Estimating the ATP cost of force production in the human gastrocnemius/soleus muscle group using 31P MRS and 1H MRI.


:Net ATP production rates in exercising human muscle were calculated from 31P MRS kinetic data collected with 1-8 s time resolution. During the exercise, the muscle output was measured using a force transducer. Muscle output (force/unit volume) is then divided by the calculated net ATP used to estimate the ATP cost of force production. These measurements have been performed using an exercise protocol of isometric maximum voluntary contraction of the gastrocnemius/soleus muscle group. Results show that by the end of 30 s of exercise, total ATP production and ATP cost of force production had stabilized and remained constant (within the measurement errors) until the end of the 2-min period. The results also demonstrate that either the ATP cost of force production in the human gastrocnemius/soleus is lower in the first second than at any other time in the 2-min window which was investigated, or that the ATP production is being underestimated at the later time points. These data on ATP production rates, and the data relating to ATP cost of force production in muscle will aid in understanding the causes of muscle failure as well as the progression and treatment of muscle disease.


NMR Biomed


NMR in biomedicine


Boska M




Has Abstract


1991-08-01 00:00:00












  • Amide proton transfer imaging of the human breast at 7T: development and reproducibility.

    abstract::Chemical exchange saturation transfer (CEST) can offer information about protons associated with mobile proteins through the amide proton transfer (APT) effect, which has been shown to discriminate tumor from healthy tissue and, more recently, has been suggested as a prognosticator of response to therapy. Despite this...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Klomp DW,Dula AN,Arlinghaus LR,Italiaander M,Dortch RD,Zu Z,Williams JM,Gochberg DF,Luijten PR,Gore JC,Yankeelov TE,Smith SA

    更新日期:2013-10-01 00:00:00

  • Correlation chemical shift imaging with low-power adiabatic pulses and constant-density spiral trajectories.

    abstract::In this work we introduce the concept of correlation chemical shift imaging (CCSI). Novel CCSI pulse sequences are demonstrated on clinical scanners for two-dimensional Correlation Spectroscopy (COSY) and Total Correlation Spectroscopy (TOCSY) imaging experiments. To date there has been limited progress reported towar...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Andronesi OC,Gagoski BA,Adalsteinsson E,Sorensen AG

    更新日期:2012-02-01 00:00:00

  • 13C NMR spectroscopic analysis of phospholipid metabolism in adrenal chromaffin cells.

    abstract::Phosphatidylcholine (PC) metabolism in bovine adrenal chromaffin cells has been studied in vivo with 100 MHz 13C NMR spectroscopy. The incorporation of 13[CH3]choline was examined in cells embedded in 1% agarose strands and perfused at 37 degrees C. The pattern of 13C NMR spectroscopy. The incorporation of [13CH3]chol...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Rivera CJ,Plishker GA,Morrisett JD,Moore J,Percy AK

    更新日期:1991-06-01 00:00:00

  • Concurrent recording of RF pulses and gradient fields - comprehensive field monitoring for MRI.

    abstract::Reconstruction of MRI data is based on exact knowledge of all magnetic field dynamics, since the interplay of RF and gradient pulses generates the signal, defines the contrast and forms the basis of resolution in spatial and spectral dimensions. Deviations caused by various sources, such as system imperfections, delay...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Brunner DO,Dietrich BE,Çavuşoğlu M,Wilm BJ,Schmid T,Gross S,Barmet C,Pruessmann KP

    更新日期:2016-09-01 00:00:00

  • Combined DCE-MRI and single-voxel 2D MRS for differentiation between benign and malignant breast lesions.

    abstract::Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and proton (1H) magnetic resonance spectroscopy (MRS) provide structural and biochemical information, including vascular volume, vascular permeability and tissue metabolism. In this study, we performed analysis of the enhancement characteristic from DCE-...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Lipnick S,Liu X,Sayre J,Bassett LW,Debruhl N,Thomas MA

    更新日期:2010-10-01 00:00:00

  • Cardiac lipid levels show diurnal changes and long-term variations in healthy human subjects.

    abstract::(1) H-MRS is regularly applied to determine lipid content in ectopic tissue - mostly skeletal muscle and liver - to investigate physiological and/or pathologic conditions, e.g. insulin resistance. Technical developments also allow non-invasive in vivo assessment of cardiac lipids; however, basic data about methodologi...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Ith M,Stettler C,Xu J,Boesch C,Kreis R

