Single echo acquisition MRI using RF encoding.

abstract：:High-energy phosphate metabolism, which allows the synthesis and regeneration of adenosine triphosphate (ATP), is a vital process for neuronal survival and activity. In particular, creatine kinase (CK) serves as an energy reservoir for the rapid buffering of ATP levels. Altered CK enzyme activity, reflecting compromis...

journal_title：NMR in biomedicine

authors： Jeong EK,Sung YH,Kim SE,Zuo C,Shi X,Mellon EA,Renshaw PF

更新日期：2011-08-01 00:00:00

abstract：:T1ρ relaxation imaging is a quantitative imaging technique that has been used to assess cartilage integrity, liver fibrosis, tumors, cardiac infarction, and Alzheimer's disease. T1 , T2 , and T1ρ relaxation time constants have each demonstrated different degrees of sensitivity to several markers of fibrosis and inflam...

journal_title：NMR in biomedicine

authors： Wyatt CR,Barbara TM,Guimaraes AR

更新日期：2020-05-01 00:00:00

abstract：:Most ovarian tumors are cystic structures containing variable amounts of fluid. Several studies of ovarian cyst fluid focus on one specific metabolite using conventional assay systems. We examined the potential of (1)H-nuclear magnetic resonance spectroscopy in evaluation of the overall metabolic composition of cyst f...

journal_title：NMR in biomedicine

authors： Boss EA,Moolenaar SH,Massuger LF,Boonstra H,Engelke UF,de Jong JG,Wevers RA

更新日期：2000-08-01 00:00:00

abstract：:The current study aims to evaluate the feasibility of creatine (Cr) chemical exchange saturation transfer (CEST)-weighted MRI at 7 T in the human brain by optimizing the saturation pulse parameters and computing contrast using a Z-spectral fitting approach. The Cr-weighted (Cr-w) CEST contrast was computed from phanto...

journal_title：NMR in biomedicine

authors： Singh A,Debnath A,Cai K,Bagga P,Haris M,Hariharan H,Reddy R

更新日期：2019-12-01 00:00:00

abstract：:The aim of this study was to analyze Na+ fluxes in whole perfused hearts using Li+ as a Na+ congener and 7Li-nuclear magnetic resonance as a detection method. Hearts were equilibrated for 32 min with 15 mM LiCl added to P1-free Krebs-Henseleit buffer (intracellular space (ICS) [Li+] = 21.5 +/- 3.4 mM). Li+ efflux was ...

journal_title：NMR in biomedicine

authors： Kupriyanov VV,Xiang B,Yang L,Deslauriers R

更新日期：1997-09-01 00:00:00

abstract：:Acute hypoxia (transient cycles of hypoxia-reoxygenation) is known to occur in solid tumors and is generally believed to be caused by tumor blood flow instabilities. It was recently demonstrated that T2*-weighted (T2*w) gradient echo (GRE) MRI is a powerful non-invasive method for investigating periodic changes in tum...

journal_title：NMR in biomedicine

authors： Baudelet C,Cron GO,Ansiaux R,Crokart N,DeWever J,Feron O,Gallez B

更新日期：2006-02-01 00:00:00

abstract：:A study was undertaken to determine if the vascular characteristics measured by dynamic contrast-enhanced magnetic resonance imaging (primarily permeability surface area product and extracellular-extravascular tissue volume fraction) would be beneficial in explaining the inter-lesion metabolic heterogeneity displayed ...

journal_title：NMR in biomedicine

authors： Manton DJ,Lowry M,Rowland-Hill C,Crooks D,Mathew B,Turnbull LW

更新日期：2000-12-01 00:00:00

abstract：:Standard functional MRI (fMRI), which includes resting-state or paradigm-driven designs, is widely used in studies of brain function, aging, and disease. These fMRI studies typically use two-dimensional gradient echo-planar imaging, which inherently contains phase data that enables quantitative susceptibility mapping ...

journal_title：NMR in biomedicine

authors： Sun H,Seres P,Wilman AH

更新日期：2017-04-01 00:00:00

abstract：:In recent years, quantitative nuclear magnetic resonance imaging and spectroscopy (NMRI and NMRS) have been used more systematically as outcome measures in natural history and clinical trial studies for Duchenne muscular dystrophy (DMD). Whereas most of these studies have emphasized the evaluation of the fat fraction ...

journal_title：NMR in biomedicine

authors： Reyngoudt H,Turk S,Carlier PG

更新日期：2018-01-01 00:00:00

abstract：:The availability of high-field-strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatment of diseases, su...

