-02-01 00:00:00
abstract::31P NMR spectra were obtained from sera of 22 healthy volunteers and 20 patients with multiple myeloma at the time of diagnosis and repeated up to five times during therapy. All spectra consisted of a Pi peak (used as a reference peak) and two peaks from phospholipids (PL): one peak due to phosphatidylethanolamine and...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940080308
更新日期:1995-05-01 00:00:00
abstract::The application of 31P MR spectroscopy in the characterization and treatment of malignant human extremity tumors is reviewed and placed in the perspective of results obtained in murine sarcomas. Despite the now widespread acquisition of gradient localized spectral maps, the low spatial resolution that can be achieved ...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1492(1998110)11:7<341::aid-nbm5
更新日期:1998-11-01 00:00:00