Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3 T.

Abstract:

:Hippocampal dysfunction is known to be associated with several neurological and neuropsychiatric disorders such as Alzheimer's disease, epilepsy, schizophrenia and depression; therefore, there has been significant clinical interest in studying hippocampal neurochemistry. However, the hippocampus is a challenging region to study using (1) H MRS, hence the use of MRS for clinical research in this region has been limited. Our goal was therefore to investigate the feasibility of obtaining high-quality hippocampal spectra that allow reliable quantification of a neurochemical profile and to establish inter-session reproducibility of hippocampal MRS, including reproducibility of voxel placement, spectral quality and neurochemical concentrations. Ten healthy volunteers were scanned in two consecutive sessions using a standard clinical 3 T MR scanner. Neurochemical profiles were obtained with a short-echo (T(E) = 28 ms) semi-LASER localization sequence from a relatively small (~4 mL) voxel that covered about 62% of the hippocampal volume as calculated from segmentation of T1 -weighted images. Voxel composition was highly reproducible between sessions, with test-retest coefficients of variation (CVs) of 3.5% and 7.5% for gray and white matter volume fraction, respectively. Excellent signal-to-noise ratio (~54 based on the N-acetylaspartate (NAA) methyl peak in non-apodized spectra) and linewidths (~9 Hz for water) were achieved reproducibly in all subjects. The spectral quality allowed quantification of NAA, total choline, total creatine, myo-inositol and glutamate with high scan-rescan reproducibility (CV ≤ 6%) and quantification precision (Cramér-Rao lower bound, CRLB < 9%). Four other metabolites, including glutathione and glucose, were quantified with scan-rescan CV below 20%. Therefore, the highly optimized, short-echo semi-LASER sequence together with FASTMAP shimming substantially improved the reproducibility and number of quantifiable metabolites relative to prior reports. In addition, the between-session variation in metabolite concentrations, as well as CRLB, was lower than the between-subject variation of the concentrations for most metabolites, indicating that the method has the sensitivity to detect inter-individual differences in the healthy brain.

journal_name

NMR Biomed

journal_title

NMR in biomedicine

authors

Bednařík P,Moheet A,Deelchand DK,Emir UE,Eberly LE,Bareš M,Seaquist ER,Öz G

doi

10.1002/nbm.3309

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

685-93

issue

6

eissn

0952-3480

issn

1099-1492

journal_volume

28

pub_type

杂志文章
  • Electro-optic probe for real-time assessments of RF electric field produced in an MRI scanner: Feasibility tests at 3 and 4.7 T.

    abstract::During magnetic resonance imaging (MRI) examinations, the average specific absorption rate (SAR) of the whole body is calculated as an index of global energy deposition in biological tissue without taking into account the presence of metallic implants or conductive materials. However, this global SAR calculation is no...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3849

    authors: Saniour I,Gaborit G,Perrier AL,Gillette L,Revillod G,Sablong R,Duvillaret L,Beuf O

    更新日期:2018-01-01 00:00:00

  • Evaluating the feasibility of creatine-weighted CEST MRI in human brain at 7 T using a Z-spectral fitting approach.

    abstract::The current study aims to evaluate the feasibility of creatine (Cr) chemical exchange saturation transfer (CEST)-weighted MRI at 7 T in the human brain by optimizing the saturation pulse parameters and computing contrast using a Z-spectral fitting approach. The Cr-weighted (Cr-w) CEST contrast was computed from phanto...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.4176

    authors: Singh A,Debnath A,Cai K,Bagga P,Haris M,Hariharan H,Reddy R

    更新日期:2019-12-01 00:00:00

  • 13C NMR spectroscopic analysis of phospholipid metabolism in adrenal chromaffin cells.

    abstract::Phosphatidylcholine (PC) metabolism in bovine adrenal chromaffin cells has been studied in vivo with 100 MHz 13C NMR spectroscopy. The incorporation of 13[CH3]choline was examined in cells embedded in 1% agarose strands and perfused at 37 degrees C. The pattern of 13C NMR spectroscopy. The incorporation of [13CH3]chol...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1940040304

    authors: Rivera CJ,Plishker GA,Morrisett JD,Moore J,Percy AK

    更新日期:1991-06-01 00:00:00

  • Scyllo-inositol in normal aging human brain: 1H magnetic resonance spectroscopy study at 4 Tesla.

    abstract::The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test-retest studies performed on 10 normal su...

    journal_title:NMR in biomedicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/nbm.927

    authors: Kaiser LG,Schuff N,Cashdollar N,Weiner MW

    更新日期:2005-02-01 00:00:00

  • Signal-to-noise ratio of a mouse brain (13) C CryoProbe™ system in comparison with room temperature coils: spectroscopic phantom and in vivo results.

