Abstract:
:In vivo 1H MRS is rapidly developing as a clinical tool for diagnosing and characterizing breast cancers. Many in vivo and in vitro experiments have demonstrated that alterations in concentrations of choline-containing metabolites are associated with malignant transformation. In recent years, considerable efforts have been made to evaluate the role of 1H MRS measurements of total choline-containing compounds in the management of patients with breast cancer. Current technological developments, including the use of high-field MR scanners and quantitative spectroscopic analysis methods, promise to increase the sensitivity and accuracy of breast MRS. This article reviews the literature describing in vivo MRS in breast cancer, with an emphasis on the development of high-field MR scanning and quantitative methods. Potential applications of these technologies for diagnosing suspicious lesions and monitoring response to chemotherapy are discussed.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Haddadin IS,McIntosh A,Meisamy S,Corum C,Styczynski Snyder AL,Powell NJ,Nelson MT,Yee D,Garwood M,Bolan PJdoi
10.1002/nbm.1217subject
Has Abstractpub_date
2009-01-01 00:00:00pages
65-76issue
1eissn
0952-3480issn
1099-1492journal_volume
22pub_type
杂志文章,评审abstract::A recent analysis of the optimization of magnetization transfer experiments to estimate first-order rate constants is extended to the design of experiments for measuring these constants and T1 when both parameters are initially unknown. When the number of measurement times is fixed, an optimal design will consist of a...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(SICI)1099-1492(199605)9:3<135::AID-NBM404
更新日期:1996-05-01 00:00:00
abstract::In this study the conjugated macromolecular ligand, diethylenetriaminepentaacetic acid (DTPA)-amide-dextran, was synthesized by attaching DTPA to the dextran macromolecule (M(r) approximately 6000) by a covalent amide bond. Subsequently, DTPA-amide-dextran was complexed with either of the two lanthanide metal ions dys...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940080404
更新日期:1995-06-01 00:00:00
abstract::The goal of this study was to validate metabolite quantification at short TE, with particular focus on how to best account for the macromolecular signal contribution. A robust, short-TE PRESS protocol is presented, which allows reliable quantification, in vivo, of metabolite signals at 3 T in human brain. Water suppre...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1219
更新日期:2008-06-01 00:00:00
abstract::Natural abundance proton-decoupled (13)C magnetic resonance spectroscopy was used to establish the in vivo lipid composition of normal adipose tissue and the corresponding effects of altered lipid diets. Experiments were performed on a standard 1.5 T clinical MR scanner using a double-tuned (1)H-(13)C coil. Peaks from...
journal_title:NMR in biomedicine
pub_type: 临床试验,杂志文章
doi:10.1002/nbm.824
更新日期:2003-05-01 00:00:00
abstract::Evaluation of high intensity focused ultrasound (HIFU) treatment with MRI is generally based on assessment of the non-perfused volume from contrast-enhanced T1-weighted images. However, the vascular status of tissue surrounding the non-perfused volume has not been extensively investigated with MRI. In this study, clus...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3406
更新日期:2015-11-01 00:00:00
abstract::The purpose of the present study was to characterize the metabolic profile of the visual cortex in streptozotocin-induced Type 1 diabetic rats by means of in vivo proton MRS. Several metabolite concentration ratios in the visual cortex were calculated. In addition, postmortem histologic analyses for retinal ganglion c...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3783
更新日期:2017-11-01 00:00:00
abstract::An evaluation of the reproducibility and accuracy of the NMR human blood test for cancer described by Fossel, E. T., Carr, J. M. and McDonagh, J., (New England Journal of Medicine 315, 1369-1376) in 1986 has been conducted jointly at the National Cancer Institute-Frederick Cancer Research Facility, Frederick, MD (NCI-...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940010307
更新日期:1988-06-01 00:00:00
abstract::The steady-state distribution of the general anesthetic halothane in different rat tissues, including a renal adenocarcinoma with and without hyperthermia treatment, has been evaluated by in vivo 19F NMR spectroscopy. The 19F spectra of halothane (which is a hydrophobic probe) from within tissue show differences in th...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940060502
