Abstract:
:It is generally accepted that tumour microcirculation, blood flow, oxygen and nutrient supply, tissue pH distribution, and the bioenergetic status--factors which are usually closely linked and which define the so-called metabolic microenvironment--can markedly influence the therapeutic response of malignant tumours to conventional irradiation, chemotherapy, other non-surgical treatment modalities, and the cell proliferation activity within the tumours. Currently available information on the parameters defining the metabolic micromilieu in human tumours is presented in this paper. According to these data, significant variations in these relevant factors are likely to occur between different locations within a tumour, and between tumours of the same grading and clinical staging. Therefore, evaluation of the metabolic microenvironment in individual tumours before therapy and a corresponding 'fine-tuning' of treatment protocols for individual patients may result in an improved tumour response to treatment.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Vaupel Pdoi
10.1002/nbm.1940050505subject
Has Abstractpub_date
1992-09-01 00:00:00pages
220-5issue
5eissn
0952-3480issn
1099-1492journal_volume
5pub_type
杂志文章,评审abstract::A number of NMR spectroscopic and microscopic MRI (microMRI) techniques were used to study proton dynamics in canine tendon and articular cartilage immersed in normal saline solution (NaCl solution) and high-concentration phosphate-buffered saline (PBS) solution. In a proton CPMG experiment on tendons, the T(2) relaxa...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1294
更新日期:2009-02-01 00:00:00
abstract::This introductory article addresses approaches currently in use to process in vivo spectra. First, a brief overview is given of the information content represented by the parameters of MR signals. Subsequently, common steps in the processing of MR spectra such as pre-processing, normalisation and quantification and th...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.707
更新日期:2001-06-01 00:00:00
abstract::Transceiver surface coil arrays improve transmit performance (B1/√kW) and B1 homogeneity for head imaging up to 9.4 T. To further improve reception performance and parallel imaging, the number of array elements must be increased with a corresponding decrease in their size. With a large number of small interacting ante...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2989
更新日期:2013-11-01 00:00:00
abstract::This review assesses the progress of NMR in the field of hemorheology, i.e., the assessment of the mechanical and physical characteristics of flowing blood. The review deals with the intrinsic rheological properties of the red cell and its constituents (membrane, cytoplasm), which are dominant in the microcirculation,...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940020102
更新日期:1989-06-01 00:00:00
abstract::Exercise studies investigating the metabolic response of calf muscles using 31 P MRS are usually performed with a single knee angle. However, during natural movement, the distribution of workload between the main contributors to force, gastrocnemius and soleus is influenced by the knee angle. Hence, it is of interest ...
journal_title:NMR in biomedicine
pub_type: 临床试验,杂志文章
doi:10.1002/nbm.3905
更新日期:2018-06-01 00:00:00
abstract::The application of diffusion tensor imaging (DTI) to the evaluation of developing brain remains an area of active investigation. This review focuses on the changes in DTI parameters which accompany both brain maturation and injury. The two primary pieces of information available from DTI studies-water apparent diffusi...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.784
更新日期:2002-11-01 00:00:00
abstract::Evaluation of high intensity focused ultrasound (HIFU) treatment with MRI is generally based on assessment of the non-perfused volume from contrast-enhanced T1-weighted images. However, the vascular status of tissue surrounding the non-perfused volume has not been extensively investigated with MRI. In this study, clus...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3406
更新日期:2015-11-01 00:00:00
abstract::In this work, we report a case study of a stroke model in animals using two methods of quantification of the deviations from Gaussian behaviour: diffusion kurtosis imaging (DKI) and log-normal distribution function imaging (LNDFI). The affected regions were predominantly in grey rather than in white matter. The parame...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2802
更新日期:2012-11-01 00:00:00
abstract::An effective method for in vivo detection of early therapeutic response of patients with non-Hodgkin's lymphoma would enable personalized clinical management of cancer therapy and facilitate the design of optimal treatment regimens. This study evaluates the feasibility of T(2)-weighted MRI (T2WI) and diffusion-weighte...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1261
更新日期:2008-11-01 00:00:00
abstract::Nuclear Overhauser enhancement (NOE) is a type of magnetization transfer using cross-relaxation. It originates from mobile macromolecules, which may have relevance to the evaluation of tumor features. We studied the value of NOE imaging at 7 and 3 T and suggest a utility for diagnosing human brain tumors. Two types of...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3735
更新日期:2017-09-01 00:00:00
abstract::Encoding of spatial information in magnetic resonance imaging is conventionally accomplished by using magnetic field gradients. During gradient encoding, the position in k-space is determined by a time-integral of the gradient field, resulting in a limitation in imaging speed due to either gradient power or secondary ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1399
更新日期:2009-11-01 00:00:00
abstract::One of the hallmarks of diffusion NMR and MRI is its ability to utilize restricted diffusion to probe compartments much smaller than the excited volume or the MRI voxel, respectively, and to extract microstructural information from them. Single-pulsed field gradient (s-PFG) MR methodologies have been employed with gre...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1550
更新日期:2010-08-01 00:00:00
abstract::The purpose of this study was to identify the optimal tracer kinetic model from T1 -weighted dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data and evaluate whether parameters estimated from the optimal model predict tumor aggressiveness determined from histopathology in patients with papillary thyroi...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4166
更新日期:2020-01-01 00:00:00