    abstract::MRI and MRS in small rodents demand very high sensitivity. Cryogenic transmit/receive radiofrequency probes (CryoProbes) designed for (1) H MRI of mouse brain provide an attractive option for increasing the performance of small-animal MR systems. As the Larmor frequency of (13) C nuclei is four times lower than that f...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3110

    authors: Sack M,Wetterling F,Sartorius A,Ende G,Weber-Fahr W

    更新日期:2014-06-01 00:00:00

  • Current awareness in NMR in biomedicine.

    abstract::In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of NMR in biomedicine. Each bibliography is divided into 9 sections: 1 Books, Re...

    journal_title:NMR in biomedicine

    pub_type:

    doi:10.1002/nbm.667

    authors: Wennerberg AB,Jonsson T,Forssberg H,Li TQ

    更新日期:2001-02-01 00:00:00

  • Carbohydrate metabolism of the rat C6 glioma. An in vivo 13C and in vitro 1H magnetic resonance spectroscopy study.

    abstract::Surface coil 13C nuclear magnetic resonance (NMR) spectroscopy was used to investigate the in vivo carbohydrate metabolism of rat C6 gliomas during and after infusion with [1-13C] glucose. In vivo 1H-decoupled 13C NMR spectra of the glioma following infusion with [1-13C]glucose revealed the direct production of [3-13C...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1940010105

    authors: Ross BD,Higgins RJ,Boggan JE,Willis JA,Knittel B,Unger SW

    更新日期:1988-02-01 00:00:00

  • Short-TE localised 1H MRS of the human brain at 3 T: quantification of the metabolite signals using two approaches to account for macromolecular signal contributions.

    abstract::The goal of this study was to validate metabolite quantification at short TE, with particular focus on how to best account for the macromolecular signal contribution. A robust, short-TE PRESS protocol is presented, which allows reliable quantification, in vivo, of metabolite signals at 3 T in human brain. Water suppre...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1219

    authors: Gottschalk M,Lamalle L,Segebarth C

    更新日期:2008-06-01 00:00:00

  • A comparison of signal instability in 2D and 3D EPI resting-state fMRI.

    abstract::Spatiotemporally structured noise, such as physiological noise, is a potential source of artifacts in functional magnetic resonance imaging (fMRI) and is the main limiting factor for the detection of small blood oxygen level-dependent (BOLD) signal variations. fMRI was employed to detect low-frequency BOLD signal fluc...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.987

    authors: Goerke U,Möller HE,Norris DG,Schwarzbauer C

    更新日期:2005-12-01 00:00:00

  • Imaging chemical exchange saturation transfer (CEST) effects following tumor-selective acidification using lonidamine.

    abstract::Increased lactate production through glycolysis in aerobic conditions is a hallmark of cancer. Some anticancer drugs have been designed to exploit elevated glycolysis in cancer cells. For example, lonidamine (LND) inhibits lactate transport, leading to intracellular acidification in cancer cells. Chemical exchange sat...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3287

    authors: McVicar N,Li AX,Meakin SO,Bartha R

    更新日期:2015-05-01 00:00:00

  • Water-suppressed one-dimensional 1H NMR chemical shift imaging of the heart before and after regional ischemia.

    abstract::This study tests the hypothesis that brief periods of ischemia result in an increase in myocardial lipids during early reperfusion. We conducted 1H NMR spectroscopy to serially measure myocardial lipids before and after regional ischemia. Localized 1H NMR spectra (spatial resolution of 1.25 mm) were obtained using a o...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1940080206

    authors: Balschi JA,Hetherington HP,Bradley EL Jr,Pohost GM

    更新日期:1995-04-01 00:00:00

  • Contrast-enhanced MRI of murine myocardial infarction - part II.

    abstract::Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审

    doi:10.1002/nbm.2767

    authors: Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

    更新日期:2012-08-01 00:00:00

  • In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology.

    abstract::Boiling histotripsy (BH) is a new high intensity focused ultrasound (HIFU) ablation technique to mechanically fragmentize soft tissue into submicrometer fragments. So far, ultrasound has been used for BH treatment guidance and evaluation. The in vivo histopathological effects of this treatment are largely unknown. Her...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3520

    authors: Hoogenboom M,Eikelenboom D,den Brok MH,Veltien A,Wassink M,Wesseling P,Dumont E,Fütterer JJ,Adema GJ,Heerschap A

    更新日期:2016-06-01 00:00:00

  • Manganese-enhanced MRI of acute cardiac ischemia and chronic infarction in pig hearts: kinetic analysis of enhancement development.

