pH and compartmentation of isolated perfused rat liver studied by 31P and 19F NMR.

abstract：:Metabolic activity in the lung is known to change in response to external insults, inflammation, and cancer. We report measurements of metabolism in the isolated, perfused rat lung of healthy controls and in diseased lungs undergoing acute inflammation using hyperpolarized 1-(13) C-labeled pyruvate. The overall appare...

journal_title：NMR in biomedicine

authors： Shaghaghi H,Kadlecek S,Deshpande C,Siddiqui S,Martinez D,Pourfathi M,Hamedani H,Ishii M,Profka H,Rizi R

更新日期：2014-08-01 00:00:00

abstract：:We introduce a new protocol to obtain very high-frame-rate cinematographic (Cine) MRI movies of the beating mouse heart within a reasonable measurement time. The method is based on a self-gated accelerated fast low-angle shot (FLASH) acquisition and compressed sensing reconstruction. Key to our approach is that we exp...

journal_title：NMR in biomedicine

authors： Motaal AG,Coolen BF,Abdurrachim D,Castro RM,Prompers JJ,Florack LM,Nicolay K,Strijkers GJ

更新日期：2013-04-01 00:00:00

abstract：:In this study, Blood Oxygenation Level Dependent (BOLD) contrast in the detection of human brain activation was compared between spin-echo and gradient-echo echo-planar sequences at 1.5 T. Time course series of spin-echo and gradient-echo images containing the primary motor cortex were collected during rest (no finger...

journal_title：NMR in biomedicine

authors： Bandettini PA,Wong EC,Jesmanowicz A,Hinks RS,Hyde JS

更新日期：1994-03-01 00:00:00

abstract：:Development and evaluation of new anticancer drugs are expedited when minimally invasive biomarkers of pharmacokinetic and pharmacodynamic behaviour are available. Gene-directed enzyme prodrug therapy (GDEPT) is a suicide gene therapy in which the anticancer drug is activated in the tumor by an exogenous enzyme previo...

journal_title：NMR in biomedicine

authors： Mancini L,Davies L,Friedlos F,Falck-Miniotis M,Dzik-Jurasz AS,Springer CJ,Leach MO,Payne GS

更新日期：2009-06-01 00:00:00

abstract：:Quantitative susceptibility mapping (QSM) is a recently developed MRI technique that provides a quantitative measure of tissue magnetic susceptibility. To compute tissue magnetic susceptibilities based on gradient echoes, QSM requires reliable unwrapping of the measured phase images and removal of contributions caused...

journal_title：NMR in biomedicine

authors： Li W,Avram AV,Wu B,Xiao X,Liu C

更新日期：2014-02-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is characterized at histology by steatosis, hepatocyte ballooning and inflammatory infiltrates, with or without fibrosis. Although diamagnetic material in fibrosis and inflammation can be detected with quantitative susceptibility imaging, fatty acid composition changes in NASH rela...

journal_title：NMR in biomedicine

authors： Leporq B,Lambert SA,Ronot M,Vilgrain V,Van Beers BE

更新日期：2017-10-01 00:00:00

abstract：:Resolution enhancement for glutamate (Glu), glutamine (Gln) and glutathione (GSH) in the human brain by TE-optimized point-resolved spectroscopy (PRESS) at 7 T is reported. Sub-TE dependences of the multiplets of Glu, Gln, GSH, γ-aminobutyric acid (GABA) and N-acetylaspartate (NAA) at 2.2-2.6 ppm were investigated wit...

journal_title：NMR in biomedicine

authors： Choi C,Dimitrov IE,Douglas D,Patel A,Kaiser LG,Amezcua CA,Maher EA

更新日期：2010-11-01 00:00:00

abstract：:The current state-of-the-art diagnosis method for deep tissue injury in muscle, a subcategory of pressure ulcers, is palpation. It is recognized that deep tissue injury is frequently preceded by altered biomechanical properties. A quantitative understanding of the changes in biomechanical properties preceding and duri...

journal_title：NMR in biomedicine

authors： Nelissen JL,Sinkus R,Nicolay K,Nederveen AJ,Oomens CWJ,Strijkers GJ

更新日期：2019-06-01 00:00:00

abstract：:The signal decay with increasing b-factor at fixed echo time from brain tissue in vivo has been measured using a line scan Stejskal-Tanner spin echo diffusion approach in eight healthy adult volunteers. The use of a 175 ms echo time and maximum gradient strengths of 10 mT/m allowed 64 b-factors to be sampled, ranging ...

journal_title：NMR in biomedicine

authors： Mulkern RV,Gudbjartsson H,Westin CF,Zengingonul HP,Gartner W,Guttmann CR,Robertson RL,Kyriakos W,Schwartz R,Holtzman D,Jolesz FA,Maier SE

