Differences in metabolism of 5-fluorouracil and 5-fluorouridine and regulation by glucosamine in human colon cancer multicell tumor spheroids.

abstract：:Manganese ions (Mn(2+) ) enter viable myocardial cells via voltage-gated calcium channels. Because of its shortening of T(1) and its relatively long half-life in cells, Mn(2+) can serve as an intracellular molecular contrast agent to study indirect calcium influx into the myocardium. One major concern in using Mn(2+) ...

journal_title：NMR in biomedicine

authors： Hu TC,Chuang KH,Yanasak N,Koretsky A

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this paper is to facilitate the comparison of magnetic resonance (MR) spectra acquired from unknown brain lesions with published spectra in order to help identify unknown lesions in clinical settings. The paper includes lists of references for published MR spectra of various brain diseases, including py...

journal_title：NMR in biomedicine

authors： Kingsley PB,Shah TC,Woldenberg R

更新日期：2006-06-01 00:00:00

abstract：:An evaluation of the reproducibility and accuracy of the NMR human blood test for cancer described by Fossel, E. T., Carr, J. M. and McDonagh, J., (New England Journal of Medicine 315, 1369-1376) in 1986 has been conducted jointly at the National Cancer Institute-Frederick Cancer Research Facility, Frederick, MD (NCI-...

journal_title：NMR in biomedicine

authors： Chmurny GN,Hilton BD,Halverson D,McGregor GN,Klose J,Issaq HJ,Muschik GM,Urba WJ,Mellini ML,Costello R

更新日期：1988-06-01 00:00:00

abstract：:Glycine (Gly) has been implicated in several neurological disorders, including malignant brain tumors. The precise measurement of Gly is challenging largely as a result of the spectral overlap with myo-inositol (mI). We report a new triple-refocusing sequence for the reliable co-detection of Gly and mI at 3 T and for ...

journal_title：NMR in biomedicine

authors： Tiwari V,An Z,Ganji SK,Baxter J,Patel TR,Pan E,Mickey BE,Maher EA,Pinho MC,Choi C

更新日期：2017-09-01 00:00:00

abstract：:NMR relaxometry can provide information about the relaxation of the magnetization in different tissues, increasing our understanding of molecular dynamics and biochemical composition in biological systems. In general, tissues have complex and heterogeneous structures composed of multiple pools. As a result, bulk magne...

journal_title：NMR in biomedicine

authors： Zibetti MVW,Helou ES,Sharafi A,Regatte RR

更新日期：2020-12-01 00:00:00

abstract：:We have developed a reliable, reproducible model of hypoxia in the gerbil. 1H and 31P NMR spectroscopy demonstrates that cerebral energy metabolism is very resistant to hypoxia. Cerebral blood flow (measured by hydrogen clearance) began to increase when the arterial oxygen tension (paO2) was reduced to 40-50 mm Hg, an...

journal_title：NMR in biomedicine

authors： Allen K,Busza AL,Crockard HA,Gadian DG

更新日期：1992-01-01 00:00:00

abstract：:A number of NMR spectroscopic and microscopic MRI (microMRI) techniques were used to study proton dynamics in canine tendon and articular cartilage immersed in normal saline solution (NaCl solution) and high-concentration phosphate-buffered saline (PBS) solution. In a proton CPMG experiment on tendons, the T(2) relaxa...

journal_title：NMR in biomedicine

authors： Zheng S,Xia Y

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVES:Quantitative MRI (qMRI) of muscles is a promising tool to measure disease progression or to assess therapeutic effects in neuromuscular diseases. Longitudinal imaging studies are needed to show sensitivity of qMRI in detecting disease progression in spinal muscular atrophy (SMA). In this pilot study we there...

journal_title：NMR in biomedicine

authors： Otto LAM,Froeling M,van Eijk RPA,Asselman FL,Wadman R,Cuppen I,Hendrikse J,van der Pol WL

更新日期：2021-01-22 00:00:00

abstract：:An outline is presented of metabolite-specific in vivo NMR spectroscopy (particularly in brain). It reviews from a physical spectroscopist's perspective, the need for and the methods of observation of, individual metabolite resonances. ...

journal_title：NMR in biomedicine

authors： Allen PS,Thompson RB,Wilman AH

更新日期：1997-12-01 00:00:00

abstract：:Recent work has shown that solid-state (1) H and (31) P MRI can provide detailed insight into bone matrix and mineral properties, thereby potentially enabling differentiation of osteoporosis from osteomalacia. However, (31) P MRI of bone mineral is hampered by unfavorable relaxation properties. Hence, accurate knowled...

journal_title：NMR in biomedicine

authors： Seifert AC,Wright AC,Wehrli SL,Ong HH,Li C,Wehrli FW

更新日期：2013-09-01 00:00:00

abstract：:A novel polarizer based on the dissolution-dynamic nuclear polarization (DNP) method has been designed, built and tested. The polarizer differs from those previously described by being designed with sterile use intent and being compatible with clinical use. The main features are: (1) an integral, disposable fluid path...

