Physiological variation of the vertebral bone marrow water T2 relaxation time.

abstract：:Natural abundance proton-decoupled (13)C magnetic resonance spectroscopy was used to establish the in vivo lipid composition of normal adipose tissue and the corresponding effects of altered lipid diets. Experiments were performed on a standard 1.5 T clinical MR scanner using a double-tuned (1)H-(13)C coil. Peaks from...

journal_title：NMR in biomedicine

authors： Hwang JH,Bluml S,Leaf A,Ross BD

更新日期：2003-05-01 00:00:00

abstract：:This introductory article addresses approaches currently in use to process in vivo spectra. First, a brief overview is given of the information content represented by the parameters of MR signals. Subsequently, common steps in the processing of MR spectra such as pre-processing, normalisation and quantification and th...

journal_title：NMR in biomedicine

authors： in 't Zandt H,van Der Graaf M,Heerschap A

更新日期：2001-06-01 00:00:00

abstract：:To understand and predict the blood-oxygenation level-dependent (BOLD) fMRI signal, an accurate knowledge of the relationship between cerebral blood flow (DeltaCBF) and volume (DeltaCBV) changes is critical. Currently, this relationship is widely assumed to be characterized by Grubb's power-law, derived from primate d...

journal_title：NMR in biomedicine

authors： Chen JJ,Pike GB

更新日期：2009-12-01 00:00:00

abstract：:Phosphatidylcholine (PC) metabolism in bovine adrenal chromaffin cells has been studied in vivo with 100 MHz 13C NMR spectroscopy. The incorporation of 13[CH3]choline was examined in cells embedded in 1% agarose strands and perfused at 37 degrees C. The pattern of 13C NMR spectroscopy. The incorporation of [13CH3]chol...

journal_title：NMR in biomedicine

authors： Rivera CJ,Plishker GA,Morrisett JD,Moore J,Percy AK

更新日期：1991-06-01 00:00:00

abstract：:Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

journal_title：NMR in biomedicine

authors： Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

更新日期：2012-08-01 00:00:00

abstract：:We have developed a reliable, reproducible model of hypoxia in the gerbil. 1H and 31P NMR spectroscopy demonstrates that cerebral energy metabolism is very resistant to hypoxia. Cerebral blood flow (measured by hydrogen clearance) began to increase when the arterial oxygen tension (paO2) was reduced to 40-50 mm Hg, an...

journal_title：NMR in biomedicine

authors： Allen K,Busza AL,Crockard HA,Gadian DG

更新日期：1992-01-01 00:00:00

abstract：:The ability to assess the perfusion territories of major cerebral arteries can be a valuable asset to the diagnosis of a number of cerebrovascular diseases. Recently, several arterial spin labeling (ASL) techniques have been proposed for determining the cerebral perfusion territories of individual arteries by three di...

journal_title：NMR in biomedicine

authors： Paiva FF,Tannús A,Silva AC

更新日期：2007-11-01 00:00:00

abstract：:Early imaging or blood biomarkers of tumor response is needed to customize anti-tumor therapy on an individual basis. This study evaluates the sensitivity and relevance of five potential MRI biomarkers. Sixty nude rats were implanted with human glioma cells (U-87 MG) and randomized into three groups: one group receive...

journal_title：NMR in biomedicine

authors： Lemasson B,Christen T,Tizon X,Farion R,Fondraz N,Provent P,Segebarth C,Barbier EL,Genne P,Duchamp O,Remy C

更新日期：2011-06-01 00:00:00

abstract：:Acute kidney injury (AKI) in mice caused by sustained ischemia followed by reperfusion is associated with acute tubular necrosis and renal dysfunctional blood flow. Although the principal role of the kidney is the maintenance of acid-base balance, current imaging approaches are unable to assess this important paramete...

journal_title：NMR in biomedicine

authors： Longo DL,Cutrin JC,Michelotti F,Irrera P,Aime S

更新日期：2017-07-01 00:00:00

abstract：:This paper describes the use of off-resonance saturation to further manipulate the blood oxygenation level dependent (BOLD) contrast of fMRI. A customized narrow bandwidth radiofrequency pulse, applied with a range of frequency offsets prior to selection of each slice, was designed and incorporated into a gradient ech...

journal_title：NMR in biomedicine

authors： Song AW,Wolff SD,Balaban RS,Jezzard P

更新日期：1997-06-01 00:00:00

abstract：:In this study, mapping of ultrashort T2 and T2* of acutely isolated porcine menisci at B0 = 9.4 T was investigated. Maps of T2 were measured from a slice through the pars intermedia with a spin echo-prepared two-dimensional ultrashort-TE T2 mapping technique published previously. T2* mapping was performed by two-dimen...

