Glioma grading using apparent diffusion coefficient map: application of histogram analysis based on automatic segmentation.

abstract：:Nuclear Overhauser enhancement (NOE) is a type of magnetization transfer using cross-relaxation. It originates from mobile macromolecules, which may have relevance to the evaluation of tumor features. We studied the value of NOE imaging at 7 and 3 T and suggest a utility for diagnosing human brain tumors. Two types of...

journal_title：NMR in biomedicine

authors： Shen Y,Xiao G,Shen Z,Zhang X,Tang X,Hu W,Zhang Z,Guan J,Wu R

更新日期：2017-09-01 00:00:00

abstract：:Despite 40 years of NMR spectroscopy and 10 years of in vivo spectroscopy in humans, the break-even point for routine clinical diagnosis has not yet been reached. Obviously there are many factors that stimulate but also restrict the use of proton NMR spectroscopy in clinical routine. ...

journal_title：NMR in biomedicine

authors： Moser E

更新日期：1994-12-01 00:00:00

abstract：:Perfusion is an important biomarker of tissue function and has been associated with tumor pathophysiology such as angiogenesis and hypoxia. Arterial spin labeling (ASL) MRI allows noninvasive and quantitative imaging of perfusion; however, the application in mouse xenograft tumor models has been challenging due to the...

journal_title：NMR in biomedicine

authors： Rajendran R,Liang J,Tang MY,Henry B,Chuang KH

更新日期：2015-08-01 00:00:00

abstract：:The current study aims to evaluate the feasibility of creatine (Cr) chemical exchange saturation transfer (CEST)-weighted MRI at 7 T in the human brain by optimizing the saturation pulse parameters and computing contrast using a Z-spectral fitting approach. The Cr-weighted (Cr-w) CEST contrast was computed from phanto...

journal_title：NMR in biomedicine

authors： Singh A,Debnath A,Cai K,Bagga P,Haris M,Hariharan H,Reddy R

更新日期：2019-12-01 00:00:00

abstract：:Hyperpolarised [1-13 C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus-1 thymidine kinase with the prodrug ganciclovir (HSV-TK/GCV) in C6 rat glioma...

journal_title：NMR in biomedicine

authors： Nivajärvi R,Olsson V,Hyppönen V,Bowen S,Leinonen HM,Lesch HP,Ardenkjaer-Larsen JH,Gröhn OHJ,Ylä-Herttuala S,Kettunen MI

更新日期：2020-04-01 00:00:00

abstract：:Aminoacylase 1 deficiency is a novel inborn error of metabolism. The clinical significance of the deficiency is under discussion, as well as the possible consequences of the defect for brain metabolism and function. This study includes the five originally published cases as well as three novel ones. NMR spectroscopy o...

journal_title：NMR in biomedicine

authors： Engelke UF,Sass JO,Van Coster RN,Gerlo E,Olbrich H,Krywawych S,Calvin J,Hart C,Omran H,Wevers RA

更新日期：2008-02-01 00:00:00

abstract：:To investigate the GABA+ modeling accuracy of MEGA-PRESS GABA+-edited MRS data with various spectral quality scenarios, the influence of varying signal-to-noise ratio (SNR) and linewidth on the model estimates was quantified. MEGA-PRESS data from 46 volunteers were averaged to generate a template MEGA-PRESS spectrum, ...

journal_title：NMR in biomedicine

authors： Zöllner HJ,Oeltzschner G,Schnitzler A,Wittsack HJ

更新日期：2021-01-01 00:00:00

abstract：:The background underpinning the clinical use of ultrashort echo time, SPRITE and other pulse sequences for imaging bone and other connective tissues with short T2 is reviewed. Features of the basic physics relevant to UTE imaging are described, including the consequences when the radiofrequency pulse duration is of th...

journal_title：NMR in biomedicine

authors： Robson MD,Bydder GM

更新日期：2006-11-01 00:00:00

abstract：:The purpose of this work was to carry out diffusion tensor imaging (DTI) at multiple diffusion times Td in skeletal muscle in normal subjects and chronic exertional compartment syndrome (CECS) patients and analyze the data with the random permeable barrier model (RPBM) for biophysical specificity. Using an institution...

journal_title：NMR in biomedicine

authors： Sigmund EE,Novikov DS,Sui D,Ukpebor O,Baete S,Babb JS,Liu K,Feiweier T,Kwon J,McGorty K,Bencardino J,Fieremans E

更新日期：2014-05-01 00:00:00

abstract：:The goals of this study were to develop an acquisition protocol and the analysis tools for Meshcher-Garwood point-resolved spectroscopy (MEGA-PRESS) in mouse brain at 9.4 T, to allow the in vivo detection of γ-aminobutyric acid (GABA) and to examine whether isoflurane alters GABA levels in the thalamus during anesthes...