journal_title：NMR in biomedicine

authors： Ardenkjaer-Larsen JH,Leach AM,Clarke N,Urbahn J,Anderson D,Skloss TW

更新日期：2011-10-01 00:00:00

abstract：:An effective method for in vivo detection of early therapeutic response of patients with non-Hodgkin's lymphoma would enable personalized clinical management of cancer therapy and facilitate the design of optimal treatment regimens. This study evaluates the feasibility of T(2)-weighted MRI (T2WI) and diffusion-weighte...

journal_title：NMR in biomedicine

authors： Huang MQ,Pickup S,Nelson DS,Qiao H,Xu HN,Li LZ,Zhou R,Delikatny EJ,Poptani H,Glickson JD

更新日期：2008-11-01 00:00:00

abstract：:Quantitative susceptibility mapping (QSM) is a recently developed MRI technique that provides a quantitative measure of tissue magnetic susceptibility. To compute tissue magnetic susceptibilities based on gradient echoes, QSM requires reliable unwrapping of the measured phase images and removal of contributions caused...

journal_title：NMR in biomedicine

authors： Li W,Avram AV,Wu B,Xiao X,Liu C

更新日期：2014-02-01 00:00:00

abstract：:The potential for using pre-polarized liquids as contrast agents in vivo is investigated and the feasibility of the method demonstrated. In this study we show the enhancement obtained following intravenous delivery of pre-polarized saline into the antecubital vein of a volunteer. This form of contrast agent provides s...

journal_title：NMR in biomedicine

authors： Young IR,deSouza NM,Hall AS,Williams AD,Hajnal JV,Coutts GA

更新日期：1999-10-01 00:00:00

abstract：:In this study, Blood Oxygenation Level Dependent (BOLD) contrast in the detection of human brain activation was compared between spin-echo and gradient-echo echo-planar sequences at 1.5 T. Time course series of spin-echo and gradient-echo images containing the primary motor cortex were collected during rest (no finger...

journal_title：NMR in biomedicine

authors： Bandettini PA,Wong EC,Jesmanowicz A,Hinks RS,Hyde JS

更新日期：1994-03-01 00:00:00

abstract：:Polycystic kidney disease (PKD) is a life-threatening disease that leads to a grotesque enlargement of the kidney and significant loss of function. Several imaging studies with MRI have demonstrated that cyst size in polycystic kidneys can determine disease severity and progression. In the present study, we found that...

journal_title：NMR in biomedicine

authors： Xie L,Qi Y,Subashi E,Liao G,Miller-DeGraff L,Jetten AM,Johnson GA

更新日期：2015-05-01 00:00:00

abstract：:By combining intravoxel incoherent motion (IVIM) and diffusion tensor imaging (DTI) we introduce a new diffusion model called intravoxel oriented flow (IVOF) that accounts for anisotropy of diffusion and the flow-related signal. An IVOF model using a simplified apparent flow fraction tensor (IVOFf ) is applied to diff...

journal_title：NMR in biomedicine

authors： Hilbert F,Bock M,Neubauer H,Veldhoen S,Wech T,Bley TA,Köstler H

更新日期：2016-10-01 00:00:00

abstract：:Exercise studies investigating the metabolic response of calf muscles using 31 P MRS are usually performed with a single knee angle. However, during natural movement, the distribution of workload between the main contributors to force, gastrocnemius and soleus is influenced by the knee angle. Hence, it is of interest ...

journal_title：NMR in biomedicine

authors： Niess F,Fiedler GB,Schmid AI,Laistler E,Frass-Kriegl R,Wolzt M,Moser E,Meyerspeer M

更新日期：2018-06-01 00:00:00

abstract：:MR spectroscopic imaging (MRSI) at ultra-high field (≥7 T) benefits from improved sensitivity that allows the detection of low-concentration metabolites in the brain. However, optimized acquisition techniques are required to overcome inherent limitations of MRSI at ultra-high field. This work describes an optimized me...

journal_title：NMR in biomedicine

authors： Coello E,Noeske R,Burns BL,Gordon JW,Jakary A,Menze B,Haase A,Larson PEZ,Li Y,Schulte RF

更新日期：2018-11-01 00:00:00

abstract：:The aim of this study was to investigate the diffusion time dependence of signal-versus-b curves obtained from diffusion-weighted magnetic resonance imaging (DW-MRI) of sub-acute ischaemic lesions in stroke patients. In this case series study, 16 patients with sub-acute ischaemic stroke were examined with DW-MRI using...

