Brain metabolism and blood flow in acute cerebral hypoxia studied by NMR spectroscopy and hydrogen clearance.

abstract：:Diffusion tensor imaging (DTI) provides an indirect measure of tissue structure on a microscopic scale. To date, DTI is the only imaging method that provides such information in vivo, and has proven to be a valuable tool in both research and clinical settings. In this study, we investigated the relationship between wh...

journal_title：NMR in biomedicine

authors： Choe AS,Stepniewska I,Colvin DC,Ding Z,Anderson AW

更新日期：2012-07-01 00:00:00

abstract：:In vivo metabolic imaging using hyperpolarized [1-(13)C]pyruvate provides localized biochemical information and is particularly useful in detecting early disease changes, as well as monitoring disease progression and treatment response. However, a major limitation of hyperpolarized magnetization is its unrecoverable d...

journal_title：NMR in biomedicine

authors： Chen WC,Teo XQ,Lee MY,Radda GK,Lee P

更新日期：2015-08-01 00:00:00

abstract：:The accurate diagnosis of glioma subtypes is critical for appropriate treatment, but conventional histopathologic diagnosis often exhibits significant intra-observer variability and sampling error. The aim of this study was to investigate whether histogram analysis using an automatically segmented region of interest (...

journal_title：NMR in biomedicine

authors： Lee J,Choi SH,Kim JH,Sohn CH,Lee S,Jeong J

更新日期：2014-09-01 00:00:00

abstract：:The development and implementation of novel MRI pulse sequences remains challenging and laborious. Gradient waveforms are typically designed using a combination of analytical and ad hoc methods to construct each gradient waveform axis independently. This strategy makes coding the pulse sequence complicated, in additio...

journal_title：NMR in biomedicine

authors： Middione MJ,Loecher M,Moulin K,Ennis DB

更新日期：2020-12-01 00:00:00

abstract：:A novel iodoacetamide label 4-perfluoro-tert-butyl-phenyliodoacetamide (PFP) containing nine fluorine atoms in equivalent positions has been synthesized. It provides a homogeneous 19F NMR resonance line which can be detected with high sensitivity when coupled to proteins. As an example, the sulfhydryl groups of actin ...

journal_title：NMR in biomedicine

authors： Kalbitzer HR,Rohr G,Nowak E,Goody RS,Kuhn W,Zimmermann H

更新日期：1992-11-01 00:00:00

abstract：:The background underpinning the clinical use of ultrashort echo time, SPRITE and other pulse sequences for imaging bone and other connective tissues with short T2 is reviewed. Features of the basic physics relevant to UTE imaging are described, including the consequences when the radiofrequency pulse duration is of th...

journal_title：NMR in biomedicine

authors： Robson MD,Bydder GM

更新日期：2006-11-01 00:00:00

abstract：:The potential for using pre-polarized liquids as contrast agents in vivo is investigated and the feasibility of the method demonstrated. In this study we show the enhancement obtained following intravenous delivery of pre-polarized saline into the antecubital vein of a volunteer. This form of contrast agent provides s...

journal_title：NMR in biomedicine

authors： Young IR,deSouza NM,Hall AS,Williams AD,Hajnal JV,Coutts GA

更新日期：1999-10-01 00:00:00

abstract：:This study aimed to demonstrate a reliable automatic segmentation method for independently separating reduced diffusion and decreased perfusion areas in ischemic stroke brains using constrained nonnegative matrix factorization (cNMF) pattern recognition in directional intravoxel incoherent motion MRI (IVIM-MRI). First...

journal_title：NMR in biomedicine

authors： Jang M,Jin S,Kang M,Han S,Cho H

更新日期：2020-05-01 00:00:00

abstract：:Acute kidney injury (AKI) in mice caused by sustained ischemia followed by reperfusion is associated with acute tubular necrosis and renal dysfunctional blood flow. Although the principal role of the kidney is the maintenance of acid-base balance, current imaging approaches are unable to assess this important paramete...

journal_title：NMR in biomedicine

authors： Longo DL,Cutrin JC,Michelotti F,Irrera P,Aime S

更新日期：2017-07-01 00:00:00

abstract：:Resolution enhancement for glutamate (Glu), glutamine (Gln) and glutathione (GSH) in the human brain by TE-optimized point-resolved spectroscopy (PRESS) at 7 T is reported. Sub-TE dependences of the multiplets of Glu, Gln, GSH, γ-aminobutyric acid (GABA) and N-acetylaspartate (NAA) at 2.2-2.6 ppm were investigated wit...

