Detection of endogenous iron deposits in the injured mouse spinal cord through high-resolution ex vivo and in vivo MRI.

abstract：:T2 relaxation time is a quantitative MRI in vivo surrogate of cerebral tissue damage in multiple sclerosis (MS) patients. Cortical T2 prolongation is a known feature in later disease stages, but has not been demonstrated in the cortical normal appearing gray matter (NAGM) in early MS. This study centers on the quantit...

journal_title：NMR in biomedicine

authors： Gracien RM,Reitz SC,Hof SM,Fleischer V,Zimmermann H,Droby A,Steinmetz H,Zipp F,Deichmann R,Klein JC

更新日期：2016-04-01 00:00:00

abstract：:In many studies, it has been demonstrated that (1)H MRSI of the human prostate has great potential to aid prostate cancer management, e.g. in the detection and localisation of cancer foci in the prostate or in the assessment of its aggressiveness. It is particularly powerful in combination with T2 -weighted MRI. Never...

journal_title：NMR in biomedicine

authors： Kobus T,Wright AJ,Scheenen TW,Heerschap A

更新日期：2014-01-01 00:00:00

abstract：:The signal decay with increasing b-factor at fixed echo time from brain tissue in vivo has been measured using a line scan Stejskal-Tanner spin echo diffusion approach in eight healthy adult volunteers. The use of a 175 ms echo time and maximum gradient strengths of 10 mT/m allowed 64 b-factors to be sampled, ranging ...

journal_title：NMR in biomedicine

authors： Mulkern RV,Gudbjartsson H,Westin CF,Zengingonul HP,Gartner W,Guttmann CR,Robertson RL,Kyriakos W,Schwartz R,Holtzman D,Jolesz FA,Maier SE

更新日期：1999-02-01 00:00:00

abstract：:In this study, metabolic changes in the 79A/C3H, ME7/VM, ME7/C3H, 87V/VM and 22A/SV scrapie mouse models were investigated during the clinical phase of the disease, using in vitro proton nuclear magnetic resonance spectroscopy. N-acetyl-aspartate was found to be significantly reduced in infected mice of the ME7/ C3H (...

journal_title：NMR in biomedicine

authors： Chung YL,Williams A,Chong A,Hope J,Williams SC,Bell JD

更新日期：1996-12-01 00:00:00

abstract：:Manganese ions (Mn(2+) ) enter viable myocardial cells via voltage-gated calcium channels. Because of its shortening of T(1) and its relatively long half-life in cells, Mn(2+) can serve as an intracellular molecular contrast agent to study indirect calcium influx into the myocardium. One major concern in using Mn(2+) ...

journal_title：NMR in biomedicine

authors： Hu TC,Chuang KH,Yanasak N,Koretsky A

更新日期：2011-01-01 00:00:00

abstract：:The goals of this study were to develop an acquisition protocol and the analysis tools for Meshcher-Garwood point-resolved spectroscopy (MEGA-PRESS) in mouse brain at 9.4 T, to allow the in vivo detection of γ-aminobutyric acid (GABA) and to examine whether isoflurane alters GABA levels in the thalamus during anesthes...

journal_title：NMR in biomedicine

authors： Guo J,Gang Z,Sun Y,Laine A,Small SA,Rothman DL

更新日期：2018-01-01 00:00:00

abstract：:In vitro (1)H MRS of human bile has shown potential in the diagnosis of various hepatopancreatobiliary (HPB) diseases. Previously, in vivo (1)H MRS of human bile in gallbladder using a 1.5 T scanner demonstrated the possibility of quantification of choline-containing phospholipids (chol-PLs). However, other lipid comp...

journal_title：NMR in biomedicine

authors： Mohajeri S,Ijare OB,Bezabeh T,King SB,Thomas MA,Minuk G,Lipschitz J,Kirkpatrick I,Smith M,Smith IC

更新日期：2014-10-01 00:00:00

abstract：:Biomarkers of early response to treatment have the potential to improve cancer therapy by allowing treatment to be tailored to the individual. Alterations in lipids detected by in vivo MRS have been suggested as noninvasive biomarkers of cell stress and early indicators of cell death. An improved understanding of the ...

journal_title：NMR in biomedicine

authors： Mirbahai L,Wilson M,Shaw CS,McConville C,Malcomson RD,Kauppinen RA,Peet AC

更新日期：2012-11-01 00:00:00

abstract：:Metabolic activity in the lung is known to change in response to external insults, inflammation, and cancer. We report measurements of metabolism in the isolated, perfused rat lung of healthy controls and in diseased lungs undergoing acute inflammation using hyperpolarized 1-(13) C-labeled pyruvate. The overall appare...

journal_title：NMR in biomedicine

authors： Shaghaghi H,Kadlecek S,Deshpande C,Siddiqui S,Martinez D,Pourfathi M,Hamedani H,Ishii M,Profka H,Rizi R

