Abstract:
:Determination of the apparent diffusion coefficient (ADC) of the prostate in men (n = 60) with raised prostate-specific antigen (PSA) or an abnormal digital rectal examination (DRE) prior to transrectal ultrasound (TRUS) guided biopsy using endorectal DWI is reported. Patients were categorized into different groups based on their PSA levels. The mean ADC was calculated from a number of regions of interest (ROIs) for the whole of the peripheral zone (PZ) and the central gland (CG). A total of 1108 ROIs were analyzed from 60 patients. The mean ADC value of the PZ was higher than that of the CG in controls. A total of 23 out of 60 patients were positive for malignancy on biopsy, and the mean ADC of the PZ was lower in these patients compared with those who were negative. Moreover, the mean ADC obtained for the whole of the PZ of the prostate in different groups of patients and controls showed a decreasing trend. A plot between PSA and mean ADC for the PZ showed non-linear association with logarithmic decrease in ADC. The mean ADC of the CG was not significantly different in patients who were positive or negative for malignancy in biopsy. In addition, a cut-off value of 1.17 x 10(-3) mm2/s (sensitivity = 73% and specificity = 74%, area under the curve = 0.83) for the mean ADC for the whole of the PZ of patients was determined by using the receiver operating characteristic curve (ROC) to predict malignancy of the PZ.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Kumar V,Jagannathan NR,Kumar R,Thulkar S,Gupta SD,Dwivedi SN,Hemal AK,Gupta NPdoi
10.1002/nbm.1114subject
Has Abstractpub_date
2007-08-01 00:00:00pages
505-11issue
5eissn
0952-3480issn
1099-1492journal_volume
20pub_type
杂志文章abstract::Progress in the development of non-proton NMR applications in medical research has been hampered by the generally low sensitivity of these nuclides as well as the lack of instrumentation readily available for studying these spins. For example, custom head coils suitable for sodium imaging of the human head are either ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940020308
更新日期:1989-09-01 00:00:00
abstract::Evaluation of high intensity focused ultrasound (HIFU) treatment with MRI is generally based on assessment of the non-perfused volume from contrast-enhanced T1-weighted images. However, the vascular status of tissue surrounding the non-perfused volume has not been extensively investigated with MRI. In this study, clus...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3406
更新日期:2015-11-01 00:00:00
abstract::MRS provides a valuable tool for the non-invasive detection of brain γ-aminobutyric acid (GABA) in vivo. GABAergic dysfunction has been observed in the aging cerebellum. The study of cerebellar GABA changes is of considerable interest in understanding certain age-related motor disorders. However, little is known about...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3381
更新日期:2015-10-01 00:00:00
abstract::In recent years considerable effort has been devoted to applying pattern recognition techniques to the complex task of data analysis in magnetic resonance spectroscopy. It may be argued that such techniques will facilitate putting MRS technology to practical clinical use. This paper reviews approaches of pattern recog...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1492(199705)10:3<99::aid-nbm461
更新日期:1997-05-01 00:00:00
abstract::Renal urea handling is central to the urine concentrating mechanism, and as such the ability to image urea transport in the kidney is an important potential imaging biomarker for renal functional assessment. Glucagon levels associated with changes in dietary protein intake have been shown to influence renal urea handl...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4028
更新日期:2019-01-01 00:00:00
abstract::Transmit efficiency specifies the amplitude of the magnetic resonance excitation field produced over a region of interest with respect to the radiofrequency (RF) power deposited in the sample. This metric is highly important at ultra-high field magnetic resonance imaging (≥7 T), where excitation inhomogeneities and el...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4383
更新日期:2020-11-01 00:00:00
abstract::The relaxation properties of water and metabolites were measured in rat brain following the occlusion of the middle cerebral artery (MCA) with localized 1H MRS. The PRESS sequence was employed to select volumes of 39 microL in the ischemic and the contralateral hemisphere. T1 and T2 relaxation times and peak intensiti...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940080604
更新日期:1995-09-01 00:00:00