journal_title：NMR in biomedicine

authors： Choi C,Dimitrov IE,Douglas D,Patel A,Kaiser LG,Amezcua CA,Maher EA

更新日期：2010-11-01 00:00:00

abstract：:Modified gradient-echo MR techniques were applied to study the effects of inflow on functional brain imaging studies using visual and motor cortex stimulation. The results demonstrate that the large signal changes, seen in previously reported gradient-echo studies at 1.5-2.0 T, are dominated by direct inflow effects, ...

journal_title：NMR in biomedicine

authors： Duyn JH,Moonen CT,van Yperen GH,de Boer RW,Luyten PR

更新日期：1994-03-01 00:00:00

abstract：:The goal of the study was to establish early hyperpolarized (HP) 13 C MRI metabolic and perfusion changes that predict effective high-intensity focused ultrasound (HIFU) ablation and lead to improved adjuvant treatment of partially treated regions. To accomplish this a combined HP dual-agent (13 C pyruvate and 13 C ur...

journal_title：NMR in biomedicine

authors： Lee JE,Diederich CJ,Bok R,Sriram R,Santos RD,Noworolski SM,Salgaonkar VA,Adams MS,Vigneron DB,Kurhanewicz J

更新日期：2019-10-01 00:00:00

abstract：:133Cs NMR is a valuable tool for non-invasively probing biological systems. As a congener of potassium, it accumulates in the intracellular space, primarily through the action of the Na+-K+ pump (ATPase). In addition, it is possible to resolve the MR signal of 133Cs in different tissue compartments on the basis of che...

journal_title：NMR in biomedicine

authors： Goodman J,Neil JJ,Ackerman JJ

更新日期：2005-04-01 00:00:00

abstract：:Obesity causes damage to several organs, including the brain. Recent studies have been focusing on understanding the mechanisms through which obesity affects brain structure and function using neuroimaging techniques. A functional biomarker, such as cerebral blood flow (CBF), is a powerful tool that can be used to exp...

journal_title：NMR in biomedicine

authors： Peng SL,Chen CM

更新日期：2020-10-01 00:00:00

abstract：:Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

journal_title：NMR in biomedicine

authors： Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

更新日期：2012-08-01 00:00:00

abstract：:A method to extract shapes of bubble polyhedra from three-dimensional nuclear magnetic resonance image data of foam has been developed. The method consists of four steps: first, to compute series of maximum intensity projection images from the three-dimensional NMR image data of foam to visualize the network structure...

journal_title：NMR in biomedicine

authors： Kashiwagi K,Kose K

更新日期：1997-01-01 00:00:00

abstract：:Metabolic activity in the lung is known to change in response to external insults, inflammation, and cancer. We report measurements of metabolism in the isolated, perfused rat lung of healthy controls and in diseased lungs undergoing acute inflammation using hyperpolarized 1-(13) C-labeled pyruvate. The overall appare...

journal_title：NMR in biomedicine

authors： Shaghaghi H,Kadlecek S,Deshpande C,Siddiqui S,Martinez D,Pourfathi M,Hamedani H,Ishii M,Profka H,Rizi R

更新日期：2014-08-01 00:00:00

abstract：:Glucosamine (GlcN) modulates fluoropyrimidine metabolism and enhances cytotoxicity of 5-fluorouridine (FUrd), but not of 5-fluorouracil (FUra), in human tumor models. To elucidate the underlying metabolic differences between FUra and FUrd, by the use of 19F and 31P NMR spectroscopy we studied these drugs in multicell ...

journal_title：NMR in biomedicine

authors： Chen TB,Bajzer Z,Macura S,Vuk-Pavlovic S

更新日期：1999-05-01 00:00:00

abstract：:The aim of the study was to establish the normal range and to evaluate the reproducibility of dynamic contrast enhanced MRI (DCE-MRI) parameter estimates in normal human pelvic tissues. Nineteen patients with prostate cancer, undergoing androgen deprivation treatment, had paired DCE-MRI examinations of the pelvis usin...

journal_title：NMR in biomedicine

authors： Padhani AR,Hayes C,Landau S,Leach MO

更新日期：2002-04-01 00:00:00

abstract：:Dynamic contrast-enhanced MRI (DCE MRI) has been used to study tumor response to treatment for many years. In this study, the modified full width at half-maximum (mFWHM), calculated from the wash-in slope histogram, is proposed as a parameter for the evaluation of changes in tumor heterogeneity which respond to radiot...

journal_title：NMR in biomedicine

authors： Peng SL,Chen CF,Liu HL,Lui CC,Huang YJ,Lee TH,Chang CC,Wang FN

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:To investigate the feasibility of using multiple flip angles in dynamic contrast enhanced (DCE) MRI to reduce the uncertainty in estimation of intracellular water lifetime (τi ). METHODS:Numerical simulation studies were conducted to assess the uncertainty in estimation of τi using dynamic contrast enhanced MR...