更新日期：2014-08-01 00:00:00

abstract：:Qualitative and quantitative (1) H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) (n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) (n = 9) and gallbladder cancer (GBC, malignant) (n = 8) was carried out to understand the mechanisms involved in the transformati...

journal_title：NMR in biomedicine

authors： Jayalakshmi K,Sonkar K,Behari A,Kapoor VK,Sinha N

更新日期：2011-05-01 00:00:00

abstract：:The cerebral blood volume (CBV) is a crucial physiological indicator of tissue viability and vascular reactivity. Thus, noninvasive CBV mapping has been of great interest. For this, ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, including monocrystalline iron oxide nanoparticles, can be used as long-ha...

journal_title：NMR in biomedicine

authors： Kim SG,Harel N,Jin T,Kim T,Lee P,Zhao F

更新日期：2013-08-01 00:00:00

abstract：:It is generally accepted that tumour microcirculation, blood flow, oxygen and nutrient supply, tissue pH distribution, and the bioenergetic status--factors which are usually closely linked and which define the so-called metabolic microenvironment--can markedly influence the therapeutic response of malignant tumours to...

journal_title：NMR in biomedicine

authors： Vaupel P

更新日期：1992-09-01 00:00:00

abstract：:The purpose of this study was to identify the optimal tracer kinetic model from T1 -weighted dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data and evaluate whether parameters estimated from the optimal model predict tumor aggressiveness determined from histopathology in patients with papillary thyroi...

journal_title：NMR in biomedicine

authors： Paudyal R,Lu Y,Hatzoglou V,Moreira A,Stambuk HE,Oh JH,Cunanan KM,Aramburu Nunez D,Mazaheri Y,Gonen M,Ho A,Fagin JA,Wong RJ,Shaha A,Tuttle RM,Shukla-Dave A

更新日期：2020-01-01 00:00:00

abstract：:In this study, Blood Oxygenation Level Dependent (BOLD) contrast in the detection of human brain activation was compared between spin-echo and gradient-echo echo-planar sequences at 1.5 T. Time course series of spin-echo and gradient-echo images containing the primary motor cortex were collected during rest (no finger...

journal_title：NMR in biomedicine

authors： Bandettini PA,Wong EC,Jesmanowicz A,Hinks RS,Hyde JS

更新日期：1994-03-01 00:00:00

abstract：:NMR relaxometry can provide information about the relaxation of the magnetization in different tissues, increasing our understanding of molecular dynamics and biochemical composition in biological systems. In general, tissues have complex and heterogeneous structures composed of multiple pools. As a result, bulk magne...

journal_title：NMR in biomedicine

authors： Zibetti MVW,Helou ES,Sharafi A,Regatte RR

更新日期：2020-12-01 00:00:00

abstract：:The aim of the study was to establish the normal range and to evaluate the reproducibility of dynamic contrast enhanced MRI (DCE-MRI) parameter estimates in normal human pelvic tissues. Nineteen patients with prostate cancer, undergoing androgen deprivation treatment, had paired DCE-MRI examinations of the pelvis usin...

journal_title：NMR in biomedicine

authors： Padhani AR,Hayes C,Landau S,Leach MO

更新日期：2002-04-01 00:00:00

abstract：INTRODUCTION:Sarcoidosis is a systemic granulomatous disease affecting in particular the respiratory tract. Cardiac magnetic resonance (CMR), including a measurement of T1 relaxation time, could potentially detect early stadia of sarcoidosis of the heart. The study aims to assess T1 mapping in the detection of early ca...

journal_title：NMR in biomedicine

authors： Panovský R,Doubková M,Holeček T,Máchal J,Feitová V,Masárová L,Opatřil L,Mojica-Pisciotti ML,Kincl V

更新日期：2020-11-01 00:00:00

abstract：:Diffusion measurements were performed on the N-acetyl aspartate (NAA) signal in in situ brains (in vivo and post-mortem) and on in vitro brain tissue at 37 degrees C using wide ranges of b-values (from 0 up to 4.5 x 10(6) s/cm2 and 35.8 x 10(6) s/cm2 for the in vivo and the in vitro cases, respectively). In vivo and i...

journal_title：NMR in biomedicine

authors： Assaf Y,Cohen Y

更新日期：1998-04-01 00:00:00

abstract：:In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of NMR in biomedicine. Each bibliography is divided into 9 sections: 1 Books, Re...

journal_title：NMR in biomedicine

authors： Wennerberg AB,Jonsson T,Forssberg H,Li TQ

更新日期：2001-02-01 00:00:00

abstract：:Transmit efficiency specifies the amplitude of the magnetic resonance excitation field produced over a region of interest with respect to the radiofrequency (RF) power deposited in the sample. This metric is highly important at ultra-high field magnetic resonance imaging (≥7 T), where excitation inhomogeneities and el...

