Signal-to-noise ratio of a mouse brain (13) C CryoProbe™ system in comparison with room temperature coils: spectroscopic phantom and in vivo results.

abstract：:At the high field strength of 7 T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures oth...

journal_title：NMR in biomedicine

authors： Marjańska M,Auerbach EJ,Valabrègue R,Van de Moortele PF,Adriany G,Garwood M

更新日期：2012-02-01 00:00:00

abstract：:The phosphorus NMR spectra of isolated perfused rat liver displays a prominent inorganic phosphate peak at 2.76 +/- 0.05 ppm relative to liver glycerolphosphocholine at 0.49 ppm. From titration curves of phosphorus-containing compounds this corresponds to a pH of 7.4. The spectra also display a shoulder on the promine...

journal_title：NMR in biomedicine

authors： Thoma WJ,Uğurbil K

更新日期：1988-04-01 00:00:00

abstract：:In recent years, quantitative nuclear magnetic resonance imaging and spectroscopy (NMRI and NMRS) have been used more systematically as outcome measures in natural history and clinical trial studies for Duchenne muscular dystrophy (DMD). Whereas most of these studies have emphasized the evaluation of the fat fraction ...

journal_title：NMR in biomedicine

authors： Reyngoudt H,Turk S,Carlier PG

更新日期：2018-01-01 00:00:00

abstract：:The aim of this study was to acquire the transient MRI signal of hyperpolarized tracers and their metabolites efficiently, for which specialized imaging sequences are required. In this work, a multi-echo balanced steady-state free precession (me-bSSFP) sequence with Iterative Decomposition with Echo Asymmetry and Leas...

journal_title：NMR in biomedicine

authors： Müller CA,Hundshammer C,Braeuer M,Skinner JG,Berner S,Leupold J,Düwel S,Nekolla SG,Månsson S,Hansen AE,von Elverfeldt D,Ardenkjaer-Larsen JH,Schilling F,Schwaiger M,Hennig J,Hövener JB

更新日期：2020-06-01 00:00:00

abstract：:Surface coil 13C nuclear magnetic resonance (NMR) spectroscopy was used to investigate the in vivo carbohydrate metabolism of rat C6 gliomas during and after infusion with [1-13C] glucose. In vivo 1H-decoupled 13C NMR spectra of the glioma following infusion with [1-13C]glucose revealed the direct production of [3-13C...

journal_title：NMR in biomedicine

authors： Ross BD,Higgins RJ,Boggan JE,Willis JA,Knittel B,Unger SW

更新日期：1988-02-01 00:00:00

abstract：:The management and treatment of high-grade glioblastoma multiforme (GBM) and solitary metastasis (MET) are very different and influence the prognosis and subsequent clinical outcomes. In the case of a solitary MET, diagnosis using conventional radiology can be equivocal. Currently, a definitive diagnosis is based on h...

journal_title：NMR in biomedicine

authors： Yang G,Jones TL,Barrick TR,Howe FA

更新日期：2014-09-01 00:00:00

abstract：INTRODUCTION:Sarcoidosis is a systemic granulomatous disease affecting in particular the respiratory tract. Cardiac magnetic resonance (CMR), including a measurement of T1 relaxation time, could potentially detect early stadia of sarcoidosis of the heart. The study aims to assess T1 mapping in the detection of early ca...

journal_title：NMR in biomedicine

authors： Panovský R,Doubková M,Holeček T,Máchal J,Feitová V,Masárová L,Opatřil L,Mojica-Pisciotti ML,Kincl V

更新日期：2020-11-01 00:00:00

abstract：:Standard functional MRI (fMRI), which includes resting-state or paradigm-driven designs, is widely used in studies of brain function, aging, and disease. These fMRI studies typically use two-dimensional gradient echo-planar imaging, which inherently contains phase data that enables quantitative susceptibility mapping ...

journal_title：NMR in biomedicine

authors： Sun H,Seres P,Wilman AH

更新日期：2017-04-01 00:00:00

abstract：:We review several methods that have been developed to infer microstructural and physiological information about isotropic and anisotropic tissues from diffusion weighted images (DWIs). These include Diffusion Imaging (DI), Diffusion Tensor Imaging (DTI), isotropically weighted imaging, and q-space imaging. Just as DI ...

journal_title：NMR in biomedicine

authors： Basser PJ

更新日期：1995-11-01 00:00:00

abstract：:Metabolomic studies by NMR spectroscopy are increasingly employed for a variety of biomedical applications. A very standardized 1D proton NMR protocol is generally employed for data acquisition, associated with multivariate statistical tests. Even if targeted approaches have been proposed to quantify metabolites from ...

