Identification of diffuse and focal brain lesions by clinical magnetic resonance spectroscopy.


:The purpose of this paper is to facilitate the comparison of magnetic resonance (MR) spectra acquired from unknown brain lesions with published spectra in order to help identify unknown lesions in clinical settings. The paper includes lists of references for published MR spectra of various brain diseases, including pyogenic abscesses, encephalitis (herpes simplex, Rasmussen's and subacute sclerosing panencephalitis), neurocysticercosis, tuberculoma, cysts (arachnoid, epidermoid and hydatid), acute disseminated encephalomyelitis (ADEM), adrenoleukodystrophy (ALD), Alexander disease, Canavan's disease, Krabbe disease (globoid cell leukodystrophy), Leigh's disease, megalencephalic leukoencephalopathy with cysts, metachromatic leukodystrophy (MLD), Pelizaeus-Merzbacher disease, Zellweger syndrome, HIV-associated lesions [cryptococcus, lymphoma, toxoplasmosis and progressive multifocal leukoencephalopathy (PML)], hydrocephalus and tuberous sclerosis. Each list includes information on the echo time(s) (TE) of the published spectra, whether a control spectrum is shown, whether the corresponding image and voxel position are shown and the patient ages if known. The references are listed in the approximate order of usefulness, based on spectral quality, number of spectra, range of echo times and whether the voxel positions are shown. Spectra of Zellweger syndrome, cryptococcal infection, toxoplasmosis and lymphoma are included, along with a spectrum showing propanediol (propylene glycol).


NMR Biomed


NMR in biomedicine


Kingsley PB,Shah TC,Woldenberg R




Has Abstract


2006-06-01 00:00:00












  • Improved target volume characterization in stereotactic treatment planning of brain lesions by using high-resolution BOLD MR-venography.

    abstract::In this methodological paper I report the stereotactic correlation of different magnetic resonance imaging (MRI) techniques [MR angiography (MRA), MRI, blood bolus tagging (STAR), functional MRI, and high-resolution BOLD venography (HRBV)] in patients with cerebral arterio-venous malformations (AVM) and brain tumors. ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Schad LR

    更新日期:2001-11-01 00:00:00

  • Rapid MR relaxometry using deep learning: An overview of current techniques and emerging trends.

    abstract::Quantitative mapping of MR tissue parameters such as the spin-lattice relaxation time (T1 ), the spin-spin relaxation time (T2 ), and the spin-lattice relaxation in the rotating frame (T1ρ ), referred to as MR relaxometry in general, has demonstrated improved assessment in a wide range of clinical applications. Compar...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Feng L,Ma D,Liu F

    更新日期:2020-10-15 00:00:00

  • Clinical ultrashort echo time imaging of bone and other connective tissues.

    abstract::The background underpinning the clinical use of ultrashort echo time, SPRITE and other pulse sequences for imaging bone and other connective tissues with short T2 is reviewed. Features of the basic physics relevant to UTE imaging are described, including the consequences when the radiofrequency pulse duration is of th...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审


    authors: Robson MD,Bydder GM

    更新日期:2006-11-01 00:00:00

  • Water-suppressed one-dimensional 1H NMR chemical shift imaging of the heart before and after regional ischemia.

    abstract::This study tests the hypothesis that brief periods of ischemia result in an increase in myocardial lipids during early reperfusion. We conducted 1H NMR spectroscopy to serially measure myocardial lipids before and after regional ischemia. Localized 1H NMR spectra (spatial resolution of 1.25 mm) were obtained using a o...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Balschi JA,Hetherington HP,Bradley EL Jr,Pohost GM

    更新日期:1995-04-01 00:00:00

  • 1 H NMRS of carnosine combined with 31 P NMRS to better characterize skeletal muscle pH dysregulation in Duchenne muscular dystrophy.

    abstract::In recent years, quantitative nuclear magnetic resonance imaging and spectroscopy (NMRI and NMRS) have been used more systematically as outcome measures in natural history and clinical trial studies for Duchenne muscular dystrophy (DMD). Whereas most of these studies have emphasized the evaluation of the fat fraction ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Reyngoudt H,Turk S,Carlier PG

    更新日期:2018-01-01 00:00:00

  • In vivo magnetic resonance spectroscopy detection of combined glutamate-glutamine in healthy upper cervical cord at 3 T.

    abstract::The possibility of quantifying the superimposed signal of glutamate and glutamine (Glx) and its components by ¹H magnetic resonance spectroscopy (MRS) in the spinal cord is an exciting challenge with important clinical applications in neurological conditions. The spinal cord is a particularly difficult region of inter...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Solanky BS,Abdel-Aziz K,Yiannakas MC,Berry AM,Ciccarelli O,Wheeler-Kingshott CA

