Glucagon infusion alters the hyperpolarized 13 C-urea renal hemodynamic signature.

abstract：:The phosphorus NMR spectra of isolated perfused rat liver displays a prominent inorganic phosphate peak at 2.76 +/- 0.05 ppm relative to liver glycerolphosphocholine at 0.49 ppm. From titration curves of phosphorus-containing compounds this corresponds to a pH of 7.4. The spectra also display a shoulder on the promine...

journal_title：NMR in biomedicine

authors： Thoma WJ,Uğurbil K

更新日期：1988-04-01 00:00:00

abstract：:The potential for using pre-polarized liquids as contrast agents in vivo is investigated and the feasibility of the method demonstrated. In this study we show the enhancement obtained following intravenous delivery of pre-polarized saline into the antecubital vein of a volunteer. This form of contrast agent provides s...

journal_title：NMR in biomedicine

authors： Young IR,deSouza NM,Hall AS,Williams AD,Hajnal JV,Coutts GA

更新日期：1999-10-01 00:00:00

abstract：:Reconstruction of MRI data is based on exact knowledge of all magnetic field dynamics, since the interplay of RF and gradient pulses generates the signal, defines the contrast and forms the basis of resolution in spatial and spectral dimensions. Deviations caused by various sources, such as system imperfections, delay...

journal_title：NMR in biomedicine

authors： Brunner DO,Dietrich BE,Çavuşoğlu M,Wilm BJ,Schmid T,Gross S,Barmet C,Pruessmann KP

更新日期：2016-09-01 00:00:00

abstract：:Manganese ions (Mn(2+) ) enter viable myocardial cells via voltage-gated calcium channels. Because of its shortening of T(1) and its relatively long half-life in cells, Mn(2+) can serve as an intracellular molecular contrast agent to study indirect calcium influx into the myocardium. One major concern in using Mn(2+) ...

journal_title：NMR in biomedicine

authors： Hu TC,Chuang KH,Yanasak N,Koretsky A

更新日期：2011-01-01 00:00:00

abstract：:Exercise studies investigating the metabolic response of calf muscles using 31 P MRS are usually performed with a single knee angle. However, during natural movement, the distribution of workload between the main contributors to force, gastrocnemius and soleus is influenced by the knee angle. Hence, it is of interest ...

journal_title：NMR in biomedicine

authors： Niess F,Fiedler GB,Schmid AI,Laistler E,Frass-Kriegl R,Wolzt M,Moser E,Meyerspeer M

更新日期：2018-06-01 00:00:00

abstract：:Patients with different types of mucopolysaccharidoses (MPS) lack specific lysosomal enzymes, which leads to tissue accumulation and urinary excretion of glycosaminoglycans (GAGs). Since little is known about the molecular composition of the excreted GAG fragments, we used two-dimensional [1H,13C]-correlation nuclear ...

journal_title：NMR in biomedicine

authors： Hochuli M,Wüthrich K,Steinmann B

更新日期：2003-06-01 00:00:00

abstract：:The purpose of this work was to carry out diffusion tensor imaging (DTI) at multiple diffusion times Td in skeletal muscle in normal subjects and chronic exertional compartment syndrome (CECS) patients and analyze the data with the random permeable barrier model (RPBM) for biophysical specificity. Using an institution...

journal_title：NMR in biomedicine

authors： Sigmund EE,Novikov DS,Sui D,Ukpebor O,Baete S,Babb JS,Liu K,Feiweier T,Kwon J,McGorty K,Bencardino J,Fieremans E

更新日期：2014-05-01 00:00:00

abstract：:In many studies, it has been demonstrated that (1)H MRSI of the human prostate has great potential to aid prostate cancer management, e.g. in the detection and localisation of cancer foci in the prostate or in the assessment of its aggressiveness. It is particularly powerful in combination with T2 -weighted MRI. Never...

journal_title：NMR in biomedicine

authors： Kobus T,Wright AJ,Scheenen TW,Heerschap A

更新日期：2014-01-01 00:00:00

abstract：:Chemical exchange saturation transfer (CEST) can offer information about protons associated with mobile proteins through the amide proton transfer (APT) effect, which has been shown to discriminate tumor from healthy tissue and, more recently, has been suggested as a prognosticator of response to therapy. Despite this...

journal_title：NMR in biomedicine

authors： Klomp DW,Dula AN,Arlinghaus LR,Italiaander M,Dortch RD,Zu Z,Williams JM,Gochberg DF,Luijten PR,Gore JC,Yankeelov TE,Smith SA

更新日期：2013-10-01 00:00:00

abstract：:The availability of high-field-strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatment of diseases, su...

