An illustrated comparison of processing methods for phase MRI and QSM: removal of background field contributions from sources outside the region of interest.

abstract：:The possibility of quantifying the superimposed signal of glutamate and glutamine (Glx) and its components by ¹H magnetic resonance spectroscopy (MRS) in the spinal cord is an exciting challenge with important clinical applications in neurological conditions. The spinal cord is a particularly difficult region of inter...

journal_title：NMR in biomedicine

authors： Solanky BS,Abdel-Aziz K,Yiannakas MC,Berry AM,Ciccarelli O,Wheeler-Kingshott CA

更新日期：2013-03-01 00:00:00

abstract：:Acute kidney injury (AKI) in mice caused by sustained ischemia followed by reperfusion is associated with acute tubular necrosis and renal dysfunctional blood flow. Although the principal role of the kidney is the maintenance of acid-base balance, current imaging approaches are unable to assess this important paramete...

journal_title：NMR in biomedicine

authors： Longo DL,Cutrin JC,Michelotti F,Irrera P,Aime S

更新日期：2017-07-01 00:00:00

abstract：:Spin-exchange NMR techniques enable the measurement of the rates of exchange of solutes between chemically or physically distinct sites in reactions taking place at chemical equilibrium. The time scale of the events that are able to be investigated lies in the neighbourhood of 1 s. The earliest studies in this area of...

journal_title：NMR in biomedicine

authors： Kuchel PW

更新日期：1990-06-01 00:00:00

abstract：:Organs consist of several types of cells with specialized functions. This cellular localization of function is often referred to as compartmentation. Due to the intrinsic low sensitivity of MR methods it is generally not possible in vivo to obtain images or spectra of single cells. Instead the MRS signal is the sum of...

journal_title：NMR in biomedicine

authors： Rothman DL

更新日期：2001-04-01 00:00:00

abstract：:The use of cerebral water as an internal intensity standard for the quantitation of spatially localized proton spectra of the human brain is investigated. The method is validated on standard samples of N-acetyl aspartate (NAA) and lactate, and possible sources of error are discussed. Using the STEAM pulse sequence, co...

journal_title：NMR in biomedicine

authors： Barker PB,Soher BJ,Blackband SJ,Chatham JC,Mathews VP,Bryan RN

更新日期：1993-01-01 00:00:00

abstract：:The purpose of this paper is to facilitate the comparison of magnetic resonance (MR) spectra acquired from unknown brain lesions with published spectra in order to help identify unknown lesions in clinical settings. The paper includes lists of references for published MR spectra of various brain diseases, including py...

journal_title：NMR in biomedicine

authors： Kingsley PB,Shah TC,Woldenberg R

更新日期：2006-06-01 00:00:00

abstract：:Quantitative mapping of MR tissue parameters such as the spin-lattice relaxation time (T1 ), the spin-spin relaxation time (T2 ), and the spin-lattice relaxation in the rotating frame (T1ρ ), referred to as MR relaxometry in general, has demonstrated improved assessment in a wide range of clinical applications. Compar...

journal_title：NMR in biomedicine

authors： Feng L,Ma D,Liu F

更新日期：2020-10-15 00:00:00

abstract：:The physiological status of anesthetized rats greatly influences blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI). Monitoring of physiological parameters, particularly partial pressure of carbon dioxide (pCO(2)) levels in the blood, is therefore an important part in the design and ...

journal_title：NMR in biomedicine

authors： Ramos-Cabrer P,Weber R,Wiedermann D,Hoehn M

更新日期：2005-11-01 00:00:00

abstract：:Here, we show that the sensitivity of (31)P MRSI of (31)P spins J-coupled to protons can be increased by almost a factor of three when compared with an optimal direct detection free induction decay. By direct detection integrated with multi-echo polarization transfer (DIMEPT), multiple signals from polarization transf...

journal_title：NMR in biomedicine

authors： van der Kemp WJ,Boer VO,Luijten PR,Klomp DW

更新日期：2014-10-01 00:00:00

abstract：:Transceiver surface coil arrays improve transmit performance (B1/√kW) and B1 homogeneity for head imaging up to 9.4 T. To further improve reception performance and parallel imaging, the number of array elements must be increased with a corresponding decrease in their size. With a large number of small interacting ante...

journal_title：NMR in biomedicine

authors： Avdievich NI,Pan JW,Hetherington HP

更新日期：2013-11-01 00:00:00

abstract：:This paper describes the use of off-resonance saturation to further manipulate the blood oxygenation level dependent (BOLD) contrast of fMRI. A customized narrow bandwidth radiofrequency pulse, applied with a range of frequency offsets prior to selection of each slice, was designed and incorporated into a gradient ech...

