Abstract:
:Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (target-specific) MRI contrast agents can be employed to visualize different processes in the cascade of events following myocardial infarction. Here, the MRI sequence has a decisive role in the detection sensitivity of a contrast agent. However, a straightforward translation of clinically available protocols for human cardiac imaging to mice is not feasible, because of the small size of the mouse heart and its extremely high heart rate. This has stimulated intense research in the development of cardiac MRI protocols specifically tuned to the mouse with regard to timing parameters, acquisition strategies, and ECG- and respiratory-triggering methods to find an optimal trade-off between sensitivity, scan time, and image quality. In this review, a detailed analysis is given of the pros and cons of different mouse cardiac MR imaging methodologies and their application in contrast-enhanced MRI of myocardial infarction.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJdoi
10.1002/nbm.2767subject
Has Abstractpub_date
2012-08-01 00:00:00pages
969-84issue
8eissn
0952-3480issn
1099-1492journal_volume
25pub_type
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journal_title:NMR in biomedicine
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abstract::Brain myelin and iron content are important parameters in neurodegenerative diseases such as multiple sclerosis (MS). Both myelin and iron content influence the brain's R2* relaxation rate. However, their quantification based on R2* maps requires a realistic tissue model that can be fitted to the measured data. In str...
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journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
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doi:10.1002/nbm.2930
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journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940070503
更新日期:1994-08-01 00:00:00
abstract::1H MR spectroscopy was used to correlate the metabolite signals in 66 untreated metastatic brain tumors with the results of Gd-DTPA enhanced MRI. Cubic volumes containing brain metastases of lung cancer (n = 17), mammary carcinoma (n = 24), melanoma (n = 12) and those originating from other tumors (n = 13) were examin...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(SICI)1099-1492(199604)9:2<65::AID-NBM397>
更新日期:1996-04-01 00:00:00
abstract::The purpose of this study was to investigate the effect of gadolinium (III) diethyltriaminepenta-acetic acid (Gd-DTPA) mixed with a fixative on the image contrast between the white and gray matter of the perfusion-fixed mouse brain. A series of microscopic MRI (microMRI) studies using different concentrations of Gd-DT...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1324
更新日期:2009-04-01 00:00:00
abstract::Raised concentrations of glucose for extended periods of time have detrimental effects on the insulin-producing beta-cell. As de novo synthesis of lipids has been observed under such conditions, it was hypothesized that newly formed lipids may preferentially contain saturated fatty acids, which in particular have been...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1197
更新日期:2008-05-01 00:00:00
abstract::This study investigated the association between the total choline (tCho) concentration and the clinical characteristics and biomarker status of breast cancer. Sixty-two patients with breast cancer, 1.5 cm or larger in size on MR images, were studied. The tCho concentration was correlated with the MRI features, contra...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1595
更新日期:2011-04-01 00:00:00
abstract::A special characteristic of the brain is the usage of lactate as alternative fuel instead of glucose to preserve its energy homeostasis. This physiological function is valid for sufficient cerebral glucose supply, as well as presumably during hypoglycemia, given that exogenous lactate infusion suppresses hormonal coun...
journal_title:NMR in biomedicine
pub_type: 杂志文章,随机对照试验
doi:10.1002/nbm.4167
更新日期:2019-11-01 00:00:00
abstract::Mice are used in many studies to determine the role of genetic and molecular factors in mammalian development and human congenital diseases. MRI has emerged as a major method for analyzing mutant and transgenic phenotypes in developing mice, at both embryonic and neonatal stages. Progress in this area is reviewed, wit...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1146
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVES:Quantitative MRI (qMRI) of muscles is a promising tool to measure disease progression or to assess therapeutic effects in neuromuscular diseases. Longitudinal imaging studies are needed to show sensitivity of qMRI in detecting disease progression in spinal muscular atrophy (SMA). In this pilot study we there...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4473
更新日期:2021-01-22 00:00:00
abstract::The purpose of this work was to harmonize data acquisition and post-processing of single voxel proton MRS ((1) H-MRS) at 7 T, and to determine metabolite concentrations and the accuracy and reproducibility of metabolite levels in the adult human brain. This study was performed in compliance with local institutional hu...
journal_title:NMR in biomedicine
pub_type: 杂志文章,多中心研究
doi:10.1002/nbm.3252
更新日期:2015-03-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:NMR in biomedicine
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2021-01-21 00:00:00
abstract::(1) H-MRS is regularly applied to determine lipid content in ectopic tissue - mostly skeletal muscle and liver - to investigate physiological and/or pathologic conditions, e.g. insulin resistance. Technical developments also allow non-invasive in vivo assessment of cardiac lipids; however, basic data about methodologi...
journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:2014-11-01 00:00:00
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journal_title:NMR in biomedicine
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更新日期:2017-11-01 00:00:00
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更新日期:2010-05-01 00:00:00
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journal_title:NMR in biomedicine
pub_type: 杂志文章
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更新日期:1990-08-01 00:00:00
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