Dynamic nuclear polarization polarizer for sterile use intent.

abstract：:Blood flow and phosphorus metabolites have been measured simultaneously in the murine RIF-1 tumour in vivo. Blood flow was measured using the H2 washout technique and 31P NMR spectroscopy was used to measure high energy phosphates, inorganic phosphate and intracellular pH within the tumour. Following NMR and flow meas...

journal_title：NMR in biomedicine

authors： Bhujwalla ZM,Tozer GM,Field SB,Proctor E,Busza A,Williams SR

更新日期：1990-08-01 00:00:00

abstract：:In this work, we report a case study of a stroke model in animals using two methods of quantification of the deviations from Gaussian behaviour: diffusion kurtosis imaging (DKI) and log-normal distribution function imaging (LNDFI). The affected regions were predominantly in grey rather than in white matter. The parame...

journal_title：NMR in biomedicine

authors： Grinberg F,Ciobanu L,Farrher E,Shah NJ

更新日期：2012-11-01 00:00:00

abstract：:Most ovarian tumors are cystic structures containing variable amounts of fluid. Several studies of ovarian cyst fluid focus on one specific metabolite using conventional assay systems. We examined the potential of (1)H-nuclear magnetic resonance spectroscopy in evaluation of the overall metabolic composition of cyst f...

journal_title：NMR in biomedicine

authors： Boss EA,Moolenaar SH,Massuger LF,Boonstra H,Engelke UF,de Jong JG,Wevers RA

更新日期：2000-08-01 00:00:00

abstract：:Diffusion tensor MRI (DTI) is a method for the noninvasive assessment of cellular organization and integrity in vivo. In this study, in vivo DTI was performed to demonstrate its ability to reflect photoreceptor cell alignment in adult C57BL/6 wild-type mice. Age-matched retinal degeneration 1 (rd1) mice were employed ...

journal_title：NMR in biomedicine

authors： Chen J,Wang Q,Chen S,Wickline SA,Song SK

更新日期：2011-06-01 00:00:00

abstract：:The measurement of pulmonary perfusion (blood delivered to the capillary bed within a voxel) using arterial spin labeling (ASL) magnetic resonance imaging is often complicated by signal artifacts from conduit vessels that carry blood destined for voxels at a distant location in the lung. One approach to dealing with c...

journal_title：NMR in biomedicine

authors： Walker SC,Asadi AK,Hopkins SR,Buxton RB,Prisk GK

更新日期：2015-09-01 00:00:00

abstract：:The present work aims to show the applicability of an analytical model for the optimisation of the STEAM sequence timing parameters for lactate detection at ultra high-field. The effects of the chemical shift displacement artefact on the J-modulated signal for a weakly-coupled spin system were considered in the three ...

journal_title：NMR in biomedicine

authors： Fernandes CC,Lanz B,Chen C,Morris PG,Salmon CG

更新日期：2020-11-02 00:00:00

abstract：:Proton magnetic resonance spectroscopy (MRS) was employed to determine the concentrations of N-acetylaspartate (NAA), total creatine (tCr), choline-containing compounds (Cho), myo-inositol (Ins), glucose (Glc), and lactate (Lac) in rat brain before and after 10 days of oral supplementation of 2.6 g Cr-monohydrate per ...

journal_title：NMR in biomedicine

authors： Michaelis T,Wick M,Fujimori H,Matsumura A,Frahm J

更新日期：1999-08-01 00:00:00

abstract：:We describe the optimal high-level postprocessing of single-voxel (1)H magnetic resonance spectra and assess the benefits and limitations of automated methods as diagnostic aids in the detection of recurrent brain tumor. In a previous clinical study, 90 long-echo-time single-voxel spectra were obtained from 52 patient...

journal_title：NMR in biomedicine

authors： Menze BH,Lichy MP,Bachert P,Kelm BM,Schlemmer HP,Hamprecht FA

更新日期：2006-08-01 00:00:00

abstract：:Mice are used in many studies to determine the role of genetic and molecular factors in mammalian development and human congenital diseases. MRI has emerged as a major method for analyzing mutant and transgenic phenotypes in developing mice, at both embryonic and neonatal stages. Progress in this area is reviewed, wit...

journal_title：NMR in biomedicine

authors： Turnbull DH,Mori S

更新日期：2007-05-01 00:00:00

abstract：:In many small animals there are distinct differences in fiber-type composition among limb muscles, and these differences typically correspond to marked disparities in the oxidative capacities. However, whether there are similar differences in the oxidative capacity among leg muscles in humans is less clear. The purpos...