journal_title：NMR in biomedicine

authors： Song AW,Wolff SD,Balaban RS,Jezzard P

更新日期：1997-06-01 00:00:00

abstract：:Polycystic kidney disease (PKD) is a life-threatening disease that leads to a grotesque enlargement of the kidney and significant loss of function. Several imaging studies with MRI have demonstrated that cyst size in polycystic kidneys can determine disease severity and progression. In the present study, we found that...

journal_title：NMR in biomedicine

authors： Xie L,Qi Y,Subashi E,Liao G,Miller-DeGraff L,Jetten AM,Johnson GA

更新日期：2015-05-01 00:00:00

abstract：:In vivo 1H MRS is rapidly developing as a clinical tool for diagnosing and characterizing breast cancers. Many in vivo and in vitro experiments have demonstrated that alterations in concentrations of choline-containing metabolites are associated with malignant transformation. In recent years, considerable efforts have...

journal_title：NMR in biomedicine

authors： Haddadin IS,McIntosh A,Meisamy S,Corum C,Styczynski Snyder AL,Powell NJ,Nelson MT,Yee D,Garwood M,Bolan PJ

更新日期：2009-01-01 00:00:00

abstract：:Biomarkers of early response to treatment have the potential to improve cancer therapy by allowing treatment to be tailored to the individual. Alterations in lipids detected by in vivo MRS have been suggested as noninvasive biomarkers of cell stress and early indicators of cell death. An improved understanding of the ...

journal_title：NMR in biomedicine

authors： Mirbahai L,Wilson M,Shaw CS,McConville C,Malcomson RD,Kauppinen RA,Peet AC

更新日期：2012-11-01 00:00:00

abstract：:This paper describes the development of a novel technique for functional MRI of the human brain at 0.135 microL resolution for a whole brain section. In comparison with conventional studies at 3 mm isotropic resolution or 27 microL voxel size, the method yields an improvement by a factor of 200. To achieve optimum ima...

journal_title：NMR in biomedicine

authors： Voit D,Frahm J

更新日期：2005-12-01 00:00:00

abstract：:The aim of this study is to fabricate and test a novel flexible flat cable antenna (FFCA) for MRI of the knee at different flexion angles. The FFCA was made of a flat cable, a tuning/matching circuit and a signal transmission line. To test its feasibility and validity, in vitro and in vivo experiments were carried out...

journal_title：NMR in biomedicine

authors： Jia F,Yuan H,Zhou D,Zhang J,Wang X,Fang J

更新日期：2015-04-01 00:00:00

abstract：:An indirect method for in vivo T2 mapping of 13 C-labeled metabolites using T2 and T2 * information of water protons obtained a priori is proposed. The T2 values of 13 C metabolites are inferred using the relationship to T2 ' of coexisting 1 H and the T2 * of 13 C metabolites, which is measured using routine hyperpola...

journal_title：NMR in biomedicine

authors： Joe E,Lee H,Lee J,Yang S,Choi YS,Wang E,Song HT,Kim DH

更新日期：2017-05-01 00:00:00

abstract：:In this study we aimed to assess the effects of continuous formalin fixation on diffusion and relaxation metrics of the ex vivo porcine heart at 7 T. Magnetic resonance imaging was performed on eight piglet hearts using a 7 T whole body system. Hearts were measured fresh within 3 hours of cardiac arrest followed by im...

journal_title：NMR in biomedicine

authors： Lohr D,Terekhov M,Veit F,Schreiber LM

更新日期：2020-07-01 00:00:00

abstract：:An optimized semi-LASER sequence that is capable of acquiring artefact-free data with an echo time (TE) of 20.1 ms on a standard clinical 3 T MR system was developed. Simulations were performed to determine the optimal TEs that minimize the expected Cramér-Rao lower bound (CRLB) as proxy for quantification accuracy of...

journal_title：NMR in biomedicine

authors： Landheer K,Gajdošík M,Juchem C

更新日期：2020-09-01 00:00:00

abstract：:Mice are used in many studies to determine the role of genetic and molecular factors in mammalian development and human congenital diseases. MRI has emerged as a major method for analyzing mutant and transgenic phenotypes in developing mice, at both embryonic and neonatal stages. Progress in this area is reviewed, wit...

journal_title：NMR in biomedicine

authors： Turnbull DH,Mori S

更新日期：2007-05-01 00:00:00

abstract：:133Cs NMR is a valuable tool for non-invasively probing biological systems. As a congener of potassium, it accumulates in the intracellular space, primarily through the action of the Na+-K+ pump (ATPase). In addition, it is possible to resolve the MR signal of 133Cs in different tissue compartments on the basis of che...