    更新日期:2013-03-01 00:00:00

  • Mapping of prostate cancer by 1H MRSI.

    abstract::In many studies, it has been demonstrated that (1)H MRSI of the human prostate has great potential to aid prostate cancer management, e.g. in the detection and localisation of cancer foci in the prostate or in the assessment of its aggressiveness. It is particularly powerful in combination with T2 -weighted MRI. Never...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章,评审


    authors: Kobus T,Wright AJ,Scheenen TW,Heerschap A

    更新日期:2014-01-01 00:00:00

  • Effect of taxane-based neoadjuvant chemotherapy on fibroglandular tissue volume and percent breast density in the contralateral normal breast evaluated by 3T MR.

    abstract::The aim of this study was to evaluate the change of breast density in the normal breast of patients receiving neoadjuvant chemotherapy (NAC). Forty-four breast cancer patients were studied. MRI acquisition was performed before treatment (baseline), and 4 and 12 weeks after treatment. A computer-algorithm-based program...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Chen JH,Pan WF,Kao J,Lu J,Chen LK,Kuo CC,Chang CK,Chen WP,McLaren CE,Bahri S,Mehta RS,Su MY

    更新日期:2013-12-01 00:00:00

  • The impact of edema and fiber crossing on diffusion MRI metrics assessed in an ex vivo nerve phantom: Multi-tensor model vs. diffusion orientation distribution function.

    abstract::Diffusion tensor imaging (DTI) has been employed for over 2 decades to noninvasively quantify central nervous system diseases/injuries. However, DTI is an inadequate simplification of diffusion modeling in the presence of coexisting inflammation, edema and crossing nerve fibers. We employed a tissue phantom using fixe...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Ye Z,Gary SE,Sun P,Mustafi SM,Glenn GR,Yeh FC,Merisaari H,Song C,Yang R,Huang GS,Kao HW,Lin CY,Wu YC,Jensen JH,Song SK

    更新日期:2021-01-01 00:00:00

  • Metabolic spectroscopy of inflammation in a bleomycin-induced lung injury model using hyperpolarized 1-(13) C pyruvate.

    abstract::Metabolic activity in the lung is known to change in response to external insults, inflammation, and cancer. We report measurements of metabolism in the isolated, perfused rat lung of healthy controls and in diseased lungs undergoing acute inflammation using hyperpolarized 1-(13) C-labeled pyruvate. The overall appare...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Shaghaghi H,Kadlecek S,Deshpande C,Siddiqui S,Martinez D,Pourfathi M,Hamedani H,Ishii M,Profka H,Rizi R

    更新日期:2014-08-01 00:00:00

  • Lung ventilation volumetry with same-breath acquisition of hyperpolarized gas and proton MRI.

    abstract::The purpose of this work was to assess the reproducibility of percentage of ventilated lung volume (PV) measured from hyperpolarized (HP) (3)He and (1)H anatomical images acquired in the same breath-hold when compared with PV measured from (3)He and (1)H images from separate breath-holds. Volumetric (3)He ventilation ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Horn FC,Tahir BA,Stewart NJ,Collier GJ,Norquay G,Leung G,Ireland RH,Parra-Robles J,Marshall H,Wild JM

    更新日期:2014-12-01 00:00:00

  • Estimation of cellular-interstitial water exchange in dynamic contrast enhanced MRI using two flip angles.

    abstract:PURPOSE:To investigate the feasibility of using multiple flip angles in dynamic contrast enhanced (DCE) MRI to reduce the uncertainty in estimation of intracellular water lifetime (τi ). METHODS:Numerical simulation studies were conducted to assess the uncertainty in estimation of τi using dynamic contrast enhanced MR...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Zhang J,Kim SG

    更新日期:2019-11-01 00:00:00

  • Optimization of magnetization transfer experiments to measure first-order rate constants and spin-lattice relaxation times.

    abstract::A recent analysis of the optimization of magnetization transfer experiments to estimate first-order rate constants is extended to the design of experiments for measuring these constants and T1 when both parameters are initially unknown. When the number of measurement times is fixed, an optimal design will consist of a...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Katki H,Weiss GH,Kiefer JE,Taitelbaum H,Spencer RG

    更新日期:1996-05-01 00:00:00

  • BOLD-specific cerebral blood volume and blood flow changes during neuronal activation in humans.