更新日期:1993-09-01 00:00:00
abstract::This study investigated the association between the total choline (tCho) concentration and the clinical characteristics and biomarker status of breast cancer. Sixty-two patients with breast cancer, 1.5 cm or larger in size on MR images, were studied. The tCho concentration was correlated with the MRI features, contra...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1595
更新日期:2011-04-01 00:00:00
abstract::In recent years considerable effort has been devoted to applying pattern recognition techniques to the complex task of data analysis in magnetic resonance spectroscopy. It may be argued that such techniques will facilitate putting MRS technology to practical clinical use. This paper reviews approaches of pattern recog...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1492(199705)10:3<99::aid-nbm461
更新日期:1997-05-01 00:00:00
abstract::Detailed (1)H and (13)C NMR spectroscopy of lipid extracts from 12 human intracranial tuberculomas and two control brain tissue samples was performed to assess the role of lipids in the disease process. One-dimensional and two-dimensional NMR techniques were used to resolve the mixture of lipid components and make res...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1191
更新日期:2008-03-01 00:00:00
abstract::Magnetic resonance elastography (MRE) is a non-invasive imaging technique used to visualise and quantify mechanical properties of tissue, providing information beyond what can be currently achieved with standard MR sequences and could, for instance, provide new insight into pathological processes in the brain. This st...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1254
更新日期:2008-08-01 00:00:00
abstract::Diffusion tensor imaging (DTI) has been employed for over 2 decades to noninvasively quantify central nervous system diseases/injuries. However, DTI is an inadequate simplification of diffusion modeling in the presence of coexisting inflammation, edema and crossing nerve fibers. We employed a tissue phantom using fixe...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4414
更新日期:2021-01-01 00:00:00
abstract::The dependence of apparent diffusion coefficients (ADCs) of molecules in biological tissues on an acquisition-specific timescale is a powerful mechanism for studying tissue microstructure. Unlike water, metabolites are confined mainly to intracellular compartments, thus providing higher specificity to tissue microstru...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3085
更新日期:2014-05-01 00:00:00
abstract::The aim of this study was to evaluate the change of breast density in the normal breast of patients receiving neoadjuvant chemotherapy (NAC). Forty-four breast cancer patients were studied. MRI acquisition was performed before treatment (baseline), and 4 and 12 weeks after treatment. A computer-algorithm-based program...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3006
更新日期:2013-12-01 00:00:00
abstract::We describe the optimal high-level postprocessing of single-voxel (1)H magnetic resonance spectra and assess the benefits and limitations of automated methods as diagnostic aids in the detection of recurrent brain tumor. In a previous clinical study, 90 long-echo-time single-voxel spectra were obtained from 52 patient...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1041
更新日期:2006-08-01 00:00:00
abstract::The cerebral blood volume (CBV) is a crucial physiological indicator of tissue viability and vascular reactivity. Thus, noninvasive CBV mapping has been of great interest. For this, ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles, including monocrystalline iron oxide nanoparticles, can be used as long-ha...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.2885
更新日期:2013-08-01 00:00:00
abstract::This introductory article addresses approaches currently in use to process in vivo spectra. First, a brief overview is given of the information content represented by the parameters of MR signals. Subsequently, common steps in the processing of MR spectra such as pre-processing, normalisation and quantification and th...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.707
更新日期:2001-06-01 00:00:00
abstract::Quantitative magnetisation transfer imaging (qMTI) is an extension of conventional MT techniques and allows the measurement of parameters that reflect tissue ultrastructure through the properties of macromolecule-bound protons; these include the bound proton fraction and the relaxation times of free and bound proton p...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1614
更新日期:2011-06-01 00:00:00