    abstract::To assess infarction development in pig hearts, Mn-enhanced and Gd-enhanced MRI were used. In domestic pigs (25-35 kg, n = 37), the first and second diagonal branches of the left anterior descending coronary artery were ligated to induce acute ischemia and infarction (ischemia+reperfusion) or chronic infarction of inc...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1297

    authors: Yang Y,Gruwel ML,Sun J,Gervai P,Yang X,Kupriyanov VV

    更新日期:2009-02-01 00:00:00

  • Correlation of Choline/Creatine and Apparent Diffusion Coefficient values with the prognostic parameters of Head and Neck Squamous Cell Carcinoma.

    abstract::The aim of this study was to measure choline/creatine (Ch/Cr) levels through (1)H-MRS and apparent diffusion coefficient (ADC) values through diffusion-weighted MRI, and to correlate these values with the prognostic parameters of head and neck squamous cell carcinoma (HNSCC). The institutional review board approved th...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3472

    authors: Razek AA,Nada N

    更新日期:2016-04-01 00:00:00

  • MRI measurements of cerebral deoxyhaemoglobin concentration [dHb]--correlation with near infrared spectroscopy (NIRS).

    abstract::Changes in physiological parameters such as cerebral blood flow, cerebral blood volume, oxygen extraction, and the size and distribution of cerebral blood vessels, result in changes in the local concentration of deoxyhaemoglobin ([dHb]). The purpose of this study was to quantitatively investigate the dependence of the...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1492(199810)11:6<281::aid-nbm52

    authors: Punwani S,Ordidge RJ,Cooper CE,Amess P,Clemence M

    更新日期:1998-10-01 00:00:00

  • Comparison of oxidative capacity among leg muscles in humans using gated 31P 2-D chemical shift imaging.

    abstract::In many small animals there are distinct differences in fiber-type composition among limb muscles, and these differences typically correspond to marked disparities in the oxidative capacities. However, whether there are similar differences in the oxidative capacity among leg muscles in humans is less clear. The purpos...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1413

    authors: Forbes SC,Slade JM,Francis RM,Meyer RA

    更新日期:2009-12-01 00:00:00

  • Pattern recognition approaches in biomedical and clinical magnetic resonance spectroscopy: a review.

    abstract::In recent years considerable effort has been devoted to applying pattern recognition techniques to the complex task of data analysis in magnetic resonance spectroscopy. It may be argued that such techniques will facilitate putting MRS technology to practical clinical use. This paper reviews approaches of pattern recog...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1099-1492(199705)10:3<99::aid-nbm461

    authors: el-Deredy W

    更新日期:1997-05-01 00:00:00

  • In vivo brain viscoelastic properties measured by magnetic resonance elastography.

    abstract::Magnetic resonance elastography (MRE) is a non-invasive imaging technique used to visualise and quantify mechanical properties of tissue, providing information beyond what can be currently achieved with standard MR sequences and could, for instance, provide new insight into pathological processes in the brain. This st...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1254

    authors: Green MA,Bilston LE,Sinkus R

    更新日期:2008-08-01 00:00:00

  • Quantification of disease progression in spinal muscular atrophy with muscle MRI-a pilot study.

    abstract:OBJECTIVES:Quantitative MRI (qMRI) of muscles is a promising tool to measure disease progression or to assess therapeutic effects in neuromuscular diseases. Longitudinal imaging studies are needed to show sensitivity of qMRI in detecting disease progression in spinal muscular atrophy (SMA). In this pilot study we there...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.4473

    authors: Otto LAM,Froeling M,van Eijk RPA,Asselman FL,Wadman R,Cuppen I,Hendrikse J,van der Pol WL

    更新日期:2021-01-22 00:00:00

  • In vivo 1H MRS of human gallbladder bile at 3 T in one and two dimensions: detection and quantification of major biliary lipids.

    abstract::In vitro (1)H MRS of human bile has shown potential in the diagnosis of various hepatopancreatobiliary (HPB) diseases. Previously, in vivo (1)H MRS of human bile in gallbladder using a 1.5 T scanner demonstrated the possibility of quantification of choline-containing phospholipids (chol-PLs). However, other lipid comp...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3173

    authors: Mohajeri S,Ijare OB,Bezabeh T,King SB,Thomas MA,Minuk G,Lipschitz J,Kirkpatrick I,Smith M,Smith IC

    更新日期:2014-10-01 00:00:00

  • Simultaneous MR quantification of hepatic fat content, fatty acid composition, transverse relaxation time and magnetic susceptibility for the diagnosis of non-alcoholic steatohepatitis.

    abstract::Non-alcoholic steatohepatitis (NASH) is characterized at histology by steatosis, hepatocyte ballooning and inflammatory infiltrates, with or without fibrosis. Although diamagnetic material in fibrosis and inflammation can be detected with quantitative susceptibility imaging, fatty acid composition changes in NASH rela...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3766

    authors: Leporq B,Lambert SA,Ronot M,Vilgrain V,Van Beers BE

    更新日期:2017-10-01 00:00:00

  • Hemispheric asymmetry in cerebrovascular reactivity of the human primary motor cortex: an in vivo study at 7 T.