journal_title：NMR in biomedicine

authors： Georgakis IP,Polimeridis AG,Lattanzi R

更新日期：2020-11-01 00:00:00

abstract：:Wilms' tumours (WTs) are large heterogeneous tumours, which typically consist of a mixture of histological cell types, together with regions of chemotherapy-induced regressive change and necrosis. The predominant cell type in a WT is assessed histologically following nephrectomy, and used to assess the tumour subtype ...

journal_title：NMR in biomedicine

authors： Hales PW,Olsen ØE,Sebire NJ,Pritchard-Jones K,Clark CA

更新日期：2015-08-01 00:00:00

abstract：:Signal of lung parenchymal tissue from the living rat and mouse lung was detected at 4.7 T with a good signal-to-noise ratio and motion-suppressed artifacts using a short TE gradient-echo sequence. Neither cardiac nor respiratory gating were applied, and animals respired freely during data collection. Mean T(2)* relax...

journal_title：NMR in biomedicine

authors： Beckmann N,Tigani B,Mazzoni L,Fozard JR

更新日期：2001-08-01 00:00:00

abstract：:More than 50% of cancers fail to respond to any individual treatment and tumour follow-up after treatment plays a major role in routine therapy planning and pharmacological research. Today, MRS is the only technological approach providing non-invasive access to tumour biochemistry. Ten years ago, expectations were rai...

journal_title：NMR in biomedicine

authors： de Certaines JD,Larsen VA,Podo F,Carpinelli G,Briot O,Henriksen O

更新日期：1993-11-01 00:00:00

abstract：:Acute hypoxia (transient cycles of hypoxia-reoxygenation) is known to occur in solid tumors and is generally believed to be caused by tumor blood flow instabilities. It was recently demonstrated that T2*-weighted (T2*w) gradient echo (GRE) MRI is a powerful non-invasive method for investigating periodic changes in tum...

journal_title：NMR in biomedicine

authors： Baudelet C,Cron GO,Ansiaux R,Crokart N,DeWever J,Feron O,Gallez B

更新日期：2006-02-01 00:00:00

abstract：:The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test-retest studies performed on 10 normal su...

journal_title：NMR in biomedicine

authors： Kaiser LG,Schuff N,Cashdollar N,Weiner MW

更新日期：2005-02-01 00:00:00

abstract：:One of the most commonly used methods for in vivo MRS detection of γ-aminobutyric acid (GABA) is the MEGA-point-resolved spectroscopy (MEGA-PRESS) technique. However, accurate quantification of GABA using MEGA-PRESS is complicated by spectral co-editing of macromolecular resonances. In this article, a new pulse sequen...

journal_title：NMR in biomedicine

authors： Near J,Simpson R,Cowen P,Jezzard P

更新日期：2011-12-01 00:00:00

abstract：:Free cytosolic [Mg2+] can be assessed in vivo by 31P MRS from the chemical shift of beta-ATP which in turn depends on the fraction of total ATP complexed to Mg2+ ions. The reliability of these in vivo measurements depends on the availability of an appropriate in vitro calibration to determine the limits of chemical sh...

journal_title：NMR in biomedicine

authors： Iotti S,Frassineti C,Alderighi L,Sabatini A,Vacca A,Barbiroli B

更新日期：1996-02-01 00:00:00

abstract：:Most ovarian tumors are cystic structures containing variable amounts of fluid. Several studies of ovarian cyst fluid focus on one specific metabolite using conventional assay systems. We examined the potential of (1)H-nuclear magnetic resonance spectroscopy in evaluation of the overall metabolic composition of cyst f...

journal_title：NMR in biomedicine

authors： Boss EA,Moolenaar SH,Massuger LF,Boonstra H,Engelke UF,de Jong JG,Wevers RA

更新日期：2000-08-01 00:00:00

abstract：:Hippocampal dysfunction is known to be associated with several neurological and neuropsychiatric disorders such as Alzheimer's disease, epilepsy, schizophrenia and depression; therefore, there has been significant clinical interest in studying hippocampal neurochemistry. However, the hippocampus is a challenging regio...

journal_title：NMR in biomedicine

authors： Bednařík P,Moheet A,Deelchand DK,Emir UE,Eberly LE,Bareš M,Seaquist ER,Öz G

更新日期：2015-06-01 00:00:00

abstract：:In this study we aimed to assess the effects of continuous formalin fixation on diffusion and relaxation metrics of the ex vivo porcine heart at 7 T. Magnetic resonance imaging was performed on eight piglet hearts using a 7 T whole body system. Hearts were measured fresh within 3 hours of cardiac arrest followed by im...

journal_title：NMR in biomedicine

authors： Lohr D,Terekhov M,Veit F,Schreiber LM

更新日期：2020-07-01 00:00:00