journal_title：NMR in biomedicine

authors： Ziser L,Meyer-Schell N,Kurniawan ND,Sullivan R,Reutens D,Chen M,Vegh V

更新日期：2018-03-01 00:00:00

abstract：:Following the impetus of early clinical and experimental investigations, in vivo and in vitro MRS studies of tumours pointed in the eighties to the possible significance of signals arising from phospholipid (PL) precursors and catabolites as novel biochemical indicators of in vivo tumour progression and response to th...

journal_title：NMR in biomedicine

authors： Podo F

更新日期：1999-11-01 00:00:00

abstract：:An indirect method for in vivo T2 mapping of 13 C-labeled metabolites using T2 and T2 * information of water protons obtained a priori is proposed. The T2 values of 13 C metabolites are inferred using the relationship to T2 ' of coexisting 1 H and the T2 * of 13 C metabolites, which is measured using routine hyperpola...

journal_title：NMR in biomedicine

authors： Joe E,Lee H,Lee J,Yang S,Choi YS,Wang E,Song HT,Kim DH

更新日期：2017-05-01 00:00:00

abstract：:(31)P MRS provides a unique non-invasive window into myocardial energy homeostasis. Mouse models of cardiac disease are widely used in preclinical studies, but the application of (31)P MRS in the in vivo mouse heart has been limited. The small-sized, fast-beating mouse heart imposes challenges regarding localized sign...

journal_title：NMR in biomedicine

authors： Bakermans AJ,Abdurrachim D,van Nierop BJ,Koeman A,van der Kroon I,Baartscheer A,Schumacher CA,Strijkers GJ,Houten SM,Zuurbier CJ,Nicolay K,Prompers JJ

更新日期：2015-10-01 00:00:00

abstract：:Wilms' tumours (WTs) are large heterogeneous tumours, which typically consist of a mixture of histological cell types, together with regions of chemotherapy-induced regressive change and necrosis. The predominant cell type in a WT is assessed histologically following nephrectomy, and used to assess the tumour subtype ...

journal_title：NMR in biomedicine

authors： Hales PW,Olsen ØE,Sebire NJ,Pritchard-Jones K,Clark CA

更新日期：2015-08-01 00:00:00

abstract：:Patients with different types of mucopolysaccharidoses (MPS) lack specific lysosomal enzymes, which leads to tissue accumulation and urinary excretion of glycosaminoglycans (GAGs). Since little is known about the molecular composition of the excreted GAG fragments, we used two-dimensional [1H,13C]-correlation nuclear ...

journal_title：NMR in biomedicine

authors： Hochuli M,Wüthrich K,Steinmann B

更新日期：2003-06-01 00:00:00

abstract：:Natural abundance proton-decoupled (13)C magnetic resonance spectroscopy was used to establish the in vivo lipid composition of normal adipose tissue and the corresponding effects of altered lipid diets. Experiments were performed on a standard 1.5 T clinical MR scanner using a double-tuned (1)H-(13)C coil. Peaks from...

journal_title：NMR in biomedicine

authors： Hwang JH,Bluml S,Leaf A,Ross BD

更新日期：2003-05-01 00:00:00

abstract：:In this study, we have performed simulations to address the effects of diffusion encoding parameters, signal-to-noise ratio (SNR) and T2 on skeletal muscle diffusion tensor indices and fiber tracts. Where appropriate, simulations were corroborated and validated by in vivo diffusion tensor imaging (DTI) of human skelet...

journal_title：NMR in biomedicine

authors： Froeling M,Nederveen AJ,Nicolay K,Strijkers GJ

更新日期：2013-11-01 00:00:00

abstract：:Hippocampal dysfunction is known to be associated with several neurological and neuropsychiatric disorders such as Alzheimer's disease, epilepsy, schizophrenia and depression; therefore, there has been significant clinical interest in studying hippocampal neurochemistry. However, the hippocampus is a challenging regio...

journal_title：NMR in biomedicine

authors： Bednařík P,Moheet A,Deelchand DK,Emir UE,Eberly LE,Bareš M,Seaquist ER,Öz G

更新日期：2015-06-01 00:00:00

abstract：:The aim of the study was to establish the normal range and to evaluate the reproducibility of dynamic contrast enhanced MRI (DCE-MRI) parameter estimates in normal human pelvic tissues. Nineteen patients with prostate cancer, undergoing androgen deprivation treatment, had paired DCE-MRI examinations of the pelvis usin...

journal_title：NMR in biomedicine

authors： Padhani AR,Hayes C,Landau S,Leach MO

更新日期：2002-04-01 00:00:00

abstract：:Metabolic activity in the lung is known to change in response to external insults, inflammation, and cancer. We report measurements of metabolism in the isolated, perfused rat lung of healthy controls and in diseased lungs undergoing acute inflammation using hyperpolarized 1-(13) C-labeled pyruvate. The overall appare...

