Abstract:
:Tumor metabolism is directly coupled to tumor blood flow (TBF) and both metabolism and blood flow may be determinants of tumor response to treatment. Since NMR has been used extensively to monitor tumor metabolism noninvasively, development of NMR-based methods for TBF measurement was motivated by the desire to examine the roles tumor metabolism and blood flow may play as determinants of therapeutic response. The concept of using deuterated water as an NMR-detectable, flow-limited tracer for the measurement of tissue blood flow (or capillary perfusion) was introduced in 1987 by Ackerman and coworkers (Proc. Natl., Acad. Sci., USA 84, 4099-4102 (1987)). Since that time, methods have been devised using both spectroscopic and imaging detection for TBF measurement based on either clearance or uptake of deuterated water. In general, the clearance methods are more straightforward to implement, while the uptake methods are less invasive to the tumor. When used with appropriate caution, both approaches yield reliable results. To date, these methods have been applied in a relatively limited number of animal tumors. However, their use is increasing and some of these methods ultimately should be applicable in human tumors.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Evelhoch JLdoi
10.1002/nbm.1940050516subject
Has Abstractpub_date
1992-09-01 00:00:00pages
290-5issue
5eissn
0952-3480issn
1099-1492journal_volume
5pub_type
杂志文章,评审abstract:PURPOSE:To investigate the feasibility of using multiple flip angles in dynamic contrast enhanced (DCE) MRI to reduce the uncertainty in estimation of intracellular water lifetime (τi ). METHODS:Numerical simulation studies were conducted to assess the uncertainty in estimation of τi using dynamic contrast enhanced MR...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4135
更新日期:2019-11-01 00:00:00
abstract::Progress in the development of non-proton NMR applications in medical research has been hampered by the generally low sensitivity of these nuclides as well as the lack of instrumentation readily available for studying these spins. For example, custom head coils suitable for sodium imaging of the human head are either ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940020308
更新日期:1989-09-01 00:00:00
abstract::Natural abundance proton-decoupled (13)C magnetic resonance spectroscopy was used to establish the in vivo lipid composition of normal adipose tissue and the corresponding effects of altered lipid diets. Experiments were performed on a standard 1.5 T clinical MR scanner using a double-tuned (1)H-(13)C coil. Peaks from...
journal_title:NMR in biomedicine
pub_type: 临床试验,杂志文章
doi:10.1002/nbm.824
更新日期:2003-05-01 00:00:00
abstract::The ability to assess the perfusion territories of major cerebral arteries can be a valuable asset to the diagnosis of a number of cerebrovascular diseases. Recently, several arterial spin labeling (ASL) techniques have been proposed for determining the cerebral perfusion territories of individual arteries by three di...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1177
更新日期:2007-11-01 00:00:00
abstract::Here, we show that the sensitivity of (31)P MRSI of (31)P spins J-coupled to protons can be increased by almost a factor of three when compared with an optimal direct detection free induction decay. By direct detection integrated with multi-echo polarization transfer (DIMEPT), multiple signals from polarization transf...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3183
更新日期:2014-10-01 00:00:00
abstract::Quantitative susceptibility mapping (QSM) is a recently developed MRI technique that provides a quantitative measure of tissue magnetic susceptibility. To compute tissue magnetic susceptibilities based on gradient echoes, QSM requires reliable unwrapping of the measured phase images and removal of contributions caused...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3056
更新日期:2014-02-01 00:00:00
abstract::At the high field strength of 7 T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures oth...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1754
更新日期:2012-02-01 00:00:00
abstract::To investigate the GABA+ modeling accuracy of MEGA-PRESS GABA+-edited MRS data with various spectral quality scenarios, the influence of varying signal-to-noise ratio (SNR) and linewidth on the model estimates was quantified. MEGA-PRESS data from 46 volunteers were averaged to generate a template MEGA-PRESS spectrum, ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4410
更新日期:2021-01-01 00:00:00
abstract::We have developed a reliable, reproducible model of hypoxia in the gerbil. 1H and 31P NMR spectroscopy demonstrates that cerebral energy metabolism is very resistant to hypoxia. Cerebral blood flow (measured by hydrogen clearance) began to increase when the arterial oxygen tension (paO2) was reduced to 40-50 mm Hg, an...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940050109
更新日期:1992-01-01 00:00:00
abstract::In order to keep subscribers up-to-date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of NMR in biomedicine. Each bibliography is divided into 9 sections: 1 Books, Re...