journal_title：NMR in biomedicine

authors： Kirsch S,Kreinest M,Reisig G,Schwarz ML,Ströbel P,Schad LR

更新日期：2013-09-01 00:00:00

abstract：:Chemical exchange saturation transfer (CEST)-derived, pH-weighted, amide proton transfer (APT) MRI has shown promise in animal studies for the prediction of infarction risk in ischemic tissue. Here, APT MRI was translated to patients with acute stroke (1-24 h post-symptom onset), and assessments of APT contrast, perfu...

journal_title：NMR in biomedicine

authors： Tietze A,Blicher J,Mikkelsen IK,Østergaard L,Strother MK,Smith SA,Donahue MJ

更新日期：2014-02-01 00:00:00

abstract：:Q-ball imaging (QBI) is an imaging technique that is capable of resolving intravoxel fiber crossings; however, the signal readout based on echo-planar imaging (EPI) introduces geometric distortions in the presence of susceptibility gradients. This study proposes an imaging technique that reduces susceptibility distort...

journal_title：NMR in biomedicine

authors： Chou MC,Huang TY,Chung HW,Hsieh TJ,Chang HC,Chen CY

更新日期：2013-12-01 00:00:00

abstract：:A study was undertaken to determine if the vascular characteristics measured by dynamic contrast-enhanced magnetic resonance imaging (primarily permeability surface area product and extracellular-extravascular tissue volume fraction) would be beneficial in explaining the inter-lesion metabolic heterogeneity displayed ...

journal_title：NMR in biomedicine

authors： Manton DJ,Lowry M,Rowland-Hill C,Crooks D,Mathew B,Turnbull LW

更新日期：2000-12-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is characterized at histology by steatosis, hepatocyte ballooning and inflammatory infiltrates, with or without fibrosis. Although diamagnetic material in fibrosis and inflammation can be detected with quantitative susceptibility imaging, fatty acid composition changes in NASH rela...

journal_title：NMR in biomedicine

authors： Leporq B,Lambert SA,Ronot M,Vilgrain V,Van Beers BE

更新日期：2017-10-01 00:00:00

abstract：:Progress in the development of non-proton NMR applications in medical research has been hampered by the generally low sensitivity of these nuclides as well as the lack of instrumentation readily available for studying these spins. For example, custom head coils suitable for sodium imaging of the human head are either ...

journal_title：NMR in biomedicine

authors： Lim KO,Wolff S,Balaban RS

更新日期：1989-09-01 00:00:00

abstract：:Human tumor and skeletal muscle tissue was studied by means of in vivo 1H, 31P, and 13C MRS. The examinations were performed with a 1.5 T whole-body MR scanner equipped with a second RF system. Localized 1H and broadband proton-decoupled 31P and 13C MR spectra were obtained in measurement times of 5, 10 and 33 min, re...

journal_title：NMR in biomedicine

authors： Bachert P,Bellemann ME,Layer G,Koch T,Semmler W,Lorenz WJ

更新日期：1992-07-01 00:00:00

abstract：:Given the importance of genetically modified mice in studies of mammalian brain development and human congenital brain diseases, MRI has the potential to provide an efficient in vivo approach for analyzing mutant phenotypes in the early postnatal mouse brain. The combination of reduced tissue contrast at the high magn...

journal_title：NMR in biomedicine

authors： Wadghiri YZ,Blind JA,Duan X,Moreno C,Yu X,Joyner AL,Turnbull DH

更新日期：2004-12-01 00:00:00

abstract：:This study tests the hypothesis that brief periods of ischemia result in an increase in myocardial lipids during early reperfusion. We conducted 1H NMR spectroscopy to serially measure myocardial lipids before and after regional ischemia. Localized 1H NMR spectra (spatial resolution of 1.25 mm) were obtained using a o...

journal_title：NMR in biomedicine

authors： Balschi JA,Hetherington HP,Bradley EL Jr,Pohost GM

更新日期：1995-04-01 00:00:00

abstract：:Quantitative mapping of MR tissue parameters such as the spin-lattice relaxation time (T1 ), the spin-spin relaxation time (T2 ), and the spin-lattice relaxation in the rotating frame (T1ρ ), referred to as MR relaxometry in general, has demonstrated improved assessment in a wide range of clinical applications. Compar...