更新日期：1999-02-01 00:00:00

abstract：:The application of diffusion tensor imaging (DTI) to the evaluation of developing brain remains an area of active investigation. This review focuses on the changes in DTI parameters which accompany both brain maturation and injury. The two primary pieces of information available from DTI studies-water apparent diffusi...

journal_title：NMR in biomedicine

authors： Neil J,Miller J,Mukherjee P,Hüppi PS

更新日期：2002-11-01 00:00:00

abstract：:This paper describes the development of a novel technique for functional MRI of the human brain at 0.135 microL resolution for a whole brain section. In comparison with conventional studies at 3 mm isotropic resolution or 27 microL voxel size, the method yields an improvement by a factor of 200. To achieve optimum ima...

journal_title：NMR in biomedicine

authors： Voit D,Frahm J

更新日期：2005-12-01 00:00:00

abstract：:Q-ball imaging (QBI) is an imaging technique that is capable of resolving intravoxel fiber crossings; however, the signal readout based on echo-planar imaging (EPI) introduces geometric distortions in the presence of susceptibility gradients. This study proposes an imaging technique that reduces susceptibility distort...

journal_title：NMR in biomedicine

authors： Chou MC,Huang TY,Chung HW,Hsieh TJ,Chang HC,Chen CY

更新日期：2013-12-01 00:00:00

abstract：:The applications of in vivo electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy have been impressive over a relatively short period despite the many obstacles which had to be overcome, such as dielectric absorption and biodestruction. The loop-gap resonators and modified loop coil syste...

journal_title：NMR in biomedicine

authors： Fujii H,Berliner LJ

更新日期：2004-08-01 00:00:00

abstract：:Diffusion tensor MRI (DTI) is a method for the noninvasive assessment of cellular organization and integrity in vivo. In this study, in vivo DTI was performed to demonstrate its ability to reflect photoreceptor cell alignment in adult C57BL/6 wild-type mice. Age-matched retinal degeneration 1 (rd1) mice were employed ...

journal_title：NMR in biomedicine

authors： Chen J,Wang Q,Chen S,Wickline SA,Song SK

更新日期：2011-06-01 00:00:00

abstract：:Spin-exchange NMR techniques enable the measurement of the rates of exchange of solutes between chemically or physically distinct sites in reactions taking place at chemical equilibrium. The time scale of the events that are able to be investigated lies in the neighbourhood of 1 s. The earliest studies in this area of...

journal_title：NMR in biomedicine

authors： Kuchel PW

更新日期：1990-06-01 00:00:00

abstract：:The performance of multichannel transmit coil layouts and parallel transmission (pTx) RF pulse design was evaluated with respect to transmit B1 (B1 (+)) homogeneity and specific absorption rate (SAR) at 3 T for a whole body coil. Five specific coils were modeled and compared: a 32-rung birdcage body coil (driven eithe...

journal_title：NMR in biomedicine

authors： Wu X,Zhang X,Tian J,Schmitter S,Hanna B,Strupp J,Pfeuffer J,Hamm M,Wang D,Nistler J,He B,Vaughan TJ,Ugurbil K,Van de Moortele PF

更新日期：2015-10-01 00:00:00

abstract：:Given the importance of genetically modified mice in studies of mammalian brain development and human congenital brain diseases, MRI has the potential to provide an efficient in vivo approach for analyzing mutant phenotypes in the early postnatal mouse brain. The combination of reduced tissue contrast at the high magn...

journal_title：NMR in biomedicine

authors： Wadghiri YZ,Blind JA,Duan X,Moreno C,Yu X,Joyner AL,Turnbull DH

更新日期：2004-12-01 00:00:00

abstract：:Free cytosolic [Mg2+] can be assessed in vivo by 31P MRS from the chemical shift of beta-ATP which in turn depends on the fraction of total ATP complexed to Mg2+ ions. The reliability of these in vivo measurements depends on the availability of an appropriate in vitro calibration to determine the limits of chemical sh...

journal_title：NMR in biomedicine

authors： Iotti S,Frassineti C,Alderighi L,Sabatini A,Vacca A,Barbiroli B

更新日期：1996-02-01 00:00:00

abstract：:We show how quantitative information about proton handling in human skeletal muscle in exercise and recovery can be obtained by 31P MRS and illustrate this with data from metabolic disorders. Proton production, proton efflux and passive buffering can be distinguished by comparing changes in [phosphocreatine] and pH at...

journal_title：NMR in biomedicine

authors： Kemp GJ,Taylor DJ,Styles P,Radda GK

更新日期：1993-01-01 00:00:00

abstract：:We review several methods that have been developed to infer microstructural and physiological information about isotropic and anisotropic tissues from diffusion weighted images (DWIs). These include Diffusion Imaging (DI), Diffusion Tensor Imaging (DTI), isotropically weighted imaging, and q-space imaging. Just as DI ...

