Abstract:
:Magnetic resonance elastography (MRE) is a non-invasive imaging technique used to visualise and quantify mechanical properties of tissue, providing information beyond what can be currently achieved with standard MR sequences and could, for instance, provide new insight into pathological processes in the brain. This study uses the MRE technique at 3 T to extract the complex shear modulus for in vivo brain tissue utilizing a full three-dimensional approach to reconstruction, removing contributions of the dilatational wave by application of the curl operator. A calibrated phantom is used to benchmark the MRE measurements, and in vivo results are presented for healthy volunteers. The results provide data for in vivo brain storage modulus (G'), finding grey matter (3.1 kPa) to be significantly stiffer than white matter (2.7 kPa). The first in vivo loss modulus (G'') measurements show no significant difference between grey matter (2.5 kPa) and white matter (2.5 kPa).
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Green MA,Bilston LE,Sinkus Rdoi
10.1002/nbm.1254subject
Has Abstractpub_date
2008-08-01 00:00:00pages
755-64issue
7eissn
0952-3480issn
1099-1492journal_volume
21pub_type
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