abstract::An often-employed strategy to enhance signals in (31) P MRS is the generation of the nuclear Overhauser effect (NOE) by saturation of the water resonance. However, NOE allegedly increases the variability of the (31) P data, because variation is reported in NOE enhancements. This would negate the signal-to-noise (SNR) ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3455
更新日期:2016-03-01 00:00:00
abstract::The aim of this work was to identify spectral markers of cell proliferation that could be of use in clinical MRS. Cultured C6 ATCC rat glioma cells were used as models for this purpose and metabolites were extracted with perchloric acid at three different growth curve stages: log, confluence and post-confluence. 1D an...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1024
更新日期:2006-04-01 00:00:00
abstract::In this study, we have performed simulations to address the effects of diffusion encoding parameters, signal-to-noise ratio (SNR) and T2 on skeletal muscle diffusion tensor indices and fiber tracts. Where appropriate, simulations were corroborated and validated by in vivo diffusion tensor imaging (DTI) of human skelet...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2959
更新日期:2013-11-01 00:00:00
abstract::We introduce a new protocol to obtain very high-frame-rate cinematographic (Cine) MRI movies of the beating mouse heart within a reasonable measurement time. The method is based on a self-gated accelerated fast low-angle shot (FLASH) acquisition and compressed sensing reconstruction. Key to our approach is that we exp...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2883
更新日期:2013-04-01 00:00:00
abstract::Hyperglycemia (blood glucose concentration >150 mg/dL) is common in extremely low gestational age newborns (ELGANs; birth at <28 week gestation). Hyperglycemia increases the risk of brain injury in the neonatal period. The long-term effects are not well understood. In adult rats, hyperglycemia alters hippocampal energ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3910
更新日期:2018-05-01 00:00:00
abstract::The combination of hyperpolarized Xe with chemical exchange saturation transfer (Hyper-CEST) is a powerful NMR technique to detect highly dilute concentrations of Xe binding sites using RF saturation pulses. Crucially, that combination of saturation pulse strength and duration that generates the maximal Hyper-CEST eff...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3307
更新日期:2015-06-01 00:00:00
abstract::A method to extract shapes of bubble polyhedra from three-dimensional nuclear magnetic resonance image data of foam has been developed. The method consists of four steps: first, to compute series of maximum intensity projection images from the three-dimensional NMR image data of foam to visualize the network structure...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199701)10:1<13::aid-nbm443
更新日期:1997-01-01 00:00:00
abstract::Hippocampal dysfunction is known to be associated with several neurological and neuropsychiatric disorders such as Alzheimer's disease, epilepsy, schizophrenia and depression; therefore, there has been significant clinical interest in studying hippocampal neurochemistry. However, the hippocampus is a challenging regio...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3309
更新日期:2015-06-01 00:00:00
abstract::In this work, we report a case study of a stroke model in animals using two methods of quantification of the deviations from Gaussian behaviour: diffusion kurtosis imaging (DKI) and log-normal distribution function imaging (LNDFI). The affected regions were predominantly in grey rather than in white matter. The parame...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2802
更新日期:2012-11-01 00:00:00
abstract::Results are presented from an in vivo study of human skin in which a zig-zag surface coil together with a three-pulse Fourier Series Window (FSW) protocol have been used to obtain minimally contaminated 31P skin spectra of the posterior calf. Phantom experiments indicate that while the fall-off in the B1 field profile...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(SICI)1099-1492(199608)9:5<195::AID-NBM416
更新日期:1996-08-01 00:00:00
abstract::The intrinsic nonuniformities in the transmit radiofrequency field from standard quadrature volume resonators at high field are particularly problematic for localized MRS in areas such as the temporal lobe, where a low signal-to-noise ratio and poor metabolite quantification result from destructive B₁⁺ field interfere...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1638
更新日期:2011-08-01 00:00:00
abstract::Localization techniques are considered an indispensable part of the clinical spectroscopy examination. The results are often a marked improvement in diagnostic information (amplification), but because of the introduction of new artifacts and the more prolonged examination time, some of the undoubted advantage is lost ...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940020525
