The production, buffering and efflux of protons in human skeletal muscle during exercise and recovery.

abstract：:In this study the conjugated macromolecular ligand, diethylenetriaminepentaacetic acid (DTPA)-amide-dextran, was synthesized by attaching DTPA to the dextran macromolecule (M(r) approximately 6000) by a covalent amide bond. Subsequently, DTPA-amide-dextran was complexed with either of the two lanthanide metal ions dys...

journal_title：NMR in biomedicine

authors： Chu WJ,Elgavish GA

更新日期：1995-06-01 00:00:00

abstract：:Spatiotemporally structured noise, such as physiological noise, is a potential source of artifacts in functional magnetic resonance imaging (fMRI) and is the main limiting factor for the detection of small blood oxygen level-dependent (BOLD) signal variations. fMRI was employed to detect low-frequency BOLD signal fluc...

journal_title：NMR in biomedicine

authors： Goerke U,Möller HE,Norris DG,Schwarzbauer C

更新日期：2005-12-01 00:00:00

abstract：:The aim of this study was to acquire high-quality in vivo (1) H spectra concurrently from two voxels at ultra-high field (7 T) without specialized hardware. To this end, an acquisition scheme was developed in which first-order shims and flip angles are dynamically updated to acquire spectra from both of the brain's mo...

journal_title：NMR in biomedicine

authors： Lemke C,Hess A,Clare S,Bachtiar V,Stagg C,Jezzard P,Emir U

更新日期：2015-07-01 00:00:00

abstract：:Hyperglycemia (blood glucose concentration >150 mg/dL) is common in extremely low gestational age newborns (ELGANs; birth at <28 week gestation). Hyperglycemia increases the risk of brain injury in the neonatal period. The long-term effects are not well understood. In adult rats, hyperglycemia alters hippocampal energ...

journal_title：NMR in biomedicine

authors： Rao R,Nashawaty M,Fatima S,Ennis K,Tkac I

更新日期：2018-05-01 00:00:00

abstract：:During magnetic resonance imaging (MRI) examinations, the average specific absorption rate (SAR) of the whole body is calculated as an index of global energy deposition in biological tissue without taking into account the presence of metallic implants or conductive materials. However, this global SAR calculation is no...

journal_title：NMR in biomedicine

authors： Saniour I,Gaborit G,Perrier AL,Gillette L,Revillod G,Sablong R,Duvillaret L,Beuf O

更新日期：2018-01-01 00:00:00

abstract：:The combination of hyperpolarized Xe with chemical exchange saturation transfer (Hyper-CEST) is a powerful NMR technique to detect highly dilute concentrations of Xe binding sites using RF saturation pulses. Crucially, that combination of saturation pulse strength and duration that generates the maximal Hyper-CEST eff...

journal_title：NMR in biomedicine

authors： Kunth M,Witte C,Schröder L

更新日期：2015-06-01 00:00:00

abstract：:The elimination of so-called background fields is an essential step in phase MRI and quantitative susceptibility mapping (QSM). Background fields, which are caused by sources outside the region of interest (ROI), are often one to two orders of magnitude stronger than tissue-related field variations from within the ROI...

journal_title：NMR in biomedicine

authors： Schweser F,Robinson SD,de Rochefort L,Li W,Bredies K

更新日期：2017-04-01 00:00:00

abstract：:133Cs NMR is a valuable tool for non-invasively probing biological systems. As a congener of potassium, it accumulates in the intracellular space, primarily through the action of the Na+-K+ pump (ATPase). In addition, it is possible to resolve the MR signal of 133Cs in different tissue compartments on the basis of che...

journal_title：NMR in biomedicine

authors： Goodman J,Neil JJ,Ackerman JJ

更新日期：2005-04-01 00:00:00

abstract：:Brain myelin and iron content are important parameters in neurodegenerative diseases such as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation rate. However, their quantification based on R2* maps requires a realistic tissue model that can be fitted to the measured data. In str...

journal_title：NMR in biomedicine

authors： Kor D,Birkl C,Ropele S,Doucette J,Xu T,Wiggermann V,Hernández-Torres E,Hametner S,Rauscher A

更新日期：2019-07-01 00:00:00

abstract：:Quantitative susceptibility mapping (QSM) is a recently developed MRI technique that provides a quantitative measure of tissue magnetic susceptibility. To compute tissue magnetic susceptibilities based on gradient echoes, QSM requires reliable unwrapping of the measured phase images and removal of contributions caused...

