Abstract:
:With a fixed time to acquire a magnetic resonance (MR) image, time can be spent to acquire better spatial resolution with decrease in signal-to-noise ratio (SNR) or decreased resolution with increase in SNR. This resolution/SNR tradeoff at fixed time has been investigated by a visual rater study using images of ex vivo mouse brains. Simulated images with a tradeoff between SNR and resolution were produced from high-quality, 3D isotropic mouse brain images to emulate shorter constant acquisition times. The tradeoff images spanned a range of SNRs (63-6) and isotropic resolutions (32-81 microm). Fourteen readers identified the image which best displayed neuroanatomy. Additional experiments tested for (i) intra-observer consistency, (ii) the effect of emulated scan time, and (iii) specifically biased questions pertaining to the perception of neuroanatomy. Optimal anatomical viewing depended primarily on the SNR of the images. Specifically, for fixed imaging time, preference lay in the SNR range of approximately 30-35 with strong consistency and there was minimal effect from overall imaging time.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Kale SC,Chen XJ,Henkelman RMdoi
10.1002/nbm.1359subject
Has Abstractpub_date
2009-06-01 00:00:00pages
488-94issue
5eissn
0952-3480issn
1099-1492journal_volume
22pub_type
杂志文章abstract::The goals of this study were to develop an acquisition protocol and the analysis tools for Meshcher-Garwood point-resolved spectroscopy (MEGA-PRESS) in mouse brain at 9.4 T, to allow the in vivo detection of γ-aminobutyric acid (GABA) and to examine whether isoflurane alters GABA levels in the thalamus during anesthes...
journal_title:NMR in biomedicine
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更新日期:2018-01-01 00:00:00
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journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1412
更新日期:2009-10-01 00:00:00
abstract::It is generally accepted that tumour microcirculation, blood flow, oxygen and nutrient supply, tissue pH distribution, and the bioenergetic status--factors which are usually closely linked and which define the so-called metabolic microenvironment--can markedly influence the therapeutic response of malignant tumours to...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2013-02-01 00:00:00
abstract::Resolution enhancement for glutamate (Glu), glutamine (Gln) and glutathione (GSH) in the human brain by TE-optimized point-resolved spectroscopy (PRESS) at 7 T is reported. Sub-TE dependences of the multiplets of Glu, Gln, GSH, γ-aminobutyric acid (GABA) and N-acetylaspartate (NAA) at 2.2-2.6 ppm were investigated wit...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
abstract::γ-Aminobutyric acid (GABA) and glutamate (Glu), major neurotransmitters in the brain, are recycled through glutamine (Gln). All three metabolites can be measured by magnetic resonance spectroscopy in vivo, although GABA measurement at 3 T requires an extra editing acquisition, such as Mescher-Garwood point-resolved sp...
journal_title:NMR in biomedicine
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更新日期:2018-01-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2796
更新日期:2012-11-01 00:00:00
abstract::To understand and predict the blood-oxygenation level-dependent (BOLD) fMRI signal, an accurate knowledge of the relationship between cerebral blood flow (DeltaCBF) and volume (DeltaCBV) changes is critical. Currently, this relationship is widely assumed to be characterized by Grubb's power-law, derived from primate d...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1411
更新日期:2009-12-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1284
更新日期:2008-11-01 00:00:00
abstract::The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test-retest studies performed on 10 normal su...
journal_title:NMR in biomedicine
pub_type: 临床试验,杂志文章
doi:10.1002/nbm.927
更新日期:2005-02-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1149
更新日期:2007-05-01 00:00:00
abstract::The measurement of pulmonary perfusion (blood delivered to the capillary bed within a voxel) using arterial spin labeling (ASL) magnetic resonance imaging is often complicated by signal artifacts from conduit vessels that carry blood destined for voxels at a distant location in the lung. One approach to dealing with c...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3358
更新日期:2015-09-01 00:00:00
abstract::Spatiotemporally structured noise, such as physiological noise, is a potential source of artifacts in functional magnetic resonance imaging (fMRI) and is the main limiting factor for the detection of small blood oxygen level-dependent (BOLD) signal variations. fMRI was employed to detect low-frequency BOLD signal fluc...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.987
更新日期:2005-12-01 00:00:00
abstract::Quantitative analysis of extracts from two Ehrlich ascites tumour cell lines (Lettre cells) by 19F NMR in vitro demonstrated that one Lettre cell line (designated LLM) metabolized 30-50% less 5-fluorouracil to 5-fluoronucleotides when compared to the other cell line (designated LHM). HPLC analysis of these cellular ex...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940040605
更新日期:1991-12-01 00:00:00
abstract::Quantitative magnetisation transfer imaging (qMTI) is an extension of conventional MT techniques and allows the measurement of parameters that reflect tissue ultrastructure through the properties of macromolecule-bound protons; these include the bound proton fraction and the relaxation times of free and bound proton p...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:NMR in biomedicine
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更新日期:2014-01-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00
abstract::Evaluation of high intensity focused ultrasound (HIFU) treatment with MRI is generally based on assessment of the non-perfused volume from contrast-enhanced T1-weighted images. However, the vascular status of tissue surrounding the non-perfused volume has not been extensively investigated with MRI. In this study, clus...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:Quantitative MRI (qMRI) of muscles is a promising tool to measure disease progression or to assess therapeutic effects in neuromuscular diseases. Longitudinal imaging studies are needed to show sensitivity of qMRI in detecting disease progression in spinal muscular atrophy (SMA). In this pilot study we there...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2021-01-22 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(SICI)1099-1492(199608)9:5<195::AID-NBM416
更新日期:1996-08-01 00:00:00
abstract::In this methodological paper I report the stereotactic correlation of different magnetic resonance imaging (MRI) techniques [MR angiography (MRA), MRI, blood bolus tagging (STAR), functional MRI, and high-resolution BOLD venography (HRBV)] in patients with cerebral arterio-venous malformations (AVM) and brain tumors. ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00