Abstract:
:More than 50% of cancers fail to respond to any individual treatment and tumour follow-up after treatment plays a major role in routine therapy planning and pharmacological research. Today, MRS is the only technological approach providing non-invasive access to tumour biochemistry. Ten years ago, expectations were raised concerning 31P MRS as an exciting and promising technical approach to the study of tumours. However the expectations have not always come to fruition. How close are we now to seeing routine 31P NMR in clinical oncology? This review of the 127 published papers shows spectroscopy results in more than 150 experimental animal tumour models. These tumour/host/treatment systems provide us with a useful basis to evaluate the current state of the art, summarize the basic knowledge presently available, determine the key points underlying the present disappointment of some clinical oncologists and stimulate new basic research. The information collected concerns the discussion of the reliability of experimental models in oncology, the technical improvement of magnetic resonance technology and the monitoring of bioenergetic status, pH regulation and phospholipid metabolism in treated and untreated tumours. Recent advances (two-thirds of the papers have been published in the last 5 years) seem to provide more optimistic perspectives than those generally accepted a few years ago, in the depressing period following early pioneering work.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
de Certaines JD,Larsen VA,Podo F,Carpinelli G,Briot O,Henriksen Odoi
10.1002/nbm.1940060602subject
Has Abstractpub_date
1993-11-01 00:00:00pages
345-65issue
6eissn
0952-3480issn
1099-1492journal_volume
6pub_type
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journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
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pub_type: 杂志文章
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3341
更新日期:2015-08-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2959
更新日期:2013-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4135
更新日期:2019-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
abstract::Early imaging or blood biomarkers of tumor response is needed to customize anti-tumor therapy on an individual basis. This study evaluates the sensitivity and relevance of five potential MRI biomarkers. Sixty nude rats were implanted with human glioma cells (U-87 MG) and randomized into three groups: one group receive...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1611
更新日期:2011-06-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2796
更新日期:2012-11-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1100
更新日期:2006-11-01 00:00:00
abstract::In order to investigate intervertebral disc (IVD) degeneration and repair, a quantitative non-invasive tool is needed. Various MRI methods including qCPMG, which yields dipolar echo relaxation time (T(DE)), magnetization transfer contrast (MTC), and (1)H and (2)H double quantum filtered (DQF) MRI were used in the pres...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:NMR in biomedicine
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pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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更新日期:1988-04-01 00:00:00
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