    abstract::To understand and predict the blood-oxygenation level-dependent (BOLD) fMRI signal, an accurate knowledge of the relationship between cerebral blood flow (DeltaCBF) and volume (DeltaCBV) changes is critical. Currently, this relationship is widely assumed to be characterized by Grubb's power-law, derived from primate d...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Chen JJ,Pike GB

    更新日期:2009-12-01 00:00:00

  • In vitro mapping of 1H ultrashort T2* and T2 of porcine menisci.

    abstract::In this study, mapping of ultrashort T2 and T2* of acutely isolated porcine menisci at B0 = 9.4 T was investigated. Maps of T2 were measured from a slice through the pars intermedia with a spin echo-prepared two-dimensional ultrashort-TE T2 mapping technique published previously. T2* mapping was performed by two-dimen...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Kirsch S,Kreinest M,Reisig G,Schwarz ML,Ströbel P,Schad LR

    更新日期:2013-09-01 00:00:00

  • In silico GABA+ MEGA-PRESS: Effects of signal-to-noise ratio and linewidth on modeling the 3 ppm GABA+ resonance.

    abstract::To investigate the GABA+ modeling accuracy of MEGA-PRESS GABA+-edited MRS data with various spectral quality scenarios, the influence of varying signal-to-noise ratio (SNR) and linewidth on the model estimates was quantified. MEGA-PRESS data from 46 volunteers were averaged to generate a template MEGA-PRESS spectrum, ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Zöllner HJ,Oeltzschner G,Schnitzler A,Wittsack HJ

    更新日期:2021-01-01 00:00:00

  • Short-TE localised 1H MRS of the human brain at 3 T: quantification of the metabolite signals using two approaches to account for macromolecular signal contributions.

    abstract::The goal of this study was to validate metabolite quantification at short TE, with particular focus on how to best account for the macromolecular signal contribution. A robust, short-TE PRESS protocol is presented, which allows reliable quantification, in vivo, of metabolite signals at 3 T in human brain. Water suppre...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Gottschalk M,Lamalle L,Segebarth C

    更新日期:2008-06-01 00:00:00

  • The combined measurement of blood flow and metabolism in RIF-1 tumours in vivo. A study using H2 flow and 31P NMR spectroscopy.

    abstract::Blood flow and phosphorus metabolites have been measured simultaneously in the murine RIF-1 tumour in vivo. Blood flow was measured using the H2 washout technique and 31P NMR spectroscopy was used to measure high energy phosphates, inorganic phosphate and intracellular pH within the tumour. Following NMR and flow meas...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Bhujwalla ZM,Tozer GM,Field SB,Proctor E,Busza A,Williams SR

    更新日期:1990-08-01 00:00:00

  • Magnetic resonance elastography of skeletal muscle deep tissue injury.

    abstract::The current state-of-the-art diagnosis method for deep tissue injury in muscle, a subcategory of pressure ulcers, is palpation. It is recognized that deep tissue injury is frequently preceded by altered biomechanical properties. A quantitative understanding of the changes in biomechanical properties preceding and duri...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Nelissen JL,Sinkus R,Nicolay K,Nederveen AJ,Oomens CWJ,Strijkers GJ

    更新日期:2019-06-01 00:00:00

  • A statistical clustering approach to discriminating perfusion from conduit vessel signal contributions in a pulmonary ASL MR image.

    abstract::The measurement of pulmonary perfusion (blood delivered to the capillary bed within a voxel) using arterial spin labeling (ASL) magnetic resonance imaging is often complicated by signal artifacts from conduit vessels that carry blood destined for voxels at a distant location in the lung. One approach to dealing with c...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Walker SC,Asadi AK,Hopkins SR,Buxton RB,Prisk GK

    更新日期:2015-09-01 00:00:00

  • Image-based tissue engineering of a total intervertebral disc implant for restoration of function to the rat lumbar spine.

    abstract::Nonbiological total disc replacement is currently being used for the treatment of intervertebral disc (IVD) disease and injury, but these implants are prone to mechanical wear, tear and possible dislodgement. Recently, tissue-engineered total disc replacement (TE-TDR) has been investigated as a possible alternative to...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Bowles RD,Gebhard HH,Dyke JP,Ballon DJ,Tomasino A,Cunningham ME,Härtl R,Bonassar LJ

    更新日期:2012-03-01 00:00:00

  • A 31P study of fatigue and metabolism in human skeletal muscle with voluntary, intermittent contractions at different forces.