journal_title：NMR in biomedicine

authors： Ziser L,Meyer-Schell N,Kurniawan ND,Sullivan R,Reutens D,Chen M,Vegh V

更新日期：2018-03-01 00:00:00

abstract：:The sodium-calcium exchanger (NCX) is one of the transporters contributing to the control of intracellular calcium (Ca(2+)) concentration by normally mediating net Ca(2+) efflux. However, the reverse mode of the NCX can cause intracellular Ca(2+) concentration overload, which exacerbates the myocardial tissue injury r...

journal_title：NMR in biomedicine

authors： Waghorn B,Yang Y,Baba A,Matsuda T,Schumacher A,Yanasak N,Hu TC

更新日期：2009-10-01 00:00:00

abstract：:Proton magnetic resonance spectroscopy (MRS) was employed to determine the concentrations of N-acetylaspartate (NAA), total creatine (tCr), choline-containing compounds (Cho), myo-inositol (Ins), glucose (Glc), and lactate (Lac) in rat brain before and after 10 days of oral supplementation of 2.6 g Cr-monohydrate per ...

journal_title：NMR in biomedicine

authors： Michaelis T,Wick M,Fujimori H,Matsumura A,Frahm J

更新日期：1999-08-01 00:00:00

abstract：:This study aimed to demonstrate a reliable automatic segmentation method for independently separating reduced diffusion and decreased perfusion areas in ischemic stroke brains using constrained nonnegative matrix factorization (cNMF) pattern recognition in directional intravoxel incoherent motion MRI (IVIM-MRI). First...

journal_title：NMR in biomedicine

authors： Jang M,Jin S,Kang M,Han S,Cho H

更新日期：2020-05-01 00:00:00

abstract：:The elimination of so-called background fields is an essential step in phase MRI and quantitative susceptibility mapping (QSM). Background fields, which are caused by sources outside the region of interest (ROI), are often one to two orders of magnitude stronger than tissue-related field variations from within the ROI...

journal_title：NMR in biomedicine

authors： Schweser F,Robinson SD,de Rochefort L,Li W,Bredies K

更新日期：2017-04-01 00:00:00

abstract：:The reliability, relation to whole-body maximal oxygen uptake (VO(2max)), and force-level sensitivity of (31)P MRS markers of mitochondrial function were studied in 39 normal-weight women. Following 90 s isometric plantar-flexion exercises at 45, 70 and 100% of maximum voluntary contraction, skeletal muscle mitochondr...

journal_title：NMR in biomedicine

authors： Larson-Meyer DE,Newcomer BR,Hunter GR,Hetherington HP,Weinsier RL

更新日期：2000-01-01 00:00:00

abstract：:The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently hampered by lack of reliable biomarkers. (1) H magnetic resona...

journal_title：NMR in biomedicine

authors： Coune PG,Craveiro M,Gaugler MN,Mlynárik V,Schneider BL,Aebischer P,Gruetter R

更新日期：2013-01-01 00:00:00

abstract：:The temporary or permanent storage of human bodies in freezers following a homicide is a documented method for criminal disposal of human corpses. In these cases, the detection of characteristics which indicate that a thawed cadaver or body part was previously frozen provides crucial information for forensic casework....

journal_title：NMR in biomedicine

authors： Gascho D,Richter H,Karampinos DC,Heimer J,Schaerli S,Thali MJ,Zoelch N

更新日期：2020-02-01 00:00:00

abstract：:13C MRS was installed on a clinical scanner at 1.5 T in order to facilitate integrated MR examinations of human brain disorders. Using a simplified protocol, (1-(13)C) glucose and/or (1-(13)C) acetate were administered orally or by intravenous infusion. (13)C spectra of diagnostic quality were acquired in more than 10...

journal_title：NMR in biomedicine

authors： Ross B,Lin A,Harris K,Bhattacharya P,Schweinsburg B

更新日期：2003-10-01 00:00:00

abstract：:MRS provides a valuable tool for the non-invasive detection of brain γ-aminobutyric acid (GABA) in vivo. GABAergic dysfunction has been observed in the aging cerebellum. The study of cerebellar GABA changes is of considerable interest in understanding certain age-related motor disorders. However, little is known about...

journal_title：NMR in biomedicine

authors： Long Z,Dyke JP,Ma R,Huang CC,Louis ED,Dydak U

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To develop a novel respiratory motion compensated three-dimensional (3D) cardiac magnetic resonance fingerprinting (cMRF) approach for whole-heart myocardial T1 and T2 mapping from a free-breathing scan. METHODS:Two-dimensional (2D) cMRF has been recently proposed for simultaneous, co-registered T1 and T2 mapp...