journal_title：NMR in biomedicine

authors： Guo J,Gang Z,Sun Y,Laine A,Small SA,Rothman DL

更新日期：2018-01-01 00:00:00

abstract：:Encoding of spatial information in magnetic resonance imaging is conventionally accomplished by using magnetic field gradients. During gradient encoding, the position in k-space is determined by a time-integral of the gradient field, resulting in a limitation in imaging speed due to either gradient power or secondary ...

journal_title：NMR in biomedicine

authors： Wright SM,McDougall MP

更新日期：2009-11-01 00:00:00

abstract：:The relaxation properties of water and metabolites were measured in rat brain following the occlusion of the middle cerebral artery (MCA) with localized 1H MRS. The PRESS sequence was employed to select volumes of 39 microL in the ischemic and the contralateral hemisphere. T1 and T2 relaxation times and peak intensiti...

journal_title：NMR in biomedicine

authors： van der Toorn A,Dijkhuizen RM,Tulleken CA,Nicolay K

更新日期：1995-09-01 00:00:00

abstract：:We show how quantitative information about proton handling in human skeletal muscle in exercise and recovery can be obtained by 31P MRS and illustrate this with data from metabolic disorders. Proton production, proton efflux and passive buffering can be distinguished by comparing changes in [phosphocreatine] and pH at...

journal_title：NMR in biomedicine

authors： Kemp GJ,Taylor DJ,Styles P,Radda GK

更新日期：1993-01-01 00:00:00

abstract：:The application of diffusion tensor imaging (DTI) to the evaluation of developing brain remains an area of active investigation. This review focuses on the changes in DTI parameters which accompany both brain maturation and injury. The two primary pieces of information available from DTI studies-water apparent diffusi...

journal_title：NMR in biomedicine

authors： Neil J,Miller J,Mukherjee P,Hüppi PS

更新日期：2002-11-01 00:00:00

abstract：:A review of the theory, technology, and use of radio frequency (RF) coils for small-animal MRI is presented. It includes a brief overview of MR signal-to-noise (S/N) analysis and discussions of the various coils commonly used in small-animal MR: surface coils, linear volume coils, birdcages, and their derivatives. The...

journal_title：NMR in biomedicine

authors： Doty FD,Entzminger G,Kulkarni J,Pamarthy K,Staab JP

更新日期：2007-05-01 00:00:00

abstract：:Wilms' tumours (WTs) are large heterogeneous tumours, which typically consist of a mixture of histological cell types, together with regions of chemotherapy-induced regressive change and necrosis. The predominant cell type in a WT is assessed histologically following nephrectomy, and used to assess the tumour subtype ...

journal_title：NMR in biomedicine

authors： Hales PW,Olsen ØE,Sebire NJ,Pritchard-Jones K,Clark CA

更新日期：2015-08-01 00:00:00

abstract：:Citicoline supplementation has been used to ameliorate memory disturbances in older people and those with Alzheimer's disease. This study used MRS to characterize the effects of citicoline on high-energy phosphate metabolites and constituents of membrane synthesis in the frontal lobe. Phosphorus ((31)P) metabolite dat...

journal_title：NMR in biomedicine

authors： Silveri MM,Dikan J,Ross AJ,Jensen JE,Kamiya T,Kawada Y,Renshaw PF,Yurgelun-Todd DA

更新日期：2008-11-01 00:00:00

abstract：:In recent years considerable effort has been devoted to applying pattern recognition techniques to the complex task of data analysis in magnetic resonance spectroscopy. It may be argued that such techniques will facilitate putting MRS technology to practical clinical use. This paper reviews approaches of pattern recog...

journal_title：NMR in biomedicine

authors： el-Deredy W

更新日期：1997-05-01 00:00:00

abstract：:The presence of the e4 allele of the apolipoprotein E (APOE) gene is the best-known genetic risk factor for Alzheimer's disease. In this study, we investigated the link between functional and behavioural differences and regional brain volume and cortical thickness differences in those who carry the e4 allele (e4+) and...

journal_title：NMR in biomedicine

authors： Dowell NG,Evans SL,Tofts PS,King SL,Tabet N,Rusted JM

更新日期：2016-05-01 00:00:00

abstract：:Glucosamine (GlcN) modulates fluoropyrimidine metabolism and enhances cytotoxicity of 5-fluorouridine (FUrd), but not of 5-fluorouracil (FUra), in human tumor models. To elucidate the underlying metabolic differences between FUra and FUrd, by the use of 19F and 31P NMR spectroscopy we studied these drugs in multicell ...

