Enhanced delineation of white matter structures of the fixed mouse brain using Gd-DTPA in microscopic MRI.

abstract：:Quantitative mapping of MR tissue parameters such as the spin-lattice relaxation time (T1 ), the spin-spin relaxation time (T2 ), and the spin-lattice relaxation in the rotating frame (T1ρ ), referred to as MR relaxometry in general, has demonstrated improved assessment in a wide range of clinical applications. Compar...

journal_title：NMR in biomedicine

authors： Feng L,Ma D,Liu F

更新日期：2020-10-15 00:00:00

abstract：:The main aim of this study was to employ high-resolution MRI to investigate the spatiotemporal development of pathological features associated with contusive spinal cord injury (SCI) in mice. Experimental mice were subjected to either sham surgery or moderate contusive SCI. A 16.4-T small-animal MR system was employed...

journal_title：NMR in biomedicine

authors： Blomster LV,Cowin GJ,Kurniawan ND,Ruitenberg MJ

更新日期：2013-02-01 00:00:00

abstract：:Obesity causes damage to several organs, including the brain. Recent studies have been focusing on understanding the mechanisms through which obesity affects brain structure and function using neuroimaging techniques. A functional biomarker, such as cerebral blood flow (CBF), is a powerful tool that can be used to exp...

journal_title：NMR in biomedicine

authors： Peng SL,Chen CM

更新日期：2020-10-01 00:00:00

abstract：:The reliability, relation to whole-body maximal oxygen uptake (VO(2max)), and force-level sensitivity of (31)P MRS markers of mitochondrial function were studied in 39 normal-weight women. Following 90 s isometric plantar-flexion exercises at 45, 70 and 100% of maximum voluntary contraction, skeletal muscle mitochondr...

journal_title：NMR in biomedicine

authors： Larson-Meyer DE,Newcomer BR,Hunter GR,Hetherington HP,Weinsier RL

更新日期：2000-01-01 00:00:00

abstract：:The goals of this study were to develop an acquisition protocol and the analysis tools for Meshcher-Garwood point-resolved spectroscopy (MEGA-PRESS) in mouse brain at 9.4 T, to allow the in vivo detection of γ-aminobutyric acid (GABA) and to examine whether isoflurane alters GABA levels in the thalamus during anesthes...

journal_title：NMR in biomedicine

authors： Guo J,Gang Z,Sun Y,Laine A,Small SA,Rothman DL

更新日期：2018-01-01 00:00:00

abstract：:By quantification of brain metabolites, localized brain proton MRS can non-invasively provide biochemical information from distinct regions of the brain. Quantification of short-TE signals is usually based on a metabolite basis set. The basis set can be obtained by two approaches: (1) by measuring the signals of metab...

journal_title：NMR in biomedicine

authors： Cudalbu C,Cavassila S,Rabeson H,van Ormondt D,Graveron-Demilly D

更新日期：2008-07-01 00:00:00

abstract：:The presence of the e4 allele of the apolipoprotein E (APOE) gene is the best-known genetic risk factor for Alzheimer's disease. In this study, we investigated the link between functional and behavioural differences and regional brain volume and cortical thickness differences in those who carry the e4 allele (e4+) and...

journal_title：NMR in biomedicine

authors： Dowell NG,Evans SL,Tofts PS,King SL,Tabet N,Rusted JM

更新日期：2016-05-01 00:00:00

abstract：:Phosphatidylcholine (PC) metabolism in bovine adrenal chromaffin cells has been studied in vivo with 100 MHz 13C NMR spectroscopy. The incorporation of 13[CH3]choline was examined in cells embedded in 1% agarose strands and perfused at 37 degrees C. The pattern of 13C NMR spectroscopy. The incorporation of [13CH3]chol...

journal_title：NMR in biomedicine

authors： Rivera CJ,Plishker GA,Morrisett JD,Moore J,Percy AK

更新日期：1991-06-01 00:00:00

abstract：:Here, we show that the sensitivity of (31)P MRSI of (31)P spins J-coupled to protons can be increased by almost a factor of three when compared with an optimal direct detection free induction decay. By direct detection integrated with multi-echo polarization transfer (DIMEPT), multiple signals from polarization transf...

journal_title：NMR in biomedicine

authors： van der Kemp WJ,Boer VO,Luijten PR,Klomp DW

更新日期：2014-10-01 00:00:00

abstract：:Phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS) has gained much interest in schizophrenia research in recent years since it allows the non-invasive measurement of high-energy phosphates and phospholipids in vivo. However, until now only differences in metabolite concentrations between certain brain areas of ...