journal_title：NMR in biomedicine

authors： Cruz G,Jaubert O,Qi H,Bustin A,Milotta G,Schneider T,Koken P,Doneva M,Botnar RM,Prieto C

更新日期：2020-10-01 00:00:00

abstract：:The current study aims to evaluate the feasibility of creatine (Cr) chemical exchange saturation transfer (CEST)-weighted MRI at 7 T in the human brain by optimizing the saturation pulse parameters and computing contrast using a Z-spectral fitting approach. The Cr-weighted (Cr-w) CEST contrast was computed from phanto...

journal_title：NMR in biomedicine

authors： Singh A,Debnath A,Cai K,Bagga P,Haris M,Hariharan H,Reddy R

更新日期：2019-12-01 00:00:00

abstract：:In this study, Blood Oxygenation Level Dependent (BOLD) contrast in the detection of human brain activation was compared between spin-echo and gradient-echo echo-planar sequences at 1.5 T. Time course series of spin-echo and gradient-echo images containing the primary motor cortex were collected during rest (no finger...

journal_title：NMR in biomedicine

authors： Bandettini PA,Wong EC,Jesmanowicz A,Hinks RS,Hyde JS

更新日期：1994-03-01 00:00:00

abstract：:Results are presented from an in vivo study of human skin in which a zig-zag surface coil together with a three-pulse Fourier Series Window (FSW) protocol have been used to obtain minimally contaminated 31P skin spectra of the posterior calf. Phantom experiments indicate that while the fall-off in the B1 field profile...

journal_title：NMR in biomedicine

authors： Cowie AG,Bastin ME,Manners DN,Hands LJ,Styles P,Radda GK

更新日期：1996-08-01 00:00:00

abstract：:Evaluation of high intensity focused ultrasound (HIFU) treatment with MRI is generally based on assessment of the non-perfused volume from contrast-enhanced T1-weighted images. However, the vascular status of tissue surrounding the non-perfused volume has not been extensively investigated with MRI. In this study, clus...

journal_title：NMR in biomedicine

authors： Jacobs I,Hectors SJ,Schabel MC,Grüll H,Strijkers GJ,Nicolay K

更新日期：2015-11-01 00:00:00

abstract：:The development and implementation of novel MRI pulse sequences remains challenging and laborious. Gradient waveforms are typically designed using a combination of analytical and ad hoc methods to construct each gradient waveform axis independently. This strategy makes coding the pulse sequence complicated, in additio...

journal_title：NMR in biomedicine

authors： Middione MJ,Loecher M,Moulin K,Ennis DB

更新日期：2020-12-01 00:00:00

abstract：:Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

journal_title：NMR in biomedicine

authors： Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

更新日期：2012-08-01 00:00:00

abstract：:The background underpinning the clinical use of ultrashort echo time, SPRITE and other pulse sequences for imaging bone and other connective tissues with short T2 is reviewed. Features of the basic physics relevant to UTE imaging are described, including the consequences when the radiofrequency pulse duration is of th...

journal_title：NMR in biomedicine

authors： Robson MD,Bydder GM

更新日期：2006-11-01 00:00:00

abstract：:Spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) MRI signal during the resting state are increasingly being studied in healthy and diseased brain in humans and animal models. Yet, the relationship between functional brain status and the characteristics of spontaneous BOLD fluctuations remains p...

journal_title：NMR in biomedicine

authors： Wang K,van Meer MP,van der Marel K,van der Toorn A,Xu L,Liu Y,Viergever MA,Jiang T,Dijkhuizen RM

更新日期：2011-01-01 00:00:00

abstract：:The applications of in vivo electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy have been impressive over a relatively short period despite the many obstacles which had to be overcome, such as dielectric absorption and biodestruction. The loop-gap resonators and modified loop coil syste...

journal_title：NMR in biomedicine

authors： Fujii H,Berliner LJ

更新日期：2004-08-01 00:00:00

abstract：INTRODUCTION:Sarcoidosis is a systemic granulomatous disease affecting in particular the respiratory tract. Cardiac magnetic resonance (CMR), including a measurement of T1 relaxation time, could potentially detect early stadia of sarcoidosis of the heart. The study aims to assess T1 mapping in the detection of early ca...

journal_title：NMR in biomedicine

authors： Panovský R,Doubková M,Holeček T,Máchal J,Feitová V,Masárová L,Opatřil L,Mojica-Pisciotti ML,Kincl V

更新日期：2020-11-01 00:00:00