解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:OBJECTIVES:Quantitative MRI (qMRI) of muscles is a promising tool to measure disease progression or to assess therapeutic effects in neuromuscular diseases. Longitudinal imaging studies are needed to show sensitivity of qMRI in detecting disease progression in spinal muscular atrophy (SMA). In this pilot study we there...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4473
更新日期:2021-01-22 00:00:00
abstract::Magnetic resonance imaging (MRI) in pregnancy is commonly undertaken in the left lateral tilt (LLT) position to prevent inferior vena cava (IVC) compression and supine hypotensive events, although this may be suboptimal for image quality. The supine position may also have an adverse effect on fetal well-being. The spi...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4475
更新日期:2021-01-21 00:00:00
abstract::Diffusion tensor imaging (DTI) has been employed for over 2 decades to noninvasively quantify central nervous system diseases/injuries. However, DTI is an inadequate simplification of diffusion modeling in the presence of coexisting inflammation, edema and crossing nerve fibers. We employed a tissue phantom using fixe...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4414
更新日期:2021-01-01 00:00:00
abstract::To investigate the GABA+ modeling accuracy of MEGA-PRESS GABA+-edited MRS data with various spectral quality scenarios, the influence of varying signal-to-noise ratio (SNR) and linewidth on the model estimates was quantified. MEGA-PRESS data from 46 volunteers were averaged to generate a template MEGA-PRESS spectrum, ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4410
更新日期:2021-01-01 00:00:00
abstract::The development and implementation of novel MRI pulse sequences remains challenging and laborious. Gradient waveforms are typically designed using a combination of analytical and ad hoc methods to construct each gradient waveform axis independently. This strategy makes coding the pulse sequence complicated, in additio...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4308
更新日期:2020-12-01 00:00:00
abstract::NMR relaxometry can provide information about the relaxation of the magnetization in different tissues, increasing our understanding of molecular dynamics and biochemical composition in biological systems. In general, tissues have complex and heterogeneous structures composed of multiple pools. As a result, bulk magne...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4318
更新日期:2020-12-01 00:00:00
abstract::The aim of this study was to investigate physiological variations of the water T2 relaxation time in vertebral bone marrow with respect to age, body mass index (BMI), sex and proton density fat fraction (PDFF) based on single-voxel magnetic resonance spectroscopy (MRS) at 3 T. Multi-TE single-voxel STEAM MRS data of a...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4439
更新日期:2020-11-17 00:00:00
abstract::The present work aims to show the applicability of an analytical model for the optimisation of the STEAM sequence timing parameters for lactate detection at ultra high-field. The effects of the chemical shift displacement artefact on the J-modulated signal for a weakly-coupled spin system were considered in the three ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4440
更新日期:2020-11-02 00:00:00
abstract::Transmit efficiency specifies the amplitude of the magnetic resonance excitation field produced over a region of interest with respect to the radiofrequency (RF) power deposited in the sample. This metric is highly important at ultra-high field magnetic resonance imaging (≥7 T), where excitation inhomogeneities and el...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4383
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION:Sarcoidosis is a systemic granulomatous disease affecting in particular the respiratory tract. Cardiac magnetic resonance (CMR), including a measurement of T1 relaxation time, could potentially detect early stadia of sarcoidosis of the heart. The study aims to assess T1 mapping in the detection of early ca...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4388
更新日期:2020-11-01 00:00:00
abstract::Increased pulmonary lactate production is correlated with severity of lung injury and outcome in acute respiratory distress syndrome (ARDS) patients. This study was conducted to investigate the relative contributions of inflammation and hypoxia to the lung's metabolic shift to glycolysis in an experimental animal mode...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4380
更新日期:2020-11-01 00:00:00
abstract::Quantitative mapping of MR tissue parameters such as the spin-lattice relaxation time (T1 ), the spin-spin relaxation time (T2 ), and the spin-lattice relaxation in the rotating frame (T1ρ ), referred to as MR relaxometry in general, has demonstrated improved assessment in a wide range of clinical applications. Compar...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4416
更新日期:2020-10-15 00:00:00
abstract::Obesity causes damage to several organs, including the brain. Recent studies have been focusing on understanding the mechanisms through which obesity affects brain structure and function using neuroimaging techniques. A functional biomarker, such as cerebral blood flow (CBF), is a powerful tool that can be used to exp...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4375
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To develop a novel respiratory motion compensated three-dimensional (3D) cardiac magnetic resonance fingerprinting (cMRF) approach for whole-heart myocardial T1 and T2 mapping from a free-breathing scan. METHODS:Two-dimensional (2D) cMRF has been recently proposed for simultaneous, co-registered T1 and T2 mapp...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4370
更新日期:2020-10-01 00:00:00
abstract::An optimized semi-LASER sequence that is capable of acquiring artefact-free data with an echo time (TE) of 20.1 ms on a standard clinical 3 T MR system was developed. Simulations were performed to determine the optimal TEs that minimize the expected Cramér-Rao lower bound (CRLB) as proxy for quantification accuracy of...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4324
更新日期:2020-09-01 00:00:00
abstract::d-amino acid oxidase (DAO) is a peroxisomal enzyme that catalyzes the oxidative deamination of several neutral and basic d-amino acids to their corresponding α-keto acids. In most mammalian species studied, high DAO activity is found in the kidney, liver, brain and polymorphonuclear leukocytes, and its main function i...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4303
更新日期:2020-07-01 00:00:00
abstract::In this study we aimed to assess the effects of continuous formalin fixation on diffusion and relaxation metrics of the ex vivo porcine heart at 7 T. Magnetic resonance imaging was performed on eight piglet hearts using a 7 T whole body system. Hearts were measured fresh within 3 hours of cardiac arrest followed by im...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4298
更新日期:2020-07-01 00:00:00
abstract::The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and their metabolites efficiently, for which specialized imaging sequences are required. In this work, a multi-echo balanced steady-state free precession (me-bSSFP) sequence with Iterative Decomposition with Echo Asymmetry and Leas...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4291
更新日期:2020-06-01 00:00:00
abstract::This study aimed to demonstrate a reliable automatic segmentation method for independently separating reduced diffusion and decreased perfusion areas in ischemic stroke brains using constrained nonnegative matrix factorization (cNMF) pattern recognition in directional intravoxel incoherent motion MRI (IVIM-MRI). First...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4268
更新日期:2020-05-01 00:00:00
abstract::T1ρ relaxation imaging is a quantitative imaging technique that has been used to assess cartilage integrity, liver fibrosis, tumors, cardiac infarction, and Alzheimer's disease. T1 , T2 , and T1ρ relaxation time constants have each demonstrated different degrees of sensitivity to several markers of fibrosis and inflam...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4284
更新日期:2020-05-01 00:00:00
abstract::Hyperpolarised [1-13 C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus-1 thymidine kinase with the prodrug ganciclovir (HSV-TK/GCV) in C6 rat glioma...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4250
更新日期:2020-04-01 00:00:00
abstract::Under normal conditions, the heart mainly relies on fatty acid oxidation to meet its energy needs. Changes in myocardial fuel preference are noted in the diseased and failing heart. The magnetic resonance signal enhancement provided by spin hyperpolarization allows the metabolism of substrates labeled with carbon-13 t...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4243
更新日期:2020-03-01 00:00:00
abstract::Cerebrovascular reactivity (CVR) can give insight into the cerebrovascular function. CVR can be estimated by measuring a blood-oxygen-level-dependent (BOLD) response combined with breath-holding (BH). The reproducibility of this technique has been addressed and existing studies have focused on short-term reproducibili...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4195
更新日期:2020-03-01 00:00:00
abstract::Balanced steady-state free precession imaging has recently been suggested for chemical exchange detection (bSSFPX). The objective of this work is to investigate the contributions of microstructural, chemical shift and chemical exchange effects to the asymmetry of the bSSFP profile at field strengths of 3 T and 9.4 T. ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4200
更新日期:2020-03-01 00:00:00
abstract::The temporary or permanent storage of human bodies in freezers following a homicide is a documented method for criminal disposal of human corpses. In these cases, the detection of characteristics which indicate that a thawed cadaver or body part was previously frozen provides crucial information for forensic casework....
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4220
更新日期:2020-02-01 00:00:00
abstract::The purpose of this study was to identify the optimal tracer kinetic model from T1 -weighted dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data and evaluate whether parameters estimated from the optimal model predict tumor aggressiveness determined from histopathology in patients with papillary thyroi...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4166
更新日期:2020-01-01 00:00:00
abstract::The current study aims to evaluate the feasibility of creatine (Cr) chemical exchange saturation transfer (CEST)-weighted MRI at 7 T in the human brain by optimizing the saturation pulse parameters and computing contrast using a Z-spectral fitting approach. The Cr-weighted (Cr-w) CEST contrast was computed from phanto...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4176
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:To investigate the feasibility of using multiple flip angles in dynamic contrast enhanced (DCE) MRI to reduce the uncertainty in estimation of intracellular water lifetime (τi ). METHODS:Numerical simulation studies were conducted to assess the uncertainty in estimation of τi using dynamic contrast enhanced MR...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4135
更新日期:2019-11-01 00:00:00
abstract::A special characteristic of the brain is the usage of lactate as alternative fuel instead of glucose to preserve its energy homeostasis. This physiological function is valid for sufficient cerebral glucose supply, as well as presumably during hypoglycemia, given that exogenous lactate infusion suppresses hormonal coun...
journal_title:NMR in biomedicine
pub_type: 杂志文章,随机对照试验
doi:10.1002/nbm.4167
更新日期:2019-11-01 00:00:00
abstract::The goal of the study was to establish early hyperpolarized (HP) 13 C MRI metabolic and perfusion changes that predict effective high-intensity focused ultrasound (HIFU) ablation and lead to improved adjuvant treatment of partially treated regions. To accomplish this a combined HP dual-agent (13 C pyruvate and 13 C ur...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3962
更新日期:2019-10-01 00:00:00
abstract::Structural high-resolution imaging of the brainstem can be of high importance in clinical practice. However, ultra-high field magnetic resonance imaging (MRI) is still restricted in use due to limited availability. Therefore, quantitative MRI techniques (quantitative susceptibility mapping [QSM], relaxation measuremen...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4118
更新日期:2019-09-01 00:00:00
abstract::Brain myelin and iron content are important parameters in neurodegenerative diseases such as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation rate. However, their quantification based on R2* maps requires a realistic tissue model that can be fitted to the measured data. In str...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4092
更新日期:2019-07-01 00:00:00
abstract::The current state-of-the-art diagnosis method for deep tissue injury in muscle, a subcategory of pressure ulcers, is palpation. It is recognized that deep tissue injury is frequently preceded by altered biomechanical properties. A quantitative understanding of the changes in biomechanical properties preceding and duri...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4087
更新日期:2019-06-01 00:00:00
abstract::Understanding typical, healthy brain development provides a baseline from which to detect and characterize brain anomalies associated with various neurological or psychiatric disorders and diseases. Diffusion MRI is well suited to study white matter development, as it can virtually extract individual tracts and yield ...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.3778
更新日期:2019-04-01 00:00:00
abstract::Renal urea handling is central to the urine concentrating mechanism, and as such the ability to image urea transport in the kidney is an important potential imaging biomarker for renal functional assessment. Glucagon levels associated with changes in dietary protein intake have been shown to influence renal urea handl...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4028
更新日期:2019-01-01 00:00:00
abstract::MR spectroscopic imaging (MRSI) at ultra-high field (≥7 T) benefits from improved sensitivity that allows the detection of low-concentration metabolites in the brain. However, optimized acquisition techniques are required to overcome inherent limitations of MRSI at ultra-high field. This work describes an optimized me...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3950
更新日期:2018-11-01 00:00:00
abstract::In MR elastography, it is common to use an elastic model for the tissue's response in order to interpret the results properly. More complex models, such as viscoelastic, fractional viscoelastic, poroelastic, or poroviscoelastic ones, are also used. These models appear at first sight to be very different, but here it i...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3854
更新日期:2018-10-01 00:00:00
abstract::Elevated brain myo-inositol (m-Ins) concentration (a putative marker of neuroinflammation) has been reported in patients suffering from type 2 diabetes mellitus (T2DM). Obesity alone and T2DM have been found to be associated with a lower concentration of N-acetyloaspartate and N-acetylaspartylglutamate (tNAA, a marker...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3957
更新日期:2018-09-01 00:00:00
abstract::Exercise studies investigating the metabolic response of calf muscles using 31 P MRS are usually performed with a single knee angle. However, during natural movement, the distribution of workload between the main contributors to force, gastrocnemius and soleus is influenced by the knee angle. Hence, it is of interest ...
journal_title:NMR in biomedicine
pub_type: 临床试验,杂志文章
doi:10.1002/nbm.3905
更新日期:2018-06-01 00:00:00
abstract::Hyperglycemia (blood glucose concentration >150 mg/dL) is common in extremely low gestational age newborns (ELGANs; birth at <28 week gestation). Hyperglycemia increases the risk of brain injury in the neonatal period. The long-term effects are not well understood. In adult rats, hyperglycemia alters hippocampal energ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3910
更新日期:2018-05-01 00:00:00