abstract::Citicoline supplementation has been used to ameliorate memory disturbances in older people and those with Alzheimer's disease. This study used MRS to characterize the effects of citicoline on high-energy phosphate metabolites and constituents of membrane synthesis in the frontal lobe. Phosphorus ((31)P) metabolite dat...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1281
更新日期:2008-11-01 00:00:00
abstract::In order to investigate intervertebral disc (IVD) degeneration and repair, a quantitative non-invasive tool is needed. Various MRI methods including qCPMG, which yields dipolar echo relaxation time (T(DE)), magnetization transfer contrast (MTC), and (1)H and (2)H double quantum filtered (DQF) MRI were used in the pres...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1493
更新日期:2010-07-01 00:00:00
abstract::One of the most commonly used methods for in vivo MRS detection of γ-aminobutyric acid (GABA) is the MEGA-point-resolved spectroscopy (MEGA-PRESS) technique. However, accurate quantification of GABA using MEGA-PRESS is complicated by spectral co-editing of macromolecular resonances. In this article, a new pulse sequen...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1688
更新日期:2011-12-01 00:00:00
abstract::Changes in physiological parameters such as cerebral blood flow, cerebral blood volume, oxygen extraction, and the size and distribution of cerebral blood vessels, result in changes in the local concentration of deoxyhaemoglobin ([dHb]). The purpose of this study was to quantitatively investigate the dependence of the...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199810)11:6<281::aid-nbm52
更新日期:1998-10-01 00:00:00
abstract::We show how quantitative information about proton handling in human skeletal muscle in exercise and recovery can be obtained by 31P MRS and illustrate this with data from metabolic disorders. Proton production, proton efflux and passive buffering can be distinguished by comparing changes in [phosphocreatine] and pH at...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940060112
更新日期:1993-01-01 00:00:00
abstract::A novel iodoacetamide label 4-perfluoro-tert-butyl-phenyliodoacetamide (PFP) containing nine fluorine atoms in equivalent positions has been synthesized. It provides a homogeneous 19F NMR resonance line which can be detected with high sensitivity when coupled to proteins. As an example, the sulfhydryl groups of actin ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940050605
更新日期:1992-11-01 00:00:00
abstract::In recent years, quantitative nuclear magnetic resonance imaging and spectroscopy (NMRI and NMRS) have been used more systematically as outcome measures in natural history and clinical trial studies for Duchenne muscular dystrophy (DMD). Whereas most of these studies have emphasized the evaluation of the fat fraction ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3839
更新日期:2018-01-01 00:00:00
abstract::The phosphorus NMR spectra of isolated perfused rat liver displays a prominent inorganic phosphate peak at 2.76 +/- 0.05 ppm relative to liver glycerolphosphocholine at 0.49 ppm. From titration curves of phosphorus-containing compounds this corresponds to a pH of 7.4. The spectra also display a shoulder on the promine...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940010207
更新日期:1988-04-01 00:00:00
abstract::We introduce a new protocol to obtain very high-frame-rate cinematographic (Cine) MRI movies of the beating mouse heart within a reasonable measurement time. The method is based on a self-gated accelerated fast low-angle shot (FLASH) acquisition and compressed sensing reconstruction. Key to our approach is that we exp...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2883
更新日期:2013-04-01 00:00:00
abstract::One of the hallmarks of diffusion NMR and MRI is its ability to utilize restricted diffusion to probe compartments much smaller than the excited volume or the MRI voxel, respectively, and to extract microstructural information from them. Single-pulsed field gradient (s-PFG) MR methodologies have been employed with gre...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1550
更新日期:2010-08-01 00:00:00
abstract::Following the impetus of early clinical and experimental investigations, in vivo and in vitro MRS studies of tumours pointed in the eighties to the possible significance of signals arising from phospholipid (PL) precursors and catabolites as novel biochemical indicators of in vivo tumour progression and response to th...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1099-1492(199911)12:7<413::aid-nbm58
更新日期:1999-11-01 00:00:00