    abstract::Normal subjects performed voluntary, isometric exercise 1 s contraction, 1 s rest for 10 min) of the first dorsal interosseous (FDI) muscle with a target force of 25, 50 and 100% of the maximal voluntary contraction (MVC) force. 31P NMR spectra were collected continuously before, during and after exercise. Data were a...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Newham DJ,Cady EB

    更新日期:1990-10-01 00:00:00

  • Cluster analysis of DCE-MRI data identifies regional tracer-kinetic changes after tumor treatment with high intensity focused ultrasound.

    abstract::Evaluation of high intensity focused ultrasound (HIFU) treatment with MRI is generally based on assessment of the non-perfused volume from contrast-enhanced T1-weighted images. However, the vascular status of tissue surrounding the non-perfused volume has not been extensively investigated with MRI. In this study, clus...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Jacobs I,Hectors SJ,Schabel MC,Grüll H,Strijkers GJ,Nicolay K

    更新日期:2015-11-01 00:00:00

  • Apparent exchange rate for breast cancer characterization.

    abstract::Although diffusion MRI has shown promise for the characterization of breast cancer, it has low specificity to malignant subtypes. Higher specificity might be achieved if the effects of cell morphology and molecular exchange across cell membranes could be disentangled. The quantification of exchange might thus allow th...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Lasič S,Oredsson S,Partridge SC,Saal LH,Topgaard D,Nilsson M,Bryskhe K

    更新日期:2016-05-01 00:00:00

  • pH and compartmentation of isolated perfused rat liver studied by 31P and 19F NMR.

    abstract::The phosphorus NMR spectra of isolated perfused rat liver displays a prominent inorganic phosphate peak at 2.76 +/- 0.05 ppm relative to liver glycerolphosphocholine at 0.49 ppm. From titration curves of phosphorus-containing compounds this corresponds to a pH of 7.4. The spectra also display a shoulder on the promine...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Thoma WJ,Uğurbil K

    更新日期:1988-04-01 00:00:00

  • Optimal classification of long echo time in vivo magnetic resonance spectra in the detection of recurrent brain tumors.

    abstract::We describe the optimal high-level postprocessing of single-voxel (1)H magnetic resonance spectra and assess the benefits and limitations of automated methods as diagnostic aids in the detection of recurrent brain tumor. In a previous clinical study, 90 long-echo-time single-voxel spectra were obtained from 52 patient...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Menze BH,Lichy MP,Bachert P,Kelm BM,Schlemmer HP,Hamprecht FA

    更新日期:2006-08-01 00:00:00

  • Lithium ion as a probe of Na+ channel activity in isolated rat hearts: a multinuclear NMR study.

    abstract::The aim of this study was to analyze Na+ fluxes in whole perfused hearts using Li+ as a Na+ congener and 7Li-nuclear magnetic resonance as a detection method. Hearts were equilibrated for 32 min with 15 mM LiCl added to P1-free Krebs-Henseleit buffer (intracellular space (ICS) [Li+] = 21.5 +/- 3.4 mM). Li+ efflux was ...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Kupriyanov VV,Xiang B,Yang L,Deslauriers R

    更新日期:1997-09-01 00:00:00

  • Effect of phosphate electrolyte buffer on the dynamics of water in tendon and cartilage.

    abstract::A number of NMR spectroscopic and microscopic MRI (microMRI) techniques were used to study proton dynamics in canine tendon and articular cartilage immersed in normal saline solution (NaCl solution) and high-concentration phosphate-buffered saline (PBS) solution. In a proton CPMG experiment on tendons, the T(2) relaxa...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Zheng S,Xia Y

    更新日期:2009-02-01 00:00:00

  • Spring-damper equivalents of the fractional, poroelastic, and poroviscoelastic models for elastography.

    abstract::In MR elastography, it is common to use an elastic model for the tissue's response in order to interpret the results properly. More complex models, such as viscoelastic, fractional viscoelastic, poroelastic, or poroviscoelastic ones, are also used. These models appear at first sight to be very different, but here it i...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Holm S

    更新日期:2018-10-01 00:00:00

  • A pilot validation of multi-echo based echo-planar correlated spectroscopic imaging in human calf muscles.

    abstract::A current limitation of MR spectroscopic imaging of multiple skeletal muscles is prolonged scan duration. A significant reduction in the total scan duration using the echo-planar correlated spectroscopic imaging (EP-COSI) sequence was accomplished using two bipolar readout trains with different phase-encoded echoes fo...

    journal_title:NMR in biomedicine

    pub_type: 杂志文章


    authors: Furuyama JK,Nagarajan R,Roberts CK,Lee CC,Hahn TJ,Thomas MA

    更新日期:2014-10-01 00:00:00