journal_title：NMR in biomedicine

authors： Riehemann S,Volz HP,Wenda B,Hübner G,Rössger G,Rzanny R,Sauer H

更新日期：1999-12-01 00:00:00

abstract：:Glucose metabolism in control and estrogen stimulated rat uteri was investigated using 13C NMR spectroscopy. By employing an NMR adapted perifusion system, and developing protocols and methods based on the application of [1-13C]glucose labeling, it was possible to measure, with a temporal resolution of 10 min, the kin...

journal_title：NMR in biomedicine

authors： Shinkarenko L,Kaye AM,Degani H

更新日期：1994-08-01 00:00:00

abstract：:MRI detects changes in blood-oxygenation-level dependent (BOLD) contrast in tumors caused by tumor oxygenating agents. These changes can be used to guide the design of improved tumor oxygenating treatments (TOXs). The conventional approach to detection of BOLD effects assumes that the water resonance is a single, homo...

journal_title：NMR in biomedicine

authors： Al-Hallaq HA,Fan X,Zamora M,River JN,Moulder JE,Karczmar GS

更新日期：2002-02-01 00:00:00

abstract：:Balanced steady-state free precession imaging has recently been suggested for chemical exchange detection (bSSFPX). The objective of this work is to investigate the contributions of microstructural, chemical shift and chemical exchange effects to the asymmetry of the bSSFP profile at field strengths of 3 T and 9.4 T. ...

journal_title：NMR in biomedicine

authors： Heule R,Deshmane A,Zaiss M,Herz K,Ehses P,Scheffler K

更新日期：2020-03-01 00:00:00

abstract：:Lung cancer is a primary cause of cancer deaths worldwide. Timely detection of this pathology is necessary to delay or interrupt lung cancer progression, ultimately resulting in a possible better prognosis for the patient. In this context, magnetic resonance imaging (MRI) is especially promising. Ultra-short echo time...

journal_title：NMR in biomedicine

authors： Bianchi A,Gobbo OL,Dufort S,Sancey L,Lux F,Tillement O,Coll JL,Crémillieux Y

更新日期：2017-11-01 00:00:00

abstract：:Surface coil 13C nuclear magnetic resonance (NMR) spectroscopy was used to investigate the in vivo carbohydrate metabolism of rat C6 gliomas during and after infusion with [1-13C] glucose. In vivo 1H-decoupled 13C NMR spectra of the glioma following infusion with [1-13C]glucose revealed the direct production of [3-13C...

journal_title：NMR in biomedicine

authors： Ross BD,Higgins RJ,Boggan JE,Willis JA,Knittel B,Unger SW

更新日期：1988-02-01 00:00:00

abstract：:Following the impetus of early clinical and experimental investigations, in vivo and in vitro MRS studies of tumours pointed in the eighties to the possible significance of signals arising from phospholipid (PL) precursors and catabolites as novel biochemical indicators of in vivo tumour progression and response to th...

journal_title：NMR in biomedicine

authors： Podo F

更新日期：1999-11-01 00:00:00

abstract：:Mouse models are increasingly used to study the pathophysiology of myocardial infarction in vivo. In this area, MRI has become the gold standard imaging modality, because it combines high spatial and temporal resolution functional imaging with a large variety of methods to generate soft tissue contrast. In addition, (...

journal_title：NMR in biomedicine

authors： Coolen BF,Paulis LE,Geelen T,Nicolay K,Strijkers GJ

更新日期：2012-08-01 00:00:00

abstract：:We review several methods that have been developed to infer microstructural and physiological information about isotropic and anisotropic tissues from diffusion weighted images (DWIs). These include Diffusion Imaging (DI), Diffusion Tensor Imaging (DTI), isotropically weighted imaging, and q-space imaging. Just as DI ...

journal_title：NMR in biomedicine

authors： Basser PJ

更新日期：1995-11-01 00:00:00

abstract：:Reconstruction of MRI data is based on exact knowledge of all magnetic field dynamics, since the interplay of RF and gradient pulses generates the signal, defines the contrast and forms the basis of resolution in spatial and spectral dimensions. Deviations caused by various sources, such as system imperfections, delay...

journal_title：NMR in biomedicine

authors： Brunner DO,Dietrich BE,Çavuşoğlu M,Wilm BJ,Schmid T,Gross S,Barmet C,Pruessmann KP

更新日期：2016-09-01 00:00:00

abstract：:Hippocampal dysfunction is known to be associated with several neurological and neuropsychiatric disorders such as Alzheimer's disease, epilepsy, schizophrenia and depression; therefore, there has been significant clinical interest in studying hippocampal neurochemistry. However, the hippocampus is a challenging regio...

