Abstract:
:The aim of the study was to establish the normal range and to evaluate the reproducibility of dynamic contrast enhanced MRI (DCE-MRI) parameter estimates in normal human pelvic tissues. Nineteen patients with prostate cancer, undergoing androgen deprivation treatment, had paired DCE-MRI examinations of the pelvis using spoiled gradient-echo sequences. Quantitative enhancement parameters were calculated for each examination: transfer constant (K(trans)), leakage space (v(e)) and maximum contrast medium accumulation (MCMA) of pelvic muscles, bone marrow and fat. Descriptive and reproducibility statistics were calculated: within-patient standard deviation (wSD), repeatability and within-patient coefficient of variation (wCV). The femoral head and ischiorectal fat showed large numbers of non-enhancing pixels (81 and 88%, respectively). The ischial bone marrow had the highest values of kinetic parameter estimates (K(trans) 0.554 min(-1), v(e) 18.5% and MCMA 0.164 mmol/kg). Muscle parameters values were lower (K(trans) 0.126-0.137 min(-1), v(e) 10.6-11.5% and MCMA 0.077-0.086 mmol/kg). The mean difference between paired examinations was not significantly different from zero for any parameter. v(e) and MCMA had the lowest wCV (between 19 and 29%). For individuals, a log(10) K(trans) change of approximately 0.90 in muscles and 0.52 in the ischium would be statistically significant. The corresponding absolute changes for v(e) are 6.7% in muscle and 13.6% in the ischium. For a group of 19 patients, small changes are statistically significant (muscle log(10) K(trans) 0.208 and v(e) 1.5% and ischium log(10) K(trans) 0.123 and v(e) 3.1%). Fat and the femoral head are unreliable tissues from which to obtain kinetic parameter estimates due to poor enhancement. v(e) and MCMA have smaller coefficient of variation than K(trans) in muscles and ischium. Reproducibility studies of normal and pathological tissues should be incorporated into clinical research protocols that measure treatment effects by DCE-MRI techniques.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Padhani AR,Hayes C,Landau S,Leach MOdoi
10.1002/nbm.732subject
Has Abstractpub_date
2002-04-01 00:00:00pages
143-53issue
2eissn
0952-3480issn
1099-1492pii
10.1002/nbm.732journal_volume
15pub_type
杂志文章abstract::Brain myelin and iron content are important parameters in neurodegenerative diseases such as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation rate. However, their quantification based on R2* maps requires a realistic tissue model that can be fitted to the measured data. In str...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4092
更新日期:2019-07-01 00:00:00
abstract::High grade and metastatic brain tumours exhibit considerable spatial variations in proliferation, angiogenesis, invasion, necrosis and oedema. Vascular heterogeneity arising from vascular co-option in regions of invasive growth (in which the blood-brain barrier remains intact) and neoangiogenesis is a major challenge ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3594
更新日期:2016-11-01 00:00:00
abstract::The purpose of this study was to investigate the feasibility of interventional MRI-guided local agent delivery into pig common bile duct (CBD) walls using a newly designed MR-compatible, needle-integrated balloon catheter system. We first designed a needle-integrated balloon catheter system that comprised of a 22 G MR...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3308
更新日期:2015-06-01 00:00:00
abstract::The application of diffusion tensor imaging (DTI) to the evaluation of developing brain remains an area of active investigation. This review focuses on the changes in DTI parameters which accompany both brain maturation and injury. The two primary pieces of information available from DTI studies-water apparent diffusi...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.784
更新日期:2002-11-01 00:00:00
abstract::In this study, Blood Oxygenation Level Dependent (BOLD) contrast in the detection of human brain activation was compared between spin-echo and gradient-echo echo-planar sequences at 1.5 T. Time course series of spin-echo and gradient-echo images containing the primary motor cortex were collected during rest (no finger...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940070104
更新日期:1994-03-01 00:00:00
abstract::In this study, mapping of ultrashort T2 and T2* of acutely isolated porcine menisci at B0 = 9.4 T was investigated. Maps of T2 were measured from a slice through the pars intermedia with a spin echo-prepared two-dimensional ultrashort-TE T2 mapping technique published previously. T2* mapping was performed by two-dimen...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2931
更新日期:2013-09-01 00:00:00
