Imaging chemical exchange saturation transfer (CEST) effects following tumor-selective acidification using lonidamine.

abstract：:The aim of this study was to evaluate the change of breast density in the normal breast of patients receiving neoadjuvant chemotherapy (NAC). Forty-four breast cancer patients were studied. MRI acquisition was performed before treatment (baseline), and 4 and 12 weeks after treatment. A computer-algorithm-based program...

journal_title：NMR in biomedicine

authors： Chen JH,Pan WF,Kao J,Lu J,Chen LK,Kuo CC,Chang CK,Chen WP,McLaren CE,Bahri S,Mehta RS,Su MY

更新日期：2013-12-01 00:00:00

abstract：:The ability to assess the perfusion territories of major cerebral arteries can be a valuable asset to the diagnosis of a number of cerebrovascular diseases. Recently, several arterial spin labeling (ASL) techniques have been proposed for determining the cerebral perfusion territories of individual arteries by three di...

journal_title：NMR in biomedicine

authors： Paiva FF,Tannús A,Silva AC

更新日期：2007-11-01 00:00:00

abstract：:MRI and MRS in small rodents demand very high sensitivity. Cryogenic transmit/receive radiofrequency probes (CryoProbes) designed for (1) H MRI of mouse brain provide an attractive option for increasing the performance of small-animal MR systems. As the Larmor frequency of (13) C nuclei is four times lower than that f...

journal_title：NMR in biomedicine

authors： Sack M,Wetterling F,Sartorius A,Ende G,Weber-Fahr W

更新日期：2014-06-01 00:00:00

abstract：:The potential for using pre-polarized liquids as contrast agents in vivo is investigated and the feasibility of the method demonstrated. In this study we show the enhancement obtained following intravenous delivery of pre-polarized saline into the antecubital vein of a volunteer. This form of contrast agent provides s...

journal_title：NMR in biomedicine

authors： Young IR,deSouza NM,Hall AS,Williams AD,Hajnal JV,Coutts GA

更新日期：1999-10-01 00:00:00

abstract：:The aim of this study was to investigate proton changes of the parotid gland after gustatory stimulation by semi-quantitative parameters and an empirical mathematical model (EMM) using high-temporal-resolution, double-echo, echo-planar imaging (EPI). Approved by a local institutional review board, this study examined ...

journal_title：NMR in biomedicine

authors： Liu YJ,Lee YH,Chang HC,Chiu HC,Chiu TW,Hsu K,Pen CM,Hsu HH,Juan CJ

更新日期：2018-03-01 00:00:00

abstract：:(31)P MRS provides a unique non-invasive window into myocardial energy homeostasis. Mouse models of cardiac disease are widely used in preclinical studies, but the application of (31)P MRS in the in vivo mouse heart has been limited. The small-sized, fast-beating mouse heart imposes challenges regarding localized sign...

journal_title：NMR in biomedicine

authors： Bakermans AJ,Abdurrachim D,van Nierop BJ,Koeman A,van der Kroon I,Baartscheer A,Schumacher CA,Strijkers GJ,Houten SM,Zuurbier CJ,Nicolay K,Prompers JJ

更新日期：2015-10-01 00:00:00

abstract：:The intimal and medial linings of the pulmonary artery consist largely of vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs), respectively. The migration of these cell types to a potential tissue-engineered pulmonary valve (TEPV) implant process is therefore of interest in understanding the val...

journal_title：NMR in biomedicine

authors： Ramaswamy S,Schornack PA,Smelko AG,Boronyak SM,Ivanova J,Mayer JE Jr,Sacks MS

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:To develop a novel respiratory motion compensated three-dimensional (3D) cardiac magnetic resonance fingerprinting (cMRF) approach for whole-heart myocardial T1 and T2 mapping from a free-breathing scan. METHODS:Two-dimensional (2D) cMRF has been recently proposed for simultaneous, co-registered T1 and T2 mapp...

journal_title：NMR in biomedicine

authors： Cruz G,Jaubert O,Qi H,Bustin A,Milotta G,Schneider T,Koken P,Doneva M,Botnar RM,Prieto C

更新日期：2020-10-01 00:00:00

abstract：:Dynamic contrast-enhanced MRI (DCE MRI) has been used to study tumor response to treatment for many years. In this study, the modified full width at half-maximum (mFWHM), calculated from the wash-in slope histogram, is proposed as a parameter for the evaluation of changes in tumor heterogeneity which respond to radiot...

journal_title：NMR in biomedicine

authors： Peng SL,Chen CF,Liu HL,Lui CC,Huang YJ,Lee TH,Chang CC,Wang FN

更新日期：2013-04-01 00:00:00

abstract：:133Cs NMR is a valuable tool for non-invasively probing biological systems. As a congener of potassium, it accumulates in the intracellular space, primarily through the action of the Na+-K+ pump (ATPase). In addition, it is possible to resolve the MR signal of 133Cs in different tissue compartments on the basis of che...