journal_title：NMR in biomedicine

authors： Bednařík P,Moheet A,Deelchand DK,Emir UE,Eberly LE,Bareš M,Seaquist ER,Öz G

更新日期：2015-06-01 00:00:00

abstract：:An outline is presented of metabolite-specific in vivo NMR spectroscopy (particularly in brain). It reviews from a physical spectroscopist's perspective, the need for and the methods of observation of, individual metabolite resonances. ...

journal_title：NMR in biomedicine

authors： Allen PS,Thompson RB,Wilman AH

更新日期：1997-12-01 00:00:00

abstract：:In many small animals there are distinct differences in fiber-type composition among limb muscles, and these differences typically correspond to marked disparities in the oxidative capacities. However, whether there are similar differences in the oxidative capacity among leg muscles in humans is less clear. The purpos...

journal_title：NMR in biomedicine

authors： Forbes SC,Slade JM,Francis RM,Meyer RA

更新日期：2009-12-01 00:00:00

abstract：:The possibility of quantifying the superimposed signal of glutamate and glutamine (Glx) and its components by ¹H magnetic resonance spectroscopy (MRS) in the spinal cord is an exciting challenge with important clinical applications in neurological conditions. The spinal cord is a particularly difficult region of inter...

journal_title：NMR in biomedicine

authors： Solanky BS,Abdel-Aziz K,Yiannakas MC,Berry AM,Ciccarelli O,Wheeler-Kingshott CA

更新日期：2013-03-01 00:00:00

abstract：:The background underpinning the clinical use of ultrashort echo time, SPRITE and other pulse sequences for imaging bone and other connective tissues with short T2 is reviewed. Features of the basic physics relevant to UTE imaging are described, including the consequences when the radiofrequency pulse duration is of th...

journal_title：NMR in biomedicine

authors： Robson MD,Bydder GM

更新日期：2006-11-01 00:00:00

abstract：:In vitro (1)H MRS of human bile has shown potential in the diagnosis of various hepatopancreatobiliary (HPB) diseases. Previously, in vivo (1)H MRS of human bile in gallbladder using a 1.5 T scanner demonstrated the possibility of quantification of choline-containing phospholipids (chol-PLs). However, other lipid comp...

journal_title：NMR in biomedicine

authors： Mohajeri S,Ijare OB,Bezabeh T,King SB,Thomas MA,Minuk G,Lipschitz J,Kirkpatrick I,Smith M,Smith IC

更新日期：2014-10-01 00:00:00

abstract：:In this work we introduce the concept of correlation chemical shift imaging (CCSI). Novel CCSI pulse sequences are demonstrated on clinical scanners for two-dimensional Correlation Spectroscopy (COSY) and Total Correlation Spectroscopy (TOCSY) imaging experiments. To date there has been limited progress reported towar...

journal_title：NMR in biomedicine

authors： Andronesi OC,Gagoski BA,Adalsteinsson E,Sorensen AG

更新日期：2012-02-01 00:00:00

abstract：:In the unstimulated brain energy is primarily supplied by the oxidation of glucose. However the oxygen-to-glucose index (OGI), which is the ratio of metabolic rates of oxygen to glucose, CMR(O2)/CMR(glc), diverges from the theoretical value of 6 as activity is increased. In vivo measurements of brain lactate show its ...

journal_title：NMR in biomedicine

authors： Shulman RG,Hyder F,Rothman DL

更新日期：2001-11-01 00:00:00

abstract：:The aim of this study is to fabricate and test a novel flexible flat cable antenna (FFCA) for MRI of the knee at different flexion angles. The FFCA was made of a flat cable, a tuning/matching circuit and a signal transmission line. To test its feasibility and validity, in vitro and in vivo experiments were carried out...

journal_title：NMR in biomedicine

authors： Jia F,Yuan H,Zhou D,Zhang J,Wang X,Fang J

更新日期：2015-04-01 00:00:00

abstract：:The emergence and rapid development of activatable contrast agents (CAs), whose relaxivity changes in response to the variation of a specific marker in the surrounding physiological microenvironment, have expanded the scope of MRI beyond anatomical and functional imaging to also convey information at the cellular and ...

journal_title：NMR in biomedicine

authors： Tu C,Louie AY

更新日期：2013-07-01 00:00:00

abstract：:We propose a very high-resolution, three-dimensional (3D) gradient-echo technique with a twofold parallel imaging acceleration using a specialized occipital receiver coil at 3 T to perform functional MRI (fMRI) of the visual cortex. This configuration makes it possible to acquire 3D fMRI data within a timescale compat...

journal_title：NMR in biomedicine

authors： Barth M,Norris DG

更新日期：2007-08-01 00:00:00