journal_title：NMR in biomedicine

authors： Li W,Avram AV,Wu B,Xiao X,Liu C

更新日期：2014-02-01 00:00:00

abstract：:Diffusion measurements were performed on the N-acetyl aspartate (NAA) signal in in situ brains (in vivo and post-mortem) and on in vitro brain tissue at 37 degrees C using wide ranges of b-values (from 0 up to 4.5 x 10(6) s/cm2 and 35.8 x 10(6) s/cm2 for the in vivo and the in vitro cases, respectively). In vivo and i...

journal_title：NMR in biomedicine

authors： Assaf Y,Cohen Y

更新日期：1998-04-01 00:00:00

abstract：:Spin-exchange NMR techniques enable the measurement of the rates of exchange of solutes between chemically or physically distinct sites in reactions taking place at chemical equilibrium. The time scale of the events that are able to be investigated lies in the neighbourhood of 1 s. The earliest studies in this area of...

journal_title：NMR in biomedicine

authors： Kuchel PW

更新日期：1990-06-01 00:00:00

abstract：:NMR relaxometry can provide information about the relaxation of the magnetization in different tissues, increasing our understanding of molecular dynamics and biochemical composition in biological systems. In general, tissues have complex and heterogeneous structures composed of multiple pools. As a result, bulk magne...

journal_title：NMR in biomedicine

authors： Zibetti MVW,Helou ES,Sharafi A,Regatte RR

更新日期：2020-12-01 00:00:00

abstract：:Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

journal_title：NMR in biomedicine

authors： Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

更新日期：2012-08-01 00:00:00

abstract：:In this study, metabolic changes in the 79A/C3H, ME7/VM, ME7/C3H, 87V/VM and 22A/SV scrapie mouse models were investigated during the clinical phase of the disease, using in vitro proton nuclear magnetic resonance spectroscopy. N-acetyl-aspartate was found to be significantly reduced in infected mice of the ME7/ C3H (...

journal_title：NMR in biomedicine

authors： Chung YL,Williams A,Chong A,Hope J,Williams SC,Bell JD

更新日期：1996-12-01 00:00:00

abstract：:The sodium-calcium exchanger (NCX) is one of the transporters contributing to the control of intracellular calcium (Ca(2+)) concentration by normally mediating net Ca(2+) efflux. However, the reverse mode of the NCX can cause intracellular Ca(2+) concentration overload, which exacerbates the myocardial tissue injury r...

journal_title：NMR in biomedicine

authors： Waghorn B,Yang Y,Baba A,Matsuda T,Schumacher A,Yanasak N,Hu TC

更新日期：2009-10-01 00:00:00

abstract：:1H NMR spin-echo spectroscopy has been used to study the metabolism of exogenous compounds in human erythrocytes. The non-invasive nature of the technique and the continuous monitoring makes it ideal to investigate both the conversion of substrates and the occurrence and the nature of the products. Hydrolysis rates ma...

journal_title：NMR in biomedicine

authors： Skibsted U,Hansen PE

更新日期：1990-12-01 00:00:00

abstract：:This introductory article addresses approaches currently in use to process in vivo spectra. First, a brief overview is given of the information content represented by the parameters of MR signals. Subsequently, common steps in the processing of MR spectra such as pre-processing, normalisation and quantification and th...

journal_title：NMR in biomedicine

authors： in 't Zandt H,van Der Graaf M,Heerschap A

更新日期：2001-06-01 00:00:00

abstract：:At the high field strength of 7 T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures oth...

journal_title：NMR in biomedicine

authors： Marjańska M,Auerbach EJ,Valabrègue R,Van de Moortele PF,Adriany G,Garwood M

更新日期：2012-02-01 00:00:00

abstract：:Tumor metabolism is directly coupled to tumor blood flow (TBF) and both metabolism and blood flow may be determinants of tumor response to treatment. Since NMR has been used extensively to monitor tumor metabolism noninvasively, development of NMR-based methods for TBF measurement was motivated by the desire to examin...

journal_title：NMR in biomedicine

authors： Evelhoch JL

更新日期：1992-09-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) in pregnancy is commonly undertaken in the left lateral tilt (LLT) position to prevent inferior vena cava (IVC) compression and supine hypotensive events, although this may be suboptimal for image quality. The supine position may also have an adverse effect on fetal well-being. The spi...

journal_title：NMR in biomedicine

authors： Hughes EJ,Price AN,McCabe L,Hiscocks S,Waite L,Green E,Hutter J,Pegoretti K,Cordero-Grande L,Edwards DA,Hajnal JV,Rutherford MA