journal_title：NMR in biomedicine

authors： Feng L,Ma D,Liu F

更新日期：2020-10-15 00:00:00

abstract：:High-resolution MR imaging (312 microns in plane resolution) and MR spectroscopy (0.36 cm3 nominal voxel) have been performed on human frontal cortex using a 3 in surface coil. Localized proton spectra have been obtained from contiguous 6 x 6 x 10 mm voxels using one-dimensional phase encoding, TR 2000 ms and TE 31 ms...

journal_title：NMR in biomedicine

authors： López-Villegas D,Kimura H,Tunlayadechanont S,Lenkinski RE

更新日期：1996-10-01 00:00:00

abstract：:Changes in physiological parameters such as cerebral blood flow, cerebral blood volume, oxygen extraction, and the size and distribution of cerebral blood vessels, result in changes in the local concentration of deoxyhaemoglobin ([dHb]). The purpose of this study was to quantitatively investigate the dependence of the...

journal_title：NMR in biomedicine

authors： Punwani S,Ordidge RJ,Cooper CE,Amess P,Clemence M

更新日期：1998-10-01 00:00:00

abstract：:The purpose of this work was to harmonize data acquisition and post-processing of single voxel proton MRS ((1) H-MRS) at 7 T, and to determine metabolite concentrations and the accuracy and reproducibility of metabolite levels in the adult human brain. This study was performed in compliance with local institutional hu...

journal_title：NMR in biomedicine

authors： van de Bank BL,Emir UE,Boer VO,van Asten JJ,Maas MC,Wijnen JP,Kan HE,Oz G,Klomp DW,Scheenen TW

更新日期：2015-03-01 00:00:00

abstract：:Increased lactate production through glycolysis in aerobic conditions is a hallmark of cancer. Some anticancer drugs have been designed to exploit elevated glycolysis in cancer cells. For example, lonidamine (LND) inhibits lactate transport, leading to intracellular acidification in cancer cells. Chemical exchange sat...

journal_title：NMR in biomedicine

authors： McVicar N,Li AX,Meakin SO,Bartha R

更新日期：2015-05-01 00:00:00

abstract：:Diffusion tensor imaging (DTI) provides an indirect measure of tissue structure on a microscopic scale. To date, DTI is the only imaging method that provides such information in vivo, and has proven to be a valuable tool in both research and clinical settings. In this study, we investigated the relationship between wh...

journal_title：NMR in biomedicine

authors： Choe AS,Stepniewska I,Colvin DC,Ding Z,Anderson AW

更新日期：2012-07-01 00:00:00

abstract：:Brain myelin and iron content are important parameters in neurodegenerative diseases such as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation rate. However, their quantification based on R2* maps requires a realistic tissue model that can be fitted to the measured data. In str...

journal_title：NMR in biomedicine

authors： Kor D,Birkl C,Ropele S,Doucette J,Xu T,Wiggermann V,Hernández-Torres E,Hametner S,Rauscher A

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:To investigate the feasibility of using multiple flip angles in dynamic contrast enhanced (DCE) MRI to reduce the uncertainty in estimation of intracellular water lifetime (τi ). METHODS:Numerical simulation studies were conducted to assess the uncertainty in estimation of τi using dynamic contrast enhanced MR...

journal_title：NMR in biomedicine

authors： Zhang J,Kim SG

更新日期：2019-11-01 00:00:00

abstract：:Under normal conditions, the heart mainly relies on fatty acid oxidation to meet its energy needs. Changes in myocardial fuel preference are noted in the diseased and failing heart. The magnetic resonance signal enhancement provided by spin hyperpolarization allows the metabolism of substrates labeled with carbon-13 t...

journal_title：NMR in biomedicine

authors： Yoshihara HAI,Bastiaansen JAM,Karlsson M,Lerche MH,Comment A,Schwitter J

更新日期：2020-03-01 00:00:00

abstract：:Central obesity is the hallmark of a number of non-inheritable disorders. The advent of imaging techniques such as MRI has allowed for a fast and accurate assessment of body fat content and distribution. However, image analysis continues to be one of the major obstacles to the use of MRI in large-scale studies. In thi...

journal_title：NMR in biomedicine

authors： Borga M,Thomas EL,Romu T,Rosander J,Fitzpatrick J,Dahlqvist Leinhard O,Bell JD

更新日期：2015-12-01 00:00:00

abstract：:The scyllo-inositol and myo-inositol concentrations of 24 normal human subjects were measured in vivo using 1H magnetic resonance spectroscopy at 4 T. Single-voxel short-echo (TE = 15 ms) metabolite spectra were collected from the white matter region of the corona radiata. Test-retest studies performed on 10 normal su...

journal_title：NMR in biomedicine

authors： Kaiser LG,Schuff N,Cashdollar N,Weiner MW

更新日期：2005-02-01 00:00:00