journal_title：NMR in biomedicine

authors： Lätt J,Nilsson M,van Westen D,Wirestam R,Ståhlberg F,Brockstedt S

更新日期：2009-07-01 00:00:00

abstract：:Acute hypoxia (transient cycles of hypoxia-reoxygenation) is known to occur in solid tumors and is generally believed to be caused by tumor blood flow instabilities. It was recently demonstrated that T2*-weighted (T2*w) gradient echo (GRE) MRI is a powerful non-invasive method for investigating periodic changes in tum...

journal_title：NMR in biomedicine

authors： Baudelet C,Cron GO,Ansiaux R,Crokart N,DeWever J,Feron O,Gallez B

更新日期：2006-02-01 00:00:00

abstract：PURPOSE:To develop a novel respiratory motion compensated three-dimensional (3D) cardiac magnetic resonance fingerprinting (cMRF) approach for whole-heart myocardial T1 and T2 mapping from a free-breathing scan. METHODS:Two-dimensional (2D) cMRF has been recently proposed for simultaneous, co-registered T1 and T2 mapp...

journal_title：NMR in biomedicine

authors： Cruz G,Jaubert O,Qi H,Bustin A,Milotta G,Schneider T,Koken P,Doneva M,Botnar RM,Prieto C

更新日期：2020-10-01 00:00:00

abstract：:133Cs NMR is a valuable tool for non-invasively probing biological systems. As a congener of potassium, it accumulates in the intracellular space, primarily through the action of the Na+-K+ pump (ATPase). In addition, it is possible to resolve the MR signal of 133Cs in different tissue compartments on the basis of che...

journal_title：NMR in biomedicine

authors： Goodman J,Neil JJ,Ackerman JJ

更新日期：2005-04-01 00:00:00

abstract：:T1ρ relaxation imaging is a quantitative imaging technique that has been used to assess cartilage integrity, liver fibrosis, tumors, cardiac infarction, and Alzheimer's disease. T1 , T2 , and T1ρ relaxation time constants have each demonstrated different degrees of sensitivity to several markers of fibrosis and inflam...

journal_title：NMR in biomedicine

authors： Wyatt CR,Barbara TM,Guimaraes AR

更新日期：2020-05-01 00:00:00

abstract：:The relaxation properties of water and metabolites were measured in rat brain following the occlusion of the middle cerebral artery (MCA) with localized 1H MRS. The PRESS sequence was employed to select volumes of 39 microL in the ischemic and the contralateral hemisphere. T1 and T2 relaxation times and peak intensiti...

journal_title：NMR in biomedicine

authors： van der Toorn A,Dijkhuizen RM,Tulleken CA,Nicolay K

更新日期：1995-09-01 00:00:00

abstract：:Metabolomic studies by NMR spectroscopy are increasingly employed for a variety of biomedical applications. A very standardized 1D proton NMR protocol is generally employed for data acquisition, associated with multivariate statistical tests. Even if targeted approaches have been proposed to quantify metabolites from ...

journal_title：NMR in biomedicine

authors： Martineau E,Tea I,Akoka S,Giraudeau P

更新日期：2012-08-01 00:00:00

abstract：:Proton magnetic resonance spectroscopy at 1.9 T was used to quantify dolichols, cholesterols, choline-containing phospholipids and double bonds in unsaturated acyl chains in lipid extracts of four types of thyroid tissue [normal (n = 27), papillary cancer (n = 15), adenoma (n = 13) and Basedow disease (n = 6)]. In nor...

journal_title：NMR in biomedicine

authors： Yoshioka Y,Sasaki J,Yamamoto M,Saitoh K,Nakaya S,Kubokawa M

更新日期：2000-11-01 00:00:00

abstract：:More than 50% of cancers fail to respond to any individual treatment and tumour follow-up after treatment plays a major role in routine therapy planning and pharmacological research. Today, MRS is the only technological approach providing non-invasive access to tumour biochemistry. Ten years ago, expectations were rai...

journal_title：NMR in biomedicine

authors： de Certaines JD,Larsen VA,Podo F,Carpinelli G,Briot O,Henriksen O

更新日期：1993-11-01 00:00:00

abstract：:This paper compares two spectral processing methods for obtaining quantitative measures from in vivo prostate spectra, evaluates their effectiveness, and discusses the necessary modifications for accurate results. A frequency domain analysis (FDA) method based on peak integration was compared with a time domain fittin...

journal_title：NMR in biomedicine

authors： Pels P,Ozturk-Isik E,Swanson MG,Vanhamme L,Kurhanewicz J,Nelson SJ,Van Huffel S

更新日期：2006-04-01 00:00:00

abstract：:One of the hallmarks of diffusion NMR and MRI is its ability to utilize restricted diffusion to probe compartments much smaller than the excited volume or the MRI voxel, respectively, and to extract microstructural information from them. Single-pulsed field gradient (s-PFG) MR methodologies have been employed with gre...

journal_title：NMR in biomedicine

authors： Shemesh N,Ozarslan E,Komlosh ME,Basser PJ,Cohen Y

更新日期：2010-08-01 00:00:00