journal_title：NMR in biomedicine

authors： Zhang J,Kim SG

更新日期：2019-11-01 00:00:00

abstract：:The combination of hyperpolarized Xe with chemical exchange saturation transfer (Hyper-CEST) is a powerful NMR technique to detect highly dilute concentrations of Xe binding sites using RF saturation pulses. Crucially, that combination of saturation pulse strength and duration that generates the maximal Hyper-CEST eff...

journal_title：NMR in biomedicine

authors： Kunth M,Witte C,Schröder L

更新日期：2015-06-01 00:00:00

abstract：:A simple technique permitting long term 31P magnetic resonance spectroscopy of cultured mammalian cells is described. Cells are encapsulated in calcium alginate gels and perfused with a new phosphate-fre medium designed for maintenance of high cell viability. Intracellular pH and beta-NTP/Pi ratios, studied in three c...

journal_title：NMR in biomedicine

authors： Narayan KS,Moress EA,Chatham JC,Barker PB

更新日期：1990-02-01 00:00:00

abstract：:One of the major goals of hyperpolarized-gas MR imaging has been to obtain (129)Xe dissolved-phase images in humans. Since the dissolved-phase signal is much weaker than the gas-phase signal, highly optimized MR pulse sequences are required to obtain adequate images during a single breath-hold. In particular, a solid ...

journal_title：NMR in biomedicine

authors： Ruppert K,Brookeman JR,Hagspiel KD,Driehuys B,Mugler JP 3rd

更新日期：2000-06-01 00:00:00

abstract：:Glycine (Gly) has been implicated in several neurological disorders, including malignant brain tumors. The precise measurement of Gly is challenging largely as a result of the spectral overlap with myo-inositol (mI). We report a new triple-refocusing sequence for the reliable co-detection of Gly and mI at 3 T and for ...

journal_title：NMR in biomedicine

authors： Tiwari V,An Z,Ganji SK,Baxter J,Patel TR,Pan E,Mickey BE,Maher EA,Pinho MC,Choi C

更新日期：2017-09-01 00:00:00

abstract：:In the unstimulated brain energy is primarily supplied by the oxidation of glucose. However the oxygen-to-glucose index (OGI), which is the ratio of metabolic rates of oxygen to glucose, CMR(O2)/CMR(glc), diverges from the theoretical value of 6 as activity is increased. In vivo measurements of brain lactate show its ...

journal_title：NMR in biomedicine

authors： Shulman RG,Hyder F,Rothman DL

更新日期：2001-11-01 00:00:00

abstract：INTRODUCTION:Sarcoidosis is a systemic granulomatous disease affecting in particular the respiratory tract. Cardiac magnetic resonance (CMR), including a measurement of T1 relaxation time, could potentially detect early stadia of sarcoidosis of the heart. The study aims to assess T1 mapping in the detection of early ca...

journal_title：NMR in biomedicine

authors： Panovský R,Doubková M,Holeček T,Máchal J,Feitová V,Masárová L,Opatřil L,Mojica-Pisciotti ML,Kincl V

更新日期：2020-11-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a genetic imprinting disorder characterized mainly by hyperphagia and early childhood obesity. Previous functional neuroimaging studies used visual stimuli to examine abnormal activities in the eating-related neural circuitry of patients with PWS. It was found that patients with PWS exhi...

journal_title：NMR in biomedicine

authors： Zhang Y,Zhao H,Qiu S,Tian J,Wen X,Miller JL,von Deneen KM,Zhou Z,Gold MS,Liu Y

更新日期：2013-06-01 00:00:00

abstract：:The signal decay with increasing b-factor at fixed echo time from brain tissue in vivo has been measured using a line scan Stejskal-Tanner spin echo diffusion approach in eight healthy adult volunteers. The use of a 175 ms echo time and maximum gradient strengths of 10 mT/m allowed 64 b-factors to be sampled, ranging ...

journal_title：NMR in biomedicine

authors： Mulkern RV,Gudbjartsson H,Westin CF,Zengingonul HP,Gartner W,Guttmann CR,Robertson RL,Kyriakos W,Schwartz R,Holtzman D,Jolesz FA,Maier SE

更新日期：1999-02-01 00:00:00

abstract：:Biomarkers of early response to treatment have the potential to improve cancer therapy by allowing treatment to be tailored to the individual. Alterations in lipids detected by in vivo MRS have been suggested as noninvasive biomarkers of cell stress and early indicators of cell death. An improved understanding of the ...

journal_title：NMR in biomedicine

authors： Mirbahai L,Wilson M,Shaw CS,McConville C,Malcomson RD,Kauppinen RA,Peet AC

更新日期：2012-11-01 00:00:00