journal_title：NMR in biomedicine

authors： Chen TB,Bajzer Z,Macura S,Vuk-Pavlovic S

更新日期：1999-05-01 00:00:00

abstract：:Metabolic activity in the lung is known to change in response to external insults, inflammation, and cancer. We report measurements of metabolism in the isolated, perfused rat lung of healthy controls and in diseased lungs undergoing acute inflammation using hyperpolarized 1-(13) C-labeled pyruvate. The overall appare...

journal_title：NMR in biomedicine

authors： Shaghaghi H,Kadlecek S,Deshpande C,Siddiqui S,Martinez D,Pourfathi M,Hamedani H,Ishii M,Profka H,Rizi R

更新日期：2014-08-01 00:00:00

abstract：:Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and proton (1H) magnetic resonance spectroscopy (MRS) provide structural and biochemical information, including vascular volume, vascular permeability and tissue metabolism. In this study, we performed analysis of the enhancement characteristic from DCE-...

journal_title：NMR in biomedicine

authors： Lipnick S,Liu X,Sayre J,Bassett LW,Debruhl N,Thomas MA

更新日期：2010-10-01 00:00:00

abstract：:This review assesses the progress of NMR in the field of hemorheology, i.e., the assessment of the mechanical and physical characteristics of flowing blood. The review deals with the intrinsic rheological properties of the red cell and its constituents (membrane, cytoplasm), which are dominant in the microcirculation,...

journal_title：NMR in biomedicine

authors： Berling C,Hall LD

更新日期：1989-06-01 00:00:00

abstract：:The purpose of this study was to investigate the reliability of 3D isotropic MRI and quantitative multi-parametric MRI characterization on an orthotopic pancreatic head tumor model in rats. 3D isotropic T2 -weighted MRI was performed as a routine for tumor longitudinal follow-up and volume estimation. Common bile duct...

journal_title：NMR in biomedicine

authors： Yin T,Peeters R,Feng Y,Liu Y,Yu J,Dymarkowski S,Himmelreich U,Oyen R,Ni Y

更新日期：2017-02-01 00:00:00

abstract：:Polycystic kidney disease (PKD) is a life-threatening disease that leads to a grotesque enlargement of the kidney and significant loss of function. Several imaging studies with MRI have demonstrated that cyst size in polycystic kidneys can determine disease severity and progression. In the present study, we found that...

journal_title：NMR in biomedicine

authors： Xie L,Qi Y,Subashi E,Liao G,Miller-DeGraff L,Jetten AM,Johnson GA

更新日期：2015-05-01 00:00:00

abstract：:T2 of NAA, creatine and choline-containing compounds were measured in posterior frontal white matter and occipital grey matter in 10 healthy human volunteers. Decay curves comprised signals from eight TE times ranging from 30 to 800 ms with TR 2000 ms acquired with a PRESS sequence on a 1.5 T clinical scanner. Simulat...

journal_title：NMR in biomedicine

authors： Brief EE,Whittall KP,Li DK,MacKay AL

更新日期：2005-02-01 00:00:00

abstract：:The management and treatment of high-grade glioblastoma multiforme (GBM) and solitary metastasis (MET) are very different and influence the prognosis and subsequent clinical outcomes. In the case of a solitary MET, diagnosis using conventional radiology can be equivocal. Currently, a definitive diagnosis is based on h...

journal_title：NMR in biomedicine

authors： Yang G,Jones TL,Barrick TR,Howe FA

更新日期：2014-09-01 00:00:00

abstract：:Quantitative mapping of MR tissue parameters such as the spin-lattice relaxation time (T1 ), the spin-spin relaxation time (T2 ), and the spin-lattice relaxation in the rotating frame (T1ρ ), referred to as MR relaxometry in general, has demonstrated improved assessment in a wide range of clinical applications. Compar...

journal_title：NMR in biomedicine

authors： Feng L,Ma D,Liu F

更新日期：2020-10-15 00:00:00

abstract：:The purpose of the present study was to characterize the metabolic profile of the visual cortex in streptozotocin-induced Type 1 diabetic rats by means of in vivo proton MRS. Several metabolite concentration ratios in the visual cortex were calculated. In addition, postmortem histologic analyses for retinal ganglion c...

journal_title：NMR in biomedicine

authors： Li S,Wang X,Yang J,Lei H,Wang X,Xiang Y

更新日期：2017-11-01 00:00:00

abstract：:Cross-talk between adipose tissue and liver is disturbed in the metabolic syndrome. Moreover, the relative fatty acid composition of adipose and liver fat is poorly characterized. Long-TE (1)H MRS can determine the unsaturation and polyunsaturation of adipose tissue. The aim of this study was to use long-TE (1)H MRS t...

journal_title：NMR in biomedicine

authors： Lundbom J,Hakkarainen A,Söderlund S,Westerbacka J,Lundbom N,Taskinen MR

更新日期：2011-04-01 00:00:00