Abstract:
:An effective method for in vivo detection of early therapeutic response of patients with non-Hodgkin's lymphoma would enable personalized clinical management of cancer therapy and facilitate the design of optimal treatment regimens. This study evaluates the feasibility of T(2)-weighted MRI (T2WI) and diffusion-weighted MRI (DWI) for in vivo detection of response of human diffuse large B-cell lymphoma xenografts in severe combined immunodeficient mice to chemotherapy. Each cycle of combination chemotherapy with cyclophosphamide, hydroxydoxorubicin, Oncovin, prednisone, and bryostatin 1 (CHOPB) was administered to tumor-carrying mice weekly for up to four cycles. T2WI and DWI were performed before the initiation of CHOPB and after each cycle of CHOPB. In order to corroborate the MRI results, histological analyses were carried out on control tumors and treated tumors after completion of all MRI studies. DWI revealed a significant (P < 0.03) increase in the mean apparent diffusion coefficient in CHOPB-treated tumors as early as 1 week after initiation of CHOPB. However, a significant (P < 0.03) decrease in mean T(2) was observed only after two cycles of CHOPB. Both MRI methods produced high-resolution (0.1 x 0.1 x 1.0 mm(3)) maps of regional therapeutic response in the treated tumors based on local apparent diffusion coefficient and T(2). Only a specific region of the tumors (in 3 of the 5 tumors) corresponding to about one third of the tumor volume exhibited a response-associate increase in ADC and decrease in T(2). An adjacent region exhibited an increase in T(2) and no change in ADC. The rest of the tumor was indistinguishable from sham-treated controls by MRI criteria. The therapeutic response of the treated tumors detected by MRI was accompanied by changes in tumor cell density, proliferation and apoptosis revealed by histological studies performed upon completion of the longitudinal study. The mechanism producing the regional response of the tumor remains to be elucidated.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Huang MQ,Pickup S,Nelson DS,Qiao H,Xu HN,Li LZ,Zhou R,Delikatny EJ,Poptani H,Glickson JDdoi
10.1002/nbm.1261subject
Has Abstractpub_date
2008-11-01 00:00:00pages
1021-9issue
10eissn
0952-3480issn
1099-1492journal_volume
21pub_type
杂志文章abstract::We show how quantitative information about proton handling in human skeletal muscle in exercise and recovery can be obtained by 31P MRS and illustrate this with data from metabolic disorders. Proton production, proton efflux and passive buffering can be distinguished by comparing changes in [phosphocreatine] and pH at...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940060112
更新日期:1993-01-01 00:00:00
abstract::In this study the conjugated macromolecular ligand, diethylenetriaminepentaacetic acid (DTPA)-amide-dextran, was synthesized by attaching DTPA to the dextran macromolecule (M(r) approximately 6000) by a covalent amide bond. Subsequently, DTPA-amide-dextran was complexed with either of the two lanthanide metal ions dys...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940080404
更新日期:1995-06-01 00:00:00
abstract::Brain activation studies in humans have shown the dynamic nature of neuronal N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) based on changes in their MRS signals in response to stimulation. These studies demonstrated that upon visual stimulation there was a focal increase in cerebral blood flow (CBF) and...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3629
更新日期:2016-12-01 00:00:00
abstract::An MR thermometry method is proposed for measuring in vivo small temperature changes engendered by external RF heat sources. The method relies on reproducible and stable respiration and therefore currently applies to ventilated animals whose breathing is carefully controlled. It first consists in characterizing the st...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3232
更新日期:2015-01-01 00:00:00
abstract::Standard functional MRI (fMRI), which includes resting-state or paradigm-driven designs, is widely used in studies of brain function, aging, and disease. These fMRI studies typically use two-dimensional gradient echo-planar imaging, which inherently contains phase data that enables quantitative susceptibility mapping ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3619
更新日期:2017-04-01 00:00:00
abstract::Diffusion tensor imaging (DTI) provides an indirect measure of tissue structure on a microscopic scale. To date, DTI is the only imaging method that provides such information in vivo, and has proven to be a valuable tool in both research and clinical settings. In this study, we investigated the relationship between wh...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1810
更新日期:2012-07-01 00:00:00
abstract::Early imaging or blood biomarkers of tumor response is needed to customize anti-tumor therapy on an individual basis. This study evaluates the sensitivity and relevance of five potential MRI biomarkers. Sixty nude rats were implanted with human glioma cells (U-87 MG) and randomized into three groups: one group receive...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1611
更新日期:2011-06-01 00:00:00