journal_title:NMR in biomedicine
pub_type:
doi:10.1002/nbm.667
更新日期:2001-02-01 00:00:00
abstract::Balanced steady-state free precession imaging has recently been suggested for chemical exchange detection (bSSFPX). The objective of this work is to investigate the contributions of microstructural, chemical shift and chemical exchange effects to the asymmetry of the bSSFP profile at field strengths of 3 T and 9.4 T. ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4200
更新日期:2020-03-01 00:00:00
abstract::The relaxation properties of water and metabolites were measured in rat brain following the occlusion of the middle cerebral artery (MCA) with localized 1H MRS. The PRESS sequence was employed to select volumes of 39 microL in the ischemic and the contralateral hemisphere. T1 and T2 relaxation times and peak intensiti...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940080604
更新日期:1995-09-01 00:00:00
abstract::Understanding typical, healthy brain development provides a baseline from which to detect and characterize brain anomalies associated with various neurological or psychiatric disorders and diseases. Diffusion MRI is well suited to study white matter development, as it can virtually extract individual tracts and yield ...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.3778
更新日期:2019-04-01 00:00:00
abstract::Transmit efficiency specifies the amplitude of the magnetic resonance excitation field produced over a region of interest with respect to the radiofrequency (RF) power deposited in the sample. This metric is highly important at ultra-high field magnetic resonance imaging (≥7 T), where excitation inhomogeneities and el...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4383
更新日期:2020-11-01 00:00:00
abstract::Determination of the apparent diffusion coefficient (ADC) of the prostate in men (n = 60) with raised prostate-specific antigen (PSA) or an abnormal digital rectal examination (DRE) prior to transrectal ultrasound (TRUS) guided biopsy using endorectal DWI is reported. Patients were categorized into different groups ba...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1114
更新日期:2007-08-01 00:00:00
abstract::The elimination of so-called background fields is an essential step in phase MRI and quantitative susceptibility mapping (QSM). Background fields, which are caused by sources outside the region of interest (ROI), are often one to two orders of magnitude stronger than tissue-related field variations from within the ROI...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.3604
更新日期:2017-04-01 00:00:00
abstract::Two FDA-approved agents, ferumoxides (Feridex), a suspension of superparamagnetic iron oxide (SPIO) nanoparticles and protamine sulfate, a drug used to reverse heparin anticoagulation, can be complexed and used to label cells magnetically ex vivo. Labeling stem cells with ferumoxides-protamine sulfate (FePro) complexe...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.991
更新日期:2005-12-01 00:00:00
abstract::A method to extract shapes of bubble polyhedra from three-dimensional nuclear magnetic resonance image data of foam has been developed. The method consists of four steps: first, to compute series of maximum intensity projection images from the three-dimensional NMR image data of foam to visualize the network structure...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199701)10:1<13::aid-nbm443
更新日期:1997-01-01 00:00:00
abstract::Owing to the small quantity of tissue available in human biopsy specimens, aqueous and lipid components often have to be determined in the same tissue sample. Perchloric acid (PCA) used for the extraction of aqueous metabolites has a deleterious effect on lipid components; the severity of the damage is not known. In t...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1159
更新日期:2008-02-01 00:00:00
abstract::Increased sensitivity and chemical shift dispersion at ultra-high magnetic fields enable the precise quantification of an extended range of brain metabolites from (1)H MRS. However, all previous neurochemical profiling studies using single-voxel MRS at 7 T have been limited to data acquired from the occipital lobe wit...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1727
更新日期:2012-01-01 00:00:00
abstract::Qualitative and quantitative (1) H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) (n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) (n = 9) and gallbladder cancer (GBC, malignant) (n = 8) was carried out to understand the mechanisms involved in the transformati...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1594
更新日期:2011-05-01 00:00:00
abstract::Magnetic resonance elastography (MRE) is a non-invasive imaging technique used to visualise and quantify mechanical properties of tissue, providing information beyond what can be currently achieved with standard MR sequences and could, for instance, provide new insight into pathological processes in the brain. This st...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1254
更新日期:2008-08-01 00:00:00
abstract::Structural high-resolution imaging of the brainstem can be of high importance in clinical practice. However, ultra-high field magnetic resonance imaging (MRI) is still restricted in use due to limited availability. Therefore, quantitative MRI techniques (quantitative susceptibility mapping [QSM], relaxation measuremen...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4118
更新日期:2019-09-01 00:00:00
abstract::The leakage of metabolites from frozen and thawed tissue biopsies was measured semi-quantitatively by high-field (8.5 T) proton MRS. Human prostate and rat brain tissue specimens, frozen within 1 min of collection, lost significant and variable amounts of diagnostic metabolites immediately upon thawing. For prostate t...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.815
更新日期:2003-04-01 00:00:00
abstract::The purpose of the present study was to characterize the metabolic profile of the visual cortex in streptozotocin-induced Type 1 diabetic rats by means of in vivo proton MRS. Several metabolite concentration ratios in the visual cortex were calculated. In addition, postmortem histologic analyses for retinal ganglion c...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3783
更新日期:2017-11-01 00:00:00
abstract::Phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS) has gained much interest in schizophrenia research in recent years since it allows the non-invasive measurement of high-energy phosphates and phospholipids in vivo. However, until now only differences in metabolite concentrations between certain brain areas of ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199912)12:8<483::aid-nbm58
更新日期:1999-12-01 00:00:00
abstract::The intrinsic nonuniformities in the transmit radiofrequency field from standard quadrature volume resonators at high field are particularly problematic for localized MRS in areas such as the temporal lobe, where a low signal-to-noise ratio and poor metabolite quantification result from destructive B₁⁺ field interfere...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1638
更新日期:2011-08-01 00:00:00
abstract::Glucosamine (GlcN) modulates fluoropyrimidine metabolism and enhances cytotoxicity of 5-fluorouridine (FUrd), but not of 5-fluorouracil (FUra), in human tumor models. To elucidate the underlying metabolic differences between FUra and FUrd, by the use of 19F and 31P NMR spectroscopy we studied these drugs in multicell ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(199905)12:3<157::aid-nbm55
更新日期:1999-05-01 00:00:00
abstract::The physiological status of anesthetized rats greatly influences blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI). Monitoring of physiological parameters, particularly partial pressure of carbon dioxide (pCO(2)) levels in the blood, is therefore an important part in the design and ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.978
更新日期:2005-11-01 00:00:00
abstract::In this study, we have performed simulations to address the effects of diffusion encoding parameters, signal-to-noise ratio (SNR) and T2 on skeletal muscle diffusion tensor indices and fiber tracts. Where appropriate, simulations were corroborated and validated by in vivo diffusion tensor imaging (DTI) of human skelet...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2959
更新日期:2013-11-01 00:00:00