abstract::NMR relaxometry can provide information about the relaxation of the magnetization in different tissues, increasing our understanding of molecular dynamics and biochemical composition in biological systems. In general, tissues have complex and heterogeneous structures composed of multiple pools. As a result, bulk magne...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4318
更新日期:2020-12-01 00:00:00
abstract::This paper compares two spectral processing methods for obtaining quantitative measures from in vivo prostate spectra, evaluates their effectiveness, and discusses the necessary modifications for accurate results. A frequency domain analysis (FDA) method based on peak integration was compared with a time domain fittin...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1008
更新日期:2006-04-01 00:00:00
abstract::The possibility of quantifying the superimposed signal of glutamate and glutamine (Glx) and its components by ¹H magnetic resonance spectroscopy (MRS) in the spinal cord is an exciting challenge with important clinical applications in neurological conditions. The spinal cord is a particularly difficult region of inter...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2867
更新日期:2013-03-01 00:00:00
abstract::The sodium-calcium exchanger (NCX) is one of the transporters contributing to the control of intracellular calcium (Ca(2+)) concentration by normally mediating net Ca(2+) efflux. However, the reverse mode of the NCX can cause intracellular Ca(2+) concentration overload, which exacerbates the myocardial tissue injury r...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1414
更新日期:2009-10-01 00:00:00
abstract::The emergence and rapid development of activatable contrast agents (CAs), whose relaxivity changes in response to the variation of a specific marker in the surrounding physiological microenvironment, have expanded the scope of MRI beyond anatomical and functional imaging to also convey information at the cellular and ...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.2870
更新日期:2013-07-01 00:00:00
abstract::The processes of tumor invasion and metastasis have been well characterized at the molecular level, and numerous biomarkers of tumor aggressiveness have been discovered. Molecular imaging offers the opportunity to depict specific cell markers relevant to tumor aggressiveness. Here, we describe the role of MRI in ident...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1590
更新日期:2011-07-01 00:00:00
abstract::The purpose of the present study was to characterize the metabolic profile of the visual cortex in streptozotocin-induced Type 1 diabetic rats by means of in vivo proton MRS. Several metabolite concentration ratios in the visual cortex were calculated. In addition, postmortem histologic analyses for retinal ganglion c...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3783
更新日期:2017-11-01 00:00:00
abstract::The presence of the e4 allele of the apolipoprotein E (APOE) gene is the best-known genetic risk factor for Alzheimer's disease. In this study, we investigated the link between functional and behavioural differences and regional brain volume and cortical thickness differences in those who carry the e4 allele (e4+) and...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3502
更新日期:2016-05-01 00:00:00
abstract::Glucose metabolism in control and estrogen stimulated rat uteri was investigated using 13C NMR spectroscopy. By employing an NMR adapted perifusion system, and developing protocols and methods based on the application of [1-13C]glucose labeling, it was possible to measure, with a temporal resolution of 10 min, the kin...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940070503
更新日期:1994-08-01 00:00:00
abstract::The aim of this work was to identify spectral markers of cell proliferation that could be of use in clinical MRS. Cultured C6 ATCC rat glioma cells were used as models for this purpose and metabolites were extracted with perchloric acid at three different growth curve stages: log, confluence and post-confluence. 1D an...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1024
更新日期:2006-04-01 00:00:00
abstract::Increased pulmonary lactate production is correlated with severity of lung injury and outcome in acute respiratory distress syndrome (ARDS) patients. This study was conducted to investigate the relative contributions of inflammation and hypoxia to the lung's metabolic shift to glycolysis in an experimental animal mode...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4380
更新日期:2020-11-01 00:00:00
abstract::Development and evaluation of new anticancer drugs are expedited when minimally invasive biomarkers of pharmacokinetic and pharmacodynamic behaviour are available. Gene-directed enzyme prodrug therapy (GDEPT) is a suicide gene therapy in which the anticancer drug is activated in the tumor by an exogenous enzyme previo...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1375
更新日期:2009-06-01 00:00:00