abstract::Increased lactate production through glycolysis in aerobic conditions is a hallmark of cancer. Some anticancer drugs have been designed to exploit elevated glycolysis in cancer cells. For example, lonidamine (LND) inhibits lactate transport, leading to intracellular acidification in cancer cells. Chemical exchange sat...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3287
更新日期:2015-05-01 00:00:00
abstract::Both post-contrast myocardial T1 and extracellular volume (ECV) have been reported to be associated with diffuse interstitial fibrosis. Recently, the cardiovascular magnetic resonance (CMR) field is recognizing that post-contrast myocardial T1 is sensitive to several confounders and migrating towards ECV as a measure ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3221
更新日期:2014-11-01 00:00:00
abstract::Balanced steady-state free precession imaging has recently been suggested for chemical exchange detection (bSSFPX). The objective of this work is to investigate the contributions of microstructural, chemical shift and chemical exchange effects to the asymmetry of the bSSFP profile at field strengths of 3 T and 9.4 T. ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4200
更新日期:2020-03-01 00:00:00
abstract::Phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS) has gained much interest in schizophrenia research in recent years since it allows the non-invasive measurement of high-energy phosphates and phospholipids in vivo. However, until now only differences in metabolite concentrations between certain brain areas of ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199912)12:8<483::aid-nbm58
更新日期:1999-12-01 00:00:00
abstract::The steady-state distribution of the general anesthetic halothane in different rat tissues, including a renal adenocarcinoma with and without hyperthermia treatment, has been evaluated by in vivo 19F NMR spectroscopy. The 19F spectra of halothane (which is a hydrophobic probe) from within tissue show differences in th...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940060502
更新日期:1993-09-01 00:00:00
abstract::The aim of this study is to fabricate and test a novel flexible flat cable antenna (FFCA) for MRI of the knee at different flexion angles. The FFCA was made of a flat cable, a tuning/matching circuit and a signal transmission line. To test its feasibility and validity, in vitro and in vivo experiments were carried out...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3264
更新日期:2015-04-01 00:00:00
abstract::The background underpinning the clinical use of ultrashort echo time, SPRITE and other pulse sequences for imaging bone and other connective tissues with short T2 is reviewed. Features of the basic physics relevant to UTE imaging are described, including the consequences when the radiofrequency pulse duration is of th...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1100
更新日期:2006-11-01 00:00:00
abstract::Hyperglycemia (blood glucose concentration >150 mg/dL) is common in extremely low gestational age newborns (ELGANs; birth at <28 week gestation). Hyperglycemia increases the risk of brain injury in the neonatal period. The long-term effects are not well understood. In adult rats, hyperglycemia alters hippocampal energ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3910
更新日期:2018-05-01 00:00:00
abstract::The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and their metabolites efficiently, for which specialized imaging sequences are required. In this work, a multi-echo balanced steady-state free precession (me-bSSFP) sequence with Iterative Decomposition with Echo Asymmetry and Leas...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4291
更新日期:2020-06-01 00:00:00
abstract::Recent work has shown that solid-state (1) H and (31) P MRI can provide detailed insight into bone matrix and mineral properties, thereby potentially enabling differentiation of osteoporosis from osteomalacia. However, (31) P MRI of bone mineral is hampered by unfavorable relaxation properties. Hence, accurate knowled...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2930
更新日期:2013-09-01 00:00:00
abstract::The goals of this study were to develop an acquisition protocol and the analysis tools for Meshcher-Garwood point-resolved spectroscopy (MEGA-PRESS) in mouse brain at 9.4 T, to allow the in vivo detection of γ-aminobutyric acid (GABA) and to examine whether isoflurane alters GABA levels in the thalamus during anesthes...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3837
更新日期:2018-01-01 00:00:00
abstract::In this study, we have performed simulations to address the effects of diffusion encoding parameters, signal-to-noise ratio (SNR) and T2 on skeletal muscle diffusion tensor indices and fiber tracts. Where appropriate, simulations were corroborated and validated by in vivo diffusion tensor imaging (DTI) of human skelet...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2959
更新日期:2013-11-01 00:00:00
abstract::An often-employed strategy to enhance signals in (31) P MRS is the generation of the nuclear Overhauser effect (NOE) by saturation of the water resonance. However, NOE allegedly increases the variability of the (31) P data, because variation is reported in NOE enhancements. This would negate the signal-to-noise (SNR) ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3455
更新日期:2016-03-01 00:00:00
abstract::In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of NMR in biomedicine. Each bibliography is divided into 9 sections: 1 Books, Re...
