Abstract:
:The use of cerebral water as an internal intensity standard for the quantitation of spatially localized proton spectra of the human brain is investigated. The method is validated on standard samples of N-acetyl aspartate (NAA) and lactate, and possible sources of error are discussed. Using the STEAM pulse sequence, concentrations of choline, creatine and NAA in frontal lobe white matter are found to be 1.9 +/- 0.5, 10.6 +/- 1.3 and 16.6 +/- 2.3 mumol/g wet wt, respectively, in 10 normal volunteers. In the thalamus, the concentrations are 2.0 +/- 0.4, 11.6 +/- 2.0 and 17.2 +/- 1.3 mumol/g wet wt, respectively. Choline and creatine concentrations are in good agreement with conventional biochemical values: NAA concentrations are found to be three-fold higher, suggesting overlap of the NAA signal with other compounds. Quantitation relative to tissue water is a convenient and rapid means of quantitating proton spectra of the human brain.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Barker PB,Soher BJ,Blackband SJ,Chatham JC,Mathews VP,Bryan RNdoi
10.1002/nbm.1940060114subject
Has Abstractpub_date
1993-01-01 00:00:00pages
89-94issue
1eissn
0952-3480issn
1099-1492journal_volume
6pub_type
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journal_title:NMR in biomedicine
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更新日期:2009-06-01 00:00:00
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更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/nbm.1002
更新日期:2006-02-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1727
更新日期:2012-01-01 00:00:00
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更新日期:1993-11-01 00:00:00
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更新日期:2008-11-01 00:00:00
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journal_title:NMR in biomedicine
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更新日期:2015-08-01 00:00:00
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更新日期:2014-11-01 00:00:00
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