journal_title：NMR in biomedicine

authors： Forbes SC,Slade JM,Francis RM,Meyer RA

更新日期：2009-12-01 00:00:00

abstract：:Hyperpolarised (HP) (13)C NMR allows enzymatic activity to be probed in real time in live biological systems. The use of in vitro models gives excellent control of the cellular environment, crucial in the understanding of enzyme kinetics. The increased conversion of pyruvate to lactate in cancer cells has been well st...

journal_title：NMR in biomedicine

authors： Breukels V,Jansen KC,van Heijster FH,Capozzi A,van Bentum PJ,Schalken JA,Comment A,Scheenen TW

更新日期：2015-08-01 00:00:00

abstract：:The cerebral blood volume (CBV) is a crucial physiological indicator of tissue viability and vascular reactivity. Thus, noninvasive CBV mapping has been of great interest. For this, ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, including monocrystalline iron oxide nanoparticles, can be used as long-ha...

journal_title：NMR in biomedicine

authors： Kim SG,Harel N,Jin T,Kim T,Lee P,Zhao F

更新日期：2013-08-01 00:00:00

abstract：:An outline is presented of metabolite-specific in vivo NMR spectroscopy (particularly in brain). It reviews from a physical spectroscopist's perspective, the need for and the methods of observation of, individual metabolite resonances. ...

journal_title：NMR in biomedicine

authors： Allen PS,Thompson RB,Wilman AH

更新日期：1997-12-01 00:00:00

abstract：:An MR thermometry method is proposed for measuring in vivo small temperature changes engendered by external RF heat sources. The method relies on reproducible and stable respiration and therefore currently applies to ventilated animals whose breathing is carefully controlled. It first consists in characterizing the st...

journal_title：NMR in biomedicine

authors： Boulant N,Bottlaender M,Uhrig L,Giacomini E,Luong M,Amadon A,Massire A,Larrat B,Vignaud A

更新日期：2015-01-01 00:00:00

abstract：:In order to investigate intervertebral disc (IVD) degeneration and repair, a quantitative non-invasive tool is needed. Various MRI methods including qCPMG, which yields dipolar echo relaxation time (T(DE)), magnetization transfer contrast (MTC), and (1)H and (2)H double quantum filtered (DQF) MRI were used in the pres...

journal_title：NMR in biomedicine

authors： Saar G,Zilberman Y,Shinar H,Keinan-Adamsky K,Pelled G,Gazit D,Navon G

更新日期：2010-07-01 00:00:00

abstract：:In this study, metabolic changes in the 79A/C3H, ME7/VM, ME7/C3H, 87V/VM and 22A/SV scrapie mouse models were investigated during the clinical phase of the disease, using in vitro proton nuclear magnetic resonance spectroscopy. N-acetyl-aspartate was found to be significantly reduced in infected mice of the ME7/ C3H (...

journal_title：NMR in biomedicine

authors： Chung YL,Williams A,Chong A,Hope J,Williams SC,Bell JD

更新日期：1996-12-01 00:00:00

abstract：:Progress in the development of non-proton NMR applications in medical research has been hampered by the generally low sensitivity of these nuclides as well as the lack of instrumentation readily available for studying these spins. For example, custom head coils suitable for sodium imaging of the human head are either ...

journal_title：NMR in biomedicine

authors： Lim KO,Wolff S,Balaban RS

更新日期：1989-09-01 00:00:00

abstract：:Bone contains a significant fraction of water that is not detectable with ordinary Cartesian imaging sequences. The advent of ultra-short echo-time (UTE) methods has allowed the recovery of this submillisecond T(2)* water. In this work, we have developed a new three-dimensional hybrid-radial ultra-short echo-time (3D ...

journal_title：NMR in biomedicine

authors： Rad HS,Lam SC,Magland JF,Ong H,Li C,Song HK,Love J,Wehrli FW

更新日期：2011-08-01 00:00:00

abstract：:The current study aims to evaluate the feasibility of creatine (Cr) chemical exchange saturation transfer (CEST)-weighted MRI at 7 T in the human brain by optimizing the saturation pulse parameters and computing contrast using a Z-spectral fitting approach. The Cr-weighted (Cr-w) CEST contrast was computed from phanto...

journal_title：NMR in biomedicine

authors： Singh A,Debnath A,Cai K,Bagga P,Haris M,Hariharan H,Reddy R

更新日期：2019-12-01 00:00:00

abstract：:The purpose of the present study was to characterize the metabolic profile of the visual cortex in streptozotocin-induced Type 1 diabetic rats by means of in vivo proton MRS. Several metabolite concentration ratios in the visual cortex were calculated. In addition, postmortem histologic analyses for retinal ganglion c...