journal_title：NMR in biomedicine

authors： Goodman J,Neil JJ,Ackerman JJ

更新日期：2005-04-01 00:00:00

abstract：:A quantitative magnetization transfer (qMT) technique was employed to quantify the ratio of the sizes of the bound and free water proton pools in ex vivo mouse brains. The goal was to determine the pool size ratio sensitivity to myelin. Fixed brains from both shiverer mice and control littermates were imaged. The pool...

journal_title：NMR in biomedicine

authors： Ou X,Sun SW,Liang HF,Song SK,Gochberg DF

更新日期：2009-06-01 00:00:00

abstract：:A current limitation of MR spectroscopic imaging of multiple skeletal muscles is prolonged scan duration. A significant reduction in the total scan duration using the echo-planar correlated spectroscopic imaging (EP-COSI) sequence was accomplished using two bipolar readout trains with different phase-encoded echoes fo...

journal_title：NMR in biomedicine

authors： Furuyama JK,Nagarajan R,Roberts CK,Lee CC,Hahn TJ,Thomas MA

更新日期：2014-10-01 00:00:00

abstract：:The potential for using pre-polarized liquids as contrast agents in vivo is investigated and the feasibility of the method demonstrated. In this study we show the enhancement obtained following intravenous delivery of pre-polarized saline into the antecubital vein of a volunteer. This form of contrast agent provides s...

journal_title：NMR in biomedicine

authors： Young IR,deSouza NM,Hall AS,Williams AD,Hajnal JV,Coutts GA

更新日期：1999-10-01 00:00:00

abstract：:Current functional MRI (fMRI) approaches assess underlying neuronal activity through monitoring the related local variations in cerebral blood oxygenation, blood volume and blood flow. This vascular response is likely to vary across brain regions and across individuals, depending on the composition of the local vascul...

journal_title：NMR in biomedicine

authors： Driver ID,Andoh J,Blockley NP,Francis ST,Gowland PA,Paus T

更新日期：2015-05-01 00:00:00

abstract：:Quantification of metabolites is a goal of many biomedical NMR studies. To obtain absolute measurements of metabolite concentrations is often both difficult and time-consuming. In this paper a method for determining metabolite concentrations directly is described and validated. It is applicable to studies of amphibian...

journal_title：NMR in biomedicine

authors： Wray S,Wilkie DR

更新日期：1992-05-01 00:00:00

abstract：:The current study aims to evaluate the feasibility of creatine (Cr) chemical exchange saturation transfer (CEST)-weighted MRI at 7 T in the human brain by optimizing the saturation pulse parameters and computing contrast using a Z-spectral fitting approach. The Cr-weighted (Cr-w) CEST contrast was computed from phanto...

journal_title：NMR in biomedicine

authors： Singh A,Debnath A,Cai K,Bagga P,Haris M,Hariharan H,Reddy R

更新日期：2019-12-01 00:00:00

abstract：:Diffusion measurements were performed on the N-acetyl aspartate (NAA) signal in in situ brains (in vivo and post-mortem) and on in vitro brain tissue at 37 degrees C using wide ranges of b-values (from 0 up to 4.5 x 10(6) s/cm2 and 35.8 x 10(6) s/cm2 for the in vivo and the in vitro cases, respectively). In vivo and i...

journal_title：NMR in biomedicine

authors： Assaf Y,Cohen Y

更新日期：1998-04-01 00:00:00

abstract：:NMR relaxometry can provide information about the relaxation of the magnetization in different tissues, increasing our understanding of molecular dynamics and biochemical composition in biological systems. In general, tissues have complex and heterogeneous structures composed of multiple pools. As a result, bulk magne...

journal_title：NMR in biomedicine

authors： Zibetti MVW,Helou ES,Sharafi A,Regatte RR

更新日期：2020-12-01 00:00:00

abstract：:The purpose of this study was to identify the optimal tracer kinetic model from T1 -weighted dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data and evaluate whether parameters estimated from the optimal model predict tumor aggressiveness determined from histopathology in patients with papillary thyroi...

journal_title：NMR in biomedicine

authors： Paudyal R,Lu Y,Hatzoglou V,Moreira A,Stambuk HE,Oh JH,Cunanan KM,Aramburu Nunez D,Mazaheri Y,Gonen M,Ho A,Fagin JA,Wong RJ,Shaha A,Tuttle RM,Shukla-Dave A

更新日期：2020-01-01 00:00:00