journal_title：NMR in biomedicine

authors： Basser PJ

更新日期：1995-11-01 00:00:00

abstract：:The sodium-calcium exchanger (NCX) is one of the transporters contributing to the control of intracellular calcium (Ca(2+)) concentration by normally mediating net Ca(2+) efflux. However, the reverse mode of the NCX can cause intracellular Ca(2+) concentration overload, which exacerbates the myocardial tissue injury r...

journal_title：NMR in biomedicine

authors： Waghorn B,Yang Y,Baba A,Matsuda T,Schumacher A,Yanasak N,Hu TC

更新日期：2009-10-01 00:00:00

abstract：:MRI and MRS in small rodents demand very high sensitivity. Cryogenic transmit/receive radiofrequency probes (CryoProbes) designed for (1) H MRI of mouse brain provide an attractive option for increasing the performance of small-animal MR systems. As the Larmor frequency of (13) C nuclei is four times lower than that f...

journal_title：NMR in biomedicine

authors： Sack M,Wetterling F,Sartorius A,Ende G,Weber-Fahr W

更新日期：2014-06-01 00:00:00

abstract：:Acute kidney injury (AKI) in mice caused by sustained ischemia followed by reperfusion is associated with acute tubular necrosis and renal dysfunctional blood flow. Although the principal role of the kidney is the maintenance of acid-base balance, current imaging approaches are unable to assess this important paramete...

journal_title：NMR in biomedicine

authors： Longo DL,Cutrin JC,Michelotti F,Irrera P,Aime S

更新日期：2017-07-01 00:00:00

abstract：:The purpose of this study was to identify the optimal tracer kinetic model from T1 -weighted dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data and evaluate whether parameters estimated from the optimal model predict tumor aggressiveness determined from histopathology in patients with papillary thyroi...

journal_title：NMR in biomedicine

authors： Paudyal R,Lu Y,Hatzoglou V,Moreira A,Stambuk HE,Oh JH,Cunanan KM,Aramburu Nunez D,Mazaheri Y,Gonen M,Ho A,Fagin JA,Wong RJ,Shaha A,Tuttle RM,Shukla-Dave A

更新日期：2020-01-01 00:00:00

abstract：:13C MRS was installed on a clinical scanner at 1.5 T in order to facilitate integrated MR examinations of human brain disorders. Using a simplified protocol, (1-(13)C) glucose and/or (1-(13)C) acetate were administered orally or by intravenous infusion. (13)C spectra of diagnostic quality were acquired in more than 10...

journal_title：NMR in biomedicine

authors： Ross B,Lin A,Harris K,Bhattacharya P,Schweinsburg B

更新日期：2003-10-01 00:00:00

abstract：:Qualitative and quantitative (1) H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) (n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) (n = 9) and gallbladder cancer (GBC, malignant) (n = 8) was carried out to understand the mechanisms involved in the transformati...

journal_title：NMR in biomedicine

authors： Jayalakshmi K,Sonkar K,Behari A,Kapoor VK,Sinha N

更新日期：2011-05-01 00:00:00

abstract：:Dynamic contrast-enhanced MRI (DCE MRI) has been used to study tumor response to treatment for many years. In this study, the modified full width at half-maximum (mFWHM), calculated from the wash-in slope histogram, is proposed as a parameter for the evaluation of changes in tumor heterogeneity which respond to radiot...

journal_title：NMR in biomedicine

authors： Peng SL,Chen CF,Liu HL,Lui CC,Huang YJ,Lee TH,Chang CC,Wang FN

更新日期：2013-04-01 00:00:00

abstract：:Polycystic kidney disease (PKD) is a life-threatening disease that leads to a grotesque enlargement of the kidney and significant loss of function. Several imaging studies with MRI have demonstrated that cyst size in polycystic kidneys can determine disease severity and progression. In the present study, we found that...

journal_title：NMR in biomedicine

authors： Xie L,Qi Y,Subashi E,Liao G,Miller-DeGraff L,Jetten AM,Johnson GA

更新日期：2015-05-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of gadolinium (III) diethyltriaminepenta-acetic acid (Gd-DTPA) mixed with a fixative on the image contrast between the white and gray matter of the perfusion-fixed mouse brain. A series of microscopic MRI (microMRI) studies using different concentrations of Gd-DT...

journal_title：NMR in biomedicine

authors： Kim S,Pickup S,Hsu O,Poptani H

更新日期：2009-04-01 00:00:00

abstract：:A noise figure and noise parameter measurement system was developed that consists of a combination spectrum and network analyzer, preamplifier, programmable power supply, noise source, tuning board, and desktop computer. The system uses the Y-factor method for noise figure calculation and allows calibrations to correc...

journal_title：NMR in biomedicine

authors： Lagore RL,Roberts BR,Possanzini C,Saylor C,Fallone BG,De Zanche N

更新日期：2014-08-01 00:00:00