    更新日期:2014-11-01 00:00:00

  • Short- and long-term reproducibility of BOLD signal change induced by breath-holding at 1.5 and 3 T.

    abstract::Cerebrovascular reactivity (CVR) can give insight into the cerebrovascular function. CVR can be estimated by measuring a blood-oxygen-level-dependent (BOLD) response combined with breath-holding (BH). The reproducibility of this technique has been addressed and existing studies have focused on short-term reproducibili...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Peng SL,Yang HC,Chen CM,Shih CT

    更新日期:2020-03-01 00:00:00

  • Estimation of cellular-interstitial water exchange in dynamic contrast enhanced MRI using two flip angles.

    abstract:PURPOSE:To investigate the feasibility of using multiple flip angles in dynamic contrast enhanced (DCE) MRI to reduce the uncertainty in estimation of intracellular water lifetime (τi ). METHODS:Numerical simulation studies were conducted to assess the uncertainty in estimation of τi using dynamic contrast enhanced MR...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Zhang J,Kim SG

    更新日期:2019-11-01 00:00:00

  • Contrast-enhanced MRI of murine myocardial infarction - part II.

    abstract::Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审


    authors: Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

    更新日期:2012-08-01 00:00:00

  • Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13 C dual-agent imaging of metabolism and perfusion.

    abstract::The goal of the study was to establish early hyperpolarized (HP) 13 C MRI metabolic and perfusion changes that predict effective high-intensity focused ultrasound (HIFU) ablation and lead to improved adjuvant treatment of partially treated regions. To accomplish this a combined HP dual-agent (13 C pyruvate and 13 C ur...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Lee JE,Diederich CJ,Bok R,Sriram R,Santos RD,Noworolski SM,Salgaonkar VA,Adams MS,Vigneron DB,Kurhanewicz J

    更新日期:2019-10-01 00:00:00

  • Short-echo spectroscopic imaging combined with lactate editing in a single scan.

    abstract::A short-echo spectroscopic imaging sequence extended with a frequency-selective multiple-quantum- coherence technique (Sel-MQC) is presented. The method enables acquisition of a complete water-suppressed proton spectrum with a short echo time and filtering of the J-coupling metabolite, lactate, from co-resonant lipids...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Melkus G,Mörchel P,Behr VC,Kotas M,Flentje M,Jakob PM

    更新日期:2008-11-01 00:00:00

  • Apparent exchange rate for breast cancer characterization.

    abstract::Although diffusion MRI has shown promise for the characterization of breast cancer, it has low specificity to malignant subtypes. Higher specificity might be achieved if the effects of cell morphology and molecular exchange across cell membranes could be disentangled. The quantification of exchange might thus allow th...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Lasič S,Oredsson S,Partridge SC,Saal LH,Topgaard D,Nilsson M,Bryskhe K

    更新日期:2016-05-01 00:00:00

  • A comparison of signal instability in 2D and 3D EPI resting-state fMRI.

    abstract::Spatiotemporally structured noise, such as physiological noise, is a potential source of artifacts in functional magnetic resonance imaging (fMRI) and is the main limiting factor for the detection of small blood oxygen level-dependent (BOLD) signal variations. fMRI was employed to detect low-frequency BOLD signal fluc...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Goerke U,Möller HE,Norris DG,Schwarzbauer C

    更新日期:2005-12-01 00:00:00

  • Time-domain semi-parametric estimation based on a metabolite basis set.

    abstract::A novel and fast time-domain quantitation algorithm--quantitation based on semi-parametric quantum estimation (QUEST)--invoking optimal prior knowledge is proposed and tested. This nonlinear least-squares algorithm fits a time-domain model function, made up from a basis set of quantum-mechanically simulated whole-meta...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Ratiney H,Sdika M,Coenradie Y,Cavassila S,van Ormondt D,Graveron-Demilly D

    更新日期:2005-02-01 00:00:00

  • In vivo 1H, 31P-[1H] and 13C-[1H] magnetic resonance spectroscopy of malignant histiocytoma and skeletal muscle tissue in man.

