Frontal lobe in vivo (31)P-MRS reveals gender differences in healthy controls, not in schizophrenics.

abstract：:Spin-exchange NMR techniques enable the measurement of the rates of exchange of solutes between chemically or physically distinct sites in reactions taking place at chemical equilibrium. The time scale of the events that are able to be investigated lies in the neighbourhood of 1 s. The earliest studies in this area of...

journal_title：NMR in biomedicine

authors： Kuchel PW

更新日期：1990-06-01 00:00:00

abstract：:Traditional methods of measuring magnetization in magnetic fluid samples, such as vibrating sample magnetometry (VSM), are typically limited to maximum field strengths of about 1 T. This work demonstrates the ability of MRI to measure the magnetization associated with two commercial MRI contrast agents at 3 T by compa...

journal_title：NMR in biomedicine

authors： Cantillon-Murphy P,Wald LL,Zahn M,Adalsteinsson E

更新日期：2009-10-01 00:00:00

abstract：:Manganese ions (Mn(2+) ) enter viable myocardial cells via voltage-gated calcium channels. Because of its shortening of T(1) and its relatively long half-life in cells, Mn(2+) can serve as an intracellular molecular contrast agent to study indirect calcium influx into the myocardium. One major concern in using Mn(2+) ...

journal_title：NMR in biomedicine

authors： Hu TC,Chuang KH,Yanasak N,Koretsky A

更新日期：2011-01-01 00:00:00

abstract：:While phase imaging with a gradient echo (GRE) sequence is popular, phase imaging with balanced steady-state free precession (bSSFP) has been underexplored. The purpose of this study was to investigate anatomical and functional phase imaging with multiple phase-cycled bSSFP, in expectation of increasing spatial covera...

journal_title：NMR in biomedicine

authors： Kim JW,Kim SG,Park SH

更新日期：2017-06-01 00:00:00

abstract：:Polycystic kidney disease (PKD) is a life-threatening disease that leads to a grotesque enlargement of the kidney and significant loss of function. Several imaging studies with MRI have demonstrated that cyst size in polycystic kidneys can determine disease severity and progression. In the present study, we found that...

journal_title：NMR in biomedicine

authors： Xie L,Qi Y,Subashi E,Liao G,Miller-DeGraff L,Jetten AM,Johnson GA

更新日期：2015-05-01 00:00:00

abstract：:A short-echo spectroscopic imaging sequence extended with a frequency-selective multiple-quantum- coherence technique (Sel-MQC) is presented. The method enables acquisition of a complete water-suppressed proton spectrum with a short echo time and filtering of the J-coupling metabolite, lactate, from co-resonant lipids...

journal_title：NMR in biomedicine

authors： Melkus G,Mörchel P,Behr VC,Kotas M,Flentje M,Jakob PM

更新日期：2008-11-01 00:00:00

abstract：:Dynamic contrast-enhanced MRI (DCE MRI) has been used to study tumor response to treatment for many years. In this study, the modified full width at half-maximum (mFWHM), calculated from the wash-in slope histogram, is proposed as a parameter for the evaluation of changes in tumor heterogeneity which respond to radiot...

journal_title：NMR in biomedicine

authors： Peng SL,Chen CF,Liu HL,Lui CC,Huang YJ,Lee TH,Chang CC,Wang FN

更新日期：2013-04-01 00:00:00

abstract：:The elimination of so-called background fields is an essential step in phase MRI and quantitative susceptibility mapping (QSM). Background fields, which are caused by sources outside the region of interest (ROI), are often one to two orders of magnitude stronger than tissue-related field variations from within the ROI...

journal_title：NMR in biomedicine

authors： Schweser F,Robinson SD,de Rochefort L,Li W,Bredies K

更新日期：2017-04-01 00:00:00

abstract：:One of the most commonly used methods for in vivo MRS detection of γ-aminobutyric acid (GABA) is the MEGA-point-resolved spectroscopy (MEGA-PRESS) technique. However, accurate quantification of GABA using MEGA-PRESS is complicated by spectral co-editing of macromolecular resonances. In this article, a new pulse sequen...

journal_title：NMR in biomedicine

authors： Near J,Simpson R,Cowen P,Jezzard P

更新日期：2011-12-01 00:00:00

abstract：:A study was undertaken to determine if the vascular characteristics measured by dynamic contrast-enhanced magnetic resonance imaging (primarily permeability surface area product and extracellular-extravascular tissue volume fraction) would be beneficial in explaining the inter-lesion metabolic heterogeneity displayed ...

journal_title：NMR in biomedicine

authors： Manton DJ,Lowry M,Rowland-Hill C,Crooks D,Mathew B,Turnbull LW

更新日期：2000-12-01 00:00:00

abstract：:The aim of this study was to investigate physiological variations of the water T2 relaxation time in vertebral bone marrow with respect to age, body mass index (BMI), sex and proton density fat fraction (PDFF) based on single-voxel magnetic resonance spectroscopy (MRS) at 3 T. Multi-TE single-voxel STEAM MRS data of a...

