Utility of gradient recalled echo magnetic resonance imaging for the study of myelination in cuprizone mice treated with fingolimod.

abstract：:Surface coil 13C nuclear magnetic resonance (NMR) spectroscopy was used to investigate the in vivo carbohydrate metabolism of rat C6 gliomas during and after infusion with [1-13C] glucose. In vivo 1H-decoupled 13C NMR spectra of the glioma following infusion with [1-13C]glucose revealed the direct production of [3-13C...

journal_title：NMR in biomedicine

authors： Ross BD,Higgins RJ,Boggan JE,Willis JA,Knittel B,Unger SW

更新日期：1988-02-01 00:00:00

abstract：:A number of NMR spectroscopic and microscopic MRI (microMRI) techniques were used to study proton dynamics in canine tendon and articular cartilage immersed in normal saline solution (NaCl solution) and high-concentration phosphate-buffered saline (PBS) solution. In a proton CPMG experiment on tendons, the T(2) relaxa...

journal_title：NMR in biomedicine

authors： Zheng S,Xia Y

更新日期：2009-02-01 00:00:00

abstract：:Transceiver surface coil arrays improve transmit performance (B1/√kW) and B1 homogeneity for head imaging up to 9.4 T. To further improve reception performance and parallel imaging, the number of array elements must be increased with a corresponding decrease in their size. With a large number of small interacting ante...

journal_title：NMR in biomedicine

authors： Avdievich NI,Pan JW,Hetherington HP

更新日期：2013-11-01 00:00:00

abstract：:Phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS) has gained much interest in schizophrenia research in recent years since it allows the non-invasive measurement of high-energy phosphates and phospholipids in vivo. However, until now only differences in metabolite concentrations between certain brain areas of ...

journal_title：NMR in biomedicine

authors： Riehemann S,Volz HP,Wenda B,Hübner G,Rössger G,Rzanny R,Sauer H

更新日期：1999-12-01 00:00:00

abstract：:Proton NMR spectroscopy of biological fluids has produced interesting results lately. We used the technique to investigate the effects of cryopreservation on primary porcine hepatocytes as successful cryopreservation of primary porcine hepatocytes is of importance to the development of bioartificial liver support syst...

journal_title：NMR in biomedicine

authors： Dabos KJ,Parkinson JA,Hewage C,Nelson LJ,Sadler IH,Hayes PC,Plevris JN

更新日期：2002-05-01 00:00:00

abstract：:Exercise studies investigating the metabolic response of calf muscles using 31 P MRS are usually performed with a single knee angle. However, during natural movement, the distribution of workload between the main contributors to force, gastrocnemius and soleus is influenced by the knee angle. Hence, it is of interest ...

journal_title：NMR in biomedicine

authors： Niess F,Fiedler GB,Schmid AI,Laistler E,Frass-Kriegl R,Wolzt M,Moser E,Meyerspeer M

更新日期：2018-06-01 00:00:00

abstract：:Manganese ions (Mn(2+) ) enter viable myocardial cells via voltage-gated calcium channels. Because of its shortening of T(1) and its relatively long half-life in cells, Mn(2+) can serve as an intracellular molecular contrast agent to study indirect calcium influx into the myocardium. One major concern in using Mn(2+) ...

journal_title：NMR in biomedicine

authors： Hu TC,Chuang KH,Yanasak N,Koretsky A

更新日期：2011-01-01 00:00:00

abstract：:Although diffusion MRI has shown promise for the characterization of breast cancer, it has low specificity to malignant subtypes. Higher specificity might be achieved if the effects of cell morphology and molecular exchange across cell membranes could be disentangled. The quantification of exchange might thus allow th...

journal_title：NMR in biomedicine

authors： Lasič S,Oredsson S,Partridge SC,Saal LH,Topgaard D,Nilsson M,Bryskhe K

更新日期：2016-05-01 00:00:00

abstract：:MR Z-spectroscopy allows enhanced imaging contrast on the basis of saturation transfer between the proton pools of cellular compounds and water, occurring via chemical exchange (chemical exchange saturation transfer, CEST) or dipole-dipole coupling (nuclear Overhauser effect, NOE). In previous studies, signals observe...

journal_title：NMR in biomedicine

authors： Zaiss M,Kunz P,Goerke S,Radbruch A,Bachert P

更新日期：2013-12-01 00:00:00

abstract：:Despite 40 years of NMR spectroscopy and 10 years of in vivo spectroscopy in humans, the break-even point for routine clinical diagnosis has not yet been reached. Obviously there are many factors that stimulate but also restrict the use of proton NMR spectroscopy in clinical routine. ...