journal_title：NMR in biomedicine

authors： Martineau E,Tea I,Akoka S,Giraudeau P

更新日期：2012-08-01 00:00:00

abstract：:The possibility of quantifying the superimposed signal of glutamate and glutamine (Glx) and its components by ¹H magnetic resonance spectroscopy (MRS) in the spinal cord is an exciting challenge with important clinical applications in neurological conditions. The spinal cord is a particularly difficult region of inter...

journal_title：NMR in biomedicine

authors： Solanky BS,Abdel-Aziz K,Yiannakas MC,Berry AM,Ciccarelli O,Wheeler-Kingshott CA

更新日期：2013-03-01 00:00:00

abstract：:Hyperpolarised [1-13 C]pyruvate MRI has shown promise in monitoring therapeutic efficacy in a number of cancers including glioma. In this study, we assessed the pyruvate response to the lentiviral suicide gene therapy of herpes simplex virus-1 thymidine kinase with the prodrug ganciclovir (HSV-TK/GCV) in C6 rat glioma...

journal_title：NMR in biomedicine

authors： Nivajärvi R,Olsson V,Hyppönen V,Bowen S,Leinonen HM,Lesch HP,Ardenkjaer-Larsen JH,Gröhn OHJ,Ylä-Herttuala S,Kettunen MI

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:To develop a novel respiratory motion compensated three-dimensional (3D) cardiac magnetic resonance fingerprinting (cMRF) approach for whole-heart myocardial T1 and T2 mapping from a free-breathing scan. METHODS:Two-dimensional (2D) cMRF has been recently proposed for simultaneous, co-registered T1 and T2 mapp...

journal_title：NMR in biomedicine

authors： Cruz G,Jaubert O,Qi H,Bustin A,Milotta G,Schneider T,Koken P,Doneva M,Botnar RM,Prieto C

更新日期：2020-10-01 00:00:00

abstract：:An indirect method for in vivo T2 mapping of 13 C-labeled metabolites using T2 and T2 * information of water protons obtained a priori is proposed. The T2 values of 13 C metabolites are inferred using the relationship to T2 ' of coexisting 1 H and the T2 * of 13 C metabolites, which is measured using routine hyperpola...

journal_title：NMR in biomedicine

authors： Joe E,Lee H,Lee J,Yang S,Choi YS,Wang E,Song HT,Kim DH

更新日期：2017-05-01 00:00:00

abstract：:The increased magnetic susceptibility effects at higher magnetic fields increase the demands for shimming of the B0 field for in vivo MRI and MRS. Both static and dynamic techniques have been developed to compensate for susceptibility-induced field inhomogeneities. In this study, we investigate the impact of and need ...

journal_title：NMR in biomedicine

authors： Boer VO,Luttje MP,Luijten PR,Klomp DW

更新日期：2014-06-01 00:00:00

abstract：:Chemical exchange saturation transfer (CEST)-derived, pH-weighted, amide proton transfer (APT) MRI has shown promise in animal studies for the prediction of infarction risk in ischemic tissue. Here, APT MRI was translated to patients with acute stroke (1-24 h post-symptom onset), and assessments of APT contrast, perfu...

journal_title：NMR in biomedicine

authors： Tietze A,Blicher J,Mikkelsen IK,Østergaard L,Strother MK,Smith SA,Donahue MJ

更新日期：2014-02-01 00:00:00

abstract：:Human tumor and skeletal muscle tissue was studied by means of in vivo 1H, 31P, and 13C MRS. The examinations were performed with a 1.5 T whole-body MR scanner equipped with a second RF system. Localized 1H and broadband proton-decoupled 31P and 13C MR spectra were obtained in measurement times of 5, 10 and 33 min, re...

journal_title：NMR in biomedicine

authors： Bachert P,Bellemann ME,Layer G,Koch T,Semmler W,Lorenz WJ

更新日期：1992-07-01 00:00:00

abstract：:Here, we show that the sensitivity of (31)P MRSI of (31)P spins J-coupled to protons can be increased by almost a factor of three when compared with an optimal direct detection free induction decay. By direct detection integrated with multi-echo polarization transfer (DIMEPT), multiple signals from polarization transf...

journal_title：NMR in biomedicine

authors： van der Kemp WJ,Boer VO,Luijten PR,Klomp DW

更新日期：2014-10-01 00:00:00

abstract：:The temporary or permanent storage of human bodies in freezers following a homicide is a documented method for criminal disposal of human corpses. In these cases, the detection of characteristics which indicate that a thawed cadaver or body part was previously frozen provides crucial information for forensic casework....

journal_title：NMR in biomedicine

authors： Gascho D,Richter H,Karampinos DC,Heimer J,Schaerli S,Thali MJ,Zoelch N

更新日期：2020-02-01 00:00:00

abstract：:T1ρ relaxation imaging is a quantitative imaging technique that has been used to assess cartilage integrity, liver fibrosis, tumors, cardiac infarction, and Alzheimer's disease. T1 , T2 , and T1ρ relaxation time constants have each demonstrated different degrees of sensitivity to several markers of fibrosis and inflam...