    abstract::Human tumor and skeletal muscle tissue was studied by means of in vivo 1H, 31P, and 13C MRS. The examinations were performed with a 1.5 T whole-body MR scanner equipped with a second RF system. Localized 1H and broadband proton-decoupled 31P and 13C MR spectra were obtained in measurement times of 5, 10 and 33 min, re...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Bachert P,Bellemann ME,Layer G,Koch T,Semmler W,Lorenz WJ

    更新日期:1992-07-01 00:00:00

  • Reproducibility and effect of tissue composition on cerebellar γ-aminobutyric acid (GABA) MRS in an elderly population.

    abstract::MRS provides a valuable tool for the non-invasive detection of brain γ-aminobutyric acid (GABA) in vivo. GABAergic dysfunction has been observed in the aging cerebellum. The study of cerebellar GABA changes is of considerable interest in understanding certain age-related motor disorders. However, little is known about...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Long Z,Dyke JP,Ma R,Huang CC,Louis ED,Dydak U

    更新日期:2015-10-01 00:00:00

  • Stimulation-induced transient changes in neuronal activity, blood flow and N-acetylaspartate content in rat prefrontal cortex: a chemogenetic fMRS-BOLD study.

    abstract::Brain activation studies in humans have shown the dynamic nature of neuronal N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) based on changes in their MRS signals in response to stimulation. These studies demonstrated that upon visual stimulation there was a focal increase in cerebral blood flow (CBF) and...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Baslow MH,Cain CK,Sears R,Wilson DA,Bachman A,Gerum S,Guilfoyle DN

    更新日期:2016-12-01 00:00:00

  • Absolute quantification of metabolites in breast cancer cell extracts by quantitative 2D (1) H INADEQUATE NMR.

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    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Martineau E,Tea I,Akoka S,Giraudeau P

    更新日期:2012-08-01 00:00:00

  • In silico GABA+ MEGA-PRESS: Effects of signal-to-noise ratio and linewidth on modeling the 3 ppm GABA+ resonance.

    abstract::To investigate the GABA+ modeling accuracy of MEGA-PRESS GABA+-edited MRS data with various spectral quality scenarios, the influence of varying signal-to-noise ratio (SNR) and linewidth on the model estimates was quantified. MEGA-PRESS data from 46 volunteers were averaged to generate a template MEGA-PRESS spectrum, ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Zöllner HJ,Oeltzschner G,Schnitzler A,Wittsack HJ

    更新日期:2021-01-01 00:00:00

  • Knee MRI under varying flexion angles utilizing a flexible flat cable antenna.

    abstract::The aim of this study is to fabricate and test a novel flexible flat cable antenna (FFCA) for MRI of the knee at different flexion angles. The FFCA was made of a flat cable, a tuning/matching circuit and a signal transmission line. To test its feasibility and validity, in vitro and in vivo experiments were carried out...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Jia F,Yuan H,Zhou D,Zhang J,Wang X,Fang J

    更新日期:2015-04-01 00:00:00

  • Leakage of metabolites from tissue biopsies can result in large errors in quantitation by MRS.

    abstract::The leakage of metabolites from frozen and thawed tissue biopsies was measured semi-quantitatively by high-field (8.5 T) proton MRS. Human prostate and rat brain tissue specimens, frozen within 1 min of collection, lost significant and variable amounts of diagnostic metabolites immediately upon thawing. For prostate t...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Bourne R,Dzendrowskyj T,Mountford C

    更新日期:2003-04-01 00:00:00

  • NMR studies of preimplantation embryo metabolism in human assisted reproductive techniques: a new biomarker for assessment of embryo implantation potential.

    abstract::There has been growing interest in understanding energy metabolism in human embryos generated using assisted reproductive techniques (ART) for improving the overall success rate of the method. Using NMR spectroscopy as a noninvasive tool, we studied human embryo metabolism to identify specific biomarkers to assess the...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Pudakalakatti SM,Uppangala S,D'Souza F,Kalthur G,Kumar P,Adiga SK,Atreya HS

    更新日期:2013-01-01 00:00:00

  • An illustrated comparison of processing methods for phase MRI and QSM: removal of background field contributions from sources outside the region of interest.