journal_title：NMR in biomedicine

authors： Moser E

更新日期：1994-12-01 00:00:00

abstract：:The sodium-calcium exchanger (NCX) is one of the transporters contributing to the control of intracellular calcium (Ca(2+)) concentration by normally mediating net Ca(2+) efflux. However, the reverse mode of the NCX can cause intracellular Ca(2+) concentration overload, which exacerbates the myocardial tissue injury r...

journal_title：NMR in biomedicine

authors： Waghorn B,Yang Y,Baba A,Matsuda T,Schumacher A,Yanasak N,Hu TC

更新日期：2009-10-01 00:00:00

abstract：:Encoding of spatial information in magnetic resonance imaging is conventionally accomplished by using magnetic field gradients. During gradient encoding, the position in k-space is determined by a time-integral of the gradient field, resulting in a limitation in imaging speed due to either gradient power or secondary ...

journal_title：NMR in biomedicine

authors： Wright SM,McDougall MP

更新日期：2009-11-01 00:00:00

abstract：:The phosphorus NMR spectra of isolated perfused rat liver displays a prominent inorganic phosphate peak at 2.76 +/- 0.05 ppm relative to liver glycerolphosphocholine at 0.49 ppm. From titration curves of phosphorus-containing compounds this corresponds to a pH of 7.4. The spectra also display a shoulder on the promine...

journal_title：NMR in biomedicine

authors： Thoma WJ,Uğurbil K

更新日期：1988-04-01 00:00:00

abstract：:Increased lactate production through glycolysis in aerobic conditions is a hallmark of cancer. Some anticancer drugs have been designed to exploit elevated glycolysis in cancer cells. For example, lonidamine (LND) inhibits lactate transport, leading to intracellular acidification in cancer cells. Chemical exchange sat...

journal_title：NMR in biomedicine

authors： McVicar N,Li AX,Meakin SO,Bartha R

更新日期：2015-05-01 00:00:00

abstract：:The aim of this study was to investigate proton changes of the parotid gland after gustatory stimulation by semi-quantitative parameters and an empirical mathematical model (EMM) using high-temporal-resolution, double-echo, echo-planar imaging (EPI). Approved by a local institutional review board, this study examined ...

journal_title：NMR in biomedicine

authors： Liu YJ,Lee YH,Chang HC,Chiu HC,Chiu TW,Hsu K,Pen CM,Hsu HH,Juan CJ

更新日期：2018-03-01 00:00:00

abstract：:To understand and predict the blood-oxygenation level-dependent (BOLD) fMRI signal, an accurate knowledge of the relationship between cerebral blood flow (DeltaCBF) and volume (DeltaCBV) changes is critical. Currently, this relationship is widely assumed to be characterized by Grubb's power-law, derived from primate d...

journal_title：NMR in biomedicine

authors： Chen JJ,Pike GB

更新日期：2009-12-01 00:00:00

abstract：:A recent analysis of the optimization of magnetization transfer experiments to estimate first-order rate constants is extended to the design of experiments for measuring these constants and T1 when both parameters are initially unknown. When the number of measurement times is fixed, an optimal design will consist of a...

journal_title：NMR in biomedicine

authors： Katki H,Weiss GH,Kiefer JE,Taitelbaum H,Spencer RG

更新日期：1996-05-01 00:00:00

abstract：:Detailed (1)H and (13)C NMR spectroscopy of lipid extracts from 12 human intracranial tuberculomas and two control brain tissue samples was performed to assess the role of lipids in the disease process. One-dimensional and two-dimensional NMR techniques were used to resolve the mixture of lipid components and make res...

journal_title：NMR in biomedicine

authors： Subramanian A,Shankar Joshi B,Roy AD,Roy R,Gupta V,Dang RS

更新日期：2008-03-01 00:00:00

abstract：:Wilms' tumours (WTs) are large heterogeneous tumours, which typically consist of a mixture of histological cell types, together with regions of chemotherapy-induced regressive change and necrosis. The predominant cell type in a WT is assessed histologically following nephrectomy, and used to assess the tumour subtype ...

journal_title：NMR in biomedicine

authors： Hales PW,Olsen ØE,Sebire NJ,Pritchard-Jones K,Clark CA

更新日期：2015-08-01 00:00:00

abstract：:In this methodological paper I report the stereotactic correlation of different magnetic resonance imaging (MRI) techniques [MR angiography (MRA), MRI, blood bolus tagging (STAR), functional MRI, and high-resolution BOLD venography (HRBV)] in patients with cerebral arterio-venous malformations (AVM) and brain tumors. ...

journal_title：NMR in biomedicine

authors： Schad LR

更新日期：2001-11-01 00:00:00

abstract：:Several obstacles usually confound a straightforward perfusion analysis using dynamic-susceptibility contrast-based magnetic resonance imaging (DSC-MRI). In this work, it became possible to eliminate some of these sources of error by combining a multiple gradient-echo technique with parallel imaging (PI): first, the l...