abstract::Hyperpolarised [1-13 C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus-1 thymidine kinase with the prodrug ganciclovir (HSV-TK/GCV) in C6 rat glioma...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4250
更新日期:2020-04-01 00:00:00
abstract::In many studies, it has been demonstrated that (1)H MRSI of the human prostate has great potential to aid prostate cancer management, e.g. in the detection and localisation of cancer foci in the prostate or in the assessment of its aggressiveness. It is particularly powerful in combination with T2 -weighted MRI. Never...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.2973
更新日期:2014-01-01 00:00:00
abstract::The intimal and medial linings of the pulmonary artery consist largely of vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs), respectively. The migration of these cell types to a potential tissue-engineered pulmonary valve (TEPV) implant process is therefore of interest in understanding the val...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1642
更新日期:2012-03-01 00:00:00
abstract::Resolution enhancement for glutamate (Glu), glutamine (Gln) and glutathione (GSH) in the human brain by TE-optimized point-resolved spectroscopy (PRESS) at 7 T is reported. Sub-TE dependences of the multiplets of Glu, Gln, GSH, γ-aminobutyric acid (GABA) and N-acetylaspartate (NAA) at 2.2-2.6 ppm were investigated wit...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1529
更新日期:2010-11-01 00:00:00
abstract::Two FDA-approved agents, ferumoxides (Feridex), a suspension of superparamagnetic iron oxide (SPIO) nanoparticles and protamine sulfate, a drug used to reverse heparin anticoagulation, can be complexed and used to label cells magnetically ex vivo. Labeling stem cells with ferumoxides-protamine sulfate (FePro) complexe...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.991
更新日期:2005-12-01 00:00:00
abstract::In imaging of human lungs with hyperpolarised noble gases, measurements of apparent diffusion coefficient (ADC) and relaxation time provide valuable information for the assessment of lung microstructure. In this work, a sequence was developed for interleaved acquisition of ventilation images, ADC, T(2)* and flip angle...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1710
更新日期:2012-01-01 00:00:00
abstract::The present work aims to show the applicability of an analytical model for the optimisation of the STEAM sequence timing parameters for lactate detection at ultra high-field. The effects of the chemical shift displacement artefact on the J-modulated signal for a weakly-coupled spin system were considered in the three ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4440
更新日期:2020-11-02 00:00:00
abstract::During the measurement of hyperpolarized 129 Xe magnetic resonance imaging (MRI), the diffusion-weighted imaging (DWI) technique provides valuable information for the assessment of lung morphometry at the alveolar level, whereas the chemical shift saturation recovery (CSSR) technique can evaluate the gas exchange func...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3730
更新日期:2017-08-01 00:00:00
abstract::Diffusion tensor MRI (DTI) is a method for the noninvasive assessment of cellular organization and integrity in vivo. In this study, in vivo DTI was performed to demonstrate its ability to reflect photoreceptor cell alignment in adult C57BL/6 wild-type mice. Age-matched retinal degeneration 1 (rd1) mice were employed ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1609
更新日期:2011-06-01 00:00:00
abstract::Elevated brain myo-inositol (m-Ins) concentration (a putative marker of neuroinflammation) has been reported in patients suffering from type 2 diabetes mellitus (T2DM). Obesity alone and T2DM have been found to be associated with a lower concentration of N-acetyloaspartate and N-acetylaspartylglutamate (tNAA, a marker...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3957
更新日期:2018-09-01 00:00:00
abstract::With a fixed time to acquire a magnetic resonance (MR) image, time can be spent to acquire better spatial resolution with decrease in signal-to-noise ratio (SNR) or decreased resolution with increase in SNR. This resolution/SNR tradeoff at fixed time has been investigated by a visual rater study using images of ex viv...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1359
更新日期:2009-06-01 00:00:00
abstract::Acute hypoxia (transient cycles of hypoxia-reoxygenation) is known to occur in solid tumors and is generally believed to be caused by tumor blood flow instabilities. It was recently demonstrated that T2*-weighted (T2*w) gradient echo (GRE) MRI is a powerful non-invasive method for investigating periodic changes in tum...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1002
更新日期:2006-02-01 00:00:00
abstract::To assess infarction development in pig hearts, Mn-enhanced and Gd-enhanced MRI were used. In domestic pigs (25-35 kg, n = 37), the first and second diagonal branches of the left anterior descending coronary artery were ligated to induce acute ischemia and infarction (ischemia+reperfusion) or chronic infarction of inc...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1297
更新日期:2009-02-01 00:00:00
abstract::13C MRS was installed on a clinical scanner at 1.5 T in order to facilitate integrated MR examinations of human brain disorders. Using a simplified protocol, (1-(13)C) glucose and/or (1-(13)C) acetate were administered orally or by intravenous infusion. (13)C spectra of diagnostic quality were acquired in more than 10...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.852
更新日期:2003-10-01 00:00:00
abstract::A quantitative magnetization transfer (qMT) technique was employed to quantify the ratio of the sizes of the bound and free water proton pools in ex vivo mouse brains. The goal was to determine the pool size ratio sensitivity to myelin. Fixed brains from both shiverer mice and control littermates were imaged. The pool...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1358
更新日期:2009-06-01 00:00:00
abstract::Localization techniques are considered an indispensable part of the clinical spectroscopy examination. The results are often a marked improvement in diagnostic information (amplification), but because of the introduction of new artifacts and the more prolonged examination time, some of the undoubted advantage is lost ...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940020525
更新日期:1989-12-01 00:00:00
abstract:OBJECTIVES:Quantitative MRI (qMRI) of muscles is a promising tool to measure disease progression or to assess therapeutic effects in neuromuscular diseases. Longitudinal imaging studies are needed to show sensitivity of qMRI in detecting disease progression in spinal muscular atrophy (SMA). In this pilot study we there...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4473
更新日期:2021-01-22 00:00:00