journal_title：NMR in biomedicine

authors： Ruschke S,Syväri J,Dieckmeyer M,Junker D,Makowski MR,Baum T,Karampinos DC

更新日期：2020-11-17 00:00:00

abstract：:Vessel size index (VSI), a parameter related to the distribution of vessel diameters, may be estimated using two MRI approaches: (i) dynamic susceptibility contrast (DSC) MRI following the injection of a bolus of Gd-chelate. This technique is routinely applied in the clinic to assess intracranial tissue perfusion in p...

journal_title：NMR in biomedicine

authors： Pannetier N,Lemasson B,Christen T,Tachrount M,Troprès I,Farion R,Segebarth C,Rémy C,Barbier EL

更新日期：2012-02-01 00:00:00

abstract：:Tumor metabolism is directly coupled to tumor blood flow (TBF) and both metabolism and blood flow may be determinants of tumor response to treatment. Since NMR has been used extensively to monitor tumor metabolism noninvasively, development of NMR-based methods for TBF measurement was motivated by the desire to examin...

journal_title：NMR in biomedicine

authors： Evelhoch JL

更新日期：1992-09-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) in pregnancy is commonly undertaken in the left lateral tilt (LLT) position to prevent inferior vena cava (IVC) compression and supine hypotensive events, although this may be suboptimal for image quality. The supine position may also have an adverse effect on fetal well-being. The spi...

journal_title：NMR in biomedicine

authors： Hughes EJ,Price AN,McCabe L,Hiscocks S,Waite L,Green E,Hutter J,Pegoretti K,Cordero-Grande L,Edwards DA,Hajnal JV,Rutherford MA

更新日期：2021-01-21 00:00:00

abstract：:This study aimed to demonstrate a reliable automatic segmentation method for independently separating reduced diffusion and decreased perfusion areas in ischemic stroke brains using constrained nonnegative matrix factorization (cNMF) pattern recognition in directional intravoxel incoherent motion MRI (IVIM-MRI). First...

journal_title：NMR in biomedicine

authors： Jang M,Jin S,Kang M,Han S,Cho H

更新日期：2020-05-01 00:00:00

abstract：:The possibility of quantifying the superimposed signal of glutamate and glutamine (Glx) and its components by ¹H magnetic resonance spectroscopy (MRS) in the spinal cord is an exciting challenge with important clinical applications in neurological conditions. The spinal cord is a particularly difficult region of inter...

journal_title：NMR in biomedicine

authors： Solanky BS,Abdel-Aziz K,Yiannakas MC,Berry AM,Ciccarelli O,Wheeler-Kingshott CA

更新日期：2013-03-01 00:00:00

abstract：:Metabolic activity in the lung is known to change in response to external insults, inflammation, and cancer. We report measurements of metabolism in the isolated, perfused rat lung of healthy controls and in diseased lungs undergoing acute inflammation using hyperpolarized 1-(13) C-labeled pyruvate. The overall appare...

journal_title：NMR in biomedicine

authors： Shaghaghi H,Kadlecek S,Deshpande C,Siddiqui S,Martinez D,Pourfathi M,Hamedani H,Ishii M,Profka H,Rizi R

更新日期：2014-08-01 00:00:00

abstract：:Metabolomic studies by NMR spectroscopy are increasingly employed for a variety of biomedical applications. A very standardized 1D proton NMR protocol is generally employed for data acquisition, associated with multivariate statistical tests. Even if targeted approaches have been proposed to quantify metabolites from ...

journal_title：NMR in biomedicine

authors： Martineau E,Tea I,Akoka S,Giraudeau P

更新日期：2012-08-01 00:00:00

abstract：:In this study, metabolic changes in the 79A/C3H, ME7/VM, ME7/C3H, 87V/VM and 22A/SV scrapie mouse models were investigated during the clinical phase of the disease, using in vitro proton nuclear magnetic resonance spectroscopy. N-acetyl-aspartate was found to be significantly reduced in infected mice of the ME7/ C3H (...

journal_title：NMR in biomedicine

authors： Chung YL,Williams A,Chong A,Hope J,Williams SC,Bell JD

更新日期：1996-12-01 00:00:00

abstract：:High-resolution MR imaging (312 microns in plane resolution) and MR spectroscopy (0.36 cm3 nominal voxel) have been performed on human frontal cortex using a 3 in surface coil. Localized proton spectra have been obtained from contiguous 6 x 6 x 10 mm voxels using one-dimensional phase encoding, TR 2000 ms and TE 31 ms...