    abstract::Current functional MRI (fMRI) approaches assess underlying neuronal activity through monitoring the related local variations in cerebral blood oxygenation, blood volume and blood flow. This vascular response is likely to vary across brain regions and across individuals, depending on the composition of the local vascul...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3282

    authors: Driver ID,Andoh J,Blockley NP,Francis ST,Gowland PA,Paus T

    更新日期:2015-05-01 00:00:00

  • Multi-component apparent diffusion coefficients in human brain.

    abstract::The signal decay with increasing b-factor at fixed echo time from brain tissue in vivo has been measured using a line scan Stejskal-Tanner spin echo diffusion approach in eight healthy adult volunteers. The use of a 175 ms echo time and maximum gradient strengths of 10 mT/m allowed 64 b-factors to be sampled, ranging ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-1492(199902)12:1<51::aid-nbm546

    authors: Mulkern RV,Gudbjartsson H,Westin CF,Zengingonul HP,Gartner W,Guttmann CR,Robertson RL,Kyriakos W,Schwartz R,Holtzman D,Jolesz FA,Maier SE

    更新日期:1999-02-01 00:00:00

  • Dynamic 31 P-MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T.

    abstract::Phosphorus MRSI (31 P-MRSI) using a spiral-trajectory readout at 7 T was developed for high temporal resolution mapping of the mitochondrial capacity of exercising human skeletal muscle. The sensitivity and localization accuracy of the method was investigated in phantoms. In vivo performance was assessed in 12 volunte...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3662

    authors: Valkovič L,Chmelík M,Meyerspeer M,Gagoski B,Rodgers CT,Krššák M,Andronesi OC,Trattnig S,Bogner W

    更新日期:2016-12-01 00:00:00

  • Concurrent recording of RF pulses and gradient fields - comprehensive field monitoring for MRI.

    abstract::Reconstruction of MRI data is based on exact knowledge of all magnetic field dynamics, since the interplay of RF and gradient pulses generates the signal, defines the contrast and forms the basis of resolution in spatial and spectral dimensions. Deviations caused by various sources, such as system imperfections, delay...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.3359

    authors: Brunner DO,Dietrich BE,Çavuşoğlu M,Wilm BJ,Schmid T,Gross S,Barmet C,Pruessmann KP

    更新日期:2016-09-01 00:00:00

  • pH and compartmentation of isolated perfused rat liver studied by 31P and 19F NMR.

    abstract::The phosphorus NMR spectra of isolated perfused rat liver displays a prominent inorganic phosphate peak at 2.76 +/- 0.05 ppm relative to liver glycerolphosphocholine at 0.49 ppm. From titration curves of phosphorus-containing compounds this corresponds to a pH of 7.4. The spectra also display a shoulder on the promine...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1940010207

    authors: Thoma WJ,Uğurbil K

    更新日期:1988-04-01 00:00:00

  • Identifying systematic errors in quantitative dynamic-susceptibility contrast perfusion imaging by high-resolution multi-echo parallel EPI.

    abstract::Several obstacles usually confound a straightforward perfusion analysis using dynamic-susceptibility contrast-based magnetic resonance imaging (DSC-MRI). In this work, it became possible to eliminate some of these sources of error by combining a multiple gradient-echo technique with parallel imaging (PI): first, the l...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/nbm.1107

    authors: Jochimsen TH,Newbould RD,Skare ST,Clayton DB,Albers GW,Moseley ME,Bammer R

    更新日期:2007-06-01 00:00:00

  • An NMR assessment of the rheological properties of blood and its constituents: a review.

    abstract::This review assesses the progress of NMR in the field of hemorheology, i.e., the assessment of the mechanical and physical characteristics of flowing blood. The review deals with the intrinsic rheological properties of the red cell and its constituents (membrane, cytoplasm), which are dominant in the microcirculation,...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审

    doi:10.1002/nbm.1940020102

    authors: Berling C,Hall LD

    更新日期:1989-06-01 00:00:00

  • Quantitation by (1)H-NMR of dolichol, cholesterol and choline-containing lipids in extracts of normal and phathological thyroid tissue.

    abstract::Proton magnetic resonance spectroscopy at 1.9 T was used to quantify dolichols, cholesterols, choline-containing phospholipids and double bonds in unsaturated acyl chains in lipid extracts of four types of thyroid tissue [normal (n = 27), papillary cancer (n = 15), adenoma (n = 13) and Basedow disease (n = 6)]. In nor...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章

    doi:10.1002/1099-1492(200011)13:7<377::aid-nbm658>3.0.

    authors: Yoshioka Y,Sasaki J,Yamamoto M,Saitoh K,Nakaya S,Kubokawa M

    更新日期:2000-11-01 00:00:00