journal_title：NMR in biomedicine

authors： Jochimsen TH,Newbould RD,Skare ST,Clayton DB,Albers GW,Moseley ME,Bammer R

更新日期：2007-06-01 00:00:00

abstract：:The purpose of this work was to assess the reproducibility of percentage of ventilated lung volume (PV) measured from hyperpolarized (HP) (3)He and (1)H anatomical images acquired in the same breath-hold when compared with PV measured from (3)He and (1)H images from separate breath-holds. Volumetric (3)He ventilation ...

journal_title：NMR in biomedicine

authors： Horn FC,Tahir BA,Stewart NJ,Collier GJ,Norquay G,Leung G,Ireland RH,Parra-Robles J,Marshall H,Wild JM

更新日期：2014-12-01 00:00:00

abstract：:The intrinsic nonuniformities in the transmit radiofrequency field from standard quadrature volume resonators at high field are particularly problematic for localized MRS in areas such as the temporal lobe, where a low signal-to-noise ratio and poor metabolite quantification result from destructive B₁⁺ field interfere...

journal_title：NMR in biomedicine

authors： Snaar JE,Teeuwisse WM,Versluis MJ,van Buchem MA,Kan HE,Smith NB,Webb AG

更新日期：2011-08-01 00:00:00

abstract：:In this work we introduce the concept of correlation chemical shift imaging (CCSI). Novel CCSI pulse sequences are demonstrated on clinical scanners for two-dimensional Correlation Spectroscopy (COSY) and Total Correlation Spectroscopy (TOCSY) imaging experiments. To date there has been limited progress reported towar...

journal_title：NMR in biomedicine

authors： Andronesi OC,Gagoski BA,Adalsteinsson E,Sorensen AG

更新日期：2012-02-01 00:00:00

abstract：:Chemical exchange saturation transfer (CEST)-derived, pH-weighted, amide proton transfer (APT) MRI has shown promise in animal studies for the prediction of infarction risk in ischemic tissue. Here, APT MRI was translated to patients with acute stroke (1-24 h post-symptom onset), and assessments of APT contrast, perfu...

journal_title：NMR in biomedicine

authors： Tietze A,Blicher J,Mikkelsen IK,Østergaard L,Strother MK,Smith SA,Donahue MJ

更新日期：2014-02-01 00:00:00

abstract：:Raised concentrations of glucose for extended periods of time have detrimental effects on the insulin-producing beta-cell. As de novo synthesis of lipids has been observed under such conditions, it was hypothesized that newly formed lipids may preferentially contain saturated fatty acids, which in particular have been...

journal_title：NMR in biomedicine

authors： Nyblom HK,Nord LI,Andersson R,Kenne L,Bergsten P

更新日期：2008-05-01 00:00:00

abstract：:The combination of hyperpolarized Xe with chemical exchange saturation transfer (Hyper-CEST) is a powerful NMR technique to detect highly dilute concentrations of Xe binding sites using RF saturation pulses. Crucially, that combination of saturation pulse strength and duration that generates the maximal Hyper-CEST eff...

journal_title：NMR in biomedicine

authors： Kunth M,Witte C,Schröder L

更新日期：2015-06-01 00:00:00

abstract：:In this study, Blood Oxygenation Level Dependent (BOLD) contrast in the detection of human brain activation was compared between spin-echo and gradient-echo echo-planar sequences at 1.5 T. Time course series of spin-echo and gradient-echo images containing the primary motor cortex were collected during rest (no finger...

journal_title：NMR in biomedicine

authors： Bandettini PA,Wong EC,Jesmanowicz A,Hinks RS,Hyde JS

更新日期：1994-03-01 00:00:00

abstract：:The goals of this study were to develop an acquisition protocol and the analysis tools for Meshcher-Garwood point-resolved spectroscopy (MEGA-PRESS) in mouse brain at 9.4 T, to allow the in vivo detection of γ-aminobutyric acid (GABA) and to examine whether isoflurane alters GABA levels in the thalamus during anesthes...

journal_title：NMR in biomedicine

authors： Guo J,Gang Z,Sun Y,Laine A,Small SA,Rothman DL

更新日期：2018-01-01 00:00:00

abstract：:Bone contains a significant fraction of water that is not detectable with ordinary Cartesian imaging sequences. The advent of ultra-short echo-time (UTE) methods has allowed the recovery of this submillisecond T(2)* water. In this work, we have developed a new three-dimensional hybrid-radial ultra-short echo-time (3D ...

journal_title：NMR in biomedicine

authors： Rad HS,Lam SC,Magland JF,Ong H,Li C,Song HK,Love J,Wehrli FW

更新日期：2011-08-01 00:00:00