abstract::Nuclear Overhauser enhancement (NOE) is a type of magnetization transfer using cross-relaxation. It originates from mobile macromolecules, which may have relevance to the evaluation of tumor features. We studied the value of NOE imaging at 7 and 3 T and suggest a utility for diagnosing human brain tumors. Two types of...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3735
更新日期:2017-09-01 00:00:00
abstract::The steady-state distribution of the general anesthetic halothane in different rat tissues, including a renal adenocarcinoma with and without hyperthermia treatment, has been evaluated by in vivo 19F NMR spectroscopy. The 19F spectra of halothane (which is a hydrophobic probe) from within tissue show differences in th...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940060502
更新日期:1993-09-01 00:00:00
abstract::Progress in the development of non-proton NMR applications in medical research has been hampered by the generally low sensitivity of these nuclides as well as the lack of instrumentation readily available for studying these spins. For example, custom head coils suitable for sodium imaging of the human head are either ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940020308
更新日期:1989-09-01 00:00:00
abstract::The purpose of this paper is to facilitate the comparison of magnetic resonance (MR) spectra acquired from unknown brain lesions with published spectra in order to help identify unknown lesions in clinical settings. The paper includes lists of references for published MR spectra of various brain diseases, including py...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1039
更新日期:2006-06-01 00:00:00
abstract::A current limitation of MR spectroscopic imaging of multiple skeletal muscles is prolonged scan duration. A significant reduction in the total scan duration using the echo-planar correlated spectroscopic imaging (EP-COSI) sequence was accomplished using two bipolar readout trains with different phase-encoded echoes fo...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3171
更新日期:2014-10-01 00:00:00
abstract::In this study, the upper-limit volume (gas plus partial tissue volume) as well as absolute volume (gas only) of lungs measured with hyperpolarized (3)He-MR imaging is compared with that determined by micro-computed tomography (CT) under similar ventilation conditions in normal rats. Five Brown Norway rats (210-259 g) ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1470
更新日期:2010-05-01 00:00:00
abstract::Localization techniques are considered an indispensable part of the clinical spectroscopy examination. The results are often a marked improvement in diagnostic information (amplification), but because of the introduction of new artifacts and the more prolonged examination time, some of the undoubted advantage is lost ...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940020525
更新日期:1989-12-01 00:00:00
abstract::This study tests the hypothesis that brief periods of ischemia result in an increase in myocardial lipids during early reperfusion. We conducted 1H NMR spectroscopy to serially measure myocardial lipids before and after regional ischemia. Localized 1H NMR spectra (spatial resolution of 1.25 mm) were obtained using a o...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940080206
更新日期:1995-04-01 00:00:00
abstract::Proton magnetic resonance spectroscopy at 1.9 T was used to quantify dolichols, cholesterols, choline-containing phospholipids and double bonds in unsaturated acyl chains in lipid extracts of four types of thyroid tissue [normal (n = 27), papillary cancer (n = 15), adenoma (n = 13) and Basedow disease (n = 6)]. In nor...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/1099-1492(200011)13:7<377::aid-nbm658>3.0.
更新日期:2000-11-01 00:00:00
abstract::Chemical exchange saturation transfer (CEST) can offer information about protons associated with mobile proteins through the amide proton transfer (APT) effect, which has been shown to discriminate tumor from healthy tissue and, more recently, has been suggested as a prognosticator of response to therapy. Despite this...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2947
更新日期:2013-10-01 00:00:00
abstract::Determination of the apparent diffusion coefficient (ADC) of the prostate in men (n = 60) with raised prostate-specific antigen (PSA) or an abnormal digital rectal examination (DRE) prior to transrectal ultrasound (TRUS) guided biopsy using endorectal DWI is reported. Patients were categorized into different groups ba...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1114
更新日期:2007-08-01 00:00:00
abstract::We describe and discuss the application of three-dimensional (3D) time-of-flight (TOF) magnetic resonance angiography (MRA) to visualize non-invasively the cerebral vasculature of the rat. MR angiograms of healthy spontaneously hypertensive rats were obtained without the use of contrast agents. Total imaging time rang...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199906)12:4<189::aid-nbm55
更新日期:1999-06-01 00:00:00