journal_title：NMR in biomedicine

authors： Wyatt CR,Barbara TM,Guimaraes AR

更新日期：2020-05-01 00:00:00

abstract：:Owing to the small quantity of tissue available in human biopsy specimens, aqueous and lipid components often have to be determined in the same tissue sample. Perchloric acid (PCA) used for the extraction of aqueous metabolites has a deleterious effect on lipid components; the severity of the damage is not known. In t...

journal_title：NMR in biomedicine

authors： Srivastava NK,Pradhan S,Mittal B,Kumar R,Pandey CM,Gowda GA

更新日期：2008-02-01 00:00:00

abstract：:Brain activation studies in humans have shown the dynamic nature of neuronal N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) based on changes in their MRS signals in response to stimulation. These studies demonstrated that upon visual stimulation there was a focal increase in cerebral blood flow (CBF) and...

journal_title：NMR in biomedicine

authors： Baslow MH,Cain CK,Sears R,Wilson DA,Bachman A,Gerum S,Guilfoyle DN

更新日期：2016-12-01 00:00:00

abstract：:The use of cerebral water as an internal intensity standard for the quantitation of spatially localized proton spectra of the human brain is investigated. The method is validated on standard samples of N-acetyl aspartate (NAA) and lactate, and possible sources of error are discussed. Using the STEAM pulse sequence, co...

journal_title：NMR in biomedicine

authors： Barker PB,Soher BJ,Blackband SJ,Chatham JC,Mathews VP,Bryan RN

更新日期：1993-01-01 00:00:00

abstract：:Previous studies have demonstrated that using hyperpolarized [2-13 C]pyruvate as a contrast agent can reveal 13 C signals from metabolites associated with the tricarboxylic acid (TCA) cycle. However, the metabolites detectable from TCA cycle-mediated oxidation of [2-13 C]pyruvate are the result of several metabolic st...

journal_title：NMR in biomedicine

authors： Chen AP,Lau AZ,Gu YP,Schroeder MA,Barry J,Cunningham CH

更新日期：2018-01-01 00:00:00

abstract：:Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and proton (1H) magnetic resonance spectroscopy (MRS) provide structural and biochemical information, including vascular volume, vascular permeability and tissue metabolism. In this study, we performed analysis of the enhancement characteristic from DCE-...

journal_title：NMR in biomedicine

authors： Lipnick S,Liu X,Sayre J,Bassett LW,Debruhl N,Thomas MA

更新日期：2010-10-01 00:00:00

abstract：:Quantification of metabolites is a goal of many biomedical NMR studies. To obtain absolute measurements of metabolite concentrations is often both difficult and time-consuming. In this paper a method for determining metabolite concentrations directly is described and validated. It is applicable to studies of amphibian...

journal_title：NMR in biomedicine

authors： Wray S,Wilkie DR

更新日期：1992-05-01 00:00:00

abstract：:NMR relaxometry can provide information about the relaxation of the magnetization in different tissues, increasing our understanding of molecular dynamics and biochemical composition in biological systems. In general, tissues have complex and heterogeneous structures composed of multiple pools. As a result, bulk magne...

journal_title：NMR in biomedicine

authors： Zibetti MVW,Helou ES,Sharafi A,Regatte RR

更新日期：2020-12-01 00:00:00

abstract：:Biomarkers of early response to treatment have the potential to improve cancer therapy by allowing treatment to be tailored to the individual. Alterations in lipids detected by in vivo MRS have been suggested as noninvasive biomarkers of cell stress and early indicators of cell death. An improved understanding of the ...

journal_title：NMR in biomedicine

authors： Mirbahai L,Wilson M,Shaw CS,McConville C,Malcomson RD,Kauppinen RA,Peet AC

更新日期：2012-11-01 00:00:00

abstract：:Hyperpolarised (HP) (13)C NMR allows enzymatic activity to be probed in real time in live biological systems. The use of in vitro models gives excellent control of the cellular environment, crucial in the understanding of enzyme kinetics. The increased conversion of pyruvate to lactate in cancer cells has been well st...

journal_title：NMR in biomedicine

authors： Breukels V,Jansen KC,van Heijster FH,Capozzi A,van Bentum PJ,Schalken JA,Comment A,Scheenen TW

更新日期：2015-08-01 00:00:00

abstract：:The majority of functional MRI studies of pain processing in the brain use the blood oxygenation level-dependent (BOLD) imaging approach. However, the BOLD signal is complex as it depends on simultaneous changes in blood flow, vascular volume and oxygen metabolism. Arterial spin labeling (ASL) perfusion imaging is ano...

journal_title：NMR in biomedicine

authors： Maleki N,Brawn J,Barmettler G,Borsook D,Becerra L

更新日期：2013-06-01 00:00:00