journal_title：NMR in biomedicine

authors： Goodman J,Neil JJ,Ackerman JJ

更新日期：2005-04-01 00:00:00

abstract：:Boiling histotripsy (BH) is a new high intensity focused ultrasound (HIFU) ablation technique to mechanically fragmentize soft tissue into submicrometer fragments. So far, ultrasound has been used for BH treatment guidance and evaluation. The in vivo histopathological effects of this treatment are largely unknown. Her...

journal_title：NMR in biomedicine

authors： Hoogenboom M,Eikelenboom D,den Brok MH,Veltien A,Wassink M,Wesseling P,Dumont E,Fütterer JJ,Adema GJ,Heerschap A

更新日期：2016-06-01 00:00:00

abstract：:The aim of this study was to acquire high-quality in vivo (1) H spectra concurrently from two voxels at ultra-high field (7 T) without specialized hardware. To this end, an acquisition scheme was developed in which first-order shims and flip angles are dynamically updated to acquire spectra from both of the brain's mo...

journal_title：NMR in biomedicine

authors： Lemke C,Hess A,Clare S,Bachtiar V,Stagg C,Jezzard P,Emir U

更新日期：2015-07-01 00:00:00

abstract：:In vivo 1H MRS is rapidly developing as a clinical tool for diagnosing and characterizing breast cancers. Many in vivo and in vitro experiments have demonstrated that alterations in concentrations of choline-containing metabolites are associated with malignant transformation. In recent years, considerable efforts have...

journal_title：NMR in biomedicine

authors： Haddadin IS,McIntosh A,Meisamy S,Corum C,Styczynski Snyder AL,Powell NJ,Nelson MT,Yee D,Garwood M,Bolan PJ

更新日期：2009-01-01 00:00:00

abstract：:Encoding of spatial information in magnetic resonance imaging is conventionally accomplished by using magnetic field gradients. During gradient encoding, the position in k-space is determined by a time-integral of the gradient field, resulting in a limitation in imaging speed due to either gradient power or secondary ...

journal_title：NMR in biomedicine

authors： Wright SM,McDougall MP

更新日期：2009-11-01 00:00:00

abstract：:An often-employed strategy to enhance signals in (31) P MRS is the generation of the nuclear Overhauser effect (NOE) by saturation of the water resonance. However, NOE allegedly increases the variability of the (31) P data, because variation is reported in NOE enhancements. This would negate the signal-to-noise (SNR) ...

journal_title：NMR in biomedicine

authors： Lagemaat MW,van de Bank BL,Sati P,Li S,Maas MC,Scheenen TW

更新日期：2016-03-01 00:00:00

abstract：:The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and their metabolites efficiently, for which specialized imaging sequences are required. In this work, a multi-echo balanced steady-state free precession (me-bSSFP) sequence with Iterative Decomposition with Echo Asymmetry and Leas...

journal_title：NMR in biomedicine

authors： Müller CA,Hundshammer C,Braeuer M,Skinner JG,Berner S,Leupold J,Düwel S,Nekolla SG,Månsson S,Hansen AE,von Elverfeldt D,Ardenkjaer-Larsen JH,Schilling F,Schwaiger M,Hennig J,Hövener JB

更新日期：2020-06-01 00:00:00

abstract：:The applications of in vivo electron paramagnetic resonance (EPR) or electron spin resonance (ESR) spectroscopy have been impressive over a relatively short period despite the many obstacles which had to be overcome, such as dielectric absorption and biodestruction. The loop-gap resonators and modified loop coil syste...

journal_title：NMR in biomedicine

authors： Fujii H,Berliner LJ

更新日期：2004-08-01 00:00:00

abstract：:Increased pulmonary lactate production is correlated with severity of lung injury and outcome in acute respiratory distress syndrome (ARDS) patients. This study was conducted to investigate the relative contributions of inflammation and hypoxia to the lung's metabolic shift to glycolysis in an experimental animal mode...

journal_title：NMR in biomedicine

authors： Pourfathi M,Xin Y,Rosalino M,Cereda M,Kadlecek S,Duncan I,Profka H,Hamedani H,Siddiqui S,Ruppert K,Chatterjee S,Rizi RR

更新日期：2020-11-01 00:00:00

abstract：:Diffusion tensor imaging (DTI) has been employed for over 2 decades to noninvasively quantify central nervous system diseases/injuries. However, DTI is an inadequate simplification of diffusion modeling in the presence of coexisting inflammation, edema and crossing nerve fibers. We employed a tissue phantom using fixe...

journal_title：NMR in biomedicine

authors： Ye Z,Gary SE,Sun P,Mustafi SM,Glenn GR,Yeh FC,Merisaari H,Song C,Yang R,Huang GS,Kao HW,Lin CY,Wu YC,Jensen JH,Song SK