更新日期：2021-01-21 00:00:00

abstract：:By quantification of brain metabolites, localized brain proton MRS can non-invasively provide biochemical information from distinct regions of the brain. Quantification of short-TE signals is usually based on a metabolite basis set. The basis set can be obtained by two approaches: (1) by measuring the signals of metab...

journal_title：NMR in biomedicine

authors： Cudalbu C,Cavassila S,Rabeson H,van Ormondt D,Graveron-Demilly D

更新日期：2008-07-01 00:00:00

abstract：:In recent years, quantitative nuclear magnetic resonance imaging and spectroscopy (NMRI and NMRS) have been used more systematically as outcome measures in natural history and clinical trial studies for Duchenne muscular dystrophy (DMD). Whereas most of these studies have emphasized the evaluation of the fat fraction ...

journal_title：NMR in biomedicine

authors： Reyngoudt H,Turk S,Carlier PG

更新日期：2018-01-01 00:00:00

abstract：:The myeloproliferative leukemic virus (MPLV) induces within 2-3 weeks a massive infiltration of the adult mouse liver by hematopoietic leukemic cells. Since the metabolism of the infiltrated organ might be correlated with an interaction of two cell populations, it was decided to study the isolated hematopoietic cells ...

journal_title：NMR in biomedicine

authors： Mégnin F,Nedelec JF,Dimicoli JL,Lhoste JM

更新日期：1989-06-01 00:00:00

abstract：:We describe and discuss the application of three-dimensional (3D) time-of-flight (TOF) magnetic resonance angiography (MRA) to visualize non-invasively the cerebral vasculature of the rat. MR angiograms of healthy spontaneously hypertensive rats were obtained without the use of contrast agents. Total imaging time rang...

journal_title：NMR in biomedicine

authors： Reese T,Bochelen D,Sauter A,Beckmann N,Rudin M

更新日期：1999-06-01 00:00:00

abstract：:Transcranial direct current stimulation (tDCS) is used in numerous clinical studies and considered an effective and versatile add-on therapy in neurorehabilitation. To date, however, the underlying neurobiological mechanisms remain elusive. In a rat model of tDCS, we recently observed a polarity-dependent accumulation...

journal_title：NMR in biomedicine

authors： Keuters MH,Aswendt M,Tennstaedt A,Wiedermann D,Pikhovych A,Rotthues S,Fink GR,Schroeter M,Hoehn M,Rueger MA

更新日期：2015-02-01 00:00:00

abstract：:The aim of this study was to investigate proton changes of the parotid gland after gustatory stimulation by semi-quantitative parameters and an empirical mathematical model (EMM) using high-temporal-resolution, double-echo, echo-planar imaging (EPI). Approved by a local institutional review board, this study examined ...

journal_title：NMR in biomedicine

authors： Liu YJ,Lee YH,Chang HC,Chiu HC,Chiu TW,Hsu K,Pen CM,Hsu HH,Juan CJ

更新日期：2018-03-01 00:00:00

abstract：:We introduce a new protocol to obtain very high-frame-rate cinematographic (Cine) MRI movies of the beating mouse heart within a reasonable measurement time. The method is based on a self-gated accelerated fast low-angle shot (FLASH) acquisition and compressed sensing reconstruction. Key to our approach is that we exp...

journal_title：NMR in biomedicine

authors： Motaal AG,Coolen BF,Abdurrachim D,Castro RM,Prompers JJ,Florack LM,Nicolay K,Strijkers GJ

更新日期：2013-04-01 00:00:00

abstract：:The increased magnetic susceptibility effects at higher magnetic fields increase the demands for shimming of the B0 field for in vivo MRI and MRS. Both static and dynamic techniques have been developed to compensate for susceptibility-induced field inhomogeneities. In this study, we investigate the impact of and need ...

journal_title：NMR in biomedicine

authors： Boer VO,Luttje MP,Luijten PR,Klomp DW

更新日期：2014-06-01 00:00:00

abstract：:High-resolution MR imaging (312 microns in plane resolution) and MR spectroscopy (0.36 cm3 nominal voxel) have been performed on human frontal cortex using a 3 in surface coil. Localized proton spectra have been obtained from contiguous 6 x 6 x 10 mm voxels using one-dimensional phase encoding, TR 2000 ms and TE 31 ms...

journal_title：NMR in biomedicine

authors： López-Villegas D,Kimura H,Tunlayadechanont S,Lenkinski RE

更新日期：1996-10-01 00:00:00