journal_title:NMR in biomedicine
pub_type:
doi:10.1002/nbm.667
更新日期:2001-02-01 00:00:00
abstract::This introductory article addresses approaches currently in use to process in vivo spectra. First, a brief overview is given of the information content represented by the parameters of MR signals. Subsequently, common steps in the processing of MR spectra such as pre-processing, normalisation and quantification and th...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.707
更新日期:2001-06-01 00:00:00
abstract::Hippocampal dysfunction is known to be associated with several neurological and neuropsychiatric disorders such as Alzheimer's disease, epilepsy, schizophrenia and depression; therefore, there has been significant clinical interest in studying hippocampal neurochemistry. However, the hippocampus is a challenging regio...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3309
更新日期:2015-06-01 00:00:00
abstract::Studies of cholesteryl ester transfer protein (CETP) function in lipoprotein mixtures pose many difficulties by conventional biochemical methods. For instance, studies on the effects of CETP on the composition of apolipoprotein B containing lipoproteins (very low and low density lipoproteins) in lipoprotein mixtures a...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199710)10:7<303::aid-nbm48
更新日期:1997-10-01 00:00:00
abstract::T2 of NAA, creatine and choline-containing compounds were measured in posterior frontal white matter and occipital grey matter in 10 healthy human volunteers. Decay curves comprised signals from eight TE times ranging from 30 to 800 ms with TR 2000 ms acquired with a PRESS sequence on a 1.5 T clinical scanner. Simulat...
journal_title:NMR in biomedicine
pub_type: 临床试验,杂志文章
doi:10.1002/nbm.916
更新日期:2005-02-01 00:00:00
abstract::Qualitative and quantitative (1) H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) (n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) (n = 9) and gallbladder cancer (GBC, malignant) (n = 8) was carried out to understand the mechanisms involved in the transformati...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1594
更新日期:2011-05-01 00:00:00
abstract::Tumor metabolism is directly coupled to tumor blood flow (TBF) and both metabolism and blood flow may be determinants of tumor response to treatment. Since NMR has been used extensively to monitor tumor metabolism noninvasively, development of NMR-based methods for TBF measurement was motivated by the desire to examin...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940050516
更新日期:1992-09-01 00:00:00
abstract::The present work aims to show the applicability of an analytical model for the optimisation of the STEAM sequence timing parameters for lactate detection at ultra high-field. The effects of the chemical shift displacement artefact on the J-modulated signal for a weakly-coupled spin system were considered in the three ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4440
更新日期:2020-11-02 00:00:00
abstract::An optimized semi-LASER sequence that is capable of acquiring artefact-free data with an echo time (TE) of 20.1 ms on a standard clinical 3 T MR system was developed. Simulations were performed to determine the optimal TEs that minimize the expected Cramér-Rao lower bound (CRLB) as proxy for quantification accuracy of...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4324
更新日期:2020-09-01 00:00:00
abstract::Metabolic activity in the lung is known to change in response to external insults, inflammation, and cancer. We report measurements of metabolism in the isolated, perfused rat lung of healthy controls and in diseased lungs undergoing acute inflammation using hyperpolarized 1-(13) C-labeled pyruvate. The overall appare...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3139
更新日期:2014-08-01 00:00:00