更新日期：2021-01-01 00:00:00

abstract：:The goal of this study was to validate metabolite quantification at short TE, with particular focus on how to best account for the macromolecular signal contribution. A robust, short-TE PRESS protocol is presented, which allows reliable quantification, in vivo, of metabolite signals at 3 T in human brain. Water suppre...

journal_title：NMR in biomedicine

authors： Gottschalk M,Lamalle L,Segebarth C

更新日期：2008-06-01 00:00:00

abstract：:Hyperglycemia (blood glucose concentration >150 mg/dL) is common in extremely low gestational age newborns (ELGANs; birth at <28 week gestation). Hyperglycemia increases the risk of brain injury in the neonatal period. The long-term effects are not well understood. In adult rats, hyperglycemia alters hippocampal energ...

journal_title：NMR in biomedicine

authors： Rao R,Nashawaty M,Fatima S,Ennis K,Tkac I

更新日期：2018-05-01 00:00:00

abstract：:An optimized semi-LASER sequence that is capable of acquiring artefact-free data with an echo time (TE) of 20.1 ms on a standard clinical 3 T MR system was developed. Simulations were performed to determine the optimal TEs that minimize the expected Cramér-Rao lower bound (CRLB) as proxy for quantification accuracy of...

journal_title：NMR in biomedicine

authors： Landheer K,Gajdošík M,Juchem C

更新日期：2020-09-01 00:00:00

abstract：:One of the most commonly used methods for in vivo MRS detection of γ-aminobutyric acid (GABA) is the MEGA-point-resolved spectroscopy (MEGA-PRESS) technique. However, accurate quantification of GABA using MEGA-PRESS is complicated by spectral co-editing of macromolecular resonances. In this article, a new pulse sequen...

journal_title：NMR in biomedicine

authors： Near J,Simpson R,Cowen P,Jezzard P

更新日期：2011-12-01 00:00:00

abstract：:The sodium-calcium exchanger (NCX) is one of the transporters contributing to the control of intracellular calcium (Ca(2+)) concentration by normally mediating net Ca(2+) efflux. However, the reverse mode of the NCX can cause intracellular Ca(2+) concentration overload, which exacerbates the myocardial tissue injury r...

journal_title：NMR in biomedicine

authors： Waghorn B,Yang Y,Baba A,Matsuda T,Schumacher A,Yanasak N,Hu TC

更新日期：2009-10-01 00:00:00

abstract：:The significance of NMR water diffusion measurements performed at short diffusion times (< 10 ms) for brain tissue is examined. An apparent restriction to diffusion for both healthy and cytotoxically edematous tissue is shown: cytotoxic edema lengthens the diffusion time at which this phenomenon is visible. The dramat...

journal_title：NMR in biomedicine

authors： Norris DG,Niendorf T,Leibfritz D

更新日期：1994-11-01 00:00:00

abstract：:Brain myelin and iron content are important parameters in neurodegenerative diseases such as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation rate. However, their quantification based on R2* maps requires a realistic tissue model that can be fitted to the measured data. In str...

journal_title：NMR in biomedicine

authors： Kor D,Birkl C,Ropele S,Doucette J,Xu T,Wiggermann V,Hernández-Torres E,Hametner S,Rauscher A

更新日期：2019-07-01 00:00:00

abstract：:A special characteristic of the brain is the usage of lactate as alternative fuel instead of glucose to preserve its energy homeostasis. This physiological function is valid for sufficient cerebral glucose supply, as well as presumably during hypoglycemia, given that exogenous lactate infusion suppresses hormonal coun...

journal_title：NMR in biomedicine

authors： Richter J,Rabe D,Duysen K,Melchert UH,Oltmanns KM

更新日期：2019-11-01 00:00:00

abstract：:In MR elastography, it is common to use an elastic model for the tissue's response in order to interpret the results properly. More complex models, such as viscoelastic, fractional viscoelastic, poroelastic, or poroviscoelastic ones, are also used. These models appear at first sight to be very different, but here it i...

journal_title：NMR in biomedicine

authors： Holm S

更新日期：2018-10-01 00:00:00

abstract：:Results of the evaluation of transrectal ultrasound (TRUS) guided needle biopsy of voxels identified as suspicious of malignancy on magnetic resonance spectroscopic imaging (MRSI) in a large cohort of men (n = 83) with abnormal digital rectal examination (DRE) [prostate specific antigen (PSA) 0-4 ng/ml] or PSA less th...

journal_title：NMR in biomedicine

authors： Kumar V,Jagannathan NR,Kumar R,Thulkar S,Gupta SD,Hemal AK,Gupta NP

更新日期：2007-02-01 00:00:00

abstract：:Diffusion tensor imaging (DTI) provides an indirect measure of tissue structure on a microscopic scale. To date, DTI is the only imaging method that provides such information in vivo, and has proven to be a valuable tool in both research and clinical settings. In this study, we investigated the relationship between wh...

journal_title：NMR in biomedicine

authors： Choe AS,Stepniewska I,Colvin DC,Ding Z,Anderson AW

更新日期：2012-07-01 00:00:00