    abstract::The elimination of so-called background fields is an essential step in phase MRI and quantitative susceptibility mapping (QSM). Background fields, which are caused by sources outside the region of interest (ROI), are often one to two orders of magnitude stronger than tissue-related field variations from within the ROI...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审


    authors: Schweser F,Robinson SD,de Rochefort L,Li W,Bredies K

    更新日期:2017-04-01 00:00:00

  • Identification of diffuse and focal brain lesions by clinical magnetic resonance spectroscopy.

    abstract::The purpose of this paper is to facilitate the comparison of magnetic resonance (MR) spectra acquired from unknown brain lesions with published spectra in order to help identify unknown lesions in clinical settings. The paper includes lists of references for published MR spectra of various brain diseases, including py...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审


    authors: Kingsley PB,Shah TC,Woldenberg R

    更新日期:2006-06-01 00:00:00

  • Electro-optic probe for real-time assessments of RF electric field produced in an MRI scanner: Feasibility tests at 3 and 4.7 T.

    abstract::During magnetic resonance imaging (MRI) examinations, the average specific absorption rate (SAR) of the whole body is calculated as an index of global energy deposition in biological tissue without taking into account the presence of metallic implants or conductive materials. However, this global SAR calculation is no...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Saniour I,Gaborit G,Perrier AL,Gillette L,Revillod G,Sablong R,Duvillaret L,Beuf O

    更新日期:2018-01-01 00:00:00

  • Effect of taxane-based neoadjuvant chemotherapy on fibroglandular tissue volume and percent breast density in the contralateral normal breast evaluated by 3T MR.

    abstract::The aim of this study was to evaluate the change of breast density in the normal breast of patients receiving neoadjuvant chemotherapy (NAC). Forty-four breast cancer patients were studied. MRI acquisition was performed before treatment (baseline), and 4 and 12 weeks after treatment. A computer-algorithm-based program...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Chen JH,Pan WF,Kao J,Lu J,Chen LK,Kuo CC,Chang CK,Chen WP,McLaren CE,Bahri S,Mehta RS,Su MY

    更新日期:2013-12-01 00:00:00

  • Continuous noninvasive monitoring of transcutaneous blood gases for a stable and persistent BOLD contrast in fMRI studies in the rat.

    abstract::The physiological status of anesthetized rats greatly influences blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI). Monitoring of physiological parameters, particularly partial pressure of carbon dioxide (pCO(2)) levels in the blood, is therefore an important part in the design and ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Ramos-Cabrer P,Weber R,Wiedermann D,Hoehn M

    更新日期:2005-11-01 00:00:00

  • Analysis of the changes in the 1H NMR spectral pattern of perchloric acid extracts of C6 cells with growth.

    abstract::The aim of this work was to identify spectral markers of cell proliferation that could be of use in clinical MRS. Cultured C6 ATCC rat glioma cells were used as models for this purpose and metabolites were extracted with perchloric acid at three different growth curve stages: log, confluence and post-confluence. 1D an...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Valverde D,Quintero MR,Candiota AP,Badiella L,Cabañas ME,Arús C

    更新日期:2006-04-01 00:00:00

  • Monitoring response to chemotherapy of non-Hodgkin's lymphoma xenografts by T(2)-weighted and diffusion-weighted MRI.

    abstract::An effective method for in vivo detection of early therapeutic response of patients with non-Hodgkin's lymphoma would enable personalized clinical management of cancer therapy and facilitate the design of optimal treatment regimens. This study evaluates the feasibility of T(2)-weighted MRI (T2WI) and diffusion-weighte...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Huang MQ,Pickup S,Nelson DS,Qiao H,Xu HN,Li LZ,Zhou R,Delikatny EJ,Poptani H,Glickson JD

    更新日期:2008-11-01 00:00:00

  • Simultaneous MR quantification of hepatic fat content, fatty acid composition, transverse relaxation time and magnetic susceptibility for the diagnosis of non-alcoholic steatohepatitis.

    abstract::Non-alcoholic steatohepatitis (NASH) is characterized at histology by steatosis, hepatocyte ballooning and inflammatory infiltrates, with or without fibrosis. Although diamagnetic material in fibrosis and inflammation can be detected with quantitative susceptibility imaging, fatty acid composition changes in NASH rela...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Leporq B,Lambert SA,Ronot M,Vilgrain V,Van Beers BE

    更新日期:2017-10-01 00:00:00