journal_title：NMR in biomedicine

authors： López-Villegas D,Kimura H,Tunlayadechanont S,Lenkinski RE

更新日期：1996-10-01 00:00:00

abstract：:31P Nuclear magnetic resonance spectroscopy has been used to investigate the combined effect of 70 mM ethanol administration and hypoxia on the energetic metabolism and cytosolic pH of the perfused liver isolated from naive, fasted or chronically ethanol-treated rats. Ethanol-treatment or fasting induce a similar 25% ...

journal_title：NMR in biomedicine

authors： Desmoulin F,Canioni P,Masson S,Gérolami A,Cozzone PJ

更新日期：1990-06-01 00:00:00

abstract：:Changes in physiological parameters such as cerebral blood flow, cerebral blood volume, oxygen extraction, and the size and distribution of cerebral blood vessels, result in changes in the local concentration of deoxyhaemoglobin ([dHb]). The purpose of this study was to quantitatively investigate the dependence of the...

journal_title：NMR in biomedicine

authors： Punwani S,Ordidge RJ,Cooper CE,Amess P,Clemence M

更新日期：1998-10-01 00:00:00

abstract：:The presence of the e4 allele of the apolipoprotein E (APOE) gene is the best-known genetic risk factor for Alzheimer's disease. In this study, we investigated the link between functional and behavioural differences and regional brain volume and cortical thickness differences in those who carry the e4 allele (e4+) and...

journal_title：NMR in biomedicine

authors： Dowell NG,Evans SL,Tofts PS,King SL,Tabet N,Rusted JM

更新日期：2016-05-01 00:00:00

abstract：:MRS provides a valuable tool for the non-invasive detection of brain γ-aminobutyric acid (GABA) in vivo. GABAergic dysfunction has been observed in the aging cerebellum. The study of cerebellar GABA changes is of considerable interest in understanding certain age-related motor disorders. However, little is known about...

journal_title：NMR in biomedicine

authors： Long Z,Dyke JP,Ma R,Huang CC,Louis ED,Dydak U

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this study was to investigate the feasibility of interventional MRI-guided local agent delivery into pig common bile duct (CBD) walls using a newly designed MR-compatible, needle-integrated balloon catheter system. We first designed a needle-integrated balloon catheter system that comprised of a 22 G MR...

journal_title：NMR in biomedicine

authors： Zhang F,Bai Z,Shi Y,Wang J,Li Y,Yang X

更新日期：2015-06-01 00:00:00

abstract：:In imaging of human lungs with hyperpolarised noble gases, measurements of apparent diffusion coefficient (ADC) and relaxation time provide valuable information for the assessment of lung microstructure. In this work, a sequence was developed for interleaved acquisition of ventilation images, ADC, T(2)* and flip angle...

journal_title：NMR in biomedicine

authors： Ajraoui S,Parra-Robles J,Marshall H,Deppe MH,Clemence M,Wild JM

更新日期：2012-01-01 00:00:00

abstract：:(31)P MRS provides a unique non-invasive window into myocardial energy homeostasis. Mouse models of cardiac disease are widely used in preclinical studies, but the application of (31)P MRS in the in vivo mouse heart has been limited. The small-sized, fast-beating mouse heart imposes challenges regarding localized sign...

journal_title：NMR in biomedicine

authors： Bakermans AJ,Abdurrachim D,van Nierop BJ,Koeman A,van der Kroon I,Baartscheer A,Schumacher CA,Strijkers GJ,Houten SM,Zuurbier CJ,Nicolay K,Prompers JJ

更新日期：2015-10-01 00:00:00

abstract：:The availability of high-field-strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatment of diseases, su...

journal_title：NMR in biomedicine

authors： Ziser L,Meyer-Schell N,Kurniawan ND,Sullivan R,Reutens D,Chen M,Vegh V

更新日期：2018-03-01 00:00:00

abstract：:Development and evaluation of new anticancer drugs are expedited when minimally invasive biomarkers of pharmacokinetic and pharmacodynamic behaviour are available. Gene-directed enzyme prodrug therapy (GDEPT) is a suicide gene therapy in which the anticancer drug is activated in the tumor by an exogenous enzyme previo...

journal_title：NMR in biomedicine

authors： Mancini L,Davies L,Friedlos F,Falck-Miniotis M,Dzik-Jurasz AS,Springer CJ,Leach MO,Payne GS

更新日期：2009-06-01 00:00:00

abstract：:The goal of this study was to validate metabolite quantification at short TE, with particular focus on how to best account for the macromolecular signal contribution. A robust, short-TE PRESS protocol is presented, which allows reliable quantification, in vivo, of metabolite signals at 3 T in human brain. Water suppre...

journal_title：NMR in biomedicine

authors： Gottschalk M,Lamalle L,Segebarth C

更新日期：2008-06-01 00:00:00