journal_title：NMR in biomedicine

authors： Li S,Wang X,Yang J,Lei H,Wang X,Xiang Y

更新日期：2017-11-01 00:00:00

abstract：:MRS provides a valuable tool for the non-invasive detection of brain γ-aminobutyric acid (GABA) in vivo. GABAergic dysfunction has been observed in the aging cerebellum. The study of cerebellar GABA changes is of considerable interest in understanding certain age-related motor disorders. However, little is known about...

journal_title：NMR in biomedicine

authors： Long Z,Dyke JP,Ma R,Huang CC,Louis ED,Dydak U

更新日期：2015-10-01 00:00:00

abstract：:Electric properties tomography (EPT) derives the patient's electric properties, i.e. conductivity and permittivity, using standard magnetic resonance (MR) systems and standard MR sequences. Thus, EPT does not apply externally mounted electrodes, currents or radiofrequency (RF) probes, as is the case in competing techn...

journal_title：NMR in biomedicine

authors： Katscher U,van den Berg CAT

更新日期：2017-08-01 00:00:00

abstract：:The aim of this study was to measure choline/creatine (Ch/Cr) levels through (1)H-MRS and apparent diffusion coefficient (ADC) values through diffusion-weighted MRI, and to correlate these values with the prognostic parameters of head and neck squamous cell carcinoma (HNSCC). The institutional review board approved th...

journal_title：NMR in biomedicine

authors： Razek AA,Nada N

更新日期：2016-04-01 00:00:00

abstract：:Following the development of parallel imaging, parallel transmission describes the use of multiple RF transmit coils. Parallel transmission can be applied to improve RF excitation, in particular, multidimensional, spatially selective RF excitation. For instance, parallel transmission is able to shorten spatially selec...

journal_title：NMR in biomedicine

authors： Katscher U,Börnert P

更新日期：2006-05-01 00:00:00

abstract：:The background underpinning the clinical use of ultrashort echo time, SPRITE and other pulse sequences for imaging bone and other connective tissues with short T2 is reviewed. Features of the basic physics relevant to UTE imaging are described, including the consequences when the radiofrequency pulse duration is of th...

journal_title：NMR in biomedicine

authors： Robson MD,Bydder GM

更新日期：2006-11-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) in pregnancy is commonly undertaken in the left lateral tilt (LLT) position to prevent inferior vena cava (IVC) compression and supine hypotensive events, although this may be suboptimal for image quality. The supine position may also have an adverse effect on fetal well-being. The spi...

journal_title：NMR in biomedicine

authors： Hughes EJ,Price AN,McCabe L,Hiscocks S,Waite L,Green E,Hutter J,Pegoretti K,Cordero-Grande L,Edwards DA,Hajnal JV,Rutherford MA

更新日期：2021-01-21 00:00:00

abstract：:Wilms' tumours (WTs) are large heterogeneous tumours, which typically consist of a mixture of histological cell types, together with regions of chemotherapy-induced regressive change and necrosis. The predominant cell type in a WT is assessed histologically following nephrectomy, and used to assess the tumour subtype ...

journal_title：NMR in biomedicine

authors： Hales PW,Olsen ØE,Sebire NJ,Pritchard-Jones K,Clark CA

更新日期：2015-08-01 00:00:00

abstract：:Magnetic resonance elastography (MRE) is a non-invasive imaging technique used to visualise and quantify mechanical properties of tissue, providing information beyond what can be currently achieved with standard MR sequences and could, for instance, provide new insight into pathological processes in the brain. This st...

journal_title：NMR in biomedicine

authors： Green MA,Bilston LE,Sinkus R

更新日期：2008-08-01 00:00:00

abstract：:Increased sensitivity and chemical shift dispersion at ultra-high magnetic fields enable the precise quantification of an extended range of brain metabolites from (1)H MRS. However, all previous neurochemical profiling studies using single-voxel MRS at 7 T have been limited to data acquired from the occipital lobe wit...

journal_title：NMR in biomedicine

authors： Emir UE,Auerbach EJ,Van De Moortele PF,Marjańska M,Uğurbil K,Terpstra M,Tkáč I,Oz G

更新日期：2012-01-01 00:00:00

abstract：:MR Z-spectroscopy allows enhanced imaging contrast on the basis of saturation transfer between the proton pools of cellular compounds and water, occurring via chemical exchange (chemical exchange saturation transfer, CEST) or dipole-dipole coupling (nuclear Overhauser effect, NOE). In previous studies, signals observe...

journal_title：NMR in biomedicine

authors： Zaiss M,Kunz P,Goerke S,Radbruch A,Bachert P

更新日期：2013-12-01 00:00:00