journal_title：NMR in biomedicine

authors： Shaghaghi H,Kadlecek S,Deshpande C,Siddiqui S,Martinez D,Pourfathi M,Hamedani H,Ishii M,Profka H,Rizi R

更新日期：2014-08-01 00:00:00

abstract：:Balanced steady-state free precession imaging has recently been suggested for chemical exchange detection (bSSFPX). The objective of this work is to investigate the contributions of microstructural, chemical shift and chemical exchange effects to the asymmetry of the bSSFP profile at field strengths of 3 T and 9.4 T. ...

journal_title：NMR in biomedicine

authors： Heule R,Deshmane A,Zaiss M,Herz K,Ehses P,Scheffler K

更新日期：2020-03-01 00:00:00

abstract：:The potential for using pre-polarized liquids as contrast agents in vivo is investigated and the feasibility of the method demonstrated. In this study we show the enhancement obtained following intravenous delivery of pre-polarized saline into the antecubital vein of a volunteer. This form of contrast agent provides s...

journal_title：NMR in biomedicine

authors： Young IR,deSouza NM,Hall AS,Williams AD,Hajnal JV,Coutts GA

更新日期：1999-10-01 00:00:00

abstract：:Cerebral ischemia provokes tissue damage by two major patho-physiological mechanisms. Direct cell necrosis is induced by diminished access of neurons and glia to essential nutrients such as glucose and oxygen leading to energy failure. A second factor of cellular loss is related to the activation of immune-competent c...

journal_title：NMR in biomedicine

authors： Rausch M,Baumann D,Neubacher U,Rudin M

更新日期：2002-06-01 00:00:00

abstract：:We have developed a reliable, reproducible model of hypoxia in the gerbil. 1H and 31P NMR spectroscopy demonstrates that cerebral energy metabolism is very resistant to hypoxia. Cerebral blood flow (measured by hydrogen clearance) began to increase when the arterial oxygen tension (paO2) was reduced to 40-50 mm Hg, an...

journal_title：NMR in biomedicine

authors： Allen K,Busza AL,Crockard HA,Gadian DG

更新日期：1992-01-01 00:00:00

abstract：:This study tests the hypothesis that brief periods of ischemia result in an increase in myocardial lipids during early reperfusion. We conducted 1H NMR spectroscopy to serially measure myocardial lipids before and after regional ischemia. Localized 1H NMR spectra (spatial resolution of 1.25 mm) were obtained using a o...

journal_title：NMR in biomedicine

authors： Balschi JA,Hetherington HP,Bradley EL Jr,Pohost GM

更新日期：1995-04-01 00:00:00

abstract：:Two FDA-approved agents, ferumoxides (Feridex), a suspension of superparamagnetic iron oxide (SPIO) nanoparticles and protamine sulfate, a drug used to reverse heparin anticoagulation, can be complexed and used to label cells magnetically ex vivo. Labeling stem cells with ferumoxides-protamine sulfate (FePro) complexe...

journal_title：NMR in biomedicine

authors： Arbab AS,Yocum GT,Rad AM,Khakoo AY,Fellowes V,Read EJ,Frank JA

更新日期：2005-12-01 00:00:00

abstract：:The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently hampered by lack of reliable biomarkers. (1) H magnetic resona...

journal_title：NMR in biomedicine

authors： Coune PG,Craveiro M,Gaugler MN,Mlynárik V,Schneider BL,Aebischer P,Gruetter R

更新日期：2013-01-01 00:00:00

abstract：:Traditional methods of measuring magnetization in magnetic fluid samples, such as vibrating sample magnetometry (VSM), are typically limited to maximum field strengths of about 1 T. This work demonstrates the ability of MRI to measure the magnetization associated with two commercial MRI contrast agents at 3 T by compa...

journal_title：NMR in biomedicine

authors： Cantillon-Murphy P,Wald LL,Zahn M,Adalsteinsson E

更新日期：2009-10-01 00:00:00

abstract：:The application of diffusion tensor imaging (DTI) to the evaluation of developing brain remains an area of active investigation. This review focuses on the changes in DTI parameters which accompany both brain maturation and injury. The two primary pieces of information available from DTI studies-water apparent diffusi...

journal_title：NMR in biomedicine

authors： Neil J,Miller J,Mukherjee P,Hüppi PS

更新日期：2002-11-01 00:00:00

abstract：:31P NMR spectra were obtained from sera of 22 healthy volunteers and 20 patients with multiple myeloma at the time of diagnosis and repeated up to five times during therapy. All spectra consisted of a Pi peak (used as a reference peak) and two peaks from phospholipids (PL): one peak due to phosphatidylethanolamine and...

journal_title：NMR in biomedicine

authors： Kuliszkiewicz-Janus M,Baczyński S

更新日期：1995-05-01 00:00:00