更新日期:1989-12-01 00:00:00
abstract::Vessel size index (VSI), a parameter related to the distribution of vessel diameters, may be estimated using two MRI approaches: (i) dynamic susceptibility contrast (DSC) MRI following the injection of a bolus of Gd-chelate. This technique is routinely applied in the clinic to assess intracranial tissue perfusion in p...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1734
更新日期:2012-02-01 00:00:00
abstract::The goal of the study was to establish early hyperpolarized (HP) 13 C MRI metabolic and perfusion changes that predict effective high-intensity focused ultrasound (HIFU) ablation and lead to improved adjuvant treatment of partially treated regions. To accomplish this a combined HP dual-agent (13 C pyruvate and 13 C ur...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3962
更新日期:2019-10-01 00:00:00
abstract::To investigate the GABA+ modeling accuracy of MEGA-PRESS GABA+-edited MRS data with various spectral quality scenarios, the influence of varying signal-to-noise ratio (SNR) and linewidth on the model estimates was quantified. MEGA-PRESS data from 46 volunteers were averaged to generate a template MEGA-PRESS spectrum, ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4410
更新日期:2021-01-01 00:00:00
abstract::The cuprizone mouse model of demyelination was used to investigate the influence that white matter changes have on different magnetic resonance imaging results. In vivo T2 -weighted and magnetization transfer images (MTIs) were acquired weekly in control (n = 5) and cuprizone-fed (n = 5) mice, with significant increas...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2992
更新日期:2013-11-01 00:00:00
abstract::Proton magnetic resonance spectroscopy at 1.9 T was used to quantify dolichols, cholesterols, choline-containing phospholipids and double bonds in unsaturated acyl chains in lipid extracts of four types of thyroid tissue [normal (n = 27), papillary cancer (n = 15), adenoma (n = 13) and Basedow disease (n = 6)]. In nor...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/1099-1492(200011)13:7<377::aid-nbm658>3.0.
更新日期:2000-11-01 00:00:00
abstract::Diffusion tensor imaging (DTI) provides an indirect measure of tissue structure on a microscopic scale. To date, DTI is the only imaging method that provides such information in vivo, and has proven to be a valuable tool in both research and clinical settings. In this study, we investigated the relationship between wh...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1810
更新日期:2012-07-01 00:00:00
abstract::Owing to the small quantity of tissue available in human biopsy specimens, aqueous and lipid components often have to be determined in the same tissue sample. Perchloric acid (PCA) used for the extraction of aqueous metabolites has a deleterious effect on lipid components; the severity of the damage is not known. In t...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1159
更新日期:2008-02-01 00:00:00
abstract::It is generally accepted that tumour microcirculation, blood flow, oxygen and nutrient supply, tissue pH distribution, and the bioenergetic status--factors which are usually closely linked and which define the so-called metabolic microenvironment--can markedly influence the therapeutic response of malignant tumours to...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940050505
更新日期:1992-09-01 00:00:00
abstract::Chemical exchange saturation transfer (CEST) can offer information about protons associated with mobile proteins through the amide proton transfer (APT) effect, which has been shown to discriminate tumor from healthy tissue and, more recently, has been suggested as a prognosticator of response to therapy. Despite this...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2947
更新日期:2013-10-01 00:00:00
abstract::A novel iodoacetamide label 4-perfluoro-tert-butyl-phenyliodoacetamide (PFP) containing nine fluorine atoms in equivalent positions has been synthesized. It provides a homogeneous 19F NMR resonance line which can be detected with high sensitivity when coupled to proteins. As an example, the sulfhydryl groups of actin ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940050605
更新日期:1992-11-01 00:00:00
abstract::Acute hypoxia (transient cycles of hypoxia-reoxygenation) is known to occur in solid tumors and is generally believed to be caused by tumor blood flow instabilities. It was recently demonstrated that T2*-weighted (T2*w) gradient echo (GRE) MRI is a powerful non-invasive method for investigating periodic changes in tum...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1002
更新日期:2006-02-01 00:00:00