Abstract:
:Understanding typical, healthy brain development provides a baseline from which to detect and characterize brain anomalies associated with various neurological or psychiatric disorders and diseases. Diffusion MRI is well suited to study white matter development, as it can virtually extract individual tracts and yield parameters that may reflect alterations in the underlying neural micro-structure (e.g. myelination, axon density, fiber coherence), though it is limited by its lack of specificity and other methodological concerns. This review summarizes the last decade of diffusion imaging studies of healthy white matter development spanning childhood to early adulthood (4-35 years). Conclusions about anatomical location, rates, and timing of white matter development with age are discussed, as well as the influence of image acquisition, analysis, age range/sample size, and statistical model. Despite methodological variability between studies, some consistent findings have emerged from the literature. Specifically, diffusion studies of neurodevelopment overwhelmingly demonstrate regionally varying increases of fractional anisotropy and decreases of mean diffusivity during childhood and adolescence, some of which continue into adulthood. While most studies use linear fits to model age-related changes, studies with sufficient sample sizes and age range provide clear evidence that white matter development (as indicated by diffusion) is non-linear. Several studies further suggest that maturation in association tracts with frontal-temporal connections continues later than commissural and projection tracts. The emerging contributions of more advanced diffusion methods are also discussed, as they may reveal new aspects of white matter development. Although non-specific, diffusion changes may reflect increases of myelination, axonal packing, and/or coherence with age that may be associated with changes in cognition.
journal_name
NMR Biomedjournal_title
NMR in biomedicineauthors
Lebel C,Treit S,Beaulieu Cdoi
10.1002/nbm.3778subject
Has Abstractpub_date
2019-04-01 00:00:00pages
e3778issue
4eissn
0952-3480issn
1099-1492journal_volume
32pub_type
杂志文章,评审abstract::Net ATP production rates in exercising human muscle were calculated from 31P MRS kinetic data collected with 1-8 s time resolution. During the exercise, the muscle output was measured using a force transducer. Muscle output (force/unit volume) is then divided by the calculated net ATP used to estimate the ATP cost of ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940040404
更新日期:1991-08-01 00:00:00
abstract::We review several methods that have been developed to infer microstructural and physiological information about isotropic and anisotropic tissues from diffusion weighted images (DWIs). These include Diffusion Imaging (DI), Diffusion Tensor Imaging (DTI), isotropically weighted imaging, and q-space imaging. Just as DI ...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.1940080707
更新日期:1995-11-01 00:00:00
abstract::The steady-state distribution of the general anesthetic halothane in different rat tissues, including a renal adenocarcinoma with and without hyperthermia treatment, has been evaluated by in vivo 19F NMR spectroscopy. The 19F spectra of halothane (which is a hydrophobic probe) from within tissue show differences in th...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940060502
更新日期:1993-09-01 00:00:00
abstract::Electric properties tomography (EPT) derives the patient's electric properties, i.e. conductivity and permittivity, using standard magnetic resonance (MR) systems and standard MR sequences. Thus, EPT does not apply externally mounted electrodes, currents or radiofrequency (RF) probes, as is the case in competing techn...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.3729
更新日期:2017-08-01 00:00:00
abstract::MRI detects changes in blood-oxygenation-level dependent (BOLD) contrast in tumors caused by tumor oxygenating agents. These changes can be used to guide the design of improved tumor oxygenating treatments (TOXs). The conventional approach to detection of BOLD effects assumes that the water resonance is a single, homo...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.728
更新日期:2002-02-01 00:00:00
abstract::The reliability, relation to whole-body maximal oxygen uptake (VO(2max)), and force-level sensitivity of (31)P MRS markers of mitochondrial function were studied in 39 normal-weight women. Following 90 s isometric plantar-flexion exercises at 45, 70 and 100% of maximum voluntary contraction, skeletal muscle mitochondr...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(sici)1099-1492(200002)13:1<14::aid-nbm605
更新日期:2000-01-01 00:00:00
abstract::Chemical exchange saturation transfer (CEST) can offer information about protons associated with mobile proteins through the amide proton transfer (APT) effect, which has been shown to discriminate tumor from healthy tissue and, more recently, has been suggested as a prognosticator of response to therapy. Despite this...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2947
更新日期:2013-10-01 00:00:00
abstract::1H NMR spin-echo spectroscopy has been used to study the metabolism of exogenous compounds in human erythrocytes. The non-invasive nature of the technique and the continuous monitoring makes it ideal to investigate both the conversion of substrates and the occurrence and the nature of the products. Hydrolysis rates ma...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1940030603
更新日期:1990-12-01 00:00:00
abstract::The temporary or permanent storage of human bodies in freezers following a homicide is a documented method for criminal disposal of human corpses. In these cases, the detection of characteristics which indicate that a thawed cadaver or body part was previously frozen provides crucial information for forensic casework....
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4220
更新日期:2020-02-01 00:00:00
abstract::The possibility of quantifying the superimposed signal of glutamate and glutamine (Glx) and its components by ¹H magnetic resonance spectroscopy (MRS) in the spinal cord is an exciting challenge with important clinical applications in neurological conditions. The spinal cord is a particularly difficult region of inter...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.2867
更新日期:2013-03-01 00:00:00
abstract::The availability of high-field-strength magnetic resonance imaging (MRI) systems has brought about the development of techniques that aim to map myelination via the exploitation of various contrast mechanisms. Myelin mapping techniques have the potential to provide tools for the diagnosis and treatment of diseases, su...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3877
更新日期:2018-03-01 00:00:00
abstract::The aim of this study was to investigate physiological variations of the water T2 relaxation time in vertebral bone marrow with respect to age, body mass index (BMI), sex and proton density fat fraction (PDFF) based on single-voxel magnetic resonance spectroscopy (MRS) at 3 T. Multi-TE single-voxel STEAM MRS data of a...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4439
更新日期:2020-11-17 00:00:00
abstract::Increased lactate production through glycolysis in aerobic conditions is a hallmark of cancer. Some anticancer drugs have been designed to exploit elevated glycolysis in cancer cells. For example, lonidamine (LND) inhibits lactate transport, leading to intracellular acidification in cancer cells. Chemical exchange sat...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3287
更新日期:2015-05-01 00:00:00
abstract::The intrinsic nonuniformities in the transmit radiofrequency field from standard quadrature volume resonators at high field are particularly problematic for localized MRS in areas such as the temporal lobe, where a low signal-to-noise ratio and poor metabolite quantification result from destructive B₁⁺ field interfere...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1638
更新日期:2011-08-01 00:00:00
abstract::Patients with different types of mucopolysaccharidoses (MPS) lack specific lysosomal enzymes, which leads to tissue accumulation and urinary excretion of glycosaminoglycans (GAGs). Since little is known about the molecular composition of the excreted GAG fragments, we used two-dimensional [1H,13C]-correlation nuclear ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.833
更新日期:2003-06-01 00:00:00
abstract::Natural abundance proton-decoupled (13)C magnetic resonance spectroscopy was used to establish the in vivo lipid composition of normal adipose tissue and the corresponding effects of altered lipid diets. Experiments were performed on a standard 1.5 T clinical MR scanner using a double-tuned (1)H-(13)C coil. Peaks from...
journal_title:NMR in biomedicine
pub_type: 临床试验,杂志文章
doi:10.1002/nbm.824
更新日期:2003-05-01 00:00:00
abstract::Bone contains a significant fraction of water that is not detectable with ordinary Cartesian imaging sequences. The advent of ultra-short echo-time (UTE) methods has allowed the recovery of this submillisecond T(2)* water. In this work, we have developed a new three-dimensional hybrid-radial ultra-short echo-time (3D ...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1631
更新日期:2011-08-01 00:00:00
abstract::1H MR spectroscopy was used to correlate the metabolite signals in 66 untreated metastatic brain tumors with the results of Gd-DTPA enhanced MRI. Cubic volumes containing brain metastases of lung cancer (n = 17), mammary carcinoma (n = 24), melanoma (n = 12) and those originating from other tumors (n = 13) were examin...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/(SICI)1099-1492(199604)9:2<65::AID-NBM397>
更新日期:1996-04-01 00:00:00
abstract::The parameters that characterize the intricate water diffusion in tumors may serve to reveal their distinct pathology. Specifically, the application of diffusion magnetic resonance imaging (MRI) can aid in characterizing breast cancer, as well as monitoring response to therapy. We present here a non-invasive, quantita...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.882
更新日期:2004-06-01 00:00:00
abstract::Acute hypoxia (transient cycles of hypoxia-reoxygenation) is known to occur in solid tumors and is generally believed to be caused by tumor blood flow instabilities. It was recently demonstrated that T2*-weighted (T2*w) gradient echo (GRE) MRI is a powerful non-invasive method for investigating periodic changes in tum...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1002
更新日期:2006-02-01 00:00:00
abstract::Elevated brain myo-inositol (m-Ins) concentration (a putative marker of neuroinflammation) has been reported in patients suffering from type 2 diabetes mellitus (T2DM). Obesity alone and T2DM have been found to be associated with a lower concentration of N-acetyloaspartate and N-acetylaspartylglutamate (tNAA, a marker...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3957
更新日期:2018-09-01 00:00:00
abstract::d-amino acid oxidase (DAO) is a peroxisomal enzyme that catalyzes the oxidative deamination of several neutral and basic d-amino acids to their corresponding α-keto acids. In most mammalian species studied, high DAO activity is found in the kidney, liver, brain and polymorphonuclear leukocytes, and its main function i...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.4303
更新日期:2020-07-01 00:00:00
abstract::Most ovarian tumors are cystic structures containing variable amounts of fluid. Several studies of ovarian cyst fluid focus on one specific metabolite using conventional assay systems. We examined the potential of (1)H-nuclear magnetic resonance spectroscopy in evaluation of the overall metabolic composition of cyst f...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/1099-1492(200008)13:5<297::aid-nbm648>3.0.
更新日期:2000-08-01 00:00:00
abstract::The purpose of this study was to investigate the effect of gadolinium (III) diethyltriaminepenta-acetic acid (Gd-DTPA) mixed with a fixative on the image contrast between the white and gray matter of the perfusion-fixed mouse brain. A series of microscopic MRI (microMRI) studies using different concentrations of Gd-DT...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1324
更新日期:2009-04-01 00:00:00
abstract::Increased sensitivity and chemical shift dispersion at ultra-high magnetic fields enable the precise quantification of an extended range of brain metabolites from (1)H MRS. However, all previous neurochemical profiling studies using single-voxel MRS at 7 T have been limited to data acquired from the occipital lobe wit...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1727
更新日期:2012-01-01 00:00:00
abstract::Spontaneous fluctuations in the blood oxygenation level-dependent (BOLD) MRI signal during the resting state are increasingly being studied in healthy and diseased brain in humans and animal models. Yet, the relationship between functional brain status and the characteristics of spontaneous BOLD fluctuations remains p...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1556
更新日期:2011-01-01 00:00:00
abstract::Transcranial direct current stimulation (tDCS) is used in numerous clinical studies and considered an effective and versatile add-on therapy in neurorehabilitation. To date, however, the underlying neurobiological mechanisms remain elusive. In a rat model of tDCS, we recently observed a polarity-dependent accumulation...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3244
更新日期:2015-02-01 00:00:00
abstract::Non-alcoholic steatohepatitis (NASH) is characterized at histology by steatosis, hepatocyte ballooning and inflammatory infiltrates, with or without fibrosis. Although diamagnetic material in fibrosis and inflammation can be detected with quantitative susceptibility imaging, fatty acid composition changes in NASH rela...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.3766
更新日期:2017-10-01 00:00:00
abstract::Citicoline supplementation has been used to ameliorate memory disturbances in older people and those with Alzheimer's disease. This study used MRS to characterize the effects of citicoline on high-energy phosphate metabolites and constituents of membrane synthesis in the frontal lobe. Phosphorus ((31)P) metabolite dat...
journal_title:NMR in biomedicine
pub_type: 杂志文章
doi:10.1002/nbm.1281
更新日期:2008-11-01 00:00:00
abstract::This introductory article addresses approaches currently in use to process in vivo spectra. First, a brief overview is given of the information content represented by the parameters of MR signals. Subsequently, common steps in the processing of MR spectra such as pre-processing, normalisation and quantification and th...
journal_title:NMR in biomedicine
pub_type: 杂志文章,评审
doi:10.1002/nbm.707
更新日期:2001-06-01 00:00:00