Abstract:
:The significance of NMR water diffusion measurements performed at short diffusion times (< 10 ms) for brain tissue is examined. An apparent restriction to diffusion for both healthy and cytotoxically edematous tissue is shown: cytotoxic edema lengthens the diffusion time at which this phenomenon is visible. The dramatic reduction in apparent diffusion coefficient (ADC) observed in the core of cytotoxic edema is explained in terms of the enclosure of extracellular water in non-contiguous pockets in conjunction with the shift of water from the extra-to the intracellular space. The model presented provides an explanation for the ADC reduction without recourse to changes in the cell membrane permeability to water, or unrealistic values for the extra- and intracellular diffusion coefficients.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Norris DG,Niendorf T,Leibfritz Ddoi
10.1002/nbm.1940070703subject
Has Abstractpub_date
1994-11-01 00:00:00pages
304-10issue
7eissn
0952-3480issn
1099-1492journal_volume
7pub_type
杂志文章abstract::MR spectroscopic imaging (MRSI) at ultra-high field (≥7 T) benefits from improved sensitivity that allows the detection of low-concentration metabolites in the brain. However, optimized acquisition techniques are required to overcome inherent limitations of MRSI at ultra-high field. This work describes an optimized me...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
abstract::γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved sp...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
abstract::MRI and MRS in small rodents demand very high sensitivity. Cryogenic transmit/receive radiofrequency probes (CryoProbes) designed for (1) H MRI of mouse brain provide an attractive option for increasing the performance of small-animal MR systems. As the Larmor frequency of (13) C nuclei is four times lower than that f...
journal_title:NMR in biomedicine
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更新日期:2014-06-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00
abstract::Traditional methods of measuring magnetization in magnetic fluid samples, such as vibrating sample magnetometry (VSM), are typically limited to maximum field strengths of about 1 T. This work demonstrates the ability of MRI to measure the magnetization associated with two commercial MRI contrast agents at 3 T by compa...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
abstract::Determination of the apparent diffusion coefficient (ADC) of the prostate in men (n = 60) with raised prostate-specific antigen (PSA) or an abnormal digital rectal examination (DRE) prior to transrectal ultrasound (TRUS) guided biopsy using endorectal DWI is reported. Patients were categorized into different groups ba...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1114
更新日期:2007-08-01 00:00:00
abstract::Proton NMR spectroscopy of biological fluids has produced interesting results lately. We used the technique to investigate the effects of cryopreservation on primary porcine hepatocytes as successful cryopreservation of primary porcine hepatocytes is of importance to the development of bioartificial liver support syst...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
abstract::Obesity causes damage to several organs, including the brain. Recent studies have been focusing on understanding the mechanisms through which obesity affects brain structure and function using neuroimaging techniques. A functional biomarker, such as cerebral blood flow (CBF), is a powerful tool that can be used to exp...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3520
更新日期:2016-06-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940060502
更新日期:1993-09-01 00:00:00
abstract::Brain activation studies in humans have shown the dynamic nature of neuronal N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) based on changes in their MRS signals in response to stimulation. These studies demonstrated that upon visual stimulation there was a focal increase in cerebral blood flow (CBF) and...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3629
更新日期:2016-12-01 00:00:00
abstract::The goal of this study was to validate metabolite quantification at short TE, with particular focus on how to best account for the macromolecular signal contribution. A robust, short-TE PRESS protocol is presented, which allows reliable quantification, in vivo, of metabolite signals at 3 T in human brain. Water suppre...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1219
更新日期:2008-06-01 00:00:00
abstract::Previous studies have demonstrated that using hyperpolarized [2-13 C]pyruvate as a contrast agent can reveal 13 C signals from metabolites associated with the tricarboxylic acid (TCA) cycle. However, the metabolites detectable from TCA cycle-mediated oxidation of [2-13 C]pyruvate are the result of several metabolic st...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3845
更新日期:2018-01-01 00:00:00
abstract::The parameters that characterize the intricate water diffusion in tumors may serve to reveal their distinct pathology. Specifically, the application of diffusion magnetic resonance imaging (MRI) can aid in characterizing breast cancer, as well as monitoring response to therapy. We present here a non-invasive, quantita...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.882
更新日期:2004-06-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.732
更新日期:2002-04-01 00:00:00
abstract::An effective method for in vivo detection of early therapeutic response of patients with non-Hodgkin's lymphoma would enable personalized clinical management of cancer therapy and facilitate the design of optimal treatment regimens. This study evaluates the feasibility of T(2)-weighted MRI (T2WI) and diffusion-weighte...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1261
更新日期:2008-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940050516
更新日期:1992-09-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:1998-04-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
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更新日期:2006-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2013-03-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.978
更新日期:2005-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940020102
更新日期:1989-06-01 00:00:00
abstract::The reliability, relation to whole-body maximal oxygen uptake (VO(2max)), and force-level sensitivity of (31)P MRS markers of mitochondrial function were studied in 39 normal-weight women. Following 90 s isometric plantar-flexion exercises at 45, 70 and 100% of maximum voluntary contraction, skeletal muscle mitochondr...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(200002)13:1<14::aid-nbm605
更新日期:2000-01-01 00:00:00
abstract::T2 relaxation time is a quantitative MRI in vivo surrogate of cerebral tissue damage in multiple sclerosis (MS) patients. Cortical T2 prolongation is a known feature in later disease stages, but has not been demonstrated in the cortical normal appearing gray matter (NAGM) in early MS. This study centers on the quantit...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3486
更新日期:2016-04-01 00:00:00
abstract::This paper describes the use of off-resonance saturation to further manipulate the blood oxygenation level dependent (BOLD) contrast of fMRI. A customized narrow bandwidth radiofrequency pulse, applied with a range of frequency offsets prior to selection of each slice, was designed and incorporated into a gradient ech...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199706/08)10:4/5<208::aid-
更新日期:1997-06-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3358
更新日期:2015-09-01 00:00:00
abstract::(1) H-MRS is regularly applied to determine lipid content in ectopic tissue - mostly skeletal muscle and liver - to investigate physiological and/or pathologic conditions, e.g. insulin resistance. Technical developments also allow non-invasive in vivo assessment of cardiac lipids; however, basic data about